p38 Mitogen-Activated Protein Kinase Mediates the Sustained Phase of Hypoxic Pulmonary Vasoconstriction and Plays a Role in Phase I Vasodilation

Journal of Surgical Research

Volumn 134, Issue 2, 2006, Pages 335-341

  Morrell, Eric D ^a   Tsai, Ben M ^a   Wang, Meijing ^a   Crisostomo, Paul R ^a   Meldrum, Daniel R ^a,b  

^a INDIANA UNIVERSITY MEDICAL CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

hypoxia; lung physiology; p38 MAP kinase; pulmonary arteries

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EXPERIMENT; HYPOTHESIS; HYPOXIA; ISOLATED ARTERY; LUNG ARTERY; LUNG VASOCONSTRICTION; MALE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; STIMULATION; VASCULAR RING; VASODILATATION;

ANIMALS; ANISOMYCIN; ANOXIA; ENZYME ACTIVATION; ENZYME INHIBITORS; IMIDAZOLES; ISOMETRIC CONTRACTION; LUNG DISEASES; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLEPHRINE; PULMONARY ARTERY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; VASODILATION;

EID: 33746253900     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.01.028     Document Type: Article

References (48)

1. Brimioulle S., Julien V., Gust R., Kozlowski J.K., Naeije R., and Schuster D.P. Importance of hypoxic vasoconstriction in maintaining oxygenation during acute lung injury. Crit Care Med 30 (2002) 874
2. Brimioulle S., LeJeune P., and Naeije R. Effects of hypoxic pulmonary vasoconstriction on pulmonary gas exchange. J Appl Physiol 81 (1996) 1535
3. Thompson B.T., Steigman D.M., Spence C.L., Janssens S.P., and Hales C.A. Chronic hypoxic pulmonary hypertension in the guinea pig. effect of three levels of hypoxia. J Appl Physiol 74 (1993) 916
4. Jardin F., Gurdjian F., Delille F., and Margairaz A. Pulmonary hypertension in the adult respiratory distress syndrome (ARDS). Intensive Care Med 5 (1979) 155
5. McIntyre Jr. R.C., Banerjee A., Hahn A.R., Agrafojo J., and Fullerton D.A. Selective inhibition of cyclic adenosine monophosphate-mediated pulmonary vasodilation by acute hypoxia. Surgery 117 (1995) 314
6. Pulido E.J., Shames B.D., Fullerton D.A., et al. Differential inducible nitric oxide synthase expression in systemic and pulmonary vessels after endotoxin. Am J Physiol Regul Integr Comp Physiol 278 (2000) R1232
7. Orfanos S.E., Mavrommati I., Korovesi I., and Roussos C. Pulmonary endothelium in acute lung injury. from basic science to the critically ill. Intensive Care Med 30 (2004) 1702
8. Hopkins R.A., Bull C., Haworth S.G., de Leval M.R., and Stark J. Pulmonary hypertensive crises following surgery for congenital heart defects in young children. Eur J Cardiothorac Surg 5 (1991) 628
9. Waldman J.D., Lamberti J.J., Mathewson J.W., et al. Congenital heart disease and pulmonary artery hypertension. I. Pulmonary vasoreactivity to 15% oxygen before and after surgery. J Am Coll Cardiol 2 (1983) 1158
10. Kimblad P.O., Green K., Sjoberg T., and Steen S. Prostanoid release after lung transplantation. J Heart Lung Transplant 15 (1996) 999
11. Robin E.D., Theodore J., Burke C.M., et al. Hypoxic pulmonary vasoconstriction persists in the human transplanted lung. Clin Sci (Lond) 72 (1987) 283
12. Tsai B.M., Wang M., Turrentine M.W., Mahomed Y., Brown J.W., and Meldrum D.R. Hypoxic pulmonary vasoconstriction in cardiothoracic surgery. basic mechanisms to potential therapies. Ann Thorac Surg 78 (2004) 360
13. Karamsetty M.R., Klinger J.R., and Hill N.S. Evidence for the role of p38 MAP kinase in hypoxia-induced pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 283 (2002) L859
14. Tsai B.M., Wang M., Pitcher J.M., Meldrum K.K., and Meldrum D.R. Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. Am J Physiol Lung Cell Mol Physiol 287 (2004) L1215
15. Woodmansey P.A., Zhang F., Channer K.S., and Morice A.H. Effect of the calcium antagonist amlodipine on the two phases of hypoxic pulmonary vasoconstriction in rat large and small isolated pulmonary arteries. J Cardiovasc Pharmacol 25 (1995) 324
16. Robertson T.P., Hague D., Aaronson P.I., and Ward J.P. Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. J Physiol 525 Pt 3 (2000) 669
17. Lazor R., Feihl F., Waeber B., Kucera P., and Perret C. Endothelin-1 does not mediate the endothelium-dependent hypoxic contractions of small pulmonary arteries in rats. Chest 110 (1996) 189
18. Robertson T.P., Aaronson P.I., and Ward J.P. Ca2+ sensitization during sustained hypoxic pulmonary vasoconstriction is endothelium dependent. Am J Physiol Lung Cell Mol Physiol 284 (2003) L1121
19. Jin N., Packer C.S., and Rhoades R.A. Pulmonary arterial hypoxic contraction. signal transduction. Am J Physiol 263 (1992) L73
20. Rodman D.M., Yamaguchi T., O'Brien R.F., and McMurtry I.F. Hypoxic contraction of isolated rat pulmonary artery. J Pharmacol Exp Ther 248 (1989) 952
21. Conrad P.W., Millhorn D.E., and Beitner-Johnson D. Hypoxia differentially regulates the mitogen- and stress-activated protein kinases. Role of Ca2+/CaM in the activation of MAPK and p38 gamma. Adv Exp Med Biol 475 (2000) 293
22. Galaria I.I., Fegley A.J., Nicholl S.M., Roztocil E., and Davies M.G. Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. J Surg Res 122 (2004) 173
23. Lopez-Ilasaca M. Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades. Biochem Pharmacol 56 (1998) 269
24. Nwariaku F.E., Rothenbach P., Liu Z., Zhu X., Turnage R.H., and Terada L.S. Rho inhibition decreases TNF-induced endothelial MAPK activation and monolayer permeability. J Appl Physiol 95 (2003) 1889
25. Aaronson P.I., Robertson T.P., and Ward J.P. Endothelium-derived mediators and hypoxic pulmonary vasoconstriction. Respir Physiol Neurobiol 132 (2002) 107
26. Archer S.L., Tolins J.P., Raij L., and Weir E.K. Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun 164 (1989) 1198
27. Ananthakrishnan P., Cohen D.B., Xu da Z., Lu Q., Feketeova E., and Deitch E.A. Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model. Surgery 137 (2005) 56
28. Meldrum D.R. Tumor necrosis factor in the heart. Am J Physiol 274 (1998) R577
29. Wang M., Sankula R., Tsai B.M., et al. P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression. Shock 21 (2004) 170-174
30. Jin N., Hatton N., Swartz D.R., Xia X., Harrington M.A., Larsen S.H., and Rhoades R.A. Hypoxia activates jun-N-terminal kinase, extracellular signal-regulated protein kinase, and p38 kinase in pulmonary arteries. Am J Respir Cell Mol Biol 23 (2000) 593
31. Cuenda A., Rouse J., Doza Y.N., et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364 (1995) 229
32. Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351 (2000) 95
33. Tong L., Pav S., White D.M., et al. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat Struct Biol 4 (1997) 311
34. Barros L.F., Young M., Saklatvala J., and Baldwin S.A. Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin. p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J Physiol 504 Pt 3 (1997) 517
35. Hazzalin C.A., Le Panse R., Cano E., and Mahadevan L.C. Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Mol Cell Biol 18 (1998) 1844
36. Von Euler U., and Liljestrand S. Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12 (1946) 301
37. Guay J., Lambert H., Gingras-Breton G., Lavoie J.N., Huot J., and Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci 110 (1997) 357
38. Larsen J.K., Yamboliev I.A., Weber L.A., and Gerthoffer W.T. Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle. Am J Physiol 273 (1997) L930
39. Yamboliev I.A., Hedges J.C., Mutnick J.L., Adam L.P., and Gerthoffer W.T. Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. Am J Physiol Heart Circ Physiol 278 (2000) H1899
40. Gerthoffer W.T., and Gunst S.J. Invited review. focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J Appl Physiol 91 (2001) 963
41. Tsutsumi Y., Makita T., Yamaguchi K., Shibata O., and Sumikawa K. JTV-506, a new K(ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth 18 (2004) 210
42. Kan W., Zhao K.S., Jiang Y., et al. Lung, spleen, and kidney are the major places for inducible nitric oxide synthase expression in endotoxic shock. role of p38 mitogen-activated protein kinase in signal transduction of inducible nitric oxide synthase expression. Shock 21 (2004) 281
43. Lub-de Hooge M.N., de Jong S., Vermot-Desroches C., Tulleken J.E., de Vries E.G., and Zijlstra J.G. Endotoxin increases plasma soluble tumor necrosis factor-related apoptosis-inducing ligand level mediated by the p38 mitogen-activated protein kinase signaling pathway. Shock 22 (2004) 186
44. Castaneda J., Isusi A., and Tamayo L. Hypoxic pulmonary vasoconstriction increases during endotoxemia in the perfused rat lung. J Trauma 50 (2001) 882
45. Johnson A., and Ferro T.J. TNF-alpha augments pulmonary vasoconstriction via the inhibition of nitrovasodilator activity. J Appl Physiol 73 (1992) 2483
46. Liu S.F., Dewar A., Crawley D.E., Barnes P.J., and Evans T.W. Effect of tumor necrosis factor on hypoxic pulmonary vasoconstriction. J Appl Physiol 72 (1992) 1044
47. Stevens T., Janssen P.L., and Tucker A. Acute and long-term TNF-alpha administration increases pulmonary vascular reactivity in isolated rat lungs. J Appl Physiol 73 (1992) 708
48. Ertel W., Morrison M.H., Ayala A., and Chaudry I.H. Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release. Am J Physiol 269 (1995) R160