Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 483, Issue 1-2, 2001, Pages 65-72

  Satoh, Kimihiko ^a   Hayakari, Makoto ^a   Ookawa, Keizou ^a   Satou, Mamoru ^a   Aizawa, Syu ^a   Tanaka, Masanori ^a   Hatayama, Ichiro ^b   Tsuchida, Shigeki ^a   Uchida, Koji ^c  

^a HIROSAKI UNIVERSITY   (Japan)

^b Aomori Prefectural Institute of Public Health and Environment   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Carcinogenesis; Glutathione S transferase; Prostaglandin J2; Tumor marker enzyme

Indexed keywords

4 HYDROXYNONENAL; ACROLEIN; ALDEHYDE; CARCINOGEN; CROTONALDEHYDE; DELTA12 PROSTAGLANDIN J2; FATTY ACID BINDING PROTEIN; GLUTATHIONE TRANSFERASE; SOYBEAN OIL; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYME INDUCTION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER; MALE; NONHUMAN; PHYSIOLOGY; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CARRIER PROTEINS; FATTY ACID-BINDING PROTEINS; GLUTATHIONE TRANSFERASE; INJECTIONS, INTRAVENOUS; LIPID PEROXIDATION; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PORTAL VEIN; PRECANCEROUS CONDITIONS; PROSTAGLANDIN D2; RATS; RATS, SPRAGUE-DAWLEY; SOYBEAN OIL; TUMOR MARKERS, BIOLOGICAL;

EID: 0035500819     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00225-1     Document Type: Article

References (53)

1. Purification, induction, and distribution of placental glutathione S-transferase: A new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis
2. Glutathione S-transferases as markers of preneoplasia and neoplasia
3. Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents
4. Early detection of carcinogenic substances and modifiers in rats
5. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
6. Glutathione S-transferases structure and catalytic activity
7. Weak electrophile selective characteristics of the rat preneoplastc marker enzyme glutathione S-transferase P-form, GST-P (7-7): A theory of linear free energy relationships for evaluation of the active site hydrophobicity of isoenzymes
8. Quantitative differences in the active site hydrophobicity of five human glutathione S-transferase isoenzymes: Water-soluble carcinogen selective properties of the neoplastic GST-P (1-1) species
9. Primary and secondary structural analyses of glutathione S-transferase π-from human placenta
10. Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation of carcinogenic diol epoxide of chrysene
11. Cellular response to the redox active lipid peroxidation products: Induction of glutathione S-transferase P by 4-hydroxy-2-nonenal
12. 2-induced expression of glutathione S-transferases
13. Transient induction of single GST-P positive hepatocytes by DEN
14. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
15. d
16. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
17. Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions
18. Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen
19. Time course of hepatic injury and recovery following coadministration of carbon tetrachloride and trichloroethylene in Fischer-344 rats
20. 4-induced liver damage in rats
21. Single GST-P positive liver cells - Putative initiated hepatocytes
22. 2
23. 2-antitumor and anti-viral activities and the mechanisms involved
24. 2
25. 2 in nuclei
26. 2 is a ligand for the adipocyte determination factor PPARγ
27. Effects of diffusible products of peroxidation of rat liver microsomal lipids
28. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
29. Acrolein is a product of lipid peroxidation reaction: Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
30. 2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans
31. Deoxyguanosine adducts of trans-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: Detection and potential sources
32. The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathione in vitro
33. Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats
34. Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long-Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma
35. Association of copper to metallothionein in hepatic lysomes of Long-Evans cinnamon (LEC) rats during the development of hepatitis
36. The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens
37. 2 generation in liver mitochondria
38. Overexpression of a novel anionic glutathione S-transferase in multidrug-resistant human breast cancer cells
39. Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis
40. Mechanisms of chemical carcinogenesis
41. Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens
42. Methods for determination of aldehydic lipid peroxidation products
43. Aldehydes: Occurrence, carcinogenic potential, mechanism of action and risk assessment
44. A one-hour ELISA for quantitation of acrolein and hydroxynonenal-modified proteins by epitope-bound casein matrix method
45. Quantitative predictivity of carcinogenicity of the autoradiographic repair test (primary hepatocyte cultures) for a group of 80 chemicals belonging to different chemical classes
46. A new approach to risk estimation of food-borne carcinogens - Heterocyclic amines - Based on molecular information
47. Possible mutagens derived from lipids and lipid precursors
48. Two-year toxicity and carcinogenicity study of acrolein in rats
49. Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice
50. Glutathione interorgan translocation, turnover, and metabolism
51. Transcriptional induction of the fatty acid binding protein gene in mouse liver by bezafibrate