Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway

European Journal of Pharmacology

Volumn 570, Issue 1-3, 2007, Pages 125-134

  Yang, Yun Bo ^a,b   Yang, Yi Xin ^a   Su, Bo ^b   Tang, Yun Lian ^b   Zhu, Bing Yang ^b   Hu, Zhuo Wei ^c   Li, Gui Yuan ^a   Li, Yuan Jian ^a   Liao, Duan Fang ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Division of Pharmacoproteomics   (China)

^c INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

ERK1 2; Probucol; Vascular remodeling; VSMC

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA TOCOPHEROL; CAVEOLIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PROBUCOL; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BALLOON CATHETER; CELL MIGRATION; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT; RESTENOSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ANGIOPLASTY, BALLOON; ANIMALS; ANTIOXIDANTS; ATHEROSCLEROSIS; CAVEOLIN 1; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CORONARY RESTENOSIS; DOWN-REGULATION; DUAL SPECIFICITY PHOSPHATASE 1; GENES, MYC; HUMANS; HYPERPLASIA; MALE; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROBUCOL; RABBITS; THORACIC ARTERIES; TRANSCRIPTION FACTOR AP-1; TUNICA INTIMA;

EID: 34547841542     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.05.050     Document Type: Article

References (31)

1. Auge N., Maupas-Schwalm F., Elbaz M., Thiers J.C., Waysbort A., Itohara S., Krell H.W., Salvayre R., and Negre-Salvayre A. Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation 110 (2004) 571-578
2. Batt K.V., Patel L., Botham K.M., and Suckling K.E. Chylomicron remnants and oxidised low density lipoprotein have differential effects on the expression of mRNA for genes involved in human macrophage foam cell formation. J. Mol. Med. 82 (2004) 449-458
3. Christen T., Verin V., Bochaton-Piallat M., Popowski Y., Ramaekers F., Debruyne P., Camenzind E., van Eys G., and Gabbiani G. Mechanisms of neointima formation and remodeling in the porcine coronary artery. Circulation 103 (2001) 882-888
4. Cote G., Tardif J.C., Lesperance J., Lambert J., Bourassa M., Bonan R., Gosselin G., Joyal M., Tanguay J.F., Nattel S., Gallo R., and Crepeau J. Effects of probucol on vascular remodeling after coronary angioplasty. Multivitamins and Protocol Study Group. Circulation 99 (1999) 30-35
5. Dangas G., and Kuepper F. Cardiology patient page. Restenosis: repeat narrowing of a coronary artery: prevention and treatment. Circulation 105 (2002) 2586-2587
6. Engelman J.A., Zhang X.L., Razani B., Pestell R.G., and Lisanti M.P. p42/44 MAP kinase-dependent and-independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity. J. Biol. Chem. 274 (1999) 32333-32341
7. Faxon D.P., Coats W., and Currier J. Remodeling of the coronary artery after vascular injury. Prog. Cardiovasc. Dis. 40 (1997) 129-140
8. Fukuzawa K., Kogure K., Morita M., Hama S., Manabe S., and Tokumura A. Enhancement of nitric oxide and superoxide generations by alpha-tocopheryl succinate and its apoptotic and anticancer effects. Biochemistry 69 1 (2004) 50-57
9. Hirata A., Igarashi M., Yamaguchi H., Suwabe A., Daimon M., Kato T., and Tominaga M. Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2. Br. J. Pharmacol. 131 (2000) 1521-1530
10. Ikegaki I., Hattori T., Yamaguchi T., Sasaki Y., Satoh S.I., Asano T., and Shimokawa H. Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats. Eur. J. Pharmacol. 427 (2001) 69-75
11. Jackson C.L., and Pettersson K.S. Effects of probucol on rat carotid artery responses to balloon catheter injury. Atherosclerosis 154 (2001) 407-414
12. Jiang J.L., Li Ns N.S., Li Y.J., and Deng H.W. Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. Br. J. Pharmacol. 135 (2002) 1175-1182
13. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. Philos. Trans. R. Soc. Lond., B Biol. Sci. 351 (1996) 127-134
14. Kobayashi N., Mori Y., Mita S., Nakano S., Kobayashi T., Tsubokou Y., and Matsuoka H. Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats. Eur. J. Pharmacol. 422 (2001) 149-157
15. Lafont A., Guzman L.A., Whitlow P.L., Goormastic M., Cornhill J.F., and Chisolm G.M. Restenosis after experimental angioplasty. Intimal, medial, and adventitial changes associated with constrictive remodeling. Circ. Res. 76 (1995) 996-1002
16. Lafont A., Durand E., Samuel J.L., Besse B., Addad F., Levy B.I., Desnos M., Guerot C., and Boulanger C.M. Endothelial dysfunction and collagen accumulation: two independent factors for restenosis and constrictive remodeling after experimental angioplasty. Circulation 100 (1999) 1109-1115
17. Lau A.K., Leichtweis S.B., Hume P., Mashima R., Hou J.Y., Chaufour X., Wilkinson B., Hunt N.H., Celermajer D.S., and Stocker R.P. Probucol promotes functional reendothelialization in balloon-injured rabbit aortas. Circulation 107 (2003) 2031-2036
18. Li J.J., Westergaard C., Ghosh P., and Colburn N.H. Inhibitors of both nuclear factor-kappa B and activator protein-1 activation block the neoplastic transformation response. Cancer Res. 57 (1997) 3569-3576
19. Liao D.F., Duff J.L., Daum G., Pelech S.L., and Berk B.C. AngII stimulates MAP kinase activity in vascular smooth muscle cells, role of Raf. Circ. Res. 79 (1996) 1007-1014
20. Liao D.F., Jin Z.G., Baas A.S., Daum G., Gygi S.P., Aebersold R., and Berk B.C. Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J. Biol. Chem. 275 (2000) 189-196
21. Madrid A., Gil-Peralta A., Gonzalez-Marcos J.R., Otero A., and Crespo P. Restenosis and remodeling after percutaneous transluminal carotid angioplasty. Rev. Neurol. 27 (1998) 649-652
22. Mamputu J.C., Li L., and Renier G. Gliclazide inhibits differentiation-associated biologic events in human monocyte-derived macrophages. Metabolism 55 6 (2006) 778-785
23. Okura H., Hayase M., Shimodozono S., Bonneau H.N., Yock P.G., and Fitzgerald P.J. Impact of pre-interventional arterial remodeling on subsequent vessel behavior after balloon angioplasty: a serial intravascular ultrasound study. J. Am. Coll. Cardiol. 38 (2001) 2001-2005
24. Okura H., Shimodozono S., Hayase M., Bonneau H.N., Yock P.G., and Fitzgerald P.J. Impact of deep vessel wall injury and vessel stretching on subsequent arterial remodeling after balloon angioplasty: a serial intravascular ultrasound study. Am. Heart J. 144 (2002) 323-328
25. Pasterkamp G., de Kleijn D.P., and Borst C. Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications. Cardiovasc. Res. 45 (2000) 843-852
26. Pels K., Labinaz M., Hoffert C., and O'Brien E.R. Adventitial angiogenesis early after coronary angioplasty: correlation with arterial remodeling. Arterioscler Thromb. Vasc. Biol. 19 (1999) 229-238
27. Plows D., Briassouli P., Owen C., Zoumpourlis V., Garrett M.D., and Pintzas A. Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1. Biochem. J. 362 (2002) 305-315
28. Schiele T.M., Krotz F., and Klauss V. Vascular restenosis - striving for therapy. Expert Opin. Pharmacother. 5 (2004) 2221-2232
29. Wyttenbach R., Gallino A., Alerci M., Mahler F., Cozzi L., Di Valentino M., Badimon J.J., Fuster V., and Corti R. Effects of percutaneous transluminal angioplasty and endovascular brachytherapy on vascular remodeling of human femoropopliteal artery by noninvasive magnetic resonance imaging. Circulation 110 (2004) 1156-1161
30. Yan P.K., Liao D.F., and Yang Y.Z. Influence of caveolin-1 on cholesterol efflux in vascular smooth muscle cells. Chin. J. Arterioscler 10 5 (2002) 379-383
31. Yang Y.X., Zhou H.D., Yang Y.B., Li W.S., Zhou M., Zeng Z.Y., Xiong W., Wu M., Huang H., Zhou Y.H., Peng C., Huang C., Li X.L., and Li G.Y. LPS regulates TLR4 signaling transduction in nasopharynx epithelial cell line 5-8F via NFκB and MAPKs signaling pathway. Mol. Immunol. 44 (2007) 984-992