Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 12, 1996, Pages 5899-5904

  Bugge, Thomas H ^a,b   Flick, Matthew J ^a   Danton, Mary Jo S ^a   Daugherty, Cynthia C ^a   Rømer, John ^b   Danø, Keld ^b   Carmeliet, Peter ^c   Collen, Désiré ^c   Degen, Jay L ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b FINSEN LABORATORY   (Denmark)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

fibrinolysis; gene targeting; urokinase receptor; wound healing

Indexed keywords

FIBRIN; PLASMINOGEN; RECEPTOR; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FERTILITY; FIBRINOLYSIS; GENE TARGETING; IMMUNOBLOTTING; LIVER; MICROSCOPY; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PLASMINOGEN ACTIVATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WOUND; WOUND HEALING;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FIBRIN; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, CELL SURFACE; TISSUE PLASMINOGEN ACTIVATOR; URINARY PLASMINOGEN ACTIVATOR; WOUND HEALING;

EID: 0029952542     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.12.5899     Document Type: Article

References (45)

1. Coden, D. & Lijnen, H. R. (1994) in The Molecular Basis of Blood Diseases, eds. Stamatoyannopoulos, G. S., Nienhuis, A. W., Majerus, P. W. & Varmus, H. (Saunders, Philadelphia), pp. 725-752.
2. Bugge, T. H., Flick, M. J., Daugherty, C. C. & Degen, J. L. (1995) Genes Dev. 9, 794-807.
3. Ploplis, V. A., Carmeliet, P., Vazirzadeh, S., Van Vlaenderen, I., Moons, L., Plow, E. & Collen, D. (1995) Circulation 92, 2585-2593.
4. Carmeliet, P., Schoonjans, L., Kieckens, L., Ream, B., Degen, J. L., Bronson, R., De Vos, R., van den Oord, J. J., Collen, D. & Mulligan, R. C. (1994) Nature (London) 368, 419-424 .
5. Blasi, F., Vassalli, J.-D. & Danø, K. (1987) J. Cell Biol. 104, 801-804.
6. Ellis, V. & Danø, K. (1992) Fibrinolysis 6, 27-34.
7. Vassalli, J.-D. (1994) Fibrinolysis 8, 172-181.
8. Bugge, T. H., Suh, T. T., Flick, M. J., Daugherty, C. C., Rømer, J., Solberg, H., Ellis, V., Danø, K. & Degen, J. L. (1995) J. Biol. Chem. 270, 16886-16894.
9. Dewerchin, M., Van Nuffelen, A., Wallays, G., Bouché, A., Moons, L., Carmeliet, P., Mulligan, R. C. & Collen, D. (1996) J. Clin. Invest. 97, 870-878.
10. Rømer, J., Bugge, T. H., Pyke, C., Lund, L. R., Flick, M. J., Degen, J. L. & Danø, K. (1996) Nat. Med. 2, 287-292.
11. Rickles, R. J., Darrow, A. L. & Strickland, S. (1988)J. Biol. Chem. 263, 1563-1569.
12. Beck, E., Ludwig, G., Ausserwald, E. A., Reiss, B. & Schaller, H. (1982) Gene 19, 327-336.
13. Suh, T. T, Holmbäck, K., Jensen, N. J., Daugherty, C. C., Small, K., Simon, D. I., Potter, S. S. & Degen, J. L. (1995) Genes Dev. 9, 2020-2033.
14. Unkeless, J. C., Gordon, S. & Reich, E. (1974) J. Exp. Med. 139, 834-850.
15. Vassalli, J.-D., Hamilton, J. & Reich, E. (1977) Cell 11, 695-705.
16. Vassalli, J.-D., Wohlwend, A. & Belin, D. (1992) Curr. Top. Microbiol. Immunol. 181, 65-86.
17. Solberg, H., Løber, D., Eriksen, J., Ploug, M., Rønne, E., Behrendt, N., Danø, K. & Høyer-Hansen, G. (1992) Eur. J. Bi0chem. 205, 451-458.
18. Ploug, M., Plesner, T., Rønne, E., Ellis, V., Høyer-Hanson, G. & Danø, K. (1992) Blood 79, 1447-1455.
19. Rotoli, B. & Luzzatto, L. (1989) Semin. Hematol. 26, 201-207.
20. Larsson, L.-I., Skriver, L., Nielsen, L. S., Grøndahl-Hansen, J., Kristensen, P. & Danø, K. (1984) J. Cell Biol. 98, 894-903.
21. Kristensen, P., Eriksen, J. & Danø, K. (1991) J. Histochem. Cytochem. 39, 341-349.
22. Mars, W. M., Liu, M.-L., Kitson, R. P., Goldfarb, R. H., Gabauer, M. K. & Michalopoulos, G. K. (1995) Hepatology 21, 1695-1701.
23. Rickles, R. J. & Strickland, S. (1988) FEBS Lett. 229, 100-106.
24. Estreicher, A., Mühlhauser, J., Carpentier, J. L., Orci, L. & Vassalli, J.-D. (1990) J. Cell Biol. 111, 783-792.
25. Simon, D. I., Ezratty, A. M., Francis, S. A., Rennke, H. & Loscalzo, J. (1993) Blood 82, 2414-2422.
26. Altieri, D. C., Plescia, J. & Plow, E. F. (1993) J. Biol. Chem. 268, 1847-1853.
27. Rømer, J., Lund, L. R., Eriksen, J., Ralfkiaer, E., Zeheb, R., Gelehrter, T. D., Danø, K. & Kristensen, P. (1991) J. Invest. Dermatol. 97, 803-811.
28. Rømer, J., Lund, L. R., Eriksen, J., Pyke, C., Kristensen, P. & Danø, K. (1994) J. Invest. Dermatol. 102, 519-522.
29. Kramer, M. D., Schaefer, B. & Reinarts, J. (1995) Biol. Chem. Hoppe Seyler 376, 131-141.
30. Ross, R. (1995) Annu. Rev. Physiol. 57, 791-804.
31. Ross, R. (1993) Nature (London) 362, 801-809.
32. Dvorak, H. F. (1986) N. Engl. J. Med. 315, 1650-1659.
33. Smith, E. B. & Thompson, W. D. (1994) Thromb. Res. 73, 1-19.
34. Bini, A. & Kudryk, B. J. (1992) Ann. N.Y. Acad. Sci. 667, 112-126.
35. Grainger, D. J., Kemp, P. R., Liu, A. C., Lawn, R. M. & Metcalfe, J. C. (1994) Nature (London) 370, 460-462.
36. Danø, K., Andreasen, P. A., Grøndahl-Hansen, J., Kristensen, P., Nielsen, L. S. & Skriver, L. (1985) Adv. Cancer Res. 44, 139-266.
37. Danø, K., Behrendt, N., Brünner, N., Ellis, V., Ploug, M. & Pyke, C. (1994) Fibrinolysis 8, 189-203.
38. Lupu, F., Heim, D. A., Bachmann, F., Hurni, M., Kakkar, V. V. & Kruitof, E. K. (1995) Arterioscler. Thromb. Vasc. Biol. 15, 1444-1455.
39. Ossowski, L., Clunie, G., Masucci, M.-T. & Blasi, F. (1991) J. Cell Biol. 115, 1107-1112.
40. Ossowski, L., Russo-Payne, H. & Wilson, E. L. (1991) Cancer Res. 51, 274-281.
41. Crowley, C. W., Cohen, R. L., Lucas, B. K., Liu, G., Shuman, M. A. & Levinson, A. D. (1993) Proc. Natl. Acad. Sci. USA 90, 5021-5025.
42. Odekon, L. E., Blasi, F. & Rifken, D. B. (1994) J. Cell. Physiol. 158, 398-407.
43. He, C. S., Wilhelm, S. M., Pentland, A. P., Marmer, B. L., Grant, G. A., Eisen, A. Z. & Goldberg, G. I. (1989) Proc. Natl. Acad. Sci. USA 86, 2632-2636.
44. Guy, C. T., Cardiff, R. D. & Muller, W. J. (1992) Mol. Cell. Biol. 12, 954-961.
45. Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setala, K., Walsh, A., Verstuyft, J. G., Rubin, E. M. & Breslow, J. L. (1992) Cell 71, 343-353.