Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 8048-8059

  Chavain, Natascha ^a   Davioud Charvet, Elisabeth ^b,c   Trivelli, Xavier ^a   Mbeki, Linda ^a   Rottmann, Matthias ^d   Brun, Reto ^d   Biot, Christophe ^a  

^a UNIV LILLE   (France)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Bioorganometallics; Dual drugs; Glutathione reductase; Hemozoin; Mechanism of action

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; CHLOROQUINE; ENZYME INHIBITOR; FERROCENE DERIVATIVE; GLUTATHIONE REDUCTASE; GLUTATHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PLASMODIUM FALCIPARUM;

AMINOQUINOLINES; ANTIMALARIALS; ENZYME INHIBITORS; FERROUS COMPOUNDS; HEMIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM; PRODRUGS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 71849091387     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.008     Document Type: Article

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