A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body

Experimental Cell Research

Volumn 312, Issue 11, 2006, Pages 2018-2027

  Lindmo, Karine ^a   Simonsen, Anne ^a   Brech, Andreas ^a   Finley, Kim ^b   Rusten, Tor Erik ^a   Stenmark, Harald ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Atg8; Autophagy; Deep orange; Drosophila; Ecdysone; LC3; Lysosome; Vps

Indexed keywords

CARRIER PROTEIN; DEEP ORANGE PROTEIN; ECDYSONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; BODY FAT; CELL FUSION; CHROMOSOME PUFF; DEGRADATION; DOWN REGULATION; DROSOPHILA; DROSOPHILA MELANOGASTER; ENDOSOME; ENZYME ACTIVITY; HYPOTHESIS; LARVA; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; YEAST;

DROSOPHILA MELANOGASTER; HEXAPODA;

EID: 33744914606     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.03.002     Document Type: Article

References (39)

1. Klionsky D.J., and Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science 290 (2000) 1717-1721
2. Noda T., Suzuki K., and Ohsumi Y. Yeast autophagosomes: de novo formation of a membrane structure. Trends Cell Biol. 12 (2002) 231-235
3. Kamada Y., Sekito T., and Ohsumi Y. Autophagy in yeast: a TOR-mediated response to nutrient starvation. Curr. Top. Microbiol. Immunol. 279 (2004) 73-84
4. Scott R.C., Schuldiner O., and Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7 (2004) 167-178
5. Shintani T., and Klionsky D.J. Autophagy in health and disease: a double-edged sword. Science 306 (2004) 990-995
6. Rusten T.E., Lindmo K., Juhasz G., Sass M., Seglen P.O., Brech A., and Stenmark H. Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7 (2004) 179-192
7. Gilbert L.I. Halloween genes encode P450 enzymes that mediate steroid hormone biosynthesis in Drosophila melanogaster. Mol. Cell. Endocrinol. 215 (2004) 1-10
8. Lindmo K., and Stenmark H. Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci. 119 (2006) 605-614
9. Petiot A., Ogier-Denis E., Blommaart E.F., Meijer A.J., and Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 275 (2000) 992-998
10. Melendez A., Talloczy Z., Seaman M., Eskelinen E.L., Hall D.H., and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301 (2003) 1387-1391
11. Seglen P.O., and Bohley P. Autophagy and other vacuolar protein degradation mechanisms. Experientia 48 (1992) 158-172
12. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
13. Oldham S., and Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 (2003) 79-85
14. Maehama T., and Dixon J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 (1998) 13375-13378
15. Klionsky D.J., Cregg J.M., Dunn Jr. W.A., Emr S.D., Sakai Y., Sandoval I.V., Sibirny A., Subramani S., Thumm M., Veenhuis M., and Ohsumi Y. A unified nomenclature for yeast autophagy-related genes. Dev. Cell 5 (2003) 539-545
16. Wang C.W., and Klionsky D.J. The molecular mechanism of autophagy. Mol. Med. 9 (2003) 65-76
17. Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat. Rev., Mol. Cell Biol. 2 (2001) 211-216
18. Sato T.K., Rehling P., Peterson M.R., and Emr S.D. Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion. Mol. Cell 6 (2000) 661-671
19. Peterson M.R., and Emr S.D. The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic 2 (2001) 476-486
20. Sevrioukov E.A., He J.P., Moghrabi N., Sunio A., and Kramer H. A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila. Mol. Cell 4 (1999) 479-486
21. Sriram V., Krishnan K.S., and Mayor S. deep-orange and carnation define distinct stages in late endosomal biogenesis in Drosophila melanogaster. J. Cell Biol. 161 (2003) 593-607
22. Biyasheva Z.M., Belyaeva E.S., and Zhimulev I.F. Cytogenetic analysis of the X-chromosome region 2B1-2-2B9-10 of Drosophila melanogaster. V. Puffing disturbances carried by lethal mutations of the gene dor are due to ecdysterone deficiency. Chromosoma 92 (1985) 351-356
23. Belyaeva E.S., Vlassova I.E., Biyasheva Z.M., Kakpakov V.T., Richards G., and Zhimulev I.F. Cytogenetic analysis of the 2B3-4-2B11 region of the X chromosome of Drosophila melanogaster. II. Changes in 20-OH ecdysone puffing caused by genetic defects of puff 2B5. Chromosoma 84 (1981) 207-219
24. Kirisako T., Baba M., Ishihara N., Miyazawa K., Ohsumi M., Yoshimori T., Noda T., and Ohsumi Y. Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J. Cell Biol. 147 (1999) 435-446
25. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., and Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19 (2000) 5720-5728
26. Mizushima N., Yamamoto A., Matsui M., Yoshimori T., and Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15 (2004) 1101-1111
27. Gao X., Neufeld T.P., and Pan D. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev. Biol. 221 (2000) 404-418
28. Britton J.S., Lockwood W.K., Li L., Cohen S.M., and Edgar B.A. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2 (2002) 239-249
29. Lloyd T.E., Atkinson R., Wu M.N., Zhou Y., Pennetta G., and Bellen H.J. Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108 (2002) 261-269
30. Kozlova T., and Thummel C.S. Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorphosis. Development 129 (2002) 1739-1750
31. Asha H., Nagy I., Kovacs G., Stetson D., Ando I., and Dearolf C.R. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics 163 (2003) 203-215
32. Colombani J., Bianchini L., Layalle S., Pondeville E., Dauphin-Villemant C., Antoniewski C., Carre C., Noselli S., and Leopold P. Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 310 (2005) 667-670
33. Butterworth F.M., Emerson L., and Rasch E.M. Maturation and degeneration of the fat body in the Drosophila larva and pupa as revealed by morphometric analysis. Tissue Cell 20 (1988) 255-268
34. Kozlova T., and Thummel C.S. Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science 301 (2003) 1911-1914
35. Pulipparacharuvil S., Akbar M.A., Ray S., Sevrioukov E.A., Haberman A.S., Rohrer J., and Kramer H. Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules. J. Cell Sci. 118 (2005) 3663-3673
36. Mizushima N., Yamamoto A., Hatano M., Kobayashi Y., Kabeya Y., Suzuki K., Tokuhisa T., Ohsumi Y., and Yoshimori T. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell Biol. 152 (2001) 657-668
37. Kirisako T., Ichimura Y., Okada H., Kabeya Y., Mizushima N., Yoshimori T., Ohsumi M., Takao T., Noda T., and Ohsumi Y. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J. Cell Biol. 151 (2000) 263-276
38. Tanida I., Ueno T., and Kominami E. LC3 conjugation system in mammalian autophagy. Int. J. Biochem. Cell Biol. 36 (2004) 2503-2518
39. Partridge L., Langelan R., Fowler K., Zwaan B., and French V. Correlated responses to selection on body size in Drosophila melanogaster. Genet. Res. 74 (1999) 43-54