Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice

Biochemical and Biophysical Research Communications

Volumn 367, Issue 4, 2008, Pages 719-724

  Fukushima, Keiko ^a,b   Abiru, Norio ^a   Nagayama, Yuji ^c   Kobayashi, Masakazu ^a,e   Satoh, Tsuyoshi ^a   Nakahara, Mami ^c   Kawasaki, Eiji ^b   Yamasaki, Hironori ^a,c   Ueha, Satoshi ^d   Matsushima, Koji ^d   Liu, Edwin ^e   Eguchi, Katsumi ^a  

^a Graduate School of Biomedical Sciences   (Japan)

^b NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

CD4+ T cell; Insulin; Insulitis; Non obese diabetic mouse; Peptide; Polyinosinic polycytidylic acid; Regulatory T cell; Type 1 diabetes

Indexed keywords

AUTOANTIGEN; CD4 ANTIBODY; FOXP3 ANTIBODY; INSULIN; PEPTIDE B 9 23; POLYINOSINIC POLYCYTIDYLIC ACID; SERYLHISTIDYLLEUCYLVALYLGLUTAMYLALANYLLEUCYLTYROSYL LEUCYLVALYLCYSTEINYLGLYCYLGLUTAMYLARGINYLGLYCYL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; DRUG SYNTHESIS; FEMALE; IMMUNOFLUORESCENCE; INSULITIS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; THERAPY EFFECT;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; OBESITY; PEPTIDE FRAGMENTS; POLY I-C;

MUS;

EID: 38649120073     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.191     Document Type: Article

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