Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 1, 2007, Pages 88-92

  Wang, Jian ^a   Miao, Dongmei ^a   Babu, Sunanda ^a   Yu, Jeesuk ^a   Barker, Jennifer ^a   Klingensmith, Georgeanna ^a   Rewers, Marian ^a   Eisenbarth, George S ^a   Yu, Liping ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE 65; HEMOGLOBIN; HLA ANTIGEN CLASS 2; INSULIN; INSULIN ANTIBODY;

ADOLESCENT; ADULT; AGE; ANTIBODY DETECTION; ARTICLE; BODY MASS; CELL HETEROGENEITY; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; ETHNICITY; FEMALE; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULINOMA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET CELL; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL ANALYSIS;

EID: 33846126592     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1494     Document Type: Article

References (24)

1. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase PH, Eisenbarth GS 1996 Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933
2. Bingley PJ, Bonifacio E, Williams AJK, Genovese S, Bottazzo GF, Gale EAM 1997 Prediction on IDDM in the general population; strategies based on combinations of autoantibody markers. Diabetes 46:1701-1710
3. Hagopian WA, Sanjeevi CB, Kockum I, Landin-Olsson M, Karlsen AE, Sundkvist G, Dahlquist G, Palmer J, Lernmark A 1995 Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95:1505-1511
4. Tiberti C, Buzzetti R, Anastasi E, Dotta F, Vestal M, Petrone A, Cervoni M, Torresi P, Vecci E, Multari G, Di Mario U 2000 Autoantibody negative new onset type 1 diabetic patients lacking high risk HLA alleles in a Caucasian population: are these type 1b diabetes cases? Diabetes Metab Res Rev 16:8-14
5. Yu L, Rewers M, Gianani R, Kawasaki E, Zhang Y, Verge C, Chase P, Klingensmith G, Erlich H, Norris J, Eisenbarth GS 1996 Antiislet autoantibodies usually develop sequentially rather than simultaneously. J Clin Endocrinol Metab 81:4264-4267
6. Yu L, Robles D, Abiru N, Kaur P, Rewers M, Keleman K, Eisenbarth GS 2000 Early expression of antiinsulin autoantibodies of human and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci USA 97:1701-1706
7. Schatz D, Krischer J, Horne G, Riley W, Spillar R, Silverstein J, Winter W, Muir A, Derovanesian D, Shah S, Malone J, Maclaren N 1994 Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives. J Clin Invest 93:2403-2407
8. Krischer JP, Cuthbertson DD, Yu L, Orban T, MaClaren N, Jackson R, Winter WE, Schatz DA, Palmer JP, Eisenbarth GS; and the Diabetes Prevention Trial-Type 1 Study Group 2003 Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab 88:103-108
9. Rewers M, Bugawan TL, Norris JM, Blair A, Beaty B, Hoffman M, McDuffie Jr RS, Hamman RF, Klingensmith G, Eisenbarth GS, Erlich HA 1996 Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY). Diabetologia 39:807-812
10. Jaeger C, Allendorfer J, Hatziagelaki E, Dyrberg T, Bergis KH, Federlin K, Bretzel RG 1997 Persistent GAD 65 antibodies in longstanding IDDM are not associated with residual β-cell function, neuropathy or HLA-DR status. Horm Metab Res 29:510-515
11. Eisenbarth GS, Gianani R, Yu L, Pietropaolo M, Verge CF, Chase PH, Redondo MJ, Colman P, Harrison L, Jackson R 1998 Dual-parameter model for prediction of type I diabetes mellitus. Proc Assoc Am Physicians 110:126-135
12. Robles DT, Eisenbarth GS, Wang T, Erlich HA, Bugawan TL, Babu SR, Barriga K, Norris JM, Hoffman M, Klingensmith G, Yu L, Rewers M 2002 Diabetes Autoimmunity Study in the Young: Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies. Clin Immunol 102:217-224
13. Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E 2004 Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 114:589-597
14. Greenbaum CJ, Eisenbarth G, Atkinson M, Yu L, Babu S, Schatz D, Zeidler A, Orban T, Wasserfall C, Cuthbertson D, Krischer J 2005 DPT-1 study group: high frequency of abnormal glucose tolerance in DQA1*0102/DQB1 *0602 relatives identified as part of the Diabetes Prevention Trial-Type 1 Diabetes. Diabetologia 48:68-74
15. Caillat-Zucman S, Garchon HJ, Timsit J, Assan R, Boitard C, Djilali-Saiah I, Bougnere P, Bach JF 1992 Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus. J Clin Invest 90:2242-2250
16. Graham J, Kockum I, Sanjeevi CB, Landin-Olsson M, Nystrom L, Sundkyst G, Arnqvist H, Blohme G, Lithner F, Littorin B, Schersten B, Wibell L, Ostman J, Lernmark A, Breslow N, Dahlquist G 1999 Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset. Swedish Childhood Diabetes Study Group. Eur J Immunogenet 26:117-127
17. Lohmann T, Sessler J, Verlohren HJ, Schroder S, Rotger J, Dahn K, Morgenthaler N, Scherbaum WA 1997 Distinct genetic and immunological features in patients with onset of IDDM before and after age 40. Diabetes Care 20:524-529
18. Horton V, Stratton I, Bottazzo GF, Shattock M, Mackay I, Zimmet P, Manley S, Holman R, Turner R 1999 Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group. Diabetologia 42:608-616
19. Dabelea D, Pettitt DJ, Jones KL, Arslanian SA 1999 Type 2 diabetes mellitus in minority children and adolescents. An emerging problem. Endocrinol Metab Clin North Am 28:709-729
20. Arslanian SA 2002 Metabolic differences between Caucasian and African-American children and the relationship to type 2 diabetes mellitus. J Pediatr Endocrinol Metab 15(Suppl 1):509-517
21. Kimm SYS, Barton BA, Obarzanek E, McMahon RP, Sabry ZI, Waclawiw MA, Schreiber GB, Morrison JA, Similo S, Daniels SR 2001 Racial divergence in adiposity during adolescence: the NHLBI growth and health study. Pediatr 107:E34
22. Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S 2006 Ethnic differences in cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 49:571-579
23. Fagot-Campagna A, Pettitt DJ, Engelgau MM, Rios Burrows N, Geiss LS, Valdez R 2000 Type 2 diabetes among North American children and adolescents: an epidemiological review and a public health perspective. J Pediatr 136:664-672
24. Rami B, Schober E, Nachbauer E, Waldhör T 2003 Austrian Diabetes Incidence Study Group: type 2 diabetes mellitus is rare but not absent in children under 15 years of age in Austria. Eur J Pediatr 162:1323-1327