Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)

PLoS Medicine

Volumn 4, Issue 7, 2007, Pages 1268-1280

  Wiersinga, W Joost ^a   Wieland, Catharina W ^a   Dessing, Mark C ^a   Chantratita, Narisara ^b   Cheng, Allen C ^c   Limmathurotsakul, Direk ^b   Chierakul, Wirongrong ^b   Leendertse, Masja ^a   Florquin, Sandrine ^a   De Vos, Alex F ^a   White, Nicholas ^b,d   Dondorp, Arjen M ^b   Day, Nicholas P ^b,d   Peacock, Sharon J ^b,d   Van Der Poll, Tom ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b MAHIDOL UNIVERSITY   (Thailand)

^c MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN MD 2; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BLOOD; BURKHOLDERIA PSEUDOMALLEI; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; EMBRYO; EXPERIMENTAL INFECTION; FEMALE; GENE EXPRESSION; GRAM NEGATIVE INFECTION; GRANULOCYTE; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; INFECTION RESISTANCE; INFECTION SENSITIVITY; KNOCKOUT MOUSE; LUNG ALVEOLUS MACROPHAGE; MALE; MELIOIDOSIS; MONOCYTE; MOUSE; NONHUMAN; ORGAN INJURY; PNEUMONIA; PROTEIN FUNCTION; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL; UPREGULATION; WILD TYPE;

EID: 34547607225     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0040248     Document Type: Article

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