Phosphatidylinositol 3,5-bisphosphate: Metabolism and cellular functions

Trends in Biochemical Sciences

Volumn 31, Issue 1, 2006, Pages 52-63

  Michell, Robert H ^a   Heath, Victoria L ^a   Lemmon, Mark A ^b   Dove, Stephen K ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPSIN; INSULIN; MEMBRANE PHOSPHOLIPID; PHOSPHATE; PHOSPHATIDYLINOSITOL 3,5 BISPHOSPHATE; UNCLASSIFIED DRUG;

CELL FUNCTION; CELL METABOLISM; CORNEA DYSTROPHY; DEPHOSPHORYLATION; ENZYMOLOGY; EUKARYOTE; HEREDITARY MOTOR SENSORY NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CONSENSUS SEQUENCE; MAMMALS; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN TRANSPORT;

EUKARYOTA; MAMMALIA; MICROSPORIDIA; PROTISTA;

EID: 30944461203     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2005.11.013     Document Type: Review

References (99)

1. J.G. Carlton, and P.J. Cullen Coincidence detection in phosphoinositide signaling Trends Cell Biol. 15 2005 540 547
2. C.C. Whiteford Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts Biochem. J. 323 1997 597 601
3. S.K. Dove Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis Nature 390 1997 187 192
4. D.R. Jones The identification of phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and its regulation by interleukin-2 J. Biol. Chem. 274 1999 18407 18413
5. H.J.G. Meijer Hyperosmotic stress induces rapid synthesis of phosphatidyl-D-inositol 3,5-bisphosphate in plant cells Planta 208 1999 294 298
6. G. Odorizzi Phosphoinositide signaling and the regulation of membrane trafficking in yeast Trends Biochem. Sci. 25 2000 229 235
7. 2 Cell Biol. Int. 25 2001 1201 1206
8. F.T. Cooke Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 2002 143 151
9. J.A. Efe The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology Curr. Opin. Cell Biol. 17 2005 402 408
10. G. Leondaritis D-3 phosphoinositides of the ciliate Tetrahymena: characterization and study of their regulatory role in lysosomal enzyme secretion Biochim. Biophys. Acta 1745 2005 330 341
11. J.D. Gary Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis J. Cell Biol. 143 1998 65 79
12. F.T. Cooke The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae Curr. Biol. 8 1998 1219 1222
13. M. Morishita Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe Genes Cells 7 2002 199 215
14. D.J. Gillooly Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes Histochem. Cell Biol. 120 2003 445 453
15. A. Yamamoto Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast Mol. Biol. Cell 6 1995 525 539
16. L.S. Weisman Yeast vacuole inheritance and dynamics Annu. Rev. Genet. 37 2003 435 460
17. M. Augsten Defective hyphal induction of a Candida albicans phosphatidylinositol 3-phosphate 5-kinase null mutant on solid media does not lead to decreased virulence Infect. Immun. 70 2002 4462 4470
18. M. Onishi Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe Biosci. Biotechnol. Biochem. 67 2003 1772 1779
19. 2-specific phosphatase Mol. Biol. Cell 15 2004 24 36
20. 2 is required for delivery of endocytic cargo into the multivesicular body Traffic 4 2003 479 490
21. K. Takegawa Vesicle-mediated protein transport pathways to the vacuole in Schizosaccharomyces pombe Cell Struct. Funct. 28 2003 399 417
22. O.C. Ikonomov Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve J. Biol. Chem. 276 2001 26141 26147
23. G. Odorizzi Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body Cell 95 1998 847 858
24. 2 synthesis and Fab1-dependent protein trafficking to the multivesicular body Curr. Biol. 12 2002 885 893
25. E. Muren Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport Yeast 18 2001 163 172
26. M. Onishi Importance of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe Biosci. Biotechnol. Biochem. 67 2003 1191 1193
27. B. Zheng Isolation of yeast mutants defective for localization of vacuolar vital dyes Proc. Natl. Acad. Sci. U. S. A. 95 1998 11721 11726
28. K.P. Rabitsch A screen for genes required for meiosis and spore formation based on whole-genome expression Curr. Biol. 11 2001 1001 1009
29. S. Bidlingmaier, and M. Snyder Large-scale identification of genes important for apical growth in Saccharomyces cerevisiae by directed allele replacement technology (DART) screening Funct. Integr. Genomics 1 2002 345 356
30. P. Briza Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous deletion strains of Saccharomyces cerevisiae Yeast 19 2002 403 422
31. D. Sbrissa, and A. Shisheva Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway J. Biol. Chem. 280 2005 7883 7889
32. R.K. McEwen Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases J. Biol. Chem. 274 1999 33905 33912
33. D. Sbrissa Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomembrane localization J. Biol. Chem. 277 2002 6073 6079
34. D. Sbrissa PIKfyve lipid kinase is a protein kinase: downregulation of 5′-phosphoinositide product formation by autophosphorylation Biochemistry 39 2000 15980 15989
35. D. Sbrissa PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin J. Biol. Chem. 274 1999 21589 21597
36. 2 production for endomembrane integrity J. Biol. Chem. 277 2002 9206 9211
37. C.J. Bonangelino Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology Mol. Cell. Biol. 17 1997 6847 6858
38. C.J. Bonangelino Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p J. Cell Biol. 156 2002 1015 1028
39. D. Sbrissa A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity Mol. Cell. Biol. 24 2004 10437 10447
40. J.D. Gary Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member Mol. Biol. Cell 13 2002 1238 1251
41. S.K. Dove Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors EMBO J. 23 2004 1922 1933
42. T. Georgakopoulos Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/ peroxisomal functions and amino acid signalling pathways Yeast 18 2001 1155 1171
43. C. Pendaries Phosphoinositide signaling disorders in human diseases FEBS Lett. 546 2003 25 31
44. E. Bertini 118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy) Neuromuscul. Disord. 14 2004 387 396
45. M.J. Wishart, and J.E. Dixon PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease Trends Cell Biol. 12 2002 579 585
46. A. Bolino Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis J. Cell Biol. 167 2004 711 721
47. J. Schaletzky Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases Curr. Biol. 13 2003 504 509
48. D.M. Walker Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity Curr. Biol. 11 2001 1600 1605
49. K. Tsujita Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction J. Biol. Chem. 279 2004 13817 13824
50. Y. Xue Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans J. Biol. Chem. 278 2003 34380 34386
51. H. Dang Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans Mol. Biol. Cell 15 2004 189 196
52. H. Tronchere Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells J. Biol. Chem. 279 2004 7304 7312
53. W.R. Parrish Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast Mol. Biol. Cell 15 2004 3567 3579
54. S. Krugmann Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices Mol. Cell 9 2002 95 108
55. M.A. Kearns Novel developmentally regulated phosphoinositide binding proteins from soybean whose expression bypasses the requirement for an essential phosphatidylinositol transfer protein in yeast EMBO J. 17 1998 4004 4017
56. G.E. Cozier The phox homology (PX) domain-dependent, 3-phosphoinositide- mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation J. Biol. Chem. 277 2002 48730 48736
57. T. Lazar A novel phospholipid-binding protein from the yeast Saccharomyces cerevisiae with dual binding specificities for the transport GTPase Ypt7p and the Sec1-related Vps33p Eur. J. Cell Biol. 81 2002 635 646
58. N.J. Bryant Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment J. Cell Biol. 142 1998 651 663
59. H. Barth Mai1p is essential for maturation of proaminopeptidase I but not for autophagy FEBS Lett. 512 2002 173 179
60. T. Proikas-Cezanne WIPI-1α (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy Oncogene 23 2004 9314 9325
61. J. Guan Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris Mol. Biol. Cell 12 2001 3821 3838
62. P.E. Stromhaug Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy Mol. Biol. Cell 15 2004 3553 3566
63. K. Meiling-Wesse Atg21 is required for effective recruitment of Atg8 to the preautophagosomal structure during the Cvt pathway J. Biol. Chem. 279 2004 37741 37750
64. T.R. Jeffries PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49 Mol. Biol. Cell 15 2004 2652 2663
65. J.M. Kavran Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains J. Biol. Chem. 273 1998 30497 30508
66. K. Bowers Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae Traffic 5 2004 194 210
67. P. Whitley Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization J. Biol. Chem. 278 2003 38786 38795
68. 2 effector required for protein sorting to the multivesicular body Dev. Cell 5 2003 499 511
69. A. Eugster Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body Mol. Biol. Cell 15 2004 3031 3041
70. 2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes Science 291 2001 1051 1055
71. T. Itoh Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis Science 291 2001 1047 1051
72. T. Itoh, and T. Takenawa Phosphoinositide-binding domains: functional units for temporal and spatial regulation of intracellular signalling Cell. Signal. 14 2002 733 743
73. T.S. Hyun HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains J. Biol. Chem. 279 2004 14294 14306
74. T.L. Howard CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins J. Cell Sci. 114 2001 2395 2404
75. H. Hartman, and A. Fedorov The origin of the eukaryotic cell: a genomic investigation Proc. Natl. Acad. Sci. U. S. A. 99 2002 1420 1425
76. L. Zonia, and T. Munnik Osmotically induced cell swelling versus cell shrinking elicits specific changes in phospholipid signals in tobacco pollen tubes Plant Physiol. 134 2004 813 823
77. H. Banfic Biphasic activation of PKBα/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate J. Biol. Chem. 273 1998 11630 11637
78. S. Li Mutations in PIP5K3 are associated with Francois-Neetens mouchetee fleck corneal dystrophy Am. J. Hum. Genet. 77 2005 54 63
79. O.C. Ikonomov Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects Endocrinology 143 2002 4742 4754
80. D. Sbrissa Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells J. Biol. Chem. 277 2002 47276 47284
81. A. Shisheva Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes J. Biol. Chem. 276 2001 11859 11869
82. D. Sbrissa Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation Endocrinology 145 2004 4853 4865
83. D.C. Berwick Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles J. Cell Sci. 117 2004 5985 5993
84. O.C. Ikonomov Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40 J. Biol. Chem. 278 2003 50863 50871
85. O.C. Ikonomov PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacuolating activity of Helicobacter pylori VacA toxin J. Biol. Chem. 277 2002 46785 46790
86. O.C. Ikonomov PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis Mol. Biol. Cell 14 2003 4581 4591
87. L.D. Hernandez Salmonella modulates vesicular traffic by altering phosphoinositide metabolism Science 304 2004 1805 1807
88. J.L. Murray Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus J. Virol. 79 2005 11742 11751
89. H. Santos, and M.S. da Costa Compatible solutes of organisms that live in hot saline environments Environ. Microbiol. 4 2002 501 509
90. C. Civera Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily Proteins 58 2005 354 366
91. G. Pappenberger Crystal structure of the CCTγ apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin J. Mol. Biol. 318 2002 1367 1379
92. J.M. Valpuesta Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT FEBS Lett. 529 2002 11 16
93. C. Spiess Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets Trends Cell Biol. 14 2004 598 604
94. B. Morgenstern DIALIGN: finding local similarities by multiple sequence alignment Bioinformatics 14 1998 290 294
95. J. Kunz The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity Mol. Cell 5 2000 1 11
96. L.A. Kelley Enhanced genome annotation using structural profiles in the program 3D-PSSM J. Mol. Biol. 299 2000 499 520
97. M.G. Williams Sequence-structure homology recognition by iterative alignment refinement and comparative modeling Proteins (Suppl 5) 2001 92 97
98. Y. Xiong AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana Plant J. 42 2005 535 546
99. H. Barth Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p FEBS Lett. 508 2001 23 28