Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells

Laboratory Investigation

Volumn 79, Issue 12, 1999, Pages 1573-1582

  Herold Mende, Christel ^a,c   Steiner, Hans Herbert ^a   Andl, Thomas ^b   Riede, Daniela ^a   Buttler, Annette ^a   Reisser, Christoph ^a   Fusenig, Norbert E ^d   Mueller, Margareta M ^d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY ENDOTHELIUM; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GLIOMA; HUMAN; HUMAN CELL; OXYGEN SUPPLY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TUMOR CELL CULTURE; TUMOR VASCULARIZATION; TUMOR VOLUME;

BASE SEQUENCE; CELL DIVISION; CELL MOVEMENT; CULTURE MEDIA, CONDITIONED; DNA PRIMERS; GLIOMA; HUMANS; MELANOMA; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 0033396726     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Ahmed A, Dunk C, Kniss D, and Wilkes M (1997). Role of VEGF receptor-1 (flt-1) in mediating calcium-dependent nitric oxide release and limiting DNA synthesis in human trophoblast cells. Lab Invest 76:779-791.
2. Bellamy WT, Richter L, Frutiger Y, and Grogan TM (1999). Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. Cancer Res 59: 728-733.
3. Berard M, Sordello S, Ortega N, Carrier J-L, Peyri N, Wassef M, Bertrand N, Enjolras O, Drouet L, and Plouet J (1997). Vascular endothelial growth factor confers a growth advantage in vitro and in vivo to stromal cells cultured from neonatal hemangiomas. Am J Pathol 150:1315-1326.
4. Berkman RA, Merrill MJ, Reinhold WC, Monacci WT, Saxena A, Clark WC, Robertson JT, Ali IU, and Oldfield EH (1993). Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous neoplasms. J Clin Invest 91:153-159.
5. Boocock C, Charnock-Jones D, Sharkey A, McLaren J, Barker P, Wright K, Twentyman P, and Smith S (1995). Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst 87:506-516.
6. Brown LF, Detmar M, Tognazzi K, Abu-Jawdeh G, and Iruela-Arispe ML (1997). Uterine smooth muscle cells express functional receptors (FLT-1 and KDR) for vascular permeability factor/vascular endothelial growth factor. Lab Invest 2:245-255.
7. Bruce JN, Criscuolo GR, Merrill MJ, Moquin RR, Blacklock JB, and Oldfield EH (1987). Vascular permeability induced by protein product of malignant brain tumors: Inhibition by dexamethasone. J Neurosurg 67:880-884.
8. Burger PC, and Green S (1987). Patient age, histological features and length of survival in patients with glioblastoma multiforme. Cancer 59:1617-1625.
9. Cavallo T, Sade R, Folkman J, and Cotran RS (1972). Tumor angiogenesis: Rapid induction of endothelial mitoses demonstrated by autoradiography. J Cell Biol 54:408-420.
10. Charnock-Jones D, Sharkey A, Boocock C, Ahmed A, Plevin R, Ferrara N, and Smith S (1994). Vascular endothelial growth factor receptor localization and activation in human trophoblast and choriocarcinoma cells. Biol Reprod 51:524-530.
11. Claffey KL, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ, and Dvorak HF (1996). Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 56:172-181.
12. Cohadon F (1990). Indications for surgery in the management of gliomas. Adv Tech Stand Neurosurg 17:1-5.
13. Cohen T, Gitay GH, Sharon R, Shibuya M, Halaban R, Levi BZ, and Neufeld G (1995). VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to VEGF receptors of human melanoma cells. J Biol Chem 270:11322-11326.
14. Conn G, Sodermann DD, Schaeffer M, Wile M, Hatcher VB, and Thomas KA (1990). Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line. Biochemistry 87:1323-1327.
15. De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, and Williams LT (1992). The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991.
16. Easty DJ, Herlyn M, and Bennett DC (1995). Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Int J Cancer 60:129-136.
17. Finkenzeller G, Marme D, Weich HA, and Hug H (1993). Platelet derived growth factor-induced transcription of vascular endothelial growth factor gene is mediated by protein kinase C. Cancer Res 52:4821-4823.
18. Folkman J (1990). What is the evidence that tumors are angiogenesis dependent. J Natl Cancer Inst 82:4-6.
19. Folkman J, and Klagsburn M (1987). Angiogenic factors. Science 235:442-447.
20. Fong G-H, Rossant J, Gertsenstein M, and Breitman ML (1995). Role of Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66-70.
21. Gitay-Goren H, Halaban R, and Neufeld G (1993). Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors. Biochem Biophys Res Commun 190:702-709.
22. Gitay-Goren H, Soker SM, Vlodavsky I, and Neufeld G (1992). The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules. J Biol Chem 267:6093-6098.
23. Guerrin M, Moukadiri H, Chollet P, Moro F, Dutt K, Malecaze F, and Plouet J (1995). Vasculotropin/vascular endothelial growth factor is an autocrine growth factor for human retinal pigment cells cultured in vitro. J Cell Physiol 164:385-394.
24. Herold-Mende C, Seiter S, Born AI, Patzelt E, Schupp M, Zoeller JI, Bosch FX, and Zoeller M (1996). Expression of CD44 splice variants in squamous epithelia and squamous cell carcinomas of the head and neck. J Pathol 179:66-73.
25. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, and Leung DW (1991). The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5:1806-1814.
26. Ikeda E, Achen MG, Breier G, Risau W (1995). Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270:19761-19766.
27. Jensen RL (1998). Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review. Surg Neurol 49:189-196.
28. Leung DW, Cachianes G, Kuang W, Goeddel DV, and Ferrara N (1989). Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306-1309.
29. Liu B, Earl HM, Baban D, Shoaibi M, Fabra A, Kerr DJ, and Seymour LW (1995). Melanoma cell lines express VEGF receptor KDR and respond to exogeneously added VEGF. Biochem Biophys Res Commun 217:721-727.
30. Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, and Alittalo K (1999). Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. J Biol Chem 274:21217-21222.
31. Masood R, Cai J, Zheng T, Smith DL, Naidu Y, and Gill PS (1997). Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma. Proc Natl Acad Sci USA 94:979-984.
32. Miao HQ, Soker S, Feiner L, Alonso JL, Raper JA, and Klagsbrun M (1999). Neuropilin-1 mediates collapsin-1/ semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol 146:233-242.
33. Millauer B, Wizigmann-Voos S, Schnuerch H, Martinez R, Moller NPH, Risau W, and Ullrich A (1993). High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835-846.
34. Mueller MM, and Fusenig NE (In press, 1999). Constitutive expression of G-CSF and GM-CSF in human skin carcinoma cells with functional consequence for tumor progression. Int J Cancer.
35. Nomura M, Yamagaishi S, Harada S, Hayashi Y, Yamashima T, Yamashita J, and Yamamoto H (1995). Possible participation of autocrine and paracrine vascular endothelia growth factors in hypoxia-induced proliferation of endothelial cells and pericytes. J Biol Chem 270:28316-28324.
36. Oberg C, Waltenberger J, Claesson-Welsh L, and Welsh M (1994). Expression of protein tyrosine kinases in islet cells: Possible role of the Flk-1 receptor for beta-cell maturation from duct cells. Growth Factors 10:115-126.
37. Peters KG, De VC, and Williams LT (1993). Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 90:8915-8919.
38. Pousztai L, Lewis E, Lorenzen J, and McGee J (1993). Growth factors: Regulation of normal and neoplastic growth. J Pathol 169:191-201.
39. Quinn TP, Peters KG, De Vries C, Ferrara N, and Williams LT (1993). Fetal liver kinase I is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 90:7533-7537.
40. Samoto K, Ikezaki K, Ono M, Shono T, Kohno K, Kuwano M, and Fukui M (1995). Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Res 55:1189-1193.
41. Senger DR, Van de Water L, Brown LF, Nagy JA, Yeo KT, Berse B, Jackman RW, Dvorak AM, and Dcorak HF (1993). Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev 12:303-324.
42. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu X-F, Breitman ML, and Schuh AC (1995). Failure of blood island formation and vasculogenesis in flk-1 deficient mice. Nature 376:62-66.
43. Shawn LM, Itin LM, McMahon G, App H, Schreck R, Kuchler WR, Longhi MP, Hui TH, Tang C, Levitzki A, Gazit A, Chen I, Keri G, Laszlo O, Risau W, Flamme I, Ullrich A, Hirth P, and Shawver LK (1996). Flk-1 as a target for tumor growth inhibition. Cancer Res 56:3540-3545.
44. Shen H, Clauss M, Ryan J, Schmidt AM, Tijburg P, Borden L, Conolly D, Stern D, and Kao J (1993). Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood 81:2767-2773.
45. Shibuya H, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, and Sato M (1990). Nucleotide sequence and expression of a novel human receptor-type kinase gene (Flt) closely related to the fms like family. Oncogene 5:519-524.
46. Shweiki D, Itin A, Soffer D, and Keshet E (1992). Vascular endothelial growth factor induced by hypoxia-initiated angiogenesis. Nature 359:843-845.
47. Siemeister G, Martiny-Baron G, and Marme D (1998). The pivotal role of VEGF in tumor angiogenesis: Molecular facts and therapeutic opportunities. Cancer Metastasis Rev 17: 241-248.
48. Soker S, Takashima S, Maio HQ, Neufeld G, and Klagsbrun M (1998). Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 192:735-745.
49. Steiner H-H, Herold-Mende C, Bonsanto M, Geletneky K, and Kunze S (1998). Zur Prognose von Hirntumoren: Epidemiologie, Ueberlebenszeit und klinischer Verlauf. Versicherungsmedizin 5:173-178.
50. Strugar J, Rothbart D, Harrington W, and Criscoulo GR (1994). Vascular permeability factor in brain metastases: Correlation with vasogenic brain edema and tumor angiogenesis. J Neurosurg 81:560-566.
51. Theurillat JP, Hainfellner J, Maddalena A, Weissenberger J, and Aguzzi A (1999). Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice. Am J Pathol 154:581-590.
52. Tischer E, Gospodarowiez D, Mitchell R, Silva M, Schilling J, Lau K, Crisp T, Fiddes JC, and Abraham JA (1989). Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family. Biochem Biophys Res Commun 165:1198-1206.
53. Volm M, Koomägi R, Mattern J (1997). Prognostic value of vascular endothelial growth factor and its receptor flt-1 in squamous cell lung cancer. Int J Cancer 74:64-68.
54. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, and Heldin CH (1994). Different signal transduction properties of KDR and Flt-1 : Two receptors for VEGF. J Biol Chem 269:26988-26995.
55. Zagzag D (1995). Angiogenic growth factors in neural embryogenesis and neoplasia. Am J Pathol 146:293-309.