The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes

Diabetes, Obesity and Metabolism

Volumn 11, Issue SUPPL. 1, 2009, Pages 25-30

  Baschal, E E ^a,b   Aly, T A ^a,b   Jasinski, J M ^a,b   Steck, A K ^a   Johnson, K N ^a   Noble, J A ^c   Erlich, H A ^d   Eisenbarth, George S ^a,b  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^d ROCHE MOLECULAR SYSTEMS   (United States)

Author keywords

8.1 haplotype; Extended haplotypes; Major histocompatibility complex; T1DGC; Type 1 diabetes

Indexed keywords

HLA DPB1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR3 ANTIGEN; HLA DR3 B8 A1 ANTIGEN; UNCLASSIFIED DRUG;

ACCURACY; ALLELE; ARTICLE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; FAMILY ASSESSMENT; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 58549099291     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.01000.x     Document Type: Article

References (15)

1. Alper CA, Larsen CE, Dubey DP, Awdeh ZL, Fici DA, Yunis EJ. The haplotype structure of the human major histocompatibility complex. Hum Immunol 2006; 67: 73-84.
2. Aly TA, Eller E, Ide A et al. Multi-SNP analysis of MHC region: remarkable conservation of HLA-A1-B8-DR3 haplotype. Diabetes 2006; 55: 1265-1269.
3. Awdeh ZL, Raum D, Yunis EJ, Alper CA. Extended HLA/complement allele haplotypes: Evidence for T/t-like complex in man. Proc Natl Acad Sci U S A 1983; 80: 259-263.
4. Yunis EJ. 1987 Philip Levine award lecture. MHC haplotypes in biology and medicine. Am J Clin Pathol 1988; 89: 268-280.
5. Degli-Esposti MA, Leaver AL, Christiansen FT, Witt CS, Abraham LJ, Dawkins RL. Ancestral haplotypes: Conserved population MHC haplotypes. Hum Immunol 1992; 34: 242-252.
6. Yunis EJ, Larsen CE, Fernandez-Vina M et al. Inheritable variable sizes of DNA stretches in the human MHC: Conserved extended haplotypes and their fragments or blocks. Tissue Antigens 2003; 62: 1-20.
7. Bilbao JR, Calvo B, Aransay AM et al. Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease. Genes Immun 2006; 7: 550-554.
8. Romero V, Larsen CE, Duke-Cohan JS et al. Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E. BMC Genet 2007; 8: 14.
9. Aly TA, Baschal EE, Jahromi MM et al. Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. Diabetes 2008; 57: 770-776.
10. Kelly H, McCann VJ, Kay PH, Dawkins RL. Susceptibility to IDDM is marked by MHC supratypes rather than individual alleles. Immunogenetics 1985; 22: 643-651.
11. Robinson WP, Barbosa J, Rich SS, Thomson G. Homozygous parent affected sib pair method for detecting disease predisposing variants: Application to insulin-dependent diabetes mellitus. Genet Epidemiol 1993; 10: 273-288.
12. Erlich H, Valdes AM, Noble J et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the type 1 diabetes genetics consortium families. Diabetes 2008; 57: 1084-1092.
13. O'Connell JR, Weeks DE. PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266.
14. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97-101.
15. Thomson G. Mapping disease genes: Family-based association studies. Am J Hum Genet 1995; 57: 487-498.