Effect of reactive oxygen species on iron regulatory protein activity

Annals of the New York Academy of Sciences

Volumn 851, Issue , 1998, Pages 179-186

  Cairo, G ^a   Tacchini, L ^a   Recalcati, S ^a   Azzimonti, B ^a   Minotti, G ^b   Bernelli Zazzera, A ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; FERRITIN; HYDROGEN PEROXIDE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; IRON; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; RNA BINDING PROTEIN; TRANSFERRIN RECEPTOR; XANTHINE OXIDASE;

CONFERENCE PAPER; HOMEOSTASIS; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; ISCHEMIA; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; REPERFUSION;

ANIMALIA;

EID: 0031876380     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb08992.x     Document Type: Conference Paper

References (37)

1. AISEN, P. & I. LISIOWSKY. 1980. Iron transport and storage proteins. Ann. Rev. Biochem. 49: 357-393.
2. GORDEUK, V. R., B. R. BACON & G. M. BRITTENHAM. 1987. Iron overload: Causes and consequences. Ann. Rev. Nutr. 7: 485-508.
3. WORWOOD, M. 1989. An overview of iron metabolism at a molecular level. J. Intern. Med. 226: 381-391.
4. LEIBOLD, E. A. & B. GUO. 1992. Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding proteins. Ann. Rev. Nutr. 12: 345-368.
5. KLAUSNER, R. D., T. A. ROUAULT & J. B. HARFORD. 1993. Regulating the fate of mRNA: The control of cellular iron. Cell 72: 19-28.
6. HENTZE, M. W. & L. C. KUHN. 1996. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. USA 93: 8175-8182.
7. BEINERT, H. & M. C. KENNEDY. 1993. Aconitase, a two-faced protein: Enzyme and iron regulatory factor. FASEB J. 7: 1442-1449.
8. HENDERSON, B. R. 1996. Iron regulatory protein 1 and 2. Bioessays 18: 739-746.
9. B a second iron-responsive element-binding protein. J. Biol. Chem. 269: 6405-6409.
10. CAIRO, G. & A. PIETRANGELO, 1995. Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation. Eur. J. Biochem. 232: 358-363.
11. PANTOPOULOS, K., G. WEISS & M. W. HENTZE. 1994. Nitric oxide and the post-transcriptional control of cellular iron traffic. Trends Cell. Biol. 4: 82-86.
12. 2) control mammalian iron metabolism by different pathways. Mol. Cell. Biol. 16: 3781-3788.
13. HENTZE, M. W., T. A. ROUAULT, J. B. HARFORD & R. D. KLAUSNER. 1989. Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science 244: 357-359.
14. MULLNER, E. W., S. ROTHENBERGER, A. M. MULLER & L. C. KUHN. 1992. In vivo and in vitro modulation of the mRNA-binding activity of iron-regulatory factor. Eur. J. Biochem. 208: 597-605.
15. CAIRO, G., L. TACCHLNI, G. POGLIAGHI, E. ANZON, A. TOMASI & A. BERNELLI-ZAZZERA. 1995. Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the "free" iron pool. J. Biol. Chem. 270: 700-703.
16. PHILPOTT, C. C., D. HAILE, T. A. ROUAULT & R. D. KLAUSNER. 1993. Modification of free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding. J. Biol. Chem. 268: 17655-17658.
17. HIRLING, H., B. R. HENDERSON & L. C. KUHN. 1994. Mutational analysis of the [4Fe-4S] cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase. EMBO J. 13: 453-161.
18. MARTINS, E. A. L., R. L. ROBALINHO & R. MENEGHINI. 1995. Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake. Arch. Biochem. Biophys. 316: 128-134.
19. PANTOPOULOS, K. & M. W. HENTZE. 1995. Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J. 14: 2917-2924.
20. PANTOPOULOS, K., S. MUELLER, A. ATZBERGER, W. ANSORGE, W. STREMMEL & M. W. HENTZE. 1997. Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intra-cellular oxidative stress. J. Biol. Chem. 272: 9802-9808.
21. LEIBOLD, E. A. & H. N. MUNRO. 1988. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated regions of ferritin heavy- and light-subunit mRNAs. Proc. Natl. Acad. Sci. USA 85: 2171-2175.
22. MULLNER, E. W., B. NEUPERT & L. C. KUHN. 1989. A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell 58: 373-382.
23. 3+: evidence for Superoxide dismutase-like activity. Arch. Biochem. Biophys. 253: 257-267.
24. BERNELLI-ZAZZERA, A. & G. GAJA. 1964. Some aspects of glycogen metabolism following reversible or irreversible ischemia. Exp. Mol. Pathol. 3: 331-333.
25. RYAN, T. P. & S. D. AUST. 1992. The role of iron in oxygen radical-mediated toxicities. Crit. Rev. Toxicol. 22: 119-141.
26. POWIS, G. 1989. Free radical formation by antitumor quinones. Free Radical Biol. & Med. 6: 63-101.
27. BIEMOND, P., A. G. J. SWAAK, C. M. BEIDORFF & J. F. KOSTER. 1986. Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Biochem. J. 239: 169-173.
28. MINOTTI, G. 1993. Sources and role of iron in lipid peroxidation. Chem. Res. Toxicol. 6: 134-146.
29. CONSTABLE, A., S. QUICK, N. K. GRAY & M. W. HENTZE. 1992. Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: Switching between enzymatic and genetic function? Proc. Natl. Acad. Sci. USA 89: 4554-4558.
30. GRAY, N. K., S. QUICK, B. GOOSSEN, A. CONSTABLE, H. HIRLLMG, L. C. KUHN & M. W. HENTZE. 1993. Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational represser and an aconitase: A functional assay for translational repression and direct demonstration of the iron switch. Eur. J. Biochem. 218: 657-667.
31. CAIRO, G., E. CASTRUSLMI, G. MLXOTTI & A. BERNELLI-ZAZZERA. 1996. Superoxide and hydrogen peroxide-dependent inhibition of iron regulatory protein activity: A protective stratagem against oxidative injury. FASEB J. 10: 1326-1335.
32. GRACE, P. A. 1994. Ischaemia-reperfusion injury. Br. J. Surg. 81: 637-647.
33. SIES, H. 1993. Strategies of antioxidant defense. Eur. J. Biochem. 215: 213-219.
34. DINARELLO, C. H. 1994. The interleukin-1 family: 10 years of discovery. FASEB J. 8: 1314-1325.
35. VANNER, G. A., W. ERTEL, P. MULLER, Y. HOFER, R. LEIDERER, M. D. MENGER & K. MESSMER. 1996. Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation. Shock 5: 34-40.
36. BREUER, W., E. GREENBERG & Z. I. CABANTCHIK. 1997. Newly delivered transferrin iron and oxidative cell injury. FEBS Lett. 403: 213-219.
37. BALLA, G., H. S. JACOB, J. BALLA, M. ROSENBERG, K. NATH, F. APPLE, J. W. EATON & G. M. VERCELLOTTI. 1992. Ferritin: A cytoprotective antioxidant stratagem of endothelium. J. Biol. Chem. 267: 18148-18153.