Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis

Journal of Immunology

Volumn 184, Issue 6, 2010, Pages 3079-3086

  Wiersinga, W Joost ^a   Kager, Liesbeth M ^a   Hovius, Joppe W R ^a   Van Der Windt, Gerritje J W ^a   De Vos, Alex F ^a   Meijers, Joost C M ^a   Roelofs, Joris J ^a   Dondorp, Arjen ^b   Levi, Marcel ^a   Day, Nicholas P ^b,c   Peacock, Sharon J ^b,c   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MAHIDOL UNIVERSITY   (Thailand)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; UROKINASE RECEPTOR;

ADULT; AGED; ANIMAL CELL; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; BACTERIAL GROWTH; BACTERIAL IMMUNITY; BURKHOLDERIA PSEUDOMALLEI; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; GRANULOCYTE; HEPATITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MELIOIDOSIS; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PNEUMONIA; PRIORITY JOURNAL; WILD TYPE; ADOLESCENT; ANIMAL; BACTEREMIA; BACTERIAL PNEUMONIA; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; GENETICS; IMMUNOLOGY; MICROBIOLOGY; MIDDLE AGED; MIGRATION INHIBITION; MOUSE MUTANT; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BACTEREMIA; BURKHOLDERIA PSEUDOMALLEI; CELL MIGRATION INHIBITION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; MELIOIDOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; NEUTROPHIL INFILTRATION; NEUTROPHILS; PHAGOCYTOSIS; PNEUMONIA, BACTERIAL; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR;

EID: 77951918695     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901008     Document Type: Article

References (47)

1. Blasi, F., and P. Carmeliet. 2002. uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell Biol. 3: 932-943.
2. Plesner, T., N. Behrendt, and M. Ploug. 1997. Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR. Stem Cells 15: 398-408. (Pubitemid 27513714)
3. Mondino, A., and F. Blasi. 2004. uPA and uPAR in fibrinolysis, immunity and pathology. Trends Immunol. 25: 450-455. (Pubitemid 38951087)
4. Bergmann, S., and S. Hammerschmidt. 2007. Fibrinolysis and host response in bacterial infections. Thromb. Haemost. 98: 512-520.
5. Wei, C., C. C. Möller, M. M. Altintas, J. Li, K. Schwarz, S. Zacchigna, L. Xie, A. Henger, H. Schmid, M. P. Rastaldi, et al. 2008. Modification of kidney barrier function by the urokinase receptor. Nat. Med. 14: 55-63.
6. Idell, S. 2003. Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit. Care Med. 31: (4 Suppl)S213-S220.
7. Gyetko, M. R., S. Sud, T. Kendall, J. A. Fuller, M. W. Newstead, and T. J. Standiford. 2000. Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J. Immunol. 165: 1513-1519.
8. Rijneveld, A.W., M. Levi, S. Florquin, P. Speelman, P. Carmeliet, and T. van Der Poll. 2002. Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. J. Immunol. 168: 3507-3511.
9. Dekkers, P. E., T. ten Hove, A. A. te Velde, S. J. van Deventer, and T. van Der Poll. 2000. Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia. Infect. Immun. 68: 2156-2160.
10. Juffermans, N. P., P. E. Dekkers, A. Verbon, P. Speelman, S. J. van Deventer, and T. van der Poll. 2001. Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia. Infect. Immun. 69: 5182-5185.
11. White, N. J. 2003. Melioidosis. Lancet 361: 1715-1722.
12. Wiersinga, W. J., T. van der Poll, N. J. White, N. P. Day, and S. J. Peacock. 2006. Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat. Rev. Microbiol. 4: 272-282.
13. Wiersinga, W. J., J. C. Meijers, M. Levi, C. Van 't Veer, N. P. Day, S. J. Peacock, and T. van der Poll. 2008. Activation of coagulation with concurrent impairment of anticoagulant mechanisms correlates with a poor outcome in severe melioidosis. J. Thromb. Haemost. 6: 32-39.
14. Currie, B. J. 2003. Melioidosis: an important cause of pneumonia in residents of and travellers returned from endemic regions. Eur. Respir. J. 22: 542-550.
15. Easton, A., A. Haque, K. Chu, R. Lukaszewski, and G. J. Bancroft. 2007. A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei. J. Infect. Dis. 195: 99-107.
16. Wiersinga, W. J., C. T. Veer, C. W. Wieland, S. Gibot, B. Hooibrink, N. P. Day, S. J. Peacock, and T. van der Poll. 2007. Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis. J. Infect. Dis. 196: 1707-1716.
17. Jones, A. L., T. J. Beveridge, and D. E. Woods. 1996. Intracellular survival of Burkholderia pseudomallei. Infect. Immun. 64: 782-790.
18. Egan, A. M., and D. L. Gordon. 1996. Burkholderia pseudomallei activates complement and is ingested but not killed by polymorphonuclear leukocytes. Infect. Immun. 64: 4952-4959.
19. Breitbach, K., K. Rottner, S. Klocke, M. Rohde, A. Jenzora, J. Wehland, and I. Steinmetz. 2003.Actin-basedmotility of Burkholderia pseudomallei involves theArp 2/3 complex, but not N-WASP and Ena/VASP proteins. Cell. Microbiol. 5: 385-393.
20. Stevens, M. P., M. W. Wood, L. A. Taylor, P. Monaghan, P. Hawes, P. W. Jones, T. S. Wallis, and E. E. Galyov. 2002. An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen. Mol. Microbiol. 46: 649-659.
21. Levy, M. M., M. P. Fink, J. C. Marshall, E. Abraham, D. Angus, D. Cook, J. Cohen, S. M. Opal, J. L. Vincent, G. Ramsay, and SCCM/ESICM/ACCP/ATS/SIS. 2003. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit. Care Med. 31: 1250-1256.
22. Wiersinga, W. J., C. W. Wieland, M. C. Dessing, N. Chantratita, A. C. Cheng, D. Limmathurotsakul, W. Chierakul, M. Leendertse, S. Florquin, A. F. de Vos, et al. 2007. Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med. 4: e248.
23. Lupberger, J., K. A. Kreuzer, G. Baskaynak, U. R. Peters, P. le Coutre, and C. A. Schmidt. 2002. Quantitative analysis of beta-actin, beta-2-microglobulin and porphobilinogen deaminase mRNA and their comparison as control transcripts for RT-PCR. Mol. Cell. Probes 16: 25-30.
24. Dewerchin, M., A. V. Nuffelen, G. Wallays, A. Bouché, L. Moons, P. Carmeliet, R. C. Mulligan, and D. Collen. 1996. Generation and characterization of urokinase receptor-deficient mice. J. Clin. Invest. 97: 870-878.
25. DeShazer, D. 2004. Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei-specific prophage in B. pseudomallei 1026b. J. Bacteriol. 186: 3938-3950. (Pubitemid 38746070)
26. Jeddeloh, J. A., D. L. Fritz, D. M. Waag, J. M. Hartings, and G. P. Andrews. 2003. Biodefense-driven murine model of pneumonic melioidosis. Infect. Immun. 71: 584-587.
27. Knapp, S., U. Matt, N. Leitinger, and T. van der Poll. 2007. Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo. J. Immunol. 178: 993-1001. (Pubitemid 46095173)
28. Verheijen, J. H., E. Mullaart, G. T. Chang, C. Kluft, and G. Wijngaards. 1982. A simple, sensitive spectrophotometric assay for extrinsic (tissue-type) plasminogen activator applicable to measurements in plasma. Thromb. Haemost. 48: 266-269.
29. Wiersinga, W. J., A. F. de Vos, R. de Beer, C. W. Wieland, J. J. Roelofs, D. E. Woods, and T. van der Poll. 2008. Inflammation patterns induced by different Burkholderia species in mice. Cell. Microbiol. 10: 81-87.
30. Roelofs, J. J., K. M. Rouschop, J. C. Leemans, N. Claessen, A. M. de Boer, W. M. Frederiks, H. R. Lijnen, J. J. Weening, and S. Florquin. 2006. Tissue-type plasminogen activator modulates inflammatory responses and renal function in ischemia reperfusion injury. J. Am. Soc. Nephrol. 17: 131-140.
31. Rijneveld, A.W., S. Weijer, S. Florquin, C. T. Esmon, J. C. Meijers, P. Speelman, P. H. Reitsma, H. Ten Cate, and T. van der Poll. 2004. Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. Blood 103: 1702-1709.
32. Blander, J. M., and R. Medzhitov. 2004. Regulation of phagosome maturation by signals from toll-like receptors. Science 304: 1014-1018.
33. Wan, C. P., C. S. Park, and B. H. Lau. 1993. A rapid and simple microfluorometric phagocytosis assay. J. Immunol. Methods 162: 1-7. (Pubitemid 23171267)
34. Wiersinga, W. J., A. F. de Vos, R. de Beer, C. W. Wieland, J. J. Roelofs, D. E. Woods, and T. van der Poll. 2008. Inflammation patterns induced by different Burkholderia species in mice. Cell Microbiol 10: 81-87.
35. Strieter, R. M., J. A. Belperio, and M. P. Keane. 2002. Cytokines in innate host defense in the lung. J. Clin. Invest. 109: 699-705.
36. Florquin, S., J. G. van den Berg, D. P. Olszyna, N. Claessen, S. M. Opal, J. J. Weening, and T. van der Poll. 2001. Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia. Kidney Int. 59: 2054-2061. (Pubitemid 32467596)
37. Wagner, J. G., and R. A. Roth. 2000. Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature. Pharmacol. Rev. 52: 349-374.
38. Craig, A., J. Mai, S. Cai, and S. Jeyaseelan. 2009. Neutrophil recruitment to the lungs during bacterial pneumonia. Infect. Immun. 77: 568-575.
39. Gyetko, M. R., D. Aizenberg, and L. Mayo-Bond. 2004. Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro. J. Leukoc. Biol. 76: 648-656.
40. Paul, R., F. Winkler, I. Bayerlein, B. Popp, H. W. Pfister, and U. Koedel. 2005. Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental pneumococcal meningitis. J. Infect. Dis. 191: 776-782.
41. Kespichayawattana, W., P. Intachote, P. Utaisincharoen, and S. Sirisinha. 2004. Virulent Burkholderia pseudomallei is more efficient than avirulent Burkholderia thailandensis in invasion of and adherence to cultured human epithelial cells. Microb. Pathog. 36: 287-292.
42. Roelofs, J. J., K. M. Rouschop, G. J. Teske, N. Claessen, J. J. Weening, T. van der Poll, and S. Florquin. 2006. The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis. Kidney Int. 70: 1942-1947.
43. D'Alessio, S., and F. Blasi. 2009. The urokinase receptor as an entertainer of signal transduction. Front. Biosci. 14: 4575-4587.
44. Paul, R., B. Obermaier, J. Van Ziffle, B. Angele, H. W. Pfister, C. A. Lowell, and U. Koedel. 2008. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J. Leukoc. Biol. 84: 1141-1150.
45. Bugge, T. H., M. J. Flick, M. J. Danton, C. C. Daugherty, J. Romer, K. Dano, P. Carmeliet, D. Collen, and J. L. Degen. 1996. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proc. Natl. Acad. Sci. USA 93: 5899-5904.
46. Yamamoto, K., and D. J. Loskutoff. 1996. Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator. J. Clin. Invest. 97: 2440-2451.
47. Barazzone, C., D. Belin, P. F. Piguet, J. D. Vassalli, and A. P. Sappino. 1996. Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. J. Clin. Invest. 98: 2666-2673.