Mechanism-Based Inactivation of Thioredoxin Reductase from Plasmodium falciparum by Mannich Bases. Implication for Cytotoxicity

Biochemistry

Volumn 42, Issue 45, 2003, Pages 13319-13330

  Davioud Charvet, Elisabeth ^a,b,f   McLeish, Michael J ^a   Veine, Donna M ^b   Giegel, David ^c,g   Arscott, L David ^b   Andricopulo, Adriano D ^a,h   Becker, Katja ^d   Müller, Sylke ^e   Schirmer, R Heiner ^f   Williams Jr , Charles H ^b   Kenyon, George L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c PFIZER INC   (United States)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g Migenix Inc   (United States)

^h UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CATALYST ACTIVITY; CHEMICAL ACTIVATION; CHEMICAL MODIFICATION; DIMERS; DISEASE CONTROL; DRUG THERAPY; ENZYME INHIBITION; MOLECULAR STRUCTURE; PROTEINS; TOXICITY;

CYTOTOXICITY;

BIOCHEMISTRY;

CYSTEINE; FLAVOPROTEIN; GLUTATHIONE; MACROCYCLIC COMPOUND; MANNICH BASE; MESYLIC ACID METHYL ESTER; THIOREDOXIN; THIOREDOXIN DISULFIDE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ALKYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CYTOTOXICITY; DRUG TARGETING; ENZYME INACTIVATION; MICHAEL ADDITION; NONHUMAN; OXIDATION REDUCTION REACTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPECTROSCOPY;

ALKYLATING AGENTS; ANIMALS; DITHIONITROBENZOIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MANNICH BASES; METHYL METHANESULFONATE; MODELS, CHEMICAL; NADP; OXIDATION-REDUCTION; PLASMODIUM FALCIPARUM; PROPIOPHENONES; THIOREDOXIN REDUCTASE (NADPH);

PLASMODIUM FALCIPARUM; STAPHYLOCOCCUS PHAGE 3A;

EID: 10744226522     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0353629     Document Type: Article

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