Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: Effects on hypoxic pulmonary hypertension in mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 293, Issue 4, 2007, Pages

  Izikki, M ^a   Hanoun, N ^b   Marcos, E ^a   Savale, L ^a   Barlier Mur, A M ^a   Saurini, F ^b   Eddahibi, S ^a   Hamon, M ^b   Adnot, S ^a,b  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b INSERM   (France)

Author keywords

Transgenic mice; Vascular smooth muscle

Indexed keywords

FENCLONINE; SEROTONIN; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME DEFICIENCY; FOREBRAIN; GENE; GENETIC VARIABILITY; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; MOUSE; NONHUMAN; PARAMETER; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; TPH1 GENE; TPH2 GENE;

ANIMALS; ANOXIA; CHRONIC DISEASE; ENZYME INHIBITORS; FENCLONINE; HYPERTENSION, PULMONARY; INTESTINES; LUNG; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; POLYMORPHISM, GENETIC; PROSENCEPHALON; PULMONARY ARTERY; SEROTONIN; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN HYDROXYLASE;

EID: 35348842184     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00082.2007     Document Type: Article

References (31)

1. Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Begaud B. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group. N Engl J Med 335: 609-616, 1996.
2. Alexandre C, Popa D, Fabre V, Bouali S, Venault P, Lesch KP, Hamon M, Adrien J. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. J Neurosci 26: 5554-5564, 2006.
3. Cote F, Thevenot E, Fligny C, Fromes Y, Darmon M, Ripoche M, Bayard E, Hanoun N, Saurini F, Lechat P, Dandolo L, Hamon M, Mallet J, Vodjdani G. Disruption of the nonneuronal Tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci USA 100: 13525-13530, 2003.
4. Darmon MC, Guibert B, Leviel V, Ehret M, Maitre M, Mallet J. Sequence of two mRNAs encoding active rat tryptophan hydroxylase. J Neurochem 51: 312-316, 1988.
5. Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, Kalachikov S, Cayanis E, Fischer SG, Barst RJ, Hodge SE, Knowles JA. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor II gene. Am J Hum Genet 67: 737-744, 2000.
6. Dewachter L, Adnot S, Fadel E, Humbert M, Maitre B, Barlier-Mur AM, Simonneau G, Hamon M, Naeije R, Eddahibi S. Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. Am J Respir Crit Care Med 174: 1025-1033, 2006.
7. Eddahibi S, Fabre V, Boni C, Martres MP, Raffestin B, Hamon M, Adnot S. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ Res 84: 329-336, 1999.
8. Eddahibi S, Guignabert C, Barlier-Mur AM, Dewachter L, Fadel E, Dartevelle P, Humbert M, Simonneau G, Hanoun N, Saurini F, Hamon M, Adnot S. Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation 113: 1857-1864, 2006.
9. Eddahibi S, Hanoun N, Lanfumey L, Lesch KP, Raffestin B, Hamon M, Adnot S. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 105: 1555-1562, 2000.
10. Eddahibi S, Humbert M, Fadel E, Raffestin B, Darmon M, Capron F, Simonneau G, Dartevelle P, Hamon M, Adnot S. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J Clin Invest 108: 1141-1150, 2001.
11. Eddahibi S, Morrell N, d'Ortho M, Naeije R, Adnot S. Pathobiology of pulmonary arterial hypertension. Eur Respir J 20: 1559-1572, 2002.
12. Fanburg B, Lee SL. A new role for an old molecule: serotonin as a mitogen. Am J Physiol Lung Cell Mol Physiol 272: L795-L806, 1997.
13. Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med 351: 1655-1665, 2004.
14. Gershon MD. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol 39: S184-S193, 2005.
15. Gershon MD. Roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 13 Suppl 2: 15-30, 1999.
16. Guignabert C, Izikki M, Tu LI, Li Z, Zadigue P, Barlier-Mur AM, Hanoun N, Rodman D, Hamon M, Adnot S, Eddahibi S. Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Circ Res 98: 1323-1330, 2006.
17. Hamon M, Fattaccini C, Adrien J, Gallissot M, Martin P, Gozlan H. Alterations in central serotonin and dopamine turnover in rats treated with ipsapirone and other 5-hydroxytryptamine 1A agonists with potential anxiolytic properties. J Pharmacol Exp Ther 246: 745-752, 1988.
18. Herve P, Drouet L, Dosquet C, Launay JM, Rain B, Simonneau G, Caen J, Duroux P. Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin. Am J Med 89: 117-120, 1990.
19. Kanai Y, Hori S, Tanaka T, Yasuoka M, Watanabe K, Aikawa N, Hosoda Y. Role of 5-hydroxytryptamine in the progression of monocrotaline-induced pulmonary hypertension in rats. Cardiovasc Res 27: 1619-1623, 1993.
20. Koe B, Weissman A. p-Chlorophenylalanine: a specific depletor of brain serotonin. J Pharmacol Exp Ther 154: 499-516, 1966.
21. Lane K, Machado R, Pauciulo M, Thomson J, Phillips J, Loyd J, Nichols W, Trembath R. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat Genet 26: 3-4, 2000.
22. Launay JM, Herve P, Peoc'h K, Tournois C, Callebert J, Nebigil CG, Etienne N, Drouet L, Humbert M, Simonneau G, Maroteaux L. Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat Med 8: 1129-1135, 2002.
23. Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 98: 818-827, 2006.
24. MacLean M, Herve P, Eddahibi S, Adnot S. 5-Hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Br J Pharmacol 131: 161-168, 2000.
25. Marcos E, Fadel E, Sanchez O, Humbert M, Dartevelle P, Simonneau G, Hamon M, Adnot S, Eddahibi S. Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension. Circ Res 94: 1263-1270, 2004.
26. Sakowski SA, Geddes TJ, Thomas DM, Levi E, Hatfield JS, Kuhn DM. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Res 1085: 11-18, 2006.
27. Sato K, Webb S, Tucker A, Rabinovitch M, O'Brien RF, McMurtry IF, Stelzner TJ. Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am Rev Respir Dis 145: 793-797, 1992.
28. Tappaz ML, Pujol JF. Estimation of the rate of tryptophan hydroxylation in vivo: a sensitive microassay in discrete rat brain nuclei. J Neurochem 34: 933-940, 1980.
29. Trouvin JH, Prioux-Guyonneau M, Cohen Y, Jacquot C. Rat brain monoamine metabolism and hypobaric hypoxia: a new approach. Gen Pharmacol 17: 69-73, 1986.
30. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299: 76, 2003.
31. Zhang X, Beaulieu J, Sotnikova T, Gainetdinov R, Caron M. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305: 217, 2004.