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Volumn 24, Issue 3, 1999, Pages 177-186

Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2- ethylhexyl)phthalate after diethylnitrosamine initiation

Author keywords

Altered hepatic foci; DEHP; Dose response study; GST P positive and negative foci; Hepatocarcinogenesis; Peroxisome proliferator; Rat

Indexed keywords

CLOFIBRATE; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

EID: 0032836364     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.24.3_177     Document Type: Article
Times cited : (9)

References (43)
  • 2
    • 0023020296 scopus 로고
    • Preneoplastic lesions as end points in carcinogenicity testing. I. Hepatic neoplasia
    • Bannasch, P. (1986): Preneoplastic lesions as end points in carcinogenicity testing. I. Hepatic neoplasia. Carcinogcnesis, 7, 689-695.
    • (1986) Carcinogcnesis , vol.7 , pp. 689-695
    • Bannasch, P.1
  • 5
    • 0028021454 scopus 로고
    • Initiator-specific promotion of hepatocarcinogenesis by WY-14, 643 and clofibrate
    • Cattley, R. C., Kato, M., Popp, J. A., Teets, V. J. and Voss, K. S. (1994): Initiator-specific promotion of hepatocarcinogenesis by WY-14, 643 and clofibrate. Carcinogenesis, 15, 1763-1766.
    • (1994) Carcinogenesis , vol.15 , pp. 1763-1766
    • Cattley, R.C.1    Kato, M.2    Popp, J.A.3    Teets, V.J.4    Voss, K.S.5
  • 6
    • 0006608214 scopus 로고
    • Does DNA damage play a role in rodent liver cancer induced by peroxisome proliferators?
    • Cattley, R. C. and Preston, R. J. (1995): Does DNA damage play a role in rodent liver cancer induced by peroxisome proliferators? CIIT Activities, 15, 1-6.
    • (1995) CIIT Activities , vol.15 , pp. 1-6
    • Cattley, R.C.1    Preston, R.J.2
  • 7
    • 0028356399 scopus 로고
    • Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules
    • Chen, Z.-Y., Liu, Y.-F., He, C.-Y., White, C. C. and Eaton, D. L. (1994): Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules. Cancer Res., 54, 2622-2629.
    • (1994) Cancer Res. , vol.54 , pp. 2622-2629
    • Chen, Z.-Y.1    Liu, Y.-F.2    He, C.-Y.3    White, C.C.4    Eaton, D.L.5
  • 8
    • 0021081204 scopus 로고
    • Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant
    • Deangelo, A. B. and Garrett, C. T. (1983): Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant. Cancer Lett., 20, 199-205.
    • (1983) Cancer Lett. , vol.20 , pp. 199-205
    • Deangelo, A.B.1    Garrett, C.T.2
  • 9
    • 0025220542 scopus 로고
    • Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver
    • Gerbracht, U., Bursch, W., Kraus, P., Putz, B., Reinacher, M., Timmermann-Trosiener, I. and Schulte-Hermann, R. (1990): Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. Carcinogenesis, 11, 617-624.
    • (1990) Carcinogenesis , vol.11 , pp. 617-624
    • Gerbracht, U.1    Bursch, W.2    Kraus, P.3    Putz, B.4    Reinacher, M.5    Timmermann-Trosiener, I.6    Schulte-Hermann, R.7
  • 10
    • 0025606515 scopus 로고
    • Di(2-ethylhexyl)phthalate alters carbohydrate enzyme activities and foci incidence in rat liver
    • Gerbracht, U., Einig, C., Oesterle, D., Deml, E., Schlatterer, B. and Eigenbrodt, E. (1990): Di(2-ethylhexyl)phthalate alters carbohydrate enzyme activities and foci incidence in rat liver. Carcinogenesis, 11, 2111-2115.
    • (1990) Carcinogenesis , vol.11 , pp. 2111-2115
    • Gerbracht, U.1    Einig, C.2    Oesterle, D.3    Deml, E.4    Schlatterer, B.5    Eigenbrodt, E.6
  • 11
    • 0022525392 scopus 로고
    • Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine
    • Glauert, H. P., Beer, D., Rao, M. S., Schwarz, M., Xu, Y.-D., Goldsworthy, T. L., Coloma, J. and Pitot, H. C. (1986): Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine. Cancer, Res., 46, 4601-4606.
    • (1986) Cancer, Res. , vol.46 , pp. 4601-4606
    • Glauert, H.P.1    Beer, D.2    Rao, M.S.3    Schwarz, M.4    Xu, Y.-D.5    Goldsworthy, T.L.6    Coloma, J.7    Pitot, H.C.8
  • 13
    • 0025363455 scopus 로고
    • Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in the rat liver
    • Grasl-Kraupp, B., Huber, W., Putz, B., Gerbracht, U. and Schulte-Hermann, R. (1990): Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in the rat liver. Cancer Res., 50, 3701-3708.
    • (1990) Cancer Res. , vol.50 , pp. 3701-3708
    • Grasl-Kraupp, B.1    Huber, W.2    Putz, B.3    Gerbracht, U.4    Schulte-Hermann, R.5
  • 14
    • 0027365688 scopus 로고
    • Peroxisome enzyme induction uncoupled from enhanced DNA synthesis in putative preneoplastic liver foci of rats treated with a single dose of the peroxisome proliferator nafenopin
    • Grasl-Kraupp, B., Huber, W., Timmermann-Trosiener, I. and Schulte-Hermann, R. (1993): Peroxisome enzyme induction uncoupled from enhanced DNA synthesis in putative preneoplastic liver foci of rats treated with a single dose of the peroxisome proliferator nafenopin. Carcinogenesis, 14, 2435-2437.
    • (1993) Carcinogenesis , vol.14 , pp. 2435-2437
    • Grasl-Kraupp, B.1    Huber, W.2    Timmermann-Trosiener, I.3    Schulte-Hermann, R.4
  • 15
    • 0027517501 scopus 로고
    • Glutathione S-transferase isoenzyme patterns in different subtypes of enzymealtered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital
    • Grasl-Kraupp, B., Waldhör, T., Huber, W. and Schulte-Hermann, R. (1993): Glutathione S-transferase isoenzyme patterns in different subtypes of enzymealtered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital. Carcinogenesis, 14, 2407-2412.
    • (1993) Carcinogenesis , vol.14 , pp. 2407-2412
    • Grasl-Kraupp, B.1    Waldhör, T.2    Huber, W.3    Schulte-Hermann, R.4
  • 16
    • 0022617474 scopus 로고
    • Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: Their rate of onset and their reversibility
    • Greaves, P., Irisarri, E. and Monro, A. M. (1986): Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. J. Natl. Cancer Inst., 76, 475-484.
    • (1986) J. Natl. Cancer Inst. , vol.76 , pp. 475-484
    • Greaves, P.1    Irisarri, E.2    Monro, A.M.3
  • 17
    • 0024938605 scopus 로고
    • Morphological and steological characterization of hepatic foci of cellular alteration in control Fischer 344 rats
    • Harada, T., Maronpot, R. R., Morris, R. W., Stitzel, K. A. and Boorman, G. A. (1989): Morphological and steological characterization of hepatic foci of cellular alteration in control Fischer 344 rats. Toxicol. Pathol., 17, 579-593.
    • (1989) Toxicol. Pathol. , vol.17 , pp. 579-593
    • Harada, T.1    Maronpot, R.R.2    Morris, R.W.3    Stitzel, K.A.4    Boorman, G.A.5
  • 18
    • 0027062789 scopus 로고
    • Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis
    • Hasegawa, R. and Ito, N. (1992): Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Food Chem. Toxicol., 11, 979-992.
    • (1992) Food Chem. Toxicol. , vol.11 , pp. 979-992
    • Hasegawa, R.1    Ito, N.2
  • 19
    • 0028141931 scopus 로고
    • Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital
    • Hasegawa, R., Yoshida, T., Mizoguchi, Y., Futakuchi, M., Kim, D. J., Cui, L. and Ito, N. (1994): Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital. Cancer Lett., 83, 89-95.
    • (1994) Cancer Lett. , vol.83 , pp. 89-95
    • Hasegawa, R.1    Yoshida, T.2    Mizoguchi, Y.3    Futakuchi, M.4    Kim, D.J.5    Cui, L.6    Ito, N.7
  • 20
    • 0024377254 scopus 로고
    • Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator
    • Hosokawa, S., Tatematsu, M., Aoki, T., Nakanowatari, J., Igarashi, T. and Ito, N. (1989): Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator. Carcinogenesis, 10, 2237-2241.
    • (1989) Carcinogenesis , vol.10 , pp. 2237-2241
    • Hosokawa, S.1    Tatematsu, M.2    Aoki, T.3    Nakanowatari, J.4    Igarashi, T.5    Ito, N.6
  • 22
    • 0026727139 scopus 로고
    • Pathological markers for non-genotoxic agent-associated carcinogenesis
    • Ito, N., Hasegawa, R., Imaida, K., Masui, T., Takahashi, S. and Shirai, T. (1992): Pathological markers for non-genotoxic agent-associated carcinogenesis. Toxicol Lett, 64/65, 613-620.
    • (1992) Toxicol Lett , vol.64-65 , pp. 613-620
    • Ito, N.1    Hasegawa, R.2    Imaida, K.3    Masui, T.4    Takahashi, S.5    Shirai, T.6
  • 23
    • 0023858438 scopus 로고
    • Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats-an approach for a new medium-term bioassay system
    • Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T., Masui, T., Imaida, K., Fukushima, S. and Asamoto, M. (1988): Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats-an approach for a new medium-term bioassay system. Carcinogenesis, 9, 387-394.
    • (1988) Carcinogenesis , vol.9 , pp. 387-394
    • Ito, N.1    Tsuda, H.2    Tatematsu, M.3    Inoue, T.4    Tagawa, Y.5    Aoki, T.6    Uwagawa, S.7    Kagawa, M.8    Ogiso, T.9    Masui, T.10    Imaida, K.11    Fukushima, S.12    Asamoto, M.13
  • 24
    • 0024323931 scopus 로고
    • Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator
    • Kasai, H., Okada, Y., Nishimura, S., Rao, M. S. and Reddy, J. K. (1989): Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator. Cancer Res., 49, 2603-2605.
    • (1989) Cancer Res. , vol.49 , pp. 2603-2605
    • Kasai, H.1    Okada, Y.2    Nishimura, S.3    Rao, M.S.4    Reddy, J.K.5
  • 25
    • 0020444298 scopus 로고
    • The carcinogenicity of dietary di(2-ethylhexyl)phthalate (DEHP) in Fisher 344 rats and B6C3F1 mice
    • Kluwe, W. M., Haseman, J. K., Douglas, J. F. and Huff, J. E. (1982): The carcinogenicity of dietary di(2-ethylhexyl)phthalate (DEHP) in Fisher 344 rats and B6C3F1 mice. J. Toxicol. Environ. Health, 10, 797-815.
    • (1982) J. Toxicol. Environ. Health , vol.10 , pp. 797-815
    • Kluwe, W.M.1    Haseman, J.K.2    Douglas, J.F.3    Huff, J.E.4
  • 26
    • 0023234291 scopus 로고
    • Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl)phthalate on hepatic enzyme activities and lipid peroxidation in the rat
    • Lake, B. G., Kozlen, S. L., Evans, J. G., Tim, J. B. G., Philip, J. Y. and Gangolli, S. D. (1987): Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl)phthalate on hepatic enzyme activities and lipid peroxidation in the rat. Toxicology, 44, 213-228.
    • (1987) Toxicology , vol.44 , pp. 213-228
    • Lake, B.G.1    Kozlen, S.L.2    Evans, J.G.3    Tim, J.B.G.4    Philip, J.Y.5    Gangolli, S.D.6
  • 27
    • 0024241608 scopus 로고
    • Relationship of hepatic peroxisome proliferation and rcplicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2, 3-xylidino)-2-primidinylthio]acetic acid (Wy-14, 643) in rats
    • Marsman, D. S., Cattley, R. C., Conway, J. G. and Popp, J. A. (1988): Relationship of hepatic peroxisome proliferation and rcplicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2, 3-xylidino)-2-primidinylthio]acetic acid (Wy-14, 643) in rats. Cancer Res., 48, 6739-6744.
    • (1988) Cancer Res. , vol.48 , pp. 6739-6744
    • Marsman, D.S.1    Cattley, R.C.2    Conway, J.G.3    Popp, J.A.4
  • 28
    • 0029887093 scopus 로고    scopus 로고
    • Effect of the expression of c-met, c-mic and PPAR-alpha in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14, 643
    • Miller, R. T., Glover, S. E., Stewart, W. S., Corton, J. C., Popp, J. A. and Cattley, R. C. (1996): Effect of the expression of c-met, c-mic and PPAR-alpha in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14, 643. Carcinogenesis, 17, 1337-1341.
    • (1996) Carcinogenesis , vol.17 , pp. 1337-1341
    • Miller, R.T.1    Glover, S.E.2    Stewart, W.S.3    Corton, J.C.4    Popp, J.A.5    Cattley, R.C.6
  • 29
    • 0026100678 scopus 로고
    • Peroxisome proliferation and nongenotoxic Carcinogenesis: Commentary on a symposium
    • Moody, D. E., Reddy, J. K., Lake, B. G., Popp, J. A. and Reese, D. H. (1991): Peroxisome proliferation and nongenotoxic Carcinogenesis: Commentary on a symposium. Fund. Appl. Toxicol., 16, 233-248.
    • (1991) Fund. Appl. Toxicol. , vol.16 , pp. 233-248
    • Moody, D.E.1    Reddy, J.K.2    Lake, B.G.3    Popp, J.A.4    Reese, D.H.5
  • 30
    • 0023864961 scopus 로고
    • Promoting activity of di(2-ethylhexyl)phthalate in rat liver foci bioassay
    • Oesterle, D. and Deml, E. (1988): Promoting activity of di(2-ethylhexyl)phthalate in rat liver foci bioassay. J. Cancer Res. Clin. Oncol., 114, 133-136.
    • (1988) J. Cancer Res. Clin. Oncol. , vol.114 , pp. 133-136
    • Oesterle, D.1    Deml, E.2
  • 31
    • 0021917751 scopus 로고
    • Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl)phthalate
    • Popp, J. A., Garvey, L. K., Hamm, T. E. J. and Swenberg, J. A. (1985): Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl)phthalate. Carcinogenesis, 6, 141-144.
    • (1985) Carcinogenesis , vol.6 , pp. 141-144
    • Popp, J.A.1    Garvey, L.K.2    Hamm, T.E.J.3    Swenberg, J.A.4
  • 32
    • 0023792924 scopus 로고
    • Lack of expression of glutathione S-transferase P, γ-glutamyl transpeptidase, and α-fetoprotein messenger RNAs in liver tumor induced by peroxisome proliferators
    • Rao, M. S., Nemali, M. R., Usuda, N., Scarpelli, D. G., Makino, T., Pitot, H. C. and Reddy, J. K. (1988): Lack of expression of glutathione S-transferase P, γ-glutamyl transpeptidase, and α-fetoprotein messenger RNAs in liver tumor induced by peroxisome proliferators. Cancer Res., 48, 4919-4925.
    • (1988) Cancer Res. , vol.48 , pp. 4919-4925
    • Rao, M.S.1    Nemali, M.R.2    Usuda, N.3    Scarpelli, D.G.4    Makino, T.5    Pitot, H.C.6    Reddy, J.K.7
  • 33
    • 0023202190 scopus 로고
    • Peroxisome proliferation and hepatocarcinogenesis
    • Rao, M. S. and Reddy, J. K. (1987): Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis, 8, 631-636.
    • (1987) Carcinogenesis , vol.8 , pp. 631-636
    • Rao, M.S.1    Reddy, J.K.2
  • 34
    • 0022485360 scopus 로고
    • Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and γ-glutamyltranspeptidase
    • Rao, M. S., Tatematsu, M., Subbarao, V., Ito, N. and Reddy, J. K. (1986): Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and γ-glutamyltranspeptidase. Cancer Res., 46, 5287-5290.
    • (1986) Cancer Res. , vol.46 , pp. 5287-5290
    • Rao, M.S.1    Tatematsu, M.2    Subbarao, V.3    Ito, N.4    Reddy, J.K.5
  • 35
    • 0023221711 scopus 로고
    • Absence of γ-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F-344 rats by di-(2-ethylhexyl)phthalale, a peroxisome proliferator
    • Rao, M. S., Usuda, N., Subbarao, V. and Reddy, J. K. (1987): Absence of γ-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F-344 rats by di-(2-ethylhexyl)phthalale, a peroxisome proliferator. Carcinogenesis, 8, 1347-1350.
    • (1987) Carcinogenesis , vol.8 , pp. 1347-1350
    • Rao, M.S.1    Usuda, N.2    Subbarao, V.3    Reddy, J.K.4
  • 36
    • 0023830650 scopus 로고
    • Various short-term assays and two long-term studies with the plasticizer di(2-ethylhexyl)phthalate in the Syrian golden hamster
    • Schmerzer, P., Pool, B. L., Klein, R. G., Komitowski, D. and Schmähl, D. (1988): Various short-term assays and two long-term studies with the plasticizer di(2-ethylhexyl)phthalate in the Syrian golden hamster. Carcinogenesis, 9, 37-43.
    • (1988) Carcinogenesis , vol.9 , pp. 37-43
    • Schmerzer, P.1    Pool, B.L.2    Klein, R.G.3    Komitowski, D.4    Schmähl, D.5
  • 37
    • 0030756560 scopus 로고    scopus 로고
    • A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: A historical review of model development and summary of results from 291 tests
    • Shirai, T. (1997): A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests. Toxicol. Pathol., 25, 453-460.
    • (1997) Toxicol. Pathol. , vol.25 , pp. 453-460
    • Shirai, T.1
  • 38
    • 0025259590 scopus 로고
    • Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats folowing short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate
    • Takagi, A., Sai, K., Umemura, T., Hasegawa, R. and Kurokawa, Y. (1990): Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats folowing short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate. Jpn. J. Cancer Res., 81, 213-215.
    • (1990) Jpn. J. Cancer Res. , vol.81 , pp. 213-215
    • Takagi, A.1    Sai, K.2    Umemura, T.3    Hasegawa, R.4    Kurokawa, Y.5
  • 39
    • 0022179540 scopus 로고
    • Relative merits of immunohistochemical demonstration of placental A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutatione transferase as markers of altered foci during liver carcinogenesis in rats
    • Tatematsu, M., Mera, Y., Ito, N., Satoh, K. and Sato, K. (1985): Relative merits of immunohistochemical demonstration of placental A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutatione transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis, 6, 1621-1626.
    • (1985) Carcinogenesis , vol.6 , pp. 1621-1626
    • Tatematsu, M.1    Mera, Y.2    Ito, N.3    Satoh, K.4    Sato, K.5
  • 41
    • 0023257712 scopus 로고
    • Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver Carcinogenesis
    • Williams, G. M., Maruyama, H. and Tanaka, T. (1987): Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver Carcinogenesis. Carcinogenesis, 8, 875-880.
    • (1987) Carcinogenesis , vol.8 , pp. 875-880
    • Williams, G.M.1    Maruyama, H.2    Tanaka, T.3
  • 42
    • 0024512434 scopus 로고
    • γ-glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acethylaminofluorene
    • Yeldandi, A. V., Subbarao, V., Rajan, A. and Rao, M. S. (1989): γ-glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acethylaminofluorene. Carcinogenesis, 10, 797-799.
    • (1989) Carcinogenesis , vol.10 , pp. 797-799
    • Yeldandi, A.V.1    Subbarao, V.2    Rajan, A.3    Rao, M.S.4


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