Effects of in Vivo CD8+ T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine

Journal of Experimental Medicine

Volumn 191, Issue 11, 2000, Pages 1921-1931

  Metzner, Karin J ^a   Jin, Xia ^a   Lee, Fred V ^a   Gettie, Agegnehu ^a   Bauer, Daniel E ^a   Di Mascio, Michele ^b   Perelson, Alan S ^b   Marx, Preston A ^a,c   Ho, David D ^a   Kostrikis, Leondios G ^a   Connor, Ruth I ^a,d  

^a ROCKEFELLER UNIVERSITY   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

^c TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^d AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

CD8+ T lymphocytes; Differential PCR; Live attenuated vaccine; OKT8F; Simian immunodeficiency virus

Indexed keywords

LIVE VACCINE; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNIZATION; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; T LYMPHOCYTE; VIREMIA; VIRUS DETECTION; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; ANTIGENS, CD20; CD8-POSITIVE T-LYMPHOCYTES; DNA, VIRAL; LYMPH NODES; LYMPHOCYTE DEPLETION; MACACA MULATTA; RECEPTORS, IGG; RNA, VIRAL; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINATION; VACCINES, ATTENUATED; VIRAL LOAD; VIRAL VACCINES; VIRUS REPLICATION;

EID: 0034608653     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.11.1921     Document Type: Article

References (47)

1. Baba, T.W., Y.S. Jeong, D. Pennick, R. Bronson, M.F. Greene, and R.M. Ruprecht. 1995. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science. 267:1820-1825.
2. Baba, T.W., V. Liska, A.H. Khimani, N.B. Ray, P.J. Dailey, D. Penninck, R. Bronson, M.F. Greene, H.M. McClure, L.N. Martin, et al. 1999. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Natl. Med. 5:1-10.
3. Connor, R.I., D.C. Montefiori, J.M. Binley, J.P. Moore, S. Bonhoeffer, A. Gettie, E.A. Fenamore, K.E. Sheridan, D.D. Ho, P.J. Daileyt, et al. 1998. Temporal analysis of virus replication, immune responses and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. J. Virol. 72:7501-7509.
4. Lewis, M.G., J. Yalley-Ogunro, J.J. Greenhouse, T.P. Brennan, J.B. Jiang, T.C. VanCott, Y. Lu, G.A. Eddy, and D.L. Birx. 1999. Limited protection from a pathogenic chimeric simian-human immunodeficiency virus challenge following immunization with attenuated simian immunodeficiency virus. J. Virol. 73:1262-1270.
5. Johnson, R.P., and R.C. Desrosiers. 1998. Protective immunity induced by live, attenuated simian immunodeficiency virus. Curr. Opin. Immunol. 10:436-443.
6. Daniel, M.D., F. Kirchhoff, S.C. Czajak, P.K. Sehgal, and R.C. Desrosiers. 1992. Protective effects of a live attenuated vaccine with a deletion in the nef gene. Science. 258:1938-1941.
7. Marthas, M.L., S. Sutjipto, C.J. Miller, J. Higgnis, J. Torten, R.E. Unger, P.A. Marx, and N.C. Pedersen. 1992. Efficacy of live-attenuated and whole-inactivated SIV vaccines against intravenous and vaginal challenge. In Vaccines. Vol. 92. F. Brown, R.M. Chanock, H.S. Ginsberg, and R.A. Lerner, editors. Cold Spring Harbor Press, Cold Spring Harbor, NY. 117-121.
8. Lohman, B.L., M.B. McChesney, C.J. Miller, E. McGowan, S.M. Joye, K.K.A. Van Romapy, E. Reay, L. Antipa, N.C. Pedersen, and M.L. Marthas. 1994. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J. Virol. 68:7021-7029.
9. Clements, J.E., R.C. Montelaro, M.C. Zink, A.M. Amedee, S. Miller, A.M. Trichel, B. Jagerski, D. Hauer, L.N. Martin, R.P. Bohm, et al. 1995. Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. J. Virol. 69:2737-2744.
10. Wyand, M.S., K.H. Manson, M. Garcia-Moll, D. Montefiori, and R.C. Desrosiers. 1996. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J. Virol. 70:3724-3733.
11. Stahl-Hennig, C., U. Dittmer, T. Nisslein, H. Petry, E. Jurkiewicz, D. Fuchs, H. Wachter, K. Matz-Rensing, E.M. Kuhn, F.J. Kaup, et al. 1996. Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus. J. Gen. Virol. 77:2969-2981.
12. Norley, S., B. Beer, D. Binninger-Schinzel, C. Cosma, and R. Kurth. 1996. Protection from pathogenic SIVmac challenge following short-term infection with a nef-deficient attenuated virus. Virology. 219:195-205.
13. Shibata, R., C. Siemon, S.C. Czajak, R.C. Desrosiers, and M.A. Martin. 1997. Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus. J. Virol. 71:8141-8148.
14. Wyand, M.S., K. Manson, D.C. Montefiori, J.D. Lifson, R.P. Johnson, and R.C. Desrosiers. 1999. Protection by live, attenuated simian immunodeficiency virus against heterologous challenge. J. Virol. 73:8355-8363.
15. Montefiori, D.C., T.W. Baba, A. Li, M. Bilska, and R.M. Ruprecht. 1996. Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239Δ3 in adult and infant rhesus monkeys. J. Immunol. 157:5528-5535.
16. Cole, K.S., J.L. Rowles, M. Murphey-Corb, J.E. Clements, J. Robinson, and R.C. Montelaro. 1997. A model for the maturation of protective antibody responses to SIV envelope proteins in experimentally immunized monkeys. J. Med. Primatol. 26:51-58.
17. Gundlach, B.R., S. Reiprich, S. Sopper, R.E. Means, U. Dittmer, K. Matz-Rensing, C. Stahl-Hennig, and K. Uberla. 1998. Env-independent protection induced by live, attenuated simian immunodeficiency virus vaccines. J. Virol. 72: 7846-7851.
18. Nilsson, C., B. Mäkitalo, R. Thorstensson, S. Norley, D. Binninger-Schinzel, M. Cranage, E. Rud, G. Biberfeld, and P. Putkonen. 1998. Live, attenuated simian immunodeficiency virus (SIV)mac in macaques can induce protection against mucosal infection with SIVsm. AIDS. 12:2261-2270.
19. Robinson, J.E., K.S. Cole, D.H. Elliott, H. Lam, A.M. Amedee, R. Means, R.C. Desrosiers, J. Clements, R.C. Montelaro, and M. Murphey-Corb. 1998. Production and characterization of SIV envelope-specific rhesus monoclonal antibodies from a macaque asymptomatically infected with a live SIV vaccine. AIDS Res. Hum. Retroviruses. 14:1253-1262.
20. Almond, N., J. Rose, R. Sangster, P. Silvera, R. Stebbings, B. Walker, and E.J. Stott. 1997. Mechanisms of protection induced by attenuated simian immunodeficiency virus I. Protection cannot be transferred with immune serum. J. Gen. Virol. 78:1919-1922.
21. Dittmer, U., T. Niblein, W. Bodemer, H. Petry, U. Sauermann, C. Stahl-Hennig, and G. Hunsmann. 1995. Cellular immune response of rhesus monkeys infected with a partially attenuated nef deletion mutant of the simian immunodeficiency virus. Virology. 212:392-397.
22. Johnson, R.P., R.L. Glickman, J.Q. Yang, A. Kaur, J.T. Dion, M.J. Mulligan, and R.C. Desrosiers. 1997. Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus. J. Virol. 71:7711-7718.
23. Cranage, M.P., A.M. Whatmore, S.A. Sharpe, N. Cook, N. Polyanskaya, S. Leech, J.D. Smith, E.W. Rud, M.J. Dennis, and G.A. Hall. 1997. Macaques infected with live attenuated SIVmac are protected against superinfection via the rectal mucosa. Virology. 229:143-154.
24. Koup, R.A., J.T. Safrit, Y. Cao, C.A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D.D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary HIV-1 syndrome. J. Virol. 68: 4650-4655.
25. Reimann, K.A., K. Tenner-Racz, P. Racz, D.C. Montefiori, Y. Yasutomi, B.J. Ransil, and N.L. Letvin. 1994. Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. J. Virol. 68: 2362-2370.
26. + lymphocyte response in acutely infected rhesus monkeys. J. Virol. 67:1707-1711.
27. Cao, Y., L. Qin, L. Zhang, J. Safrit, and D.D. Ho. 1995. Virological and immunological characterization of long-term survivors of human immunodeficiency virus type I infection. N. Engl. J. Med. 332:201-208.
28. Dyer, W.B., G.S. Ogg, M.A. Demoitie, X. Jin, A.F. Geczy, S.L. Rowland-Jones, A.J. McMichael, D.F. Nixon, and J.S. Sullivan. 1999. Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank cohort patients infected with nef-defective HIV type 1. J. Virol. 73:436-443.
29. + T cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 189:991-998.
30. + lymphocytes. Science. 283:857-860.
31. Matano, T., R. Shibata, C. Siemon, M. Connors, H.C. Lane, and M.A. Martin. 1998. Administration of anti-CD8 monoclonal antibody interferes with clearance of chimeric simian/ human immunodeficiency virus during primary infections of rhesus macaques. J. Virol. 72:164-169.
32. Stebbings, R., J. Stott, N. Almond, R. Hull, J. Lines, P. Silvera, R. Sangster, T. Corcoran, J. Rose, S. Cobbold, et al. 1998. Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection. AIDS Res. Hum. Retroviruses. 14: 1187-1198.
33. Kostrikis, L.G., S. Tyagi, M.M. Mhlanga, D.D. Ho, and F.R. Kramer. 1998. Spectral genotyping of human alleles. Science. 279:1228-1229.
34. Tyagi, S., and F.R. Kramer. 1996. Molecular beacons: probes that fluoresce upon hybridization. Nat. Biotechnol. 14:303-308.
35. Tyagi, S., D.P. Bratu, and F.R. Kramer. 1998. Multicolor molecular beacons for allele discrimination. Nat. Biotechnol. 16:49-53.
36. Regier, D.A., and R.C. Desrosiers. 1990. The complete nucleotide sequence of a pathogenic clone of simian immunodeficiency virus. AIDS Res. Hum. Retroviruses. 6:1221-1231.
37. Suryanarayana, K., T.A. Wiltrout, G.M. Vasquez, V.M. Hirsch, and J.D. Lifson. 1998. Plasma SIV RNA viral load by determination by real-time quantification of product generation in reverse-transcriptase-polymerase chain reaction. AIDS Res. Hum. Restroviruses. 14:183-189.
38. Dailey, P.J., M. Zamroud, R. Kelso, J. Kolberg, and M. Urdea. 1995. Quantitation of simian immunodeficiency virus (SIV) RNA in plasma of acute and chronically infected macaques using a branched DNA (bDNA) signal amplification assay. J. Med. Primatol. 24:209.
39. + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen. J. Exp. Med. 187:1295-1303.
40. + T lymphocytes from macaques immunized with live attenuated SIV. J. Virol. 72:6315-6324.
41. Ahmed, R.K., C. Nilsson, Y. Wang, T. Lehner, G. Biberfeld, and R. Thorstensson. 1999. Beta-chemokine production in macaques vaccinated with live, attenuated virus correlates with protection against simian immunodeficiency virus (SIVsm) challenge. J. Gen. Virol. 80:1569-1574.
42. Nixon, D.F., S.M. Donahoe, W.M. Kakimoto, R.V. Samuel, K.J. Metzner, A. Gettie, T. Hanke, P.A. Marx, and R.I. Connor. 2000. Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine. Virology. 266:2113-210.
43. Jonker, M., F.J. Nooij, P. van Suylichem, P. Neuhaus, and G. Goldstein. 1986. The influence of OKT8F treatment on allograft survival in rhesus monkeys. Transplantation. 41:431-435.
44. Zlabinger, G.J., K.M. Stuhlmeier, R. Eher, S. Schmaldienst, R. Klauser, A. Vychytil, B. Watschinger, O. Traindl, J. Kovarik, and E. Pohanka. 1992. Cytokine release and dynamics of leukocyte populations after CD3/TCR monoclonal antibody treatment. J. Clin. Immunol. 12:170-177.
45. Evans, D.T., D.H. O'Connor, P. Jing, J.L. Dzuris, J. Sidney, J. da Silva, T.M. Allen, H. Horton, J.E. Venham, R.A. Rudersdorf, et al. 1999. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nat. Med. 5:1270-1276.
46. + nef-specific cytotoxic T cells in vaccinated macaques. Nat. Med. 1:1167-1173.
47. Sharpe, S.A., A.M. Whatmore, G.A. Hall, and M.P. Cranage. 1997. Macaques infected with attenuated simian immunodeficiency virus resist superinfection with virulence-revenant virus. J. Gen. Virol. 78:1923-1927.