메뉴 건너뛰기




Volumn 84, Issue 4, 2008, Pages 1141-1150

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase

Author keywords

Bacterial meninigits; Complement receptor 3

Indexed keywords

BETA2 INTEGRIN; CD11B ANTIGEN; CD18 ANTIGEN; COMPLEMENT COMPONENT C3 RECEPTOR; FC RECEPTOR; HEMATOPOIETIC CELL KINASE; PROTEIN KINASE LYN; PROTEIN P53; PROTEIN P56; PROTEIN P58; PROTEIN TYROSINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 54249148151     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0208118     Document Type: Article
Times cited : (19)

References (48)
  • 2
    • 0032781554 scopus 로고    scopus 로고
    • Integrin signaling in neutrophils and macrophages
    • Berton, G., Lowell, C. A. (1999) Integrin signaling in neutrophils and macrophages. Cell. Signal. 11, 621-635.
    • (1999) Cell. Signal , vol.11 , pp. 621-635
    • Berton, G.1    Lowell, C.A.2
  • 3
    • 0036795867 scopus 로고    scopus 로고
    • Differential expression of protein tyrosine kinase genes during microglial activation
    • Krady, J. K., Basu, A., Levison, S. W., Milner, R. J. (2002) Differential expression of protein tyrosine kinase genes during microglial activation. Glia 40, 11-24.
    • (2002) Glia , vol.40 , pp. 11-24
    • Krady, J.K.1    Basu, A.2    Levison, S.W.3    Milner, R.J.4
  • 4
    • 0034695748 scopus 로고    scopus 로고
    • Fcγ receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn
    • Fitzer-Attas, C. J., Lowry, M., Crowley, M. T., Finn, A. J., Meng, F., DeFranco, A. L., Lowell, C. A. (2000) Fcγ receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J. Exp. Med. 191, 669-682.
    • (2000) J. Exp. Med , vol.191 , pp. 669-682
    • Fitzer-Attas, C.J.1    Lowry, M.2    Crowley, M.T.3    Finn, A.J.4    Meng, F.5    DeFranco, A.L.6    Lowell, C.A.7
  • 5
    • 0030912071 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
    • Meng, F., Lowell, C. A. (1997) Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J. Exp. Med. 185, 1661-1670.
    • (1997) J. Exp. Med , vol.185 , pp. 1661-1670
    • Meng, F.1    Lowell, C.A.2
  • 6
    • 0032479979 scopus 로고    scopus 로고
    • A β 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration
    • Meng, F., Lowell, C. A. (1998) A β 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 17, 4391-4403.
    • (1998) EMBO J , vol.17 , pp. 4391-4403
    • Meng, F.1    Lowell, C.A.2
  • 7
    • 33646794638 scopus 로고    scopus 로고
    • Src-family kinases mediate an outside-in signal necessary for β2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin
    • Totani, L., Piccoli, A., Manarini, S., Federico, L., Pecce, R., Martelli, N., Cerletti, C., Piccardoni, P., Lowell, C. A., Smyth, S. S., Berton, G., Evangelista, V. (2006) Src-family kinases mediate an outside-in signal necessary for β2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem. J. 396, 89-98.
    • (2006) Biochem. J , vol.396 , pp. 89-98
    • Totani, L.1    Piccoli, A.2    Manarini, S.3    Federico, L.4    Pecce, R.5    Martelli, N.6    Cerletti, C.7    Piccardoni, P.8    Lowell, C.A.9    Smyth, S.S.10    Berton, G.11    Evangelista, V.12
  • 8
  • 10
    • 0028293147 scopus 로고
    • Functional overlap in the src gene family: Inactivation of hck and fgr impairs natural immunity
    • Lowell, C. A., Soriano, P., Varmus, H. E. (1994) Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 8, 387-398.
    • (1994) Genes Dev , vol.8 , pp. 387-398
    • Lowell, C.A.1    Soriano, P.2    Varmus, H.E.3
  • 11
    • 0037408190 scopus 로고    scopus 로고
    • Pneumococcal meningitis in adults: Spectrum of complications and prognostic factors in a series of 87 cases
    • Kastenbauer, S., Pfister, H. W. (2003) Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 126, 1015-1025.
    • (2003) Brain , vol.126 , pp. 1015-1025
    • Kastenbauer, S.1    Pfister, H.W.2
  • 12
    • 0037607198 scopus 로고    scopus 로고
    • Immunity to Streptococcus pneumoniae: Factors affecting production and efficacy
    • Casal, J., Tarrago, D. (2003) Immunity to Streptococcus pneumoniae: factors affecting production and efficacy. Curr. Opin. Infect. Dis. 16, 219-224.
    • (2003) Curr. Opin. Infect. Dis , vol.16 , pp. 219-224
    • Casal, J.1    Tarrago, D.2
  • 13
    • 5144222255 scopus 로고    scopus 로고
    • Complement: A unique innate immune sensor for danger signals
    • Gasque, P. (2004) Complement: a unique innate immune sensor for danger signals. Mol. Immunol. 41, 1089-1098.
    • (2004) Mol. Immunol , vol.41 , pp. 1089-1098
    • Gasque, P.1
  • 14
    • 27144535425 scopus 로고    scopus 로고
    • Regulation and termination of NADPH oxidase activity
    • Decoursey, T. E., Ligeti, E. (2005) Regulation and termination of NADPH oxidase activity. Cell. Mol. Life Sci. 62, 2173-2193.
    • (2005) Cell. Mol. Life Sci , vol.62 , pp. 2173-2193
    • Decoursey, T.E.1    Ligeti, E.2
  • 15
    • 0036900042 scopus 로고    scopus 로고
    • Pathogenesis and pathophysiology of pneumococcal meningitis
    • Koedel, U., Scheld, W. M., Pfister, H. W. (2002) Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect. Dis. 2, 721-736.
    • (2002) Lancet Infect. Dis , vol.2 , pp. 721-736
    • Koedel, U.1    Scheld, W.M.2    Pfister, H.W.3
  • 16
    • 33751427432 scopus 로고    scopus 로고
    • Differential regulation of blood-brain barrier permeability in brain trauma and pneumococcal meningitis-role of Src kinases
    • Paul, R., Angele, B., Popp, B., Klein, M., Riedel, E., Pfister, H. W., Koedel, U. (2007) Differential regulation of blood-brain barrier permeability in brain trauma and pneumococcal meningitis-role of Src kinases. Exp. Neurol. 203, 158-167.
    • (2007) Exp. Neurol , vol.203 , pp. 158-167
    • Paul, R.1    Angele, B.2    Popp, B.3    Klein, M.4    Riedel, E.5    Pfister, H.W.6    Koedel, U.7
  • 17
    • 13944283244 scopus 로고    scopus 로고
    • Paul, R., Winkler, F., Bayerlein, I., Popp, B., Pfister, H. W., Koedel, U. (2005) Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental Pneumococcal meningitis. J. Infect. Dis. 191, 776-782.
    • Paul, R., Winkler, F., Bayerlein, I., Popp, B., Pfister, H. W., Koedel, U. (2005) Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental Pneumococcal meningitis. J. Infect. Dis. 191, 776-782.
  • 18
    • 33749266512 scopus 로고    scopus 로고
    • TGFβ receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis
    • Malipiero, U., Koedel, U., Pfister, H. W., Leveen, P., Burki, K., Reith, W., Fontana, A. (2006) TGFβ receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis. Brain 129, 2404-2415.
    • (2006) Brain , vol.129 , pp. 2404-2415
    • Malipiero, U.1    Koedel, U.2    Pfister, H.W.3    Leveen, P.4    Burki, K.5    Reith, W.6    Fontana, A.7
  • 19
    • 0030008394 scopus 로고    scopus 로고
    • Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions
    • Lowell, C. A., Fumagalli, L., Berton, G. (1996) Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133, 895-910.
    • (1996) J. Cell Biol , vol.133 , pp. 895-910
    • Lowell, C.A.1    Fumagalli, L.2    Berton, G.3
  • 20
    • 0030483324 scopus 로고    scopus 로고
    • A novel role for the β 2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation
    • Coxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaout, M. A., Mayadas, T. N. (1996) A novel role for the β 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5, 653-666.
    • (1996) Immunity , vol.5 , pp. 653-666
    • Coxon, A.1    Rieu, P.2    Barkalow, F.J.3    Askari, S.4    Sharpe, A.H.5    von Andrian, U.H.6    Arnaout, M.A.7    Mayadas, T.N.8
  • 22
    • 0030008394 scopus 로고    scopus 로고
    • Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions
    • Lowell, C. A., Fumagalli, L., Berton, G. (1996) Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133, 895-910.
    • (1996) J. Cell Biol , vol.133 , pp. 895-910
    • Lowell, C.A.1    Fumagalli, L.2    Berton, G.3
  • 23
    • 33846504078 scopus 로고    scopus 로고
    • Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system
    • Rupprecht, T. A., Angele, B., Klein, M., Heesemann, J., Pfister, H. W., Botto, M., Koedel, U. (2007) Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system. J. Immunol. 178, 1861-1869.
    • (2007) J. Immunol , vol.178 , pp. 1861-1869
    • Rupprecht, T.A.1    Angele, B.2    Klein, M.3    Heesemann, J.4    Pfister, H.W.5    Botto, M.6    Koedel, U.7
  • 24
    • 0024421227 scopus 로고
    • Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes
    • Tuomanen, E. I., Saukkonen, K., Sande, S., Cioffe, C., Wright, S. D. (1989) Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. J. Exp. Med. 170, 959-969.
    • (1989) J. Exp. Med , vol.170 , pp. 959-969
    • Tuomanen, E.I.1    Saukkonen, K.2    Sande, S.3    Cioffe, C.4    Wright, S.D.5
  • 25
    • 0028788966 scopus 로고
    • Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis
    • Weber, J. R., Angstwurm, K., Burger, W., Einhaupl, K. M., Dirnagl, U. (1995) Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis. J. Neuroimmunol. 63, 63-68.
    • (1995) J. Neuroimmunol , vol.63 , pp. 63-68
    • Weber, J.R.1    Angstwurm, K.2    Burger, W.3    Einhaupl, K.M.4    Dirnagl, U.5
  • 26
    • 0028925552 scopus 로고
    • Urokinase plasminogen activator receptor, β 2-integrins, and Src-kinases within a single receptor complex of human monocytes
    • Bohuslav, J., Horejsi, V., Hansmann, C., Stockl, J., Weidle, U. H., Majdic, O., Bartke, I., Knapp, W., Stockinger, H. (1995) Urokinase plasminogen activator receptor, β 2-integrins, and Src-kinases within a single receptor complex of human monocytes. J. Exp. Med. 181, 1381-1390.
    • (1995) J. Exp. Med , vol.181 , pp. 1381-1390
    • Bohuslav, J.1    Horejsi, V.2    Hansmann, C.3    Stockl, J.4    Weidle, U.H.5    Majdic, O.6    Bartke, I.7    Knapp, W.8    Stockinger, H.9
  • 27
    • 0032522751 scopus 로고    scopus 로고
    • Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction
    • Konakova, M., Hucho, F., Schleuning, W. D. (1998) Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction. Eur. J. Biochem. 253, 421-429.
    • (1998) Eur. J. Biochem , vol.253 , pp. 421-429
    • Konakova, M.1    Hucho, F.2    Schleuning, W.D.3
  • 28
    • 31544441368 scopus 로고    scopus 로고
    • Differential roles for β2 integrins in experimental autoimmune bullous pemphigoid
    • Liu, Z., Zhao, M., Li, N., Diaz, L. A., Mayadas, T. N. (2006) Differential roles for β2 integrins in experimental autoimmune bullous pemphigoid. Blood 107, 1063-1069.
    • (2006) Blood , vol.107 , pp. 1063-1069
    • Liu, Z.1    Zhao, M.2    Li, N.3    Diaz, L.A.4    Mayadas, T.N.5
  • 29
    • 33745313872 scopus 로고    scopus 로고
    • The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating β 2 integrin affinity and valency in neutrophils, but are required for β 2 integrin-mediated outside-in signaling involved in sustained adhesion
    • Giagulli, C., Ottoboni, L., Caveggion, E., Rossi, B., Lowell, C., Constantin, G., Laudanna, C., Berton, G. (2006) The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating β 2 integrin affinity and valency in neutrophils, but are required for β 2 integrin-mediated outside-in signaling involved in sustained adhesion. J. Immunol. 177, 604-611.
    • (2006) J. Immunol , vol.177 , pp. 604-611
    • Giagulli, C.1    Ottoboni, L.2    Caveggion, E.3    Rossi, B.4    Lowell, C.5    Constantin, G.6    Laudanna, C.7    Berton, G.8
  • 31
    • 0029893116 scopus 로고    scopus 로고
    • Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins
    • Tang, T., Frenette, P. S., Hynes, R. O., Wagner, D. D., Mayadas, T. N. (1996) Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J. Clin. Invest. 97, 2485-2490.
    • (1996) J. Clin. Invest , vol.97 , pp. 2485-2490
    • Tang, T.1    Frenette, P.S.2    Hynes, R.O.3    Wagner, D.D.4    Mayadas, T.N.5
  • 32
    • 18544383759 scopus 로고    scopus 로고
    • CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia
    • Rijneveld, A. W., de Vos, A. F., Florquin, S., Verbeek, J. S., van der Poll, T. (2005) CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia. J. Infect. Dis. 191, 1755-1760.
    • (2005) J. Infect. Dis , vol.191 , pp. 1755-1760
    • Rijneveld, A.W.1    de Vos, A.F.2    Florquin, S.3    Verbeek, J.S.4    van der Poll, T.5
  • 33
    • 13944283244 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental pneumococcal meningitis
    • Paul, R., Winkler, F., Bayerlein, I., Popp, B., Pfister, H. W., Koedel, U. (2005) Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental pneumococcal meningitis. J. Infect. Dis. 191, 776-782.
    • (2005) J. Infect. Dis , vol.191 , pp. 776-782
    • Paul, R.1    Winkler, F.2    Bayerlein, I.3    Popp, B.4    Pfister, H.W.5    Koedel, U.6
  • 34
    • 27144521657 scopus 로고    scopus 로고
    • Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
    • Underhill, D. M., Rossnagle, E., Lowell, C. A., Simmons, R. M. (2005) Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106, 2543-2550.
    • (2005) Blood , vol.106 , pp. 2543-2550
    • Underhill, D.M.1    Rossnagle, E.2    Lowell, C.A.3    Simmons, R.M.4
  • 35
    • 0019427933 scopus 로고    scopus 로고
    • Briles, D. E., Nahm, M., Schroer, K., Davie, J., Baker, P., Kearney, J., Barletta, R. (1981) Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae. J. Exp. Med. 153, 694-705.
    • Briles, D. E., Nahm, M., Schroer, K., Davie, J., Baker, P., Kearney, J., Barletta, R. (1981) Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae. J. Exp. Med. 153, 694-705.
  • 36
    • 0019787152 scopus 로고
    • C-reactive protein is protective against Streptococcus pneumoniae infection in mice
    • Mold, C., Nakayama, S., Holzer, T. J., Gewurz, H., Du Clos, T. W. (1981) C-reactive protein is protective against Streptococcus pneumoniae infection in mice. J. Exp. Med. 154, 1703-1708.
    • (1981) J. Exp. Med , vol.154 , pp. 1703-1708
    • Mold, C.1    Nakayama, S.2    Holzer, T.J.3    Gewurz, H.4    Du Clos, T.W.5
  • 37
    • 0037097803 scopus 로고    scopus 로고
    • Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc γ receptors
    • Mold, C., Rodic-Polic, B., Du Clos, T. W. (2002) Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc γ receptors. J. Immunol. 168, 6375-6381.
    • (2002) J. Immunol , vol.168 , pp. 6375-6381
    • Mold, C.1    Rodic-Polic, B.2    Du Clos, T.W.3
  • 38
    • 0033594871 scopus 로고    scopus 로고
    • Amino acid sequences within the α subunit of integrin α M β 2 (Mac-1) critical for specific recognition of C3bi
    • Zhang, L., Plow, E. F. (1999) Amino acid sequences within the α subunit of integrin α M β 2 (Mac-1) critical for specific recognition of C3bi. Biochemistry 38, 8064-8071.
    • (1999) Biochemistry , vol.38 , pp. 8064-8071
    • Zhang, L.1    Plow, E.F.2
  • 39
    • 0026539229 scopus 로고
    • Opsonin-independent phagocytosis of group B streptococci: Role of complement receptor type three
    • Antal, J. M., Cunningham, J. V., Goodrum, K. J. (1992) Opsonin-independent phagocytosis of group B streptococci: role of complement receptor type three. Infect. Immun. 60, 1114-1121.
    • (1992) Infect. Immun , vol.60 , pp. 1114-1121
    • Antal, J.M.1    Cunningham, J.V.2    Goodrum, K.J.3
  • 40
    • 0037103252 scopus 로고    scopus 로고
    • Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively
    • Le Cabec, V., Carréno, S., Moisand, A., Bordier, C., Maridonneau-Parini, I. (2002) Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively. J. Immunol. 169, 2003-2009.
    • (2002) J. Immunol , vol.169 , pp. 2003-2009
    • Le Cabec, V.1    Carréno, S.2    Moisand, A.3    Bordier, C.4    Maridonneau-Parini, I.5
  • 41
    • 0032895697 scopus 로고    scopus 로고
    • Src-family kinase-p53/Lyn p56 plays an important role in TNF-α-stimulated production of O2- by human neutrophils adherent to fibrinogen
    • Yan, S. R., Novak, M. J. (1999) Src-family kinase-p53/Lyn p56 plays an important role in TNF-α-stimulated production of O2- by human neutrophils adherent to fibrinogen. Inflammation 23, 167-178.
    • (1999) Inflammation , vol.23 , pp. 167-178
    • Yan, S.R.1    Novak, M.J.2
  • 42
    • 27144535425 scopus 로고    scopus 로고
    • Regulation and termination of NADPH oxidase activity
    • Decoursey, T. E., Ligeti, E. (2005) Regulation and termination of NADPH oxidase activity. Cell. Mol. Life Sci. 62, 2173-2193.
    • (2005) Cell. Mol. Life Sci , vol.62 , pp. 2173-2193
    • Decoursey, T.E.1    Ligeti, E.2
  • 43
    • 33746885455 scopus 로고    scopus 로고
    • Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
    • Ellson, C. D., Davidson, K., Ferguson, G. J., O'Connor, R., Stephens, L. R., Hawkins, P. T. (2006) Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J. Exp. Med. 203, 1927-1937.
    • (2006) J. Exp. Med , vol.203 , pp. 1927-1937
    • Ellson, C.D.1    Davidson, K.2    Ferguson, G.J.3    O'Connor, R.4    Stephens, L.R.5    Hawkins, P.T.6
  • 44
    • 0032514915 scopus 로고    scopus 로고
    • p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process
    • Bouin, A. P., Grandvaux, N., Vignais, P. V., Fuchs, A. (1998) p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. J. Biol. Chem. 273, 30097-30103.
    • (1998) J. Biol. Chem , vol.273 , pp. 30097-30103
    • Bouin, A.P.1    Grandvaux, N.2    Vignais, P.V.3    Fuchs, A.4
  • 46
    • 10944238407 scopus 로고    scopus 로고
    • Distinctive activation mechanisms and functions for protein kinase Cδ
    • Steinberg, S. F. (2004) Distinctive activation mechanisms and functions for protein kinase Cδ. Biochem. J. 384, 449-459.
    • (2004) Biochem. J , vol.384 , pp. 449-459
    • Steinberg, S.F.1
  • 47
    • 20144378137 scopus 로고    scopus 로고
    • Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells
    • Chowdhury, A. K., Watkins, T., Parinandi, N. L., Saatian, B., Kleinberg, M. E., Usatyuk, P. V., Natarajan, V. (2005) Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells. J. Biol. Chem. 280, 20700-20711.
    • (2005) J. Biol. Chem , vol.280 , pp. 20700-20711
    • Chowdhury, A.K.1    Watkins, T.2    Parinandi, N.L.3    Saatian, B.4    Kleinberg, M.E.5    Usatyuk, P.V.6    Natarajan, V.7
  • 48
    • 0032957004 scopus 로고    scopus 로고
    • Oxidative stress in bacterial meningitis
    • Koedel, U., Pfister, H. W. (1999) Oxidative stress in bacterial meningitis. Brain Pathol. 9, 57- 67.
    • (1999) Brain Pathol , vol.9 , pp. 57-67
    • Koedel, U.1    Pfister, H.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.