Carcinogenic risk of copper gluconate evaluated by a rat medium-term liver carcinogenicity bioassay protocol

Archives of Toxicology

Volumn 82, Issue 8, 2008, Pages 563-571

  Abe, Masayoshi ^a   Usuda, Koji ^a   Hayashi, Seigo ^a   Ogawa, Izumi ^a   Furukawa, Satoshi ^a   Igarashi, Maki ^b   Nakae, Dai ^b,c  

^a NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Apoptosis; Copper gluconate; Inflammation; Oxidative stress; Rat medium term liver carcinogenicity bioassay protocol

Indexed keywords

8 HYDROXYGUANINE; GLUCONATE COPPER; GLUTATHIONE TRANSFERASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOASSAY; CANCER RISK; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL PROTOCOL; CONTROLLED STUDY; EVALUATION; LIVER CARCINOGENESIS; LIVER CELL; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; SHORT COURSE THERAPY; TREATMENT DURATION;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; BIOLOGICAL ASSAY; CARCINOGENICITY TESTS; CARCINOGENS; CELL PROLIFERATION; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCONATES; GLUTATHIONE TRANSFERASE; GUANINE; HEPATECTOMY; HEPATOCYTES; LIVER; LIVER NEOPLASMS; MALE; METALLOTHIONEIN; METALS; OXIDATIVE STRESS; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; RNA, MESSENGER;

RATTUS;

EID: 48749091801     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0294-x     Document Type: Article

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