Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 284, Issue 6 28-6, 2003, Pages

  Louzier, Vanessa ^a   Raffestin, Bernadette ^b   Leroux, Aude ^c   Branellec, Didier ^c   Caillaud, Jean Michel ^c   Levame, Micheline ^a   Eddahibi, Saadia ^a   Adnot, Serge ^a,d  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b Assit Publique Hopitaux Paris   (France)

^c Dept Therapie Genique Cardio Vasc ^*  (France)

^d INSERM   (France)

Author keywords

Adenoviral transfer; Angiogenic factors

Indexed keywords

ADENOVIRUS VECTOR; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; GENE OVEREXPRESSION; HEART RIGHT VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; HYPOXIA; KNOCKOUT MOUSE; LUNG EDEMA; LUNG ENDOTHELIUM; LUNG HEMODYNAMICS; LUNG WEIGHT; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT;

EID: 0037497956     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00247.2002     Document Type: Article

References (45)

1. Asahara T, Chen D, Tsurumi Y, Kearney M, Rossow S, Passeri J, Symes JF, and Isner JM. Accelerated restitution of endothelial integrity and endothelium-dependent function after phVEGF165 gene transfer. Circulation 94: 3291-302, 1996.
2. Bellomo D, Headrick JP, Silins GU, Paterson CA, Thomas PS, Gartside M, Mould A, Cahill MM, Tonks ID, Grimmond SM, Townson S, Wells C, Little M, Cummings MC, Hayward NK, and Kay GF. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res 86: E29-E35, 2000.
3. Blanche F, Cameron B, Barbot A, Ferrero L, Guillemin T, Guyot S, Somarriba S, and Bisch D. An improved anion-exchange HPLC method for the detection and purification of adenoviral particles, Gene Ther 7: 1055-1062, 2000.
4. Brody S, Metzger M, Danel C, Rozenfeld M, and Crystal R. Acute response of non-human primates to airway delivery of an adenovirus vector containing the human CFTR cDNA. Hum Gene Ther 5: 821-836, 1994.
5. Bussolati B, Dunk C, Grohman M, Kontos CD, Mason J, and Ahmed A. Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angio-genesis via nitric oxide. Am J Pathol 159: 993-1008, 2001.
6. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, and Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439, 1996.
7. Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De Mol M, Wu Y, Bono F, Devy L, Beck H, Scholz D, Acker T, DiPalma T, Dewerchin M, Noel A, Stalmans I, Barra A, Blacher S, Vandendriessche T, Ponten A, Eriksson U, Plate KH, Foidart JM, Schaper W, Charnock-Jones DS, Hicklin DJ, Herbert JM, Collen D, and Persico MG. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7: 575-583, 2001.
8. Christou H, Yoshida A, Arthur V, Morita T, and Kourembanas S. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol 18: 768-776, 1998.
9. Crouzet J, Naudin L, Orsini C, Vigne E, Ferrero L, Le Roux A, Benoit P, Latta M, Torrent C, Branellec D, Denefle P, Mayaux JF, Perricaudet M, and Yeh P. Recombinational construction in Escherichia coli of infectious adenoviral genomes. Proc Natl Acad Sci USA 94: 1414-1419, 1997.
10. Danel C, Erzurum SC, Prayssac P, Eissa NT, Crystal RG, Herve P, Baudet B, Mazmanian M, and Lemarchand P. Gene therapy for oxidant injury-related diseases: adenovirus-mediated transfer of superoxide dismutase and catalase cDNAs protects against hyperoxia but not against ischemia-reperfusion lung injury. Hum Gene Ther 9: 1487-1496, 1998.
11. DiSalvo J, Bayne ML, Conn G, Kwok PW, Trivedi PG, Soderman DD, Palisi TM, Sullivan KA, and Thomas KA. Purification and characterization of a naturally occurring vascular endothelial growth factor. Placenta growth factor heterodimer. J Biol Chem 270: 7717-7723, 1995.
12. Fagan KA, Morrissey B, Fouty BW, Sato K, Harral JW, Morris KG Jr, Hoedt-Miller M, Vidmar S, McMurtry IF, and Rodman DM. Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Respir Res 2: 306-313, 2001.
13. Fong GH, Rossant J, Gertsenstein M, and Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66-70, 1995.
14. Gess B, Schricker K, Pfeifer M, and Kurtz A. Acute hypoxia upregulates NOS gene expression in rats. Am J Physiol Regul Integr Comp Physiol 273: R905-R910, 1997.
15. Hiratsuka S, Maru Y, Okada A, Seiki M, Noda T, and Shibuya M. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res 61: 1207-1213, 2001.
16. Hiratsuka S, Minowa O, Kuno J, Noda T, and Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA 95: 9349-9354, 1998.
17. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, and Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814, 1991.
18. Jones RC and Jacobson M. Angiogenesis in the hypertensive lung: response to ambient oxygen tension. Cell Tissue Res 300: 263-284, 2000.
19. Kanno S, Oda N, Abe M, Terai Y, Ito M, Shitara K, Tabayashi K, Shibuya M, and Sato Y. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 19: 2138-2146, 2000.
20. Knight EL, Warner AJ, Maxwell A, and Prigent SA. Chimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells. Oncogene 19: 5398-53405, 2000.
21. Kroll J and Waltenberger J. VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem Biophys Res Commun 252: 743-746, 1998.
22. Kroll J and Waltenberger J. A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. Biochem Biophys Res Commun 265: 636-639, 1999.
23. Laitinen M, Zachary I, Breier G, Pakkanen T, Hakkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, and Yla-Herttuala S. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther 8: 1737-1744, 1997.
24. Le Cras TD and McMurtry IF. Nitric oxide production in the hypoxic lung. Am J Physiol Lung Cell Mol Physiol 280: L575-L582, 2001.
25. Le Cras TD, Xue C, Rengasamy A, and Johns RA. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol Lung Cell Mol Physiol 270: L164-L170, 1996.
26. Li D, Laubach VE, and Johns RA. Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS. Am J Physiol Lung Cell Mol Physiol 281: L369-L376, 2001.
27. Li D, Teng X, and Johns RA. Up-regulation of angiogenic factor expression in hypoxia-treated mouse lung demonstrated by DNA array technique. Chest 121: 78S, 2002.
28. Marti HH and Risau W. Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proc Natl Acad Sci USA 95: 15809-15814, 1998.
29. Meyrick B and Reid L. Endothelial and subintimal changes in rat hilar pulmonary artery during recovery from hypoxia. A quantitative ultrastructural study. Lab Invest 42: 603-615, 1980.
30. Monacci WT, Merrill MJ, and Oldfield EH. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am J Physiol Cell Physiol 264: C995-C1002, 1993.
31. Olofsson B, Jeltsch M, Eriksson U, and Alitalo K. Current biology of VEGF-B and VEGF-C. Curr Opin Biotechnol 10: 528-535, 1999.
32. Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, and Eriksson U. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci USA 95: 11709-11714, 1998.
33. Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, and Eriksson U. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci USA 93: 2576-2581, 1996.
34. Partovian C, Adnot S, Eddahibi S, Teiger E, Levame M, Dreyfus P, Raffestin B, and Frelin C. Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 275: H1948-H1956, 1998.
35. Partovian C, Adnot S, Raffestin B, Louzier V, Levame M, Mavier IM, Lemarchand P, and Eddahibi S. Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. Am J Respir Cell Mol Biol 23: 762-771, 2000.
36. Pascaud M, Eddahibi S, Raffestin B, Hanoun N, Hamon M, and Adnot S. Lung overexpression of the antiangiogenic factor angiostatin aggravates pulmonary hypertension in chronically hypoxic mice (Abstract). Am J Respir Crit Care Med 161: 2001.
37. Pavlicek V, Marti HH, Grad S, Gibbs JS, Kol C, Wenger RH, Gassmann M, Kohl J, Maly FE, Oelz O, Koller EA, and Schirlo C. Effects of hypobaric hypoxia on vascular endothelial growth factor and the acute phase response in subjects who are susceptible to high-altitude pulmonary oedema. Eur J Appl Physiol 81; 497-503, 2000.
38. Shen BQ, Lee DY, and Zioncheck TF. Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway. J Biol Chem 274: 33057-33063, 1999.
39. Silins G, Grimmond S, Egerton M, and Hayward N. Analysis of the promoter region of the human VEGF-related factor gene. Biochem Biophys Res Commun 230: 413-418, 1997.
40. Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon G, Waltenberger J, Voelkel NF, and Tuder RM. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J 15: 427-438, 2001.
41. Tuder RM, Flook BE, and Voelkel NF. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J Clin Invest 95: 1798-1807, 1995.
42. Voelkel NF, Hoeper M, Maloney J, and Tuder RM. Vascular endothelial growth factor in pulmonary hypertension. Ann NY Acad Sci 796: 186-193, 1996.
43. Wanstall JC, Gambino A, Jeffery TK, Cahill MM, Bellomo D, Hayward NK, and Kay GF. Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension. Cardiovasc Res 55: 361-368, 2002.
44. Xue C, Rengasamy A, Le Cras TD, Koberna PA, Dailey GC, and Johns RA. Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 267: L667-L678, 1994.
45. Zachary I and Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49: 568-581, 2001.