-
1
-
-
37049242573
-
Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept
-
Talmage DW: Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept. Science 129:1643-1648, 1959
-
(1959)
Science
, vol.129
, pp. 1643-1648
-
-
Talmage, D.W.1
-
2
-
-
0002633859
-
The new approach to immunology
-
Burnet FM: The new approach to immunology. N Engl J Med 264:24-34, 1961
-
(1961)
N Engl J Med
, vol.264
, pp. 24-34
-
-
Burnet, F.M.1
-
3
-
-
34248595506
-
T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
-
McGeachy MJ, Cua DJ: T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells. Immunity 26:547-549, 2007
-
(2007)
Immunity
, vol.26
, pp. 547-549
-
-
McGeachy, M.J.1
Cua, D.J.2
-
4
-
-
33947644716
-
Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
-
Davidson TS, DiPaolo RJ, Andersson J, Shevach EM: Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol 178:4022-4026, 2007
-
(2007)
J Immunol
, vol.178
, pp. 4022-4026
-
-
Davidson, T.S.1
DiPaolo, R.J.2
Andersson, J.3
Shevach, E.M.4
-
5
-
-
2942692039
-
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
-
Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM: CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med 199:1467-1477, 2004
-
(2004)
J Exp Med
, vol.199
, pp. 1467-1477
-
-
Tarbell, K.V.1
Yamazaki, S.2
Olson, K.3
Toy, P.4
Steinman, R.M.5
-
6
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA: Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346:1692-1698, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
-
7
-
-
32644459908
-
Antigen-specific regulatory T cells: Ex vivo expansion and therapeutic potential
-
Masteller EL, Tang Q, Bluestone JA: Antigen-specific regulatory T cells: ex vivo expansion and therapeutic potential. Semin Immunol 18:103-110, 2006
-
(2006)
Semin Immunol
, vol.18
, pp. 103-110
-
-
Masteller, E.L.1
Tang, Q.2
Bluestone, J.A.3
-
8
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR: The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121-1133, 2006
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
9
-
-
44049100797
-
Th17 cells: A new fate for differentiating helper T cells
-
Jan 3 Epub ahead of print
-
Chen Z, O'Shea JJ: Th17 cells: a new fate for differentiating helper T cells. Immunol Res Jan 3 (Epub ahead of print), 2008
-
(2008)
Immunol Res
-
-
Chen, Z.1
O'Shea, J.J.2
-
10
-
-
38749111445
-
Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production
-
Jain R, Tartar DM, Gregg RK, Divekar RD, Bell JJ, Lee HH, Yu P, Ellis JS, Hoeman CM, Franklin CL, Zaghouani H: Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med 205:207-218, 2008
-
(2008)
J Exp Med
, vol.205
, pp. 207-218
-
-
Jain, R.1
Tartar, D.M.2
Gregg, R.K.3
Divekar, R.D.4
Bell, J.J.5
Lee, H.H.6
Yu, P.7
Ellis, J.S.8
Hoeman, C.M.9
Franklin, C.L.10
Zaghouani, H.11
-
11
-
-
34347341846
-
-
Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tirgoviste C; Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC; Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG.: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39:857-864, 2007
-
Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tirgoviste C; Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC; Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG.: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39:857-864, 2007
-
-
-
-
12
-
-
0030969531
-
B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice
-
Noorchashm H, Noorchashm N, Kern J, Rostami SY, Barker CF, Naji A: B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. Diabetes 46:941-946, 1997
-
(1997)
Diabetes
, vol.46
, pp. 941-946
-
-
Noorchashm, H.1
Noorchashm, N.2
Kern, J.3
Rostami, S.Y.4
Barker, C.F.5
Naji, A.6
-
13
-
-
33846212347
-
Ito cells are liver-resident antigen-presenting cells for activating T cell responses
-
Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling PA, Modlin RL, Liblau RS, Gressner AM, Kaufmann SH: Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity 26:117-129, 2007
-
(2007)
Immunity
, vol.26
, pp. 117-129
-
-
Winau, F.1
Hegasy, G.2
Weiskirchen, R.3
Weber, S.4
Cassan, C.5
Sieling, P.A.6
Modlin, R.L.7
Liblau, R.S.8
Gressner, A.M.9
Kaufmann, S.H.10
-
14
-
-
0023252262
-
HLA-DQb gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
-
Todd JA, Bell JI, McDevitt HO: HLA-DQb gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329:599-604, 1987
-
(1987)
Nature
, vol.329
, pp. 599-604
-
-
Todd, J.A.1
Bell, J.I.2
McDevitt, H.O.3
-
15
-
-
0001657878
-
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: A family study
-
Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M: Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci U S A 85:8111-8115, 1988
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 8111-8115
-
-
Morel, P.A.1
Dorman, J.S.2
Todd, J.A.3
McDevitt, H.O.4
Trucco, M.5
-
16
-
-
0034454503
-
Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: Identification by the Diabetes Prevention Trial-type 1
-
Greenbaum CJ, Schatz DA, Cuthbertson D, Zeidler A, Eisenbarth GS, Krischer JP: Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: identification by the Diabetes Prevention Trial-type 1. J Clin Endocrinol Metab 85:1255-1260, 2000
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 1255-1260
-
-
Greenbaum, C.J.1
Schatz, D.A.2
Cuthbertson, D.3
Zeidler, A.4
Eisenbarth, G.S.5
Krischer, J.P.6
-
17
-
-
33749012255
-
Extreme genetic risk for type 1A diabetes
-
Aly TA, Ide A, Jahromi MM, Barker JM, Fernando MS, Babu SR, Yu L, Miao D, Erlich HA, Fain PR, Barriga KJ, Norris JM, Rewers MJ, Eisenbarth GS: Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A 103:14074-14079, 2006
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14074-14079
-
-
Aly, T.A.1
Ide, A.2
Jahromi, M.M.3
Barker, J.M.4
Fernando, M.S.5
Babu, S.R.6
Yu, L.7
Miao, D.8
Erlich, H.A.9
Fain, P.R.10
Barriga, K.J.11
Norris, J.M.12
Rewers, M.J.13
Eisenbarth, G.S.14
-
18
-
-
15444367789
-
Human leukocyte antigen class I B and C loci contribute to type 1 diabetes (T1D) susceptibility and age at T1D onset
-
Valdes AM, Erlich HA, Noble JA: Human leukocyte antigen class I B and C loci contribute to type 1 diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol 66:301-313, 2005
-
(2005)
Hum Immunol
, vol.66
, pp. 301-313
-
-
Valdes, A.M.1
Erlich, H.A.2
Noble, J.A.3
-
19
-
-
36849012027
-
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
-
Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA: Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450:887-892, 2007
-
(2007)
Nature
, vol.450
, pp. 887-892
-
-
Nejentsev, S.1
Howson, J.M.2
Walker, N.M.3
Szeszko, J.4
Field, S.F.5
Stevens, H.E.6
Reynolds, P.7
Hardy, M.8
King, E.9
Masters, J.10
Hulme, J.11
Maier, L.M.12
Smyth, D.13
Bailey, R.14
Cooper, J.D.15
Ribas, G.16
Campbell, R.D.17
Clayton, D.G.18
Todd, J.A.19
-
20
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS: Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435:220-223, 2005
-
(2005)
Nature
, vol.435
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Moriyama, H.3
Babaya, N.4
Liu, E.5
Miao, D.6
Yu, L.7
Wegmann, D.R.8
Hutton, J.C.9
Elliott, J.F.10
Eisenbarth, G.S.11
-
21
-
-
18744385526
-
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
-
Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA: Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435:224-228, 2005
-
(2005)
Nature
, vol.435
, pp. 224-228
-
-
Kent, S.C.1
Chen, Y.2
Bregoli, L.3
Clemmings, S.M.4
Kenyon, N.S.5
Ricordi, C.6
Hering, B.J.7
Hafler, D.A.8
-
22
-
-
3242768392
-
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes
-
Reijonen H, Mallone R, Heninger AK, Laughlin EM, Kochik SA, Falk B, Kwok WW, Greenbaum C, Nepom GT: GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes 53:1987-1994, 2004
-
(2004)
Diabetes
, vol.53
, pp. 1987-1994
-
-
Reijonen, H.1
Mallone, R.2
Heninger, A.K.3
Laughlin, E.M.4
Kochik, S.A.5
Falk, B.6
Kwok, W.W.7
Greenbaum, C.8
Nepom, G.T.9
-
23
-
-
0032823399
-
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
-
Wong FS, Karttunen J, Dumont C, Wen L, Visintin I, Pilip IM, Shastri N, Pamer EG, Janeway CA Jr: Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat Med 5:1026-1031, 1999
-
(1999)
Nat Med
, vol.5
, pp. 1026-1031
-
-
Wong, F.S.1
Karttunen, J.2
Dumont, C.3
Wen, L.4
Visintin, I.5
Pilip, I.M.6
Shastri, N.7
Pamer, E.G.8
Janeway Jr, C.A.9
-
24
-
-
0037478632
-
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
-
Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP: Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A 100:8384-8388, 2003
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8384-8388
-
-
Lieberman, S.M.1
Evans, A.M.2
Han, B.3
Takaki, T.4
Vinnitskaya, Y.5
Caldwell, J.A.6
Serreze, D.V.7
Shabanowitz, J.8
Hunt, D.F.9
Nathenson, S.G.10
Santamaria, P.11
DiLorenzo, T.P.12
-
25
-
-
29444433680
-
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes
-
Pinkse GG, Tysma OH, Bergen CA, Kester MG, Ossendorp F, van Veelen PA, Keymeulen B, Pipeleers D, Drijfhout JW, Roep BO: Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A 102:18425-18430, 2005
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18425-18430
-
-
Pinkse, G.G.1
Tysma, O.H.2
Bergen, C.A.3
Kester, M.G.4
Ossendorp, F.5
van Veelen, P.A.6
Keymeulen, B.7
Pipeleers, D.8
Drijfhout, J.W.9
Roep, B.O.10
-
26
-
-
85047690395
-
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
-
Arif S, Tree TI, Astill TP, Tremble JM, Bishop AJ, Dayan CM, Roep BO, Peakman M: Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 113:451-463, 2004
-
(2004)
J Clin Invest
, vol.113
, pp. 451-463
-
-
Arif, S.1
Tree, T.I.2
Astill, T.P.3
Tremble, J.M.4
Bishop, A.J.5
Dayan, C.M.6
Roep, B.O.7
Peakman, M.8
-
27
-
-
16944367194
-
Positional cloning of the APECED gene
-
Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M, Krohn KJE, Lalioti MD, Mullis PE, Antonarkis SE, Kawasaki K, Asakawa S, Ito F, Shimizu N: Positional cloning of the APECED gene. Nat Genet 17:393-398, 1997
-
(1997)
Nat Genet
, vol.17
, pp. 393-398
-
-
Nagamine, K.1
Peterson, P.2
Scott, H.S.3
Kudoh, J.4
Minoshima, S.5
Heino, M.6
Krohn, K.J.E.7
Lalioti, M.D.8
Mullis, P.E.9
Antonarkis, S.E.10
Kawasaki, K.11
Asakawa, S.12
Ito, F.13
Shimizu, N.14
-
28
-
-
33745211931
-
Defective regulatory and effector T cell functions in patients with FOXP3 mutations
-
Bacchetta R, Passerini L, Gambineri E, Dai M, Allan SE, Perroni L, Dagna-Bricarelli F, Sartirana C, Matthes-Martin S, Lawitschka A, Azzari C, Ziegler SF, Levings MK, Roncarolo MG: Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest 116:1713-1722, 2006
-
(2006)
J Clin Invest
, vol.116
, pp. 1713-1722
-
-
Bacchetta, R.1
Passerini, L.2
Gambineri, E.3
Dai, M.4
Allan, S.E.5
Perroni, L.6
Dagna-Bricarelli, F.7
Sartirana, C.8
Matthes-Martin, S.9
Lawitschka, A.10
Azzari, C.11
Ziegler, S.F.12
Levings, M.K.13
Roncarolo, M.G.14
-
29
-
-
34248372524
-
Loss of Aire- dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
-
Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D: Loss of Aire- dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad SciUSA104:4583-4587, 2007
-
(2007)
Proc Natl Acad SciUSA
, vol.104
, pp. 4583-4587
-
-
Gavanescu, I.1
Kessler, B.2
Ploegh, H.3
Benoist, C.4
Mathis, D.5
-
30
-
-
0025362072
-
NOD to the development of insulitis in non-obese diabetic mice
-
NOD to the development of insulitis in non-obese diabetic mice. Nature 345:722-724, 1990
-
(1990)
Nature
, vol.345
, pp. 722-724
-
-
Miyazaki, T.1
Uno, M.2
Uehira, M.3
Kikutani, H.4
Kishimoto, T.5
Kmoto, M.6
Nishimoto, H.7
Miyazaki, J.I.8
-
31
-
-
0027217789
-
Three-dimensional structure of the human class II histocompat-ibility antigen HLA-DR1
-
Brown JH, Jardetzky TS, Gorga JC, Stern LF, Urban RG, Strominger JL, Wiley DC: Three-dimensional structure of the human class II histocompat-ibility antigen HLA-DR1. Nature 364:33-39, 1993
-
(1993)
Nature
, vol.364
, pp. 33-39
-
-
Brown, J.H.1
Jardetzky, T.S.2
Gorga, J.C.3
Stern, L.F.4
Urban, R.G.5
Strominger, J.L.6
Wiley, D.C.7
-
32
-
-
42449144715
-
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the Type 1 Diabetes Genetics Consortium Families
-
Feb 5 Epub ahead of print
-
Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P: HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the Type 1 Diabetes Genetics Consortium Families. Diabetes Feb 5 (Epub ahead of print), 2008
-
(2008)
Diabetes
-
-
Erlich, H.1
Valdes, A.M.2
Noble, J.3
Carlson, J.A.4
Varney, M.5
Concannon, P.6
Mychaleckyj, J.C.7
Todd, J.A.8
Bonella, P.9
Fear, A.L.10
Lavant, E.11
Louey, A.12
Moonsamy, P.13
-
33
-
-
0031847984
-
Molecular basis for HLA-DQ association in IDDM
-
Nepom GT, Kwok WT: Molecular basis for HLA-DQ association in IDDM. Diabetes 47:1177-1184, 1998
-
(1998)
Diabetes
, vol.47
, pp. 1177-1184
-
-
Nepom, G.T.1
Kwok, W.T.2
-
34
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, et al.: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341, 2007
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
Frayling, T.M.4
Elliott, K.S.5
Lango, H.6
Timpson, N.J.7
Perry, J.R.8
Rayner, N.W.9
Freathy, R.M.10
Barrett, J.C.11
Shields, B.12
Morris, A.P.13
Ellard, S.14
Groves, C.J.15
Harries, L.W.16
Marchini, J.L.17
Owen, K.R.18
Knight, B.19
Cardon, L.R.20
more..
-
35
-
-
0028007192
-
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
-
Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94:2125-2129, 1994
-
(1994)
J Clin Invest
, vol.94
, pp. 2125-2129
-
-
Atkinson, M.A.1
Bowman, M.A.2
Campbell, L.3
Darrow, B.L.4
Kaufman, D.L.5
Maclaren, N.K.6
-
36
-
-
0033853920
-
Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes
-
Honeyman MC, Coulson BS, Stone NL, Gellert SA, Goldwater PN, Steele CE, Couper JJ, Tait BD, Colman PG, Harrison LC: Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes 49:1319-1324, 2000
-
(2000)
Diabetes
, vol.49
, pp. 1319-1324
-
-
Honeyman, M.C.1
Coulson, B.S.2
Stone, N.L.3
Gellert, S.A.4
Goldwater, P.N.5
Steele, C.E.6
Couper, J.J.7
Tait, B.D.8
Colman, P.G.9
Harrison, L.C.10
-
37
-
-
33846190681
-
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
-
Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA: TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol 178:693-701, 2007
-
(2007)
J Immunol
, vol.178
, pp. 693-701
-
-
Zipris, D.1
Lien, E.2
Nair, A.3
Xie, J.X.4
Greiner, D.L.5
Mordes, J.P.6
Rossini, A.A.7
-
38
-
-
36749013631
-
Danger-free autoimmune disease in Aire-deficient mice
-
Gray DH, Gavanescu I, Benoist C, Mathis D: Danger-free autoimmune disease in Aire-deficient mice. Proc Natl Acad Sci USA 104:18193-18198, 2007
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 18193-18198
-
-
Gray, D.H.1
Gavanescu, I.2
Benoist, C.3
Mathis, D.4
-
39
-
-
0021019885
-
Insulin antibodies in insulin-dependent diabetics before insulin treatment
-
Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL: Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222:1337-1339, 1983
-
(1983)
Science
, vol.222
, pp. 1337-1339
-
-
Palmer, J.P.1
Asplin, C.M.2
Clemons, P.3
Lyen, K.4
Tatpati, O.5
Raghu, P.K.6
Paquette, T.L.7
-
40
-
-
0027930455
-
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insuli- noma
-
Lan MS, Lu J, Goto Y, Notkins AL: Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insuli- noma. DNA Cell Biol 13:505-514, 1994
-
(1994)
DNA Cell Biol
, vol.13
, pp. 505-514
-
-
Lan, M.S.1
Lu, J.2
Goto, Y.3
Notkins, A.L.4
-
41
-
-
36749011882
-
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
-
Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC: The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad SciUSA104:17040-17045, 2007
-
(2007)
Proc Natl Acad SciUSA
, vol.104
, pp. 17040-17045
-
-
Wenzlau, J.M.1
Juhl, K.2
Yu, L.3
Moua, O.4
Sarkar, S.A.5
Gottlieb, P.6
Rewers, M.7
Eisenbarth, G.S.8
Jensen, J.9
Davidson, H.W.10
Hutton, J.C.11
-
42
-
-
0029995958
-
Prediction of type I diabetes mellitus in first degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512bdc/IA-2 autoantibodies
-
Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase PH, Eisenbarth GS: Prediction of type I diabetes mellitus in first degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933, 1996
-
(1996)
Diabetes
, vol.45
, pp. 926-933
-
-
Verge, C.F.1
Gianani, R.2
Kawasaki, E.3
Yu, L.4
Pietropaolo, M.5
Jackson, R.A.6
Chase, P.H.7
Eisenbarth, G.S.8
-
43
-
-
36448978896
-
Type 1 diabetes as a relapsing-remitting disease?
-
von Herrath M, Sanda S, Herold K: Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol 7:988-994, 2007
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 988-994
-
-
von Herrath, M.1
Sanda, S.2
Herold, K.3
-
44
-
-
29544444313
-
Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies
-
Pietropaolo M, Yu S, Libman IM, Pietropaolo SL, Riley K, LaPorte RE, Drash AL, Mazumdar S, Trucco M, Becker DJ: Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes 6:184-192, 2005
-
(2005)
Pediatr Diabetes
, vol.6
, pp. 184-192
-
-
Pietropaolo, M.1
Yu, S.2
Libman, I.M.3
Pietropaolo, S.L.4
Riley, K.5
LaPorte, R.E.6
Drash, A.L.7
Mazumdar, S.8
Trucco, M.9
Becker, D.J.10
-
45
-
-
33845316086
-
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
-
Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW: Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest 116:3258-3265, 2006
-
(2006)
J Clin Invest
, vol.116
, pp. 3258-3265
-
-
Krishnamurthy, B.1
Dudek, N.L.2
McKenzie, M.D.3
Purcell, A.W.4
Brooks, A.G.5
Gellert, S.6
Colman, P.G.7
Harrison, L.C.8
Lew, A.M.9
Thomas, H.E.10
Kay, T.W.11
-
46
-
-
0041743207
-
The toll-like receptor repertoire of human B lymphocytes: Inducible and selective expression of TLR9 and TLR10 in normal and transformed cells
-
Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A: The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 102:956-963, 2003
-
(2003)
Blood
, vol.102
, pp. 956-963
-
-
Bourke, E.1
Bosisio, D.2
Golay, J.3
Polentarutti, N.4
Mantovani, A.5
-
47
-
-
0032719206
-
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
-
Madsen LS, Andersson EC, Jansson L, krogsgaard M, Andersen CB, Engberg J, Strominger JL, Svejgaard A, Hjorth JP, Holmdahl R, Wucher- pfennig KW, Fugger L: A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet 23:343-347, 1999
-
(1999)
Nat Genet
, vol.23
, pp. 343-347
-
-
Madsen, L.S.1
Andersson, E.C.2
Jansson, L.3
krogsgaard, M.4
Andersen, C.B.5
Engberg, J.6
Strominger, J.L.7
Svejgaard, A.8
Hjorth, J.P.9
Holmdahl, R.10
Wucher- pfennig, K.W.11
Fugger, L.12
-
48
-
-
34250642773
-
Generation of T-cell receptor retrogenic mice
-
Holst J, Szymczak-Workman AL, Vignali KM, Burton AR, Workman CJ, Vignali DA: Generation of T-cell receptor retrogenic mice. Nat Protoc 1:406-417, 2006
-
(2006)
Nat Protoc
, vol.1
, pp. 406-417
-
-
Holst, J.1
Szymczak-Workman, A.L.2
Vignali, K.M.3
Burton, A.R.4
Workman, C.J.5
Vignali, D.A.6
-
49
-
-
33646401825
-
An immunologic homunculus for type 1 diabetes
-
Homann D, Eisenbarth GS: An immunologic homunculus for type 1 diabetes. J Clin Invest 116:1212-1215, 2006
-
(2006)
J Clin Invest
, vol.116
, pp. 1212-1215
-
-
Homann, D.1
Eisenbarth, G.S.2
-
50
-
-
34248233148
-
The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form
-
Levisetti MG, Suri A, Petzold SJ, Unanue ER: The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form. J Immunol 178:6051-6057, 2007
-
(2007)
J Immunol
, vol.178
, pp. 6051-6057
-
-
Levisetti, M.G.1
Suri, A.2
Petzold, S.J.3
Unanue, E.R.4
-
51
-
-
0030912279
-
Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse
-
Zekzer D, Wong FS, Wen L, Altieri M, Gurlo T, von Grafenstein H, Sherwin RS: Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse. Diabetes 46:1124-1132, 1997
-
(1997)
Diabetes
, vol.46
, pp. 1124-1132
-
-
Zekzer, D.1
Wong, F.S.2
Wen, L.3
Altieri, M.4
Gurlo, T.5
von Grafenstein, H.6
Sherwin, R.S.7
-
52
-
-
0026545730
-
Intrathymic islet cell transplantation reduces β-cell autoimmunity and prevents diabetes in NOD/Lt Mice
-
Gerling IC, Serreze DV, Christianson SW, Leiter EH: Intrathymic islet cell transplantation reduces β-cell autoimmunity and prevents diabetes in NOD/Lt Mice. Diabetes 41:1672-1676, 1992
-
(1992)
Diabetes
, vol.41
, pp. 1672-1676
-
-
Gerling, I.C.1
Serreze, D.V.2
Christianson, S.W.3
Leiter, E.H.4
-
53
-
-
0026695423
-
Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth
-
Posselt AM, Barker CF, Friedman AL, Naji A: Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth. Science 256:1321-1324, 1992
-
(1992)
Science
, vol.256
, pp. 1321-1324
-
-
Posselt, A.M.1
Barker, C.F.2
Friedman, A.L.3
Naji, A.4
-
54
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Barlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD: The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 15:293-297, 1997
-
(1997)
Nat Genet
, vol.15
, pp. 293-297
-
-
Pugliese, A.1
Zeller, M.2
Fernandez Jr, A.3
Zalcberg, L.J.4
Barlett, R.J.5
Ricordi, C.6
Pietropaolo, M.7
Eisenbarth, G.S.8
Bennett, S.T.9
Patel, D.D.10
-
55
-
-
1942506738
-
Reduced thymic expression of islet antigen contributes to loss of self tolerance
-
Mathews CE, Pietropaolo SL, Pietropaolo M: Reduced thymic expression of islet antigen contributes to loss of self tolerance. Ann N Y Acad Sci 1005:412-417, 2003
-
(2003)
Ann N Y Acad Sci
, vol.1005
, pp. 412-417
-
-
Mathews, C.E.1
Pietropaolo, S.L.2
Pietropaolo, M.3
-
57
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D: The cellular mechanism of Aire control of T cell tolerance. Immunity 23:227-239, 2005
-
(2005)
Immunity
, vol.23
, pp. 227-239
-
-
Anderson, M.S.1
Venanzi, E.S.2
Chen, Z.3
Berzins, S.P.4
Benoist, C.5
Mathis, D.6
-
58
-
-
0033579875
-
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
-
Hoglund P, Mintern J, Waltzinger C, Heath W, Benoist C, Mathis D: Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med 189:331-339, 1999
-
(1999)
J Exp Med
, vol.189
, pp. 331-339
-
-
Hoglund, P.1
Mintern, J.2
Waltzinger, C.3
Heath, W.4
Benoist, C.5
Mathis, D.6
-
59
-
-
19944432792
-
Cytokines down- regulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2 +, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL: Cytokines down- regulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2 +, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 54:452-461, 2005
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
Van Eylen, F.7
Mandrup-Poulsen, T.8
Herchuelz, A.9
Eizirik, D.L.10
-
61
-
-
33749370738
-
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid
-
Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, Thomas HE: Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes 55:2212-2219, 2006
-
(2006)
Diabetes
, vol.55
, pp. 2212-2219
-
-
Estella, E.1
McKenzie, M.D.2
Catterall, T.3
Sutton, V.R.4
Bird, P.I.5
Trapani, J.A.6
Kay, T.W.7
Thomas, H.E.8
-
62
-
-
1342282935
-
Role for oxidative stress in the regeneration of islet beta cells?
-
Haskins K, Kench J, Powers K, Bradley B, Pugazhenthi S, Reusch J, McDuffie M: Role for oxidative stress in the regeneration of islet beta cells? J Investig Med 52:45-49, 2004
-
(2004)
J Investig Med
, vol.52
, pp. 45-49
-
-
Haskins, K.1
Kench, J.2
Powers, K.3
Bradley, B.4
Pugazhenthi, S.5
Reusch, J.6
McDuffie, M.7
-
63
-
-
26244436171
-
Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt
-
Størling J, Binzer J, Andersson AK, Zullig RA, Tonnesen M, Lehmann R, Spinas GA, Sandler S, Billestrup N, Mandrup-Poulsen T: Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia 48:2039-2050, 2005
-
(2005)
Diabetologia
, vol.48
, pp. 2039-2050
-
-
Størling, J.1
Binzer, J.2
Andersson, A.K.3
Zullig, R.A.4
Tonnesen, M.5
Lehmann, R.6
Spinas, G.A.7
Sandler, S.8
Billestrup, N.9
Mandrup-Poulsen, T.10
-
64
-
-
0036195710
-
Oxidative stress and antioxidant status in type 1 diabetes mellitus
-
Vessby J, Basu S, Mohsen R, Berne C, Vessby B: Oxidative stress and antioxidant status in type 1 diabetes mellitus. J Intern Med 251:69 -76,2002
-
(2002)
J Intern Med
, vol.251
, pp. 69-76
-
-
Vessby, J.1
Basu, S.2
Mohsen, R.3
Berne, C.4
Vessby, B.5
-
65
-
-
0035845568
-
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
-
Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, Akira S, Araki E, Mori M: Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad SciUSA 98:10845-10850, 2001
-
(2001)
Proc Natl Acad SciUSA
, vol.98
, pp. 10845-10850
-
-
Oyadomari, S.1
Takeda, K.2
Takiguchi, M.3
Gotoh, T.4
Matsumoto, M.5
Wada, I.6
Akira, S.7
Araki, E.8
Mori, M.9
-
66
-
-
31344462462
-
Significance of serum CXCL10/IP-10 level in type 1 diabetes
-
Shigihara T, Oikawa Y, Kanazawa Y, Okubo Y, Narumi S, Saruta T, Shimada A: Significance of serum CXCL10/IP-10 level in type 1 diabetes. J Autoimmun 26:66-71, 2006
-
(2006)
J Autoimmun
, vol.26
, pp. 66-71
-
-
Shigihara, T.1
Oikawa, Y.2
Kanazawa, Y.3
Okubo, Y.4
Narumi, S.5
Saruta, T.6
Shimada, A.7
-
67
-
-
0033104725
-
Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes
-
Bradley LM, Asensio VC, Schioetz LK, Harbertson J, Krahl T, Patstone G, Woolf N, Campbell IL, Sarvetnick N: Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J Immunol 162:2511-2520, 1999
-
(1999)
J Immunol
, vol.162
, pp. 2511-2520
-
-
Bradley, L.M.1
Asensio, V.C.2
Schioetz, L.K.3
Harbertson, J.4
Krahl, T.5
Patstone, G.6
Woolf, N.7
Campbell, I.L.8
Sarvetnick, N.9
-
68
-
-
0031050034
-
Innate immunity: Impact on the adaptive immune response
-
Medzhitov R, Janeway CA: Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 9:4-9, 1997
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 4-9
-
-
Medzhitov, R.1
Janeway, C.A.2
-
69
-
-
0036533668
-
IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease
-
Corbaz A, ten Hove T, Herren S, Graber P, Schwartsburd B, Belzer I, Harrison J, Plitz T, Kosco-Vilbois MH, Kim SH, Dinarello CA, Novick D, van Deventer S, Chvatchko Y: IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease. J Immunol 168:3608-3616, 2002
-
(2002)
J Immunol
, vol.168
, pp. 3608-3616
-
-
Corbaz, A.1
ten Hove, T.2
Herren, S.3
Graber, P.4
Schwartsburd, B.5
Belzer, I.6
Harrison, J.7
Plitz, T.8
Kosco-Vilbois, M.H.9
Kim, S.H.10
Dinarello, C.A.11
Novick, D.12
van Deventer, S.13
Chvatchko, Y.14
-
70
-
-
33847053237
-
Altered natural killer cells in type 1 diabetic patients
-
Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D: Altered natural killer cells in type 1 diabetic patients. Diabetes 56:177-185, 2007
-
(2007)
Diabetes
, vol.56
, pp. 177-185
-
-
Rodacki, M.1
Svoren, B.2
Butty, V.3
Besse, W.4
Laffel, L.5
Benoist, C.6
Mathis, D.7
-
71
-
-
2942546678
-
NKG2D blockade prevents autoimmune diabetes in NOD mice
-
Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL: NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20:757-767, 2004
-
(2004)
Immunity
, vol.20
, pp. 757-767
-
-
Ogasawara, K.1
Hamerman, J.A.2
Ehrlich, L.R.3
Bour-Jordan, H.4
Santamaria, P.5
Bluestone, J.A.6
Lanier, L.L.7
-
72
-
-
20044385554
-
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
-
Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM: Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 11:138-145, 2005
-
(2005)
Nat Med
, vol.11
, pp. 138-145
-
-
Lang, K.S.1
Recher, M.2
Junt, T.3
Navarini, A.A.4
Harris, N.L.5
Freigang, S.6
Odermatt, B.7
Conrad, C.8
Ittner, L.M.9
Bauer, S.10
Luther, S.A.11
Uematsu, S.12
Akira, S.13
Hengartner, H.14
Zinkernagel, R.M.15
-
73
-
-
34248677854
-
Modeling the mechanisms of acute hepatitis B virus infection
-
Ciupe SM, Ribeiro RM, Nelson PW, Perelson AS: Modeling the mechanisms of acute hepatitis B virus infection. J Theor Biol 247:23-35, 2007
-
(2007)
J Theor Biol
, vol.247
, pp. 23-35
-
-
Ciupe, S.M.1
Ribeiro, R.M.2
Nelson, P.W.3
Perelson, A.S.4
|