Cruzipain and SP600125 induce p38 activation, alter NO/arginase balance and favor the survival of Trypanosoma cruzi in macrophages

Acta Tropica

Volumn 106, Issue 2, 2008, Pages 119-127

  Stempin, Cinthia C ^a   Garrido, Vanina V ^a   Dulgerian, Laura R ^a   Cerbán, Fabio M ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Arginase; Macrophage; MAPK; Nitric oxide; Trypanosoma cruzi

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARGINASE; ARGINASE 1; CRUZIPAIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PARASITE ANTIGEN; STRESS ACTIVATED PROTEIN KINASE;

ANTIGEN; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH RESPONSE; INHIBITION; PROTOZOAN; SURVIVAL;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN CELL; SURVIVAL; TRYPANOSOMA CRUZI;

ANIMALS; ANTHRACENES; ARGINASE; CELL LINE; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; IMMUNOLOGIC FACTORS; MACROPHAGES, PERITONEAL; MALE; MAP KINASE KINASE 4; MICE; MICE, INBRED BALB C; MICROBIAL VIABILITY; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SPLEEN; TRYPANOSOMA CRUZI;

MUS; TRYPANOSOMA CRUZI;

EID: 42649096304     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2008.02.004     Document Type: Article

References (36)

1. Bouzahzah B., Nagajyothi F., Desruisseaux M.S., Krishnamachary M., Factor S.M., Cohen A.W., Lisanti M.P., Petkova S.B., Pestell R.G., Wittner M., Mukherjee S., Weiss L.M., Jelicks L.A., Albanese C., and Tanowitz H.B. Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection. Cell Cycle 5 (2006) 2396-2400
2. Butcher B.A., Kim L., Johnson P.F., and Denkers E.Y. Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B. J. Immunol. 167 (2001) 2193-2201
3. Cameron P., McGachy A., Anderson M., Paul A., Coombs G.H., Mottram J.C., Alexander J., and Plevin R. Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. J. Immunol. 173 (2004) 3297-3304
4. Carrera L., Gazzinelli R.T., Badolato R., Hieny S., Muller W., Kuhn R., and Sacks D.L. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 183 (1996) 515-526
5. Cazzulo J.J., Couso R., Raimondi A., Wernstedt C., and Hellman U. Further characterization and partial amino acid sequence of a cysteine proteinase from Trypanosoma cruzi. Mol. Biochem. Parasitol. 33 (1989) 33-41
6. Chang C.I., Zoghi B., Liao J.C., and Kuo L. The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production. J. Immunol. 165 (2000) 2134-2141
7. Corraliza I.M., Campo M.L., Soler G., and Modolell M. Determination of arginase activity in macrophages: a micromethod. J. Immunol. Methods 174 (1994) 231-235
8. Denkers E.Y., Kim L., and Butcher B.A. In the belly of the beast: subversion of macrophage proinflammatory signalling cascades during Toxoplasma gondii infection. Cell Microbiol. 5 (2003) 75-83
9. Descoteaux A., Matlashewski G., and Turco S.J. Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania donovani lipophosphoglycan. J. Immunol. 149 (1992) 3008-3015
10. Feng G.J., Goodridge H.S., Harnett M.M., Wei X.Q., Nikolaev A.V., Higson A.P., and Liew F.Y. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J. Immunol. 163 (1999) 6403-6412
11. Giordanengo L., Fretes R., Diaz H., Cano R., Bacile A., Vottero-Cima E., and Gea S. Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice. Muscle Nerve 23 (2000) 1407-1413
12. Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 3 (2003) 23-35
13. 15N]nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
14. He H., and Kogut M.H. CpG-ODN-induced nitric oxide production is mediated through clathrin-dependent endocytosis, endosomal maturation, and activation of PKC, MEK1/2 and p38 MAPK, and NF-kappaB pathways in avian macrophage cells (HD11). Cell. Signal. 15 (2003) 911-917
15. Huang H., Petkova S.B., Cohen A.W., Bouzahzah B., Chan J., Zhou J., Factor S.M., Weiss L.M., Krishnamachary M., Mukherjee S., Wittner M., Kitsis R.N., Pestell R.G., Lisanti M.P., Albanese C., and Tanowitz H.B. Activation of transcription factors AP-1 and NF-κB in murine chagasic myocarditis. Infect. Immun. 71 (2003) 2859-2867
16. 2+, and adherence. J. Cell Physiol. 117 (1983) 189-194
17. Kim L., Butcher B.A., and Denkers E.Y. Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance. J. Immunol. 172 (2004) 3003-3010
18. Labriola C., Sousa M., and Cazzulo J.J. Purification of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi by affinity chromatography. Biol. Res. 26 (1993) 101-107
19. Lahti A., Jalonen U., Kankaanranta H., and Moilanen E. c-Jun NH2-terminal kinase inhibitor anthra(19-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages. Mol. Pharmacol. 64 (2003) 308-315
20. Martinez J., Campetella O., Frasch A.C., and Cazzulo J.J. The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections. Infect. Immun. 59 (1991) 4275-4277
21. Moore K.J., Labrecque S., and Matlashewski G. Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction. J. Immunol. 150 (1993) 4457-4465
22. Mosser D.M. The many faces of macrophage activation. J. Leukoc. Biol. 73 (2003) 209-212
23. Mukherjee S., Huang H., Petkova S.B., Albanese C., Pestell R.G., Braunstein V.J., Christ G.J., Wittner M., Lisanti M.P., Berman J.W., Weiss L.M., and Tanowitz H.B. Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells. Infect. Immun. 72 (2004) 5274-5282
24. Munder M., Eichmann K., and Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J. Immunol. 160 (1998) 5347-5354
25. Peiser L., Gough P.J., Kodama T., and Gordon S. Macrophage class A scavenger receptor-mediated phagocytosis of Escherichia coli: role of cell heterogeneity, microbial strain, and culture conditions in vitro. Infect. Immun. 68 (2000) 1953-1963
26. Ropert C., Almeida I.C., Closel M., Travassos L.R., Ferguson M.A., Cohen P., and Gazzinelli R.T. Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide. J. Immunol. 166 (2001) 3423-3431
27. Seljelid R., and Eskeland T. The biology of macrophages. I. General principles and properties. Eur. J. Haematol. 51 (1993) 267-275
28. Seljelid R., and Busund L.T. The biology of macrophages. II. Inflammation and tumors. Eur. J. Haematol. 52 (1994) 1-12
29. Shapira S., Speirs K., Gerstein A., Caamano J., and Hunter C.A. Suppression of NF-kappaB activation by infection with Toxoplasma gondii. J. Infect. Dis. 185 Suppl. 1 (2002) S66-S72
30. Stempin C., Giordanengo L., Gea S., and Cerban F. Alternative activation and increase of Trypanosoma cruzi survival in murine macrophages stimulated by cruzipain, a parasite antigen. J. Leukoc. Biol. 72 (2002) 727-734
31. Stempin C.C., Tanos T.B., Coso O.A., and Cerban F.M. Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways. Eur. J. Immunol. 34 (2004) 200-209
32. Su B., and Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8 (1996) 402-411
33. Tanowitz H.B., Kirchhoff L.V., Simon D., Morris S.A., Weiss L.M., and Wittner M. Chagas' disease. Clin. Microbiol. Rev. 5 (1992) 400-419
34. Tse H.M., Josephy S.I., Chan E.D., Fouts D., and Cooper A.M. Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages. J. Immunol. 168 (2002) 825-833
35. Vaishnav D., Jambal P., Reusch J.E., and Pugazhenthi S. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem. Biophys. Res. Commun. 307 (2003) 855-860
36. Wei S., Marches F., Daniel B., Sonda S., Heidenreich K., and Curiel T. Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication. Int. J. Parasitol. 32 (2002) 969-977