Molecular and functional analysis of a conserved CTL epitope in HIV-1 p24 recognized from a long-term nonprogressor: Constraints on immune escape associated with targeting a sequence essential for viral replication

Journal of Immunology

Volumn 162, Issue 6, 1999, Pages 3727-3734

  Wagner, Ralf ^a   Leschonsky, Bernd ^a   Harrer, Ellen ^b   Paulus, Christina ^a   Weber, Christine ^b   Walker, Bruce D ^c   Buchbinder, Susan ^d   Wolf, Hans ^a   Kalden, Joachim R ^b   Harrer, Thomas ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d AIDS Office San Francisco   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE;

AMINO ACID SUBSTITUTION; ANTIGEN RECOGNITION; ARTICLE; CASE REPORT; CELL CULTURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; MALE; PRIORITY JOURNAL; VIRUS INFECTIVITY; VIRUS REPLICATION;

ANIMALS; ANTIGENIC VARIATION; CELL LINE, TRANSFORMED; CONSERVED SEQUENCE; COS CELLS; DISEASE PROGRESSION; EPITOPES, T-LYMPHOCYTE; HIV CORE PROTEIN P24; HIV-1; HUMANS; IMMUNE TOLERANCE; MALE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROVIRUSES; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; VIRUS REPLICATION;

EID: 0033559908     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Buchbinder, S. P., M. H. Katz, N. A. Hessol, P. M. O'Malley, and S. D. Holmberg. 1994. Long-term HIV-1 infection without immunologic progression. AIDS 8:1123.
2. Koup, R. A., and D. D. Ho. 1994. Shutting down HIV. Nature 370:416.
3. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650.
4. Safrit, J. T., C. A. Andrews, T. Zhu, D. D. Ho, and R. A. Koup. 1994. Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope. J. Exp. Med. 179:463.
5. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68:6103.
6. Musey, L., J. Hughes, T. Schacker, T. Shea, L. Corey, and M. J. McElrath. 1997. Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N. Engl. J. Med. 337:1267.
7. Rowland-Jones, S., J. Sutton, K. Arijoshi, T. Dong, F. Gotch, S. Mo-Adam, D. Whitby, S. Sabally, A. Allimore, T. Corrah, et al. 1995. HIV-specific cytotoxic T-cells in HIV exposed but uninfected Gambian woman. Nat. Med. 1:59.
8. Bryson, Y. J., S. Pang, and L. Wi. 1995. A child found to be HIV positive shortly after birth appears now to be clear of the infection. Nurs. Times 91:11.
9. Newell, M. L., D. Dunn, A. De Maria, A. Ferrazin, A. De Rossi, C. Giaquinto, J. Levy, A. Alimenti, A. Ehrnst, A. B. Bohlin, et al. 1996. Detection of virus in vertically exposed HIV-antibody-negative children. Lancet 347:213.
10. Pinto, L. A., J. Sullivan, J. A. Berzofsky, M. Clerici, H. A. Kessler, A. L. Landay, and G. M. Shearer. 1995. ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. J. Clin. Invest. 96:867.
11. Harrer, E., T. Harrer, S. Buchbinder, D. L. Mann, M. Feinberg, T. Yilma, R. P. Johnson, and B. D. Walker. 1994. HIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons. AIDS Res. Hum. Retroviruses 10(Suppl 2):S77.
12. Rinaldo, C., X. L. Huang, Z. F. Fan, M. Ding, L. Beltz, A. Logar, D. Panicali, G. Mazzara, J. Liebmann, M. Cottrill, et al. 1995. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J. Virol. 69:5838.
13. Rinaldo, C. R., Jr., L. A. Beltz, X. L. Huang, P. Gupta, Z. Fan, and D. J. Torpey. 1995. Anti-HIV type 1 cytotoxic T lymphocyte effector activity and disease progression in the first 8 years of HIV type 1 infection of homosexual men. AIDS Res. Hum. Retroviruses 11:481.
14. Klenerman, P., R. E. Phillips, C. R. Rinaldo, L. M. Wahl, G. Ogg, R. M. May, A. J. McMichael, and M. A. Nowak. 1996. Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection. Proc. Natl. Acad. Sci. USA 93:15323.
15. Cao, Y., L. Qin, L. Zhang, J. Safrit, and D. D. Ho. 1995. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N. Engl. J. Med. 332:201.
16. Walker, B. D., S. Chakrabarti, B. Moss, T. J. Paradis, T. Flynn, A. G. Durno, R. S. Blumberg, J. C. Kaplan, M. S. Hirsch, and R. T. Schooley. 1987. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 328:345.
17. Hoffenbach, A., P. Langlade Demoyen, G. Dadaglio, E. Vilmer, F. Michel, C. Mayaud, B. Autran, and F. Plata. 1989. Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. J. Immunol. 142:452.
18. Carmichael, A., X. Jin, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249.
19. Ogg, G. S., X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland Jones, V. Cerundolo, et al. 1998. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279:2103.
20. van der Burg, S. H., M. R. Klein, O. Pontesilli, A. M. Holwerda, J. W. Drijfhout, W. M. Kast, F. Miedema, and C. J. Melief. 1997. HIV-1 reverse transcriptase-specific CTL against conserved epitopes do not protect against progression to AIDS. J. Immunol. 159:3648.
21. + A24-restricted cytotoxic T lymphocytes. J. Virol. 66: 3151.
22. Haas, G., U. Plikat, P. Debre, M. Lucchiari, C. Katlama, Y. Dudoit, O. Bonduelle, M. Bauer, H. G. Ihlenfeldt, G. Jung, et al. 1996. Dynamics of viral variants in HIV-1 Nef and specific cytotoxic T lymphocytes in vivo. J. Immunol. 157:4212.
23. Goulder, P. J., R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, and et al. 1997. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3:212.
24. Goulder, P. J., A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. 1997. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibitity leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J. Exp. Med. 185: 1423.
25. Price, D. A., P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA 94:1890.
26. Phillips, R. E., S. Rowland Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, et al. 1991. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354:453.
27. Harrer, E., T. Harrer, P. Barbosa, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. 1996. Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor. J. Infect. Dis. 173:476.
28. Harrer, T., E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. 1996. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection-breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J. Immunol. 156:2616.
29. Klein, M. R., C. A. van Baalen, A. M. Holwerda, S. R. Kerkhof Garde, R. J. Bende, I. P. Keel, J. K. Eeftinck Schattenkerk, A. D. Osterhaus, H. Schuitemaker, and F. Miedema. 1995. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressers and long-term asymptomatics. J. Exp. Med. 181:1365.
30. + lymphocyte activity. J. Infect. Dis. 172:329.
31. Harrer, T., E. Harrer, S. A. Kalams, T. Elbeik, S. I. Staprans, M. B. Feinberg, Y. Z. Cao, D. D. Ho, T. Yilma, A. M. Caliendo, et al. 1996. Strong cytotoxic T cell and weak neutralizing antibody response in a subset of persons with stable nonprogression HIV type 1 infection. AIDS Res. Hum. Retroviruses 12:585.
32. DiBrino, M., K. C. Parker, D. H. Margulies, J. Shiloach, R. V. Turner, W. E. Biddison, and J. E. Coligan. 1994. The HLA-B14 peptide binding site can accommodate peptides with different combinations of anchor residues. J. Biol. Chem. 269:32426.
33. Ratner, L., W. Haseltine, R. Patarca, K. J. Livak, B. Starcich, S. F. Josephs, E. R. Doran, J. A. Rafalski, E. A. Whitehorn, K. Baumeister, et al. 1985. Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 313:277.
34. Wills, J. W., R. C. Craven, R. A. Weldon, Jr., T. D. Nelle, and C. R. Erdie. 1991. Suppression of retroviral MA deletions by the amino-terminal membrane-binding domain of p60src. J. Virol. 65:3804.
35. Orlinsky, K. J., J. Gu, M. Hoyt, S. Sandmeyer, and T. M. Menees. 1996. Mutations in the Ty3 major homology region affect multiple steps in Ty3 retrotransposition. J. Virol. 70:3440.
36. Myers, G., B. Korber, S. Wain Hobson, K. T. Jeang, L. E. Henderson, and G. N. Pavlakis. 1994. Human Retroviruses and AIDS. A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences. Los Alamos National Laboratory, Los Alamos, NM.
37. Walker, B. D., C. Flexner, K. Birch Limberger, L. Fisher, T. J. Paradis, A. Aldovini, R. Young, B. Moss, and R. T. Schooley. 1989. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type. Proc. Natl. Acad. Sci. USA 86:9514.
38. Wagner, R., S. Modrow, T. Boltz, H. Fliessbach, M. Niedrig, A. von Brunn, and H. Wolf. 1992. Immunological reactivity of a human immunodeficiency virus type 1 derived peptide representing a consensus sequence of the GP120 major neutralizing region V3. Arch. Virol. 127:139.
39. gag/V3 chimeric vaccinia viruses. J. Gen. Virol. 74:1261.
40. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745.
41. Sussman, D. J., and G. Milman. 1984. Short-term, high-efficiency expression of transfected DNA. Mol. Cell. Biol. 4:1641.
42. Dayhoff, M. O., R. von Eck, and C. M. Park. 1972. A model for evolutionary change in proteins. In Atlas of Protein Sequence and Structure. 5th Ed. M.O. Dayhoff, ed. National Biomedical Research Foundation Washington, DC, p. 89.
43. Wills, J. W., and R. C. Craven. 1991. Form, function, and use of retroviral gag proteins. AIDS 5:639.
44. Mammano, F., A. Ohagen, S. Hoglund, and H. G. Gottlinger. 1994. Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis. J. Virol. 68:4927.
45. Strambio de Castillia, C., and E. Hunter. 1992. Mutational analysis of the major homology region of Mason-Pfizer monkey virus by use of saturation mutagenesis. J. Virol. 66:7021.
46. Craven, R. C., A. E. Leure duPree, R. A. Weldon, Jr., and J. W. Wills. 1995. Genetic analysis of the major homology region of the Rous sarcoma virus Gag protein. J. Virol. 69:4213.
47. Gamble, R. T., F. F. Vajdos, S. Yoo, M. Houseweart, W. J. Sundquist, and P. C. Hill. 1996. Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid. Cell 1285.
48. Huang, M., and M. A. Martin. 1997. Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein. J. Virol. 71:4472.
49. Tsomides, T. J., A. Aldovini, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180:1283.
50. Malkovsky, M. 1996. HLA and natural history of HIV infection. Lancet 348:142.
51. Kaslow, R. A., M. Carrington, R. Apple, L. Park, A. Munoz, A. J. Saah, J. J. Goedert, C. Winkler, S. J. O'Brien, C. Rinaldo, et al. 1996. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat. Med. 2:405.
52. McNeil, A. J., P. L. Yap, S. M. Gore, R. P. Brettle, M. McColl, R. Wyld, S. Davidson, R. Weightman, A. M. Richardson, and J. R. Robertson. 1996. Association of HLA types A1-B8-DR3 and B27 with rapid and slow progression of HIV disease. Q. J. Med. 89:177.