Modification of kidney barrier function by the urokinase receptor

Nature Medicine

Volumn 14, Issue 1, 2008, Pages 55-63

  Wei, Changli ^a   Möller, Clemens C ^a   Altintas, Mehmet M ^a   Li, Jing ^a   Schwarz, Karin ^b   Zacchigna, Serena ^c   Xie, Liang ^d   Henger, Anna ^e   Schmid, Holger ^f   Rastaldi, Maria P ^g   Cowan, Peter ^h   Kretzler, Matthias ^e   Parrilla, Roberto ⁱ   Bendayan, Moïse ^j   Gupta, Vineet ^a   Nikolic, Boris ^a   Kalluri, Raghu ^d   Carmeliet, Peter ^c   Mundel, Peter ^k   Reiser, Jochen ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Homburg University   (Germany)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF MUNICH   (Germany)

^g SAN CARLO BORROMEO HOSPITAL   (Italy)

^h ST VINCENT S HOSPITAL   (Australia)

ⁱ CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^j UNIVERSITÉ DE MONTRÉAL   (Canada)

^k MOUNT SINAI SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; LIPOPOLYSACCHARIDE; PROTEIN CDC42; RAC1 PROTEIN; UROKINASE RECEPTOR; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MOTILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEINURIA; RAT;

ANIMALS; CELL MOVEMENT; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; HUMANS; INTEGRIN ALPHAVBETA3; KIDNEY; LIPOPOLYSACCHARIDES; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PODOCYTES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

MUS;

EID: 38049032013     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1696     Document Type: Article

References (51)

1. Zandi-Nejad, K., Eddy, A.A., Glassock, R.J. & Brenner, B.M. Why is proteinuria an ominous biomarker of progressive kidney disease? Kidney Int. Suppl. 66, S76-S89 (2004).
2. Kerjaschki, D. et al. A β1-integrin receptor for fibronectin in human kidney glomeruli. Am. J. Pathol. 134, 481-489 (1989).
3. Kreidberg, J.A. et al. α3β1 integrin has a crucial role in kidney and lung organogenesis. Development 122, 3537-3547 (1996).
4. Regele, H.M. et al. Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis. J. Am. Soc. Nephrol. 11, 403-412 (2000).
5. Reiser, J., Kriz, W., Kretzler, M. & Mundel, P. The glomerular slit diaphragm is a modified adherens junction. J. Am. Soc. Nephrol. 11, 1-8 (2000).
6. Faul, C., Asanuma, K., Yanagida-Asanuma, E., Kim, K. & Mundel, P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol. 17, 428-437 (2007).
7. Tryggvason, K., Patrakka, J. & Wartiovaara, J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N. Engl. J. Med. 354, 1387-1401 (2006).
8. Sever, S. et al. Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. J. Clin. Invest. 117, 2095-2104 (2007).
9. Reiser, J. et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J. Clin. Invest. 113, 1390-1397 (2004).
10. Reiser, J. et al. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and α3 integrin. J. Biol. Chem. 279, 34827-34832 (2004).
11. Asanuma, K. et al. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat. Cell Biol. 8, 485-491 (2006).
12. Moeller, M.J. et al. Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis. J. Am. Soc. Nephrol. 15, 61-67 (2004).
13. Seiler, M.W., Venkatachalam, M.A. & Cotran, R.S. Glomerular epithelium: structural alterations induced by polycations. Science 189, 390-393 (1975).
14. Van Den Berg, J.G., Van Den Bergh Weerman, M.A., Assmann, K.J.M., Weening, J.J. & Florquin, S. Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies. Kidney Int. 66, 1901-1906 (2004).
15. Gadea, G., de Toledo, M., Anguille, C. & Roux, P. Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices. J. Cell Biol. 178, 23-30 (2007).
16. Wei, Y. et al. Regulation of integrin function by the urokinase receptor. Science 273, 1551-1555 (1996).
17. Blasi, F. & Carmeliet, P. uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell Biol. 3, 932-943 (2002).
18. Alfano, M., Sidenius, N., Panzeri, B., Blasi, F. & Poli, G. Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication. Proc. Natl. Acad. Sci. USA 99, 8862-8867 (2002).
19. Wei, Y. et al. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. Biol. Chem. 269, 32380-32388 (1994).
20. Madsen, C.D., Ferraris, G.M., Andolfo, A., Cunningham, O. & Sidenius, N. uPAR-induced cell adhesion and migration: vitronectin provides the key. J. Cell Biol. 177, 927-939 (2007).
21. Dewerchin, M. et al. Generation and characterization of urokinase receptor-deficient mice. J. Clin. Invest. 97, 870-878 (1996).
22. Carmeliet, P. et al. Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice. Ann. NY Acad. Sci. 748, 367-382 (1995).
23. Zheng, X., Saunders, T.L., Camper, S.A., Samuelson, L.C. & Ginsburg, D. Vitronectin is not essential for normal mammalian development and fertility. Proc. Natl. Acad. Sci. USA 92, 12426-12430 (1995).
24. Hodivala-Dilke, K.M. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Invest. 103, 229-238 (1999).
25. Simons, K. & Toomre, D. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31-39 (2000).
26. Schmid, H. et al. Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies. Kidney Int. 64, 356-360 (2003).
27. Nakamura, T., Ebihara, I., Shirato, I., Tomino, Y. & Koide, H. Modulation of basement membrane component gene expression in glomeruli of aminonucleoside nephrosis. Lab. Invest. 64, 640-647 (1991).
28. Kelley, V.E. & Cavallo, T. An ultrastructural study of the glomerular slit diaphragm in New Zealand black/white mice. Lab. Invest. 35, 213-220 (1976).
29. Mundel, P. et al. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J. Cell Biol. 139, 193-204 (1997).
30. Shankland, S.J., Pippin, J.W., Reiser, J. & Mundel, P. Podocytes in culture: past, present, and future. Kidney Int. 72, 26-36 (2007).
31. Mauer, S.M. et al. Effects of kidney and pancreas transplantation on streptozotocin-induced malignant kidney tumors in rats. Cancer Res. 34, 1643-1645 (1974).
32. Mayer, G., Boileau, G. & Bendayan, M. Furin interacts with proMT1-MMP and integrin αv at specialized domains of renal cell plasma membrane. J. Cell Sci. 116, 1763-1773 (2003).
33. Moeller, M.J., Sanden, S.K., Soofi, A., Wiggins, R.C. & Holzman, L.B. Podocyte-specific expression of cre recombinase in transgenic mice. Genesis 35, 39-42 (2003).
34. Velasco, B. et al. Vascular gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters. Gene Ther. 8, 897-904 (2001).
35. Zeisberg, E.M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952-961 (2007).
36. Arnaout, M.A., Mahalingam, B. & Xiong, J.P. Integrin structure, allostery, and bidirectional signaling. Annu. Rev. Cell Dev. Biol. 21, 381-410 (2005).
37. Chaurasia, P. et al. A region in urokinase plasminogen receptor domain III controlling a functional association with α5β1 integrin and tumor growth. J. Biol. Chem. 281, 14852-14863 (2006).
38. Wei, Y. et al. Urokinase receptors are required for α5β1 integrin-mediated signaling in tumor cells. J. Biol. Chem. 282, 3929-3939 (2007).
39. Degryse, B., Resnati, M., Czekay, R.P., Loskutoff, D.J. & Blasi, F. Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. J. Biol. Chem. 280, 24792-24803 (2005).
40. Pelletier, A.J., Kunicki, T. & Quaranta, V. Activation of the integrin αvβ3 involves a discrete cation-binding site that regulates conformation. J. Biol. Chem. 271, 1364-1370 (1996).
41. Honda, S. et al. Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin β3 subunit. J. Biol. Chem. 270, 11947-11954 (1995).
42. Dormond, O., Foletti, A., Paroz, C. & Ruegg, C. NSAIDs inhibit αvβ3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat. Med. 7, 1041-1047 (2001).
43. Cai, W. & Chen, X. Anti-angiogenic cancer therapy based on integrin αvβ3 antagonism. Anticancer Agents Med. Chem. 6, 407-428 (2006).
44. Schwarz, K. et al. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J. Clin. Invest. 108, 1621-1629 (2001).
45. Keller, P. & Simons, K. Cholesterol is required for surface transport of influenza virus hemagglutinin. J. Cell Biol. 140, 1357-1367 (1998).
46. Butta, N. et al. Disruption of the β3 663-687 disulfide bridge confers constitutive activity to beta3 integrins. Blood 102, 2491-2497 (2003).
47. Pampori, N. et al. Mechanisms and consequences of affinity modulation of integrin αvβ3 detected with a novel patch-engineered monovalent ligand. J. Biol. Chem. 274, 21609-21616 (1999).
48. Hughes, P.E. et al. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J. Biol. Chem. 271, 6571-6574 (1996).
49. de Jong, P.E. & Brenner, B.M. From secondary to primary prevention of progressive renal disease: the case for screening for albuminuria. Kidney Int. 66, 2109-2118 (2004).
50. Silberman, S., Janulis, M. & Schultz, R.M. Characterization of downstream Ras signals that induce alternative protease-development invasive phenotypes. J. Biol. Chem. 272, 5927-5935 (1997).
51. Gugliucci, A. & Bendayan, M. Reaction of advanced glycation endproducts with renal tissue from normal and streptozotocin-induced diabetic rats: an ultrastructural study using colloidal gold cytochemistry. J. Histochem. Cytochem. 43, 591-600 (1995).