Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide

Atherosclerosis

Volumn 201, Issue 2, 2008, Pages 281-288

  Chen, Shih Chung ^a,b,c   Liu, Yu Chi ^a   Shyu, Kou Gi ^b   Wang, Danny Ling ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Activating transcription factor 3; Hypoxia; Matrix metalloproteinase 2; Mitogen activated protein kinase; Nitric oxide; Reactive oxygen species

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE A; MITOGEN ACTIVATED PROTEIN KINASE P38; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; STRESS ACTIVATED PROTEIN KINASE; TUBULIN;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CELL STRESS; CONTROLLED STUDY; COW; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; VASCULAR DISEASE;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; ANOXIA; AORTA; CATTLE; GENE EXPRESSION REGULATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MATRIX METALLOPROTEINASE 2; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 56649119180     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.02.014     Document Type: Article

References (30)

1. Ben-Yosef Y., Miller A., Shapiro S., and Lahat N. Hypoxia of endothelial cells leads to MMP-2-dependent survival and death. Am J Physiol Cell Physiol 289 (2005) C1321-C1331
2. Semenza G.L., Agani F., Feldser D., et al. Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 475 (2000) 123-130
3. Faller D.V. Endothelial cell response to hypoxic stress. Clin Exp Pharmacol Physiol 26 (1999) 74-84
4. Lo L.L., Cheng J.J., Chiu J.J., et al. Endothelial exposure to hypoxia induces Egr-1 expression involving PKC-alpha-mediated Ras/Raf-1/ERK1/2 pathway. J Cell Physiol 188 (2001) 304-312
5. Okamoto Y., Chaves A., Chen J., et al. Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene have conduction abnormalities and contractile dysfunction. Am J Pathol 159 (2001) 639-650
6. Kawauchi J., Zhang C., Nobori K., et al. Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha -induced apoptosis through down-regulation of p53 transcription. J Biol Chem 277 (2002) 39025-39034
7. Mashima T., Udagawa S., and Tsuruo T. Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis. J Cell Physiol 188 (2001) 352-358
8. Hai T., and Hartman M.G. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273 (2001) 1-11
9. Okamoto A., Iwamoto Y., and Maru Y. Oxidative stress-responsive transcription factor atf3 potentially mediates diabetic angiopathy. Mol Cell Biol 26 (2006) 1087-1097
10. Cai Y., Zhang C., Nawa T., et al. Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element. Blood 96 (2000) 2140-2148
11. Ameri K., Hammond E.M., Culmsee C., et al. Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling. Oncogene 26 (2007) 284-289
12. Chen H.-H., and Wang D.L. Nitric oxide inhibits matrix metalloproteinase-2 expression via the induction of activating transcription factor 3 in endothelial cells. Mol Pharmacol 65 (2004) 1130-1140
13. Chandel N.S., Maltepe E., Goldwasser E., et al. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. PNAS 95 (1998) 11715-11720
14. Schafer M., Schafer C., Ewald N., Piper H.M., and Noll T. Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia. Circ Res 92 (2003) 1010-1015
15. Forstermann U., and Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113 (2006) 1708-1714
16. Park S.Y., Lee H., Hur J., et al. Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway. Molecular. Brain Res 107 (2002) 9-16
17. Johnson G.L., and Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 (2002) 1911-1912
18. Wung B.S., Cheng J.J., Chao Y.J., Hsieh H.J., and Wang D.L. Modulation of Ras/Raf/extracellular signal-regulated kinase pathway by reactive oxygen species is involved in cyclic strain-induced early growth response-1 gene expression in endothelial cells. Circ Res 84 (1999) 804-812
19. Dimmeler S., Fleming I., Fisslthaler B., et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399 (1999) 601-605
20. Nemetski S.M., and Gardner L.B. Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma. J Biol Chem 282 (2007) 240-248
21. Koditz J., Nesper J., Wottawa M., et al. Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor. Blood 110 (2007) 3610-3617
22. Muller J.M., Krauss B., Kaltschmidt C., Baeuerle P.A., and Rupec R.A. Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway. J Biol Chem 272 (1997) 23435-23439
23. Alfranca A., Gutierrez M.D., Vara A., et al. c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription. Mol Cell Biol 22 (2002) 12-22
24. Mishra O.P., Zubrow A.B., and Ashraf Q.M. Nitric oxide-mediated activation of extracellular signal-regulated kinase (erk) and c-jun n-terminal kinase (jnk) during hypoxia in cerebral cortical nuclei of newborn piglets. Neuroscience 123 (2004) 179-186
25. Laderoute K.R., Mendonca H.L., Calaoagan J.M., et al. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. J Biol Chem 274 (1999) 12890-12897
26. Dimmeler S., and Zeiher A.M. Nitric oxide apoptosis: another paradigm for the double-edged role of nitric oxide. Nitric Oxide 1 (1997) 275-281
27. Inglott F.S., and Mathie R.T. Nitric oxide and hepatic ischemia-reperfusion injury. Hepatogastroenterology 47 (2000) 1722-1725
28. Gursoy-Ozdemir Y., Bolay H., Saribas O., Dalkara T., and Beckman J.S. Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia editorial comment. Stroke 31 (2000) 1974-1981
29. Kaelin J.W.G. ROS: really involved in oxygen sensing. Cell Metab 1 (2005) 357-358
30. Yan C., Wang H., and Boyd D.D. ATF3 represses 72-kDa Type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. J Biol Chem 277 (2002) 10804-10812