Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery

Journal of Medicinal Chemistry

Volumn 49, Issue 22, 2006, Pages 6522-6531

  Cheng, Jianjun ^a,b   Zeidan, Ryan ^c   Mishra, Swaroop ^c,e   Liu, Aijie ^a   Pun, Suzie H ^a,e   Kulkarni, Rajan P ^d   Jensen, Gregory S ^a   Bellocq, Nathalie C ^a   Davis, Mark E ^c  

^a Insert Therapeutics Inc   (United States)

^b University of Illinois at Urbana Champaign   (United States)

^c California Institute of Technology   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^e University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE; ALIPHATIC AMINE; AROMATIC COMPOUND; CHLOROQUINE; CHLOROQUINE DERIVATIVE; DNA; MEPACRINE; N4 (4 PYRIDINYL) N',N' DIETHYL 1,4 PENTANEDIAMINE; N4 (4 QUINOLINYL) N1,N1 DIETHYL 1,4 PENTANEDIAMINE; NUCLEIC ACID; POLYCATION; PYRIDINE; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA DRUG COMPLEX; DRUG SYNTHESIS; ENDOSOME; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERCALATION COMPLEX; NONVIRAL GENE DELIVERY SYSTEM; PH; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TRANSGENE;

CELL LINE, TUMOR; CHLOROQUINE; CYCLODEXTRINS; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; LUCIFERASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSGENES;

EID: 33750478347     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060736s     Document Type: Article

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