Subunit interactions in ABC transporters: Towards a functional architecture

FEMS Microbiology Letters

Volumn 179, Issue 2, 1999, Pages 187-202

  Jones, Peter M ^a   George, Anthony M ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

ABC transporter; ATP binding domain; C motif; Histidine P dimer; P glycoprotein

Indexed keywords

ABC TRANSPORTER; GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEOTIDE BINDING PROTEIN;

BINDING SITE; CONFORMATIONAL TRANSITION; DIMERIZATION; GENETIC PROCEDURES; MEMBRANE CHANNEL; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SALMONELLA TYPHIMURIUM; SEQUENCE ANALYSIS;

EUKARYOTA; PROKARYOTA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032821236     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(99)00411-5     Document Type: Article

References (62)

1. Higgins, C.F. (1992) ABC transporters: From microorganisms to man. Annu. Rev. Cell Biol. 8, 67-113.
2. Ames, G.F.-L., Mimura, C.S. and Shyamala, V. (1990) Bacterial periplasmic permeases belong to a family of transport proteins operating from Escherichia coli to human: Traffic ATPases. FEMS Microbiol. Rev. 75, 429-446.
3. Blattner, F.R., Plunket III, G., Bloch, C.A., Perna, N.T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J.D., Rode, C.K., Mayhew, G.F., Gregor, J., Davis, N.W., Kirkpatrick, H.A., Goeden, M.A., Rose, D.J., Mau, B. and Shao, Y. (1997) The complete genome sequence of Escherichia coli K-12. Science 277, 1453-1474.
4. Tatusov, R.L., Koonin, E.V. and Lipman, D.J. (1997) A genomic perspective on protein families. Science 278, 631-637.
5. Ames, G.F.-L., Mimura, C., Holbrook, S. and Shyamala, V. (1992) Traffic ATPases: a superfamily of transport proteins operating from Escherichia coli to humans. Adv. Enzymol. 65, 1-47.
6. Doige, C.A. and Ames, G.F.-L. (1993) ATP-dependent transport systems in bacteria and humans: Relevance to cystic fibrosis and multidrug resistance. Annu. Rev. Microbiol. 47, 291-319.
7. Fath, M.J. and Kolter, R. (1993) ABC transporters: Bacterial exporters. Microbiol. Rev. 57, 995-1017.
8. Dean, M. and Allikmets, R. (1995) Evolution of ATP-binding cassette transporter genes. Curr. Biol. 5, 779-785.
9. Schneider, E. and Hunke, S. (1998) ATP-binding cassette (ABC) transport systems: Functional and structural aspects of the ATP-hydrolysing subunits/domains. FEMS Microbiol. Rev. 22, 1-20.
10. Croop, J.M. (1998) Evolutionary relationships among ABC transporters. Methods Enzymol. 292, 101-116.
11. Schwiebert, E.M. (1999) ABC transporter-facilitated ATP conductive transport. Am. J. Physiol. Cell Physiol. 276, C1-C8.
12. Saurin, W., Hofnung, M. and Dassa, E. (1999) Getting in or out: Early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters. J. Mol. Evol. 48, 22-41.
13. Hyde, S.C., Emsley, P., Hartshorn, M.J., Mimmack, M.M., Gileadi, U., Pearce, S.R., Gallagher, M.P., Gill, D.R., Hubbard, R.E. and Higgins, C.F. (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346, 362-365.
14. Bellamy, W. and Weinstein, R.S. (1994) Functional diversity in the multidrug resistance gene family. Lab. Invest. 71, 716-720.
15. Bolhuis, H., van Veen, H.W., Poolman, B., Driessen, A.J.M. and Konings, W.N. (1997) Mechanisms of multidrug transporters. FEMS Microbiol. Rev. 21, 55-84.
16. Hrycyna, C.A. and Gottesman, M.M. (1998) Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function. Drug Res. Updat. 1, 81-83.
17. van Veen, H.W. and Konings, W.N. (1998) The ABC family of multidrug transporters in microorganisms. Biochim. Biophys. Acta 1365, 31-36.
18. Ehrmann, M., Ehrle, R., Hofmann, E., Boos, W. and Schlosser, A. (1998) The ABC maltose transporter. Mol. Microbiol. 29, 685-694.
19. Méndez, C. and Salas, J.A. (1998) ABC transporters in antibiotic-producing actinomycetes. FEMS Microbiol. Lett. 158, 1-8.
20. van Veen, H.W., Vanema, K., Bolhuis, H., Oussenko, I., Kok, J., Poolman, B., Driessen, A.J.M. and Konings, W.N. (1996) Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. Proc. Natl. Acad. Sci. USA 93, 10668-10672.
21. van Veen, H.W., Callaghan, R., Soceneantu, L., Sardini, A., Konings, W.N. and Higgins, C.F. (1998) A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature 391, 291-295.
22. Gerlach, J.H., Endicott, J.A., Juranka, P.F., Henderson, G., Sarangi, F., Deuchlars, K.L. and Ling, V. (1986) Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature 324, 485-489.
23. Chen, C.-J., Chin, J.E., Ueda, K., Clark, D.P., Pastan, I., Gottesman, M.M. and Roninson, I.B. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47, 381-389.
24. Gros, P., Croop, J. and Housman, D. (1986) Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47, 371-380.
25. Bibi, E. and Beja, O. (1994) Membrane topology of multidrug resistance protein expressed in Escherichia coli. J. Biol. Chem. 269, 19910-19915.
26. Skach, W.R., Calayag, M.C. and Lingappa, V.R. (1993) Evidence for an alternate model of human P-glycoprotein structure and biogenesis. J. Biol. Chem. 268, 6903-6908.
27. Zhang, J.-T. and Ling, V. (1995) Involvement of cytoplasmic factors regulating the membrane orientation of P-glycoprotein sequences. Biochemistry 34, 9159-9165.
28. Jones, P.M. and George, A.M. (1998) A new structural model for P-glycoprotein. J. Membr. Biol. 166, 133-147.
29. Hung, L.-W., Wang, I.X., Nikaido, K., Liu, P.-Q., Ames, G.F.-L. and Kim, S.-H. (1998) Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 396, 703-707.
30. Pai, E.F., Krengel, U., Petsko, G.A., Goody, R.S., Kabsch, W. and Wittinghofer, A. (1990) Refined structure of the triphosphate conformation of H-ras-p21 at 1.35 Å resolution: implications for the mechanism of GTP hydrolysis. EMBO J. 9, 2351-2359.
31. Story, R.M., Weber, I.T. and Steitz, T.A. (1992) The structure of the E. coli recA protein monomer and polymer. Nature 355, 318-325.
32. Diederichs, K. and Schultz, G.E. (1990) Three-dimensional structure of the complex between the mitochondrial matrix adenylate kinase and its substrate AMP. Biochemistry 29, 8138-8144.
33. Smith, C.A. and Rayment, I. (1996) Active site comparisons highlight structural similarities between myosin and other P-loop proteins. Biophys. J. 70, 1590-1602.
34. 1-ATPase from bovine heart mitochondria. Nature 370, 621-628.
35. Walker, J.E., Saraste, M., Runswick, M.J. and Gay, N.J. (1982) Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide-binding fold. EMBO J. 1, 945-951.
36. Saraste, M., Sibbald, P.R. and Wittinghofer, A. (1990) The P-loop - a common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci. 15, 430-434.
37. 1-ATPase/recA topology: Structural model of the nucleotide-binding domains of the cystic fibrosis transmembrane conductance regulator (CFTR). J. Bioenerg. Biomembr. 29, 503-524.
38. Manavalan, P., Dearborn, D.G., McPherson, J.M. and Smith, A.E. (1995) Sequence homologies between nucleotide-binding-regions of CFTR and G-proteins suggest structural and functional similarities. FEBS Lett. 366, 87-91.
39. Noel, J.P., Hamm, H.E. and Sigler, P.B. (1993) The 2.2 Å crystal structure of transducin-α complexed with GTPγS. Nature 366, 654-663.
40. Kjeldgaard, M., Nissen, P., Thirup, S. and Nyborg, J. (1993) The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation. Structure 1, 35-50.
41. iα1 induced by GTP hydrolysis. Science 270, 954-960.
42. Park, S., Ajtai, K. and Burghardt, T.P. (1997) Mechanism for coupling free energy in ATPase to the myosin active site. Biochemistry 36, 3368-3372.
43. 1-AT-Pase. Biochemistry 37, 608-614.
44. 1-ATPase. Biochemistry 34, 3277-3285.
45. MacFarland, K.J., Shan, Q., Inman, R.B. and Cox, M.M. (1997) RecA as a motor protein. J. Biol. Chem. 272, 17675-17685.
46. Mimura, C.A., Holbrook, S.R. and Ames, G.F-L. (1991) Structural model of the nucleotide-binding conserved component of periplasmic permeases. Proc. Natl. Acad. Sci. USA 88, 84-88.
47. Beaudet, L. and Gros, P. (1995) Functional dissection of P-glycoprotein nucleotide-binding domains in chimeric and mutant proteins. J. Biol. Chem. 270, 17159-17170.
48. Beaudet, L., Urbatsch, I.L. and Gros, P. (1998) Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity. Biochemistry 37, 9073-9082.
49. Mourez, M., Jéhanno, M., Schneider, E. and Dassa, E. (1998) In vitro interaction between components of the inner membrane complex of the maltose ABC transporter of Escherichia coli: modulation by ATP. Mol. Microbiol. 30, 353-363.
50. Hoof, T., Demmer, A., Hadam, M.R., Riordan, J.R. and Tummler, B. (1994) Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1. J. Biol. Chem. 269, 20575-20583.
51. Bakos, É., Klein, I., Welker, E., Szabó, K., Müller, M., Sarkadi, B. and Váradi, A. (1997) Characterisation of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region. Biochem. J. 323, 777-783.
52. Szabó, K., Szakács, G., Hegedüs, T. and Sarkadi, B. (1999) Nucleotide occlusion in the human cystic fibrosis transmembrane regulator. J. Biol. Chem. 274, 12209-12212.
53. Nikaido, K., Liu, P.-Q. and Ames, G.F.-L. (1997) Purification and characterisation of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubilisation, dimerisation and AT-Pase activity. J. Biol. Chem. 272, 27745-27752.
54. Liu, C.E., Liu, P.-Q., Wolf, A., Lin, E. and Ames, G.F.-L. (1999) Both lobes of the soluble receptor of the periplasmic histidine permease, an ABC transporter (traffic ATPase), interact with the membrane-bound complex. J. Biol. Chem. 274, 739-747.
55. Mourez, M., Hofnung, M. and Dassa, E. (1997) Subunit interactions in ABC transporters: a conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits. EMBO J. 16, 3066-3077.
56. Shani, N., Sapag, A. and Valle, D. (1996) Characterisation and analysis of conserved motifs in a peroxisomal ATP-binding cassette transporter. J. Biol. Chem. 271, 8725-8730.
57. Wierenga, R.K., De Maeyer, M.C.H. and Hol, W.G.J. (1985) Interaction of pyrophosphate moieties with aα-helixes in dinucleotide-binding proteins. Biochemistry 24, 1346-1357.
58. Hol, W.G.J. (1985) The role of the α-helix dipole in protein function and structure. Prog. Biophys. Mol. Biol. 45, 149-195.
59. Bernstein, B.E., Michels, P.A.M. and Hols, W.G.J. (1997) Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Nature 385, 275-278.
60. Senior, A.E. (1998) Catalytic mechanism of P-glycoprotein. Acta Physiol. Scand. Suppl. 163, 213-218.
61. Szabó, K., Welker, E., Bakos, É., Müller, M., Roninson, I., Váradi, A. and Sarkadi, B. (1998) Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. J. Biol. Chem. 273, 10132-10238.
62. Evans, S.V. (1993) Setor - Hardware-lighted three-dimensional solid model representations of macromolecules. J. Mol. Graph. 11, 134-138.