Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats

Archives of Toxicology

Volumn 84, Issue 4, 2010, Pages 319-331

  Mizukami, Sayaka ^a   Ichimura, Ryohei ^a   Kemmochi, Sayaka ^a,b   Taniai, Eriko ^a   Shimamoto, Keisuke ^a,b   Ohishi, Takumi ^a   Takahashi, Miwa ^c   Mitsumori, Kunitoshi ^a   Shibutani, Makoto ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Ceruloplasmin (Cp); Metallothionein (MT) 1 2; Oxidative stress; Rat hepatocarcinogenesis; Transferrin receptor (Tfrc); Tumor promotion

Indexed keywords

4 HYDROXYNONENAL; ACROLEIN; CERULOPLASMIN; COPPER; CYCLINE; FENBENDAZOLE; GLUTATHIONE TRANSFERASE; IRON; MALONALDEHYDE; METALLOTHIONEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PHENOBARBITAL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PIPERONYL BUTOXIDE; THIOACETAMIDE; TRANSFERRIN RECEPTOR; CARCINOGEN; GLUTATHIONE TRANSFERASE P1; GSTP1 PROTEIN, RAT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CANCER STAGING; CELL FUNCTION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; LIPID PEROXIDATION; LIVER CARCINOGENESIS; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR PROMOTION; UPREGULATION; ANIMAL; CARCINOGEN TESTING; DISEASE MODEL; FISCHER 344 RAT; GENE EXPRESSION REGULATION; LIVER; LIVER TUMOR; METABOLISM;

RATTUS;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CERULOPLASMIN; COPPER; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE S-TRANSFERASE PI; IRON; LIPID PEROXIDATION; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; METALLOTHIONEIN; OXIDATIVE STRESS; PPAR ALPHA; RATS; RATS, INBRED F344; RECEPTORS, TRANSFERRIN; UP-REGULATION;

EID: 77950478437     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-009-0496-x     Document Type: Article

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