Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats

Toxicology

Volumn 236, Issue 1-2, 2007, Pages 61-75

  Muguruma, Masako ^a   Unami, Akira ^b   Kanki, Masayuki ^b   Kuroiwa, Yuichi ^c,d   Nishimura, Jihei ^a,d   Dewa, Yasuaki ^a,d   Umemura, Takashi ^c   Oishi, Yuji ^b   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d GIFU UNIVERSITY   (Japan)

Author keywords

Piperonyl butoxide; Rat; Reactive oxygen species; Two stage liver carcinogenesis model

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AMINO ACID TRANSPORTER; CYTOCHROME P450 1A1; EXCITATORY AMINO ACID TRANSPORTER 5; GLUCURONOSYLTRANSFERASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MULTIDRUG RESISTANCE PROTEIN 3; N DIETHYLNITROSAMINE; NITROSAMINE; PIPERONYL BUTOXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE QUINONE 1; UDP GLUCURONYL TRANSFERASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; LIVER HYPERTROPHY; LIVER MICROSOME; LIVER RESECTION; LIVER WEIGHT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE;

ANIMALS; DEOXYADENOSINES; DNA; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICROSOMES, LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PESTICIDE SYNERGISTS; PIPERONYL BUTOXIDE; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

RATTUS;

EID: 34248641410     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.03.025     Document Type: Article

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