Targeting Translation for Treatment of Cancer - A Novel Role for IRES?

Current Cancer Drug Targets

Volumn 4, Issue 3, 2004, Pages 299-311

  Holčik, Martin ^a  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; INITIATION FACTOR; MESSENGER RNA;

5' UNTRANSLATED REGION; APOPTOSIS; CANCER; CANCER CELL; CANCER GROWTH; CAPPING PHENOMENON; CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; DNA DAMAGE; HUMAN; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; ONCOGENE; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; RNA TRANSLATION; STRABISMUS; TRANSLATION INITIATION;

5' UNTRANSLATED REGIONS; ANIMALS; APOPTOSIS; GENES, MYC; HUMANS; NEOPLASMS; PROTEIN BIOSYNTHESIS; RIBOSOMES;

EID: 2342421272     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568009043333005     Document Type: Review

References (158)

1. Mathews, M. B.; Sonenberg, N.; Hershey, J. W. B. Origins and Principles of Translational Control. In Translational Control of Gene Expression; Sonenberg, N.; Hershey, J. W. B.; Mathews, M. B., Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory, 2000, pp. 1-32.
2. Hershey, J. W. B.; Merrick, W. C. Pathway and Mechanism of Initiation of Protein Synthesis. In Translational Control of Gene Expression; Sonenberg, N.; Hershey, J. W. B.; Mathews, M. B., Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory, 2000, pp. 33-88.
3. Kozak, M.; Shatkin, A. J. Identification of Features in 5' Terminal Fragments from Reovirus mRNA which are Important for Ribosome Binding. Cell 1978, 13, 201-212.
4. Hershey, J. W. B.; Miyamoto, S. Translational Control and Cancer. In Translational Control of Gene Expression; Sonenberg, N.; Hershey, J. W. B.; Mathews, M. B., Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory, 2000, pp. 637-654.
5. Morris, D. R. Growth Control of Translation in Mammalian Cells. Prog. Nucleic Acid Res. Mol. Biol. 1995, 51, 339-363.
6. Pain, V. M. Initiation of Protein Synthesis in Eukaryotic Cells. Eur. J. Biochem. 1996, 236, 747-771.
7. Hinnebusch, A. G. Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes. In Translational Control of Gene Expression; Sonenberg, N.; Hershey, J. W. B.; Mathews, M. B., Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory, 2000, pp. 185-243.
8. Clemens, M. J. Initiation Factor eIF2 Alpha Phosphorylation in Stress Responses and Apoptosis. Prog. Mol. Subcell. Biol. 2001, 27, 57-89.
9. Sonenberg, N.; Gingras, A. C. The mRNA 5' Cap-Binding Protein eIF4E and Control of Cell Growth. Curr. Opin. Cell Biol. 1998, 10, 268-275.
10. Lazaris-Karatzas, A.; Montine, K. S.; Sonenberg, N. Malignant Transformation by a Eukaryotic Initiation Factor Subunit That Binds to mRNA 5' Cap. Nature 1990, 345, 544-547.
11. Koromilas, A. E.; Lazaris-Karatzas, A.; Sonenberg, N. mRNAs Containing Extensive Secondary Structure in Their 5' Non-Coding Region Translate Efficiently in Cells Overexpressing Initiation Factor eIF-4E. EMBO J. 1992, 11, 4153-4158.
12. Kozak, M. An Analysis of Vertebrate mRNA Sequences: Intimations of Translational Control. J. Cell. Biol. 1991, 115, 887-903.
13. Miyagi, Y.; Sugiyama, A.; Asai, A.; Okazaki, T.; Kuchino, Y.; Kerr, S. J. Elevated Levels of Eukaryotic Translation Initiation Factor eIF-4E, mRNA in a Broad Spectrum of Transformed Cell Lines. Cancer Lett. 1995, 91, 247-252.
14. Nathan, C. A.; Carter, P.; Liu, L.; Li, B. D.; Abreo, F.; Tudor, A.; Zimmer, S. G.; De Benedetti, A. Elevated Expression of eIF4E and FGF-2 Isoforms During Vascularization of Breast Carcinomas. Oncogene 1997, 15, 1087-1094.
15. Wang, S.; Rosenwald, I. B.; Hutzler, M. J.; Pihan, G. A.; Savas, L.; Chen, J. J.; Woda, B. A. Expression of the Eukaryotic Translation Initiation Factors 4E and 2Alpha in Non-Hodgkin's Lymphomas. Am. J. Pathol. 1999, 155, 247-255.
16. Rosenwald, I. B.; Chen, J. J.; Wang, S.; Savas, L.; London, I. M.; Pullman, J. Upregulation of Protein Synthesis Initiation Factor eIF4E is an Early Event During Colon Carcinogenesis. Oncogene 1999, 18, 2507-2517.
17. Crew, J. P.; Fuggle, S.; Bicknell, R.; Cranston, D. W.; de Benedetti, A. ; Harris, A. L. Eukaryotic Initiation Factor-4E in Superficial and Muscle Invasive Bladder Cancer and its Correlation with Vascular Endothelial Growth Factor Expression and Tumour Progression. Br. J. Cancer, 2000, 82, 161-166.
18. Li, B. D.; Liu, L.; Dawson, M.; De Benedetti, A. Overexpression of Eukaryotic Initiation Factor 4E (eIF4E) in Breast Carcinoma. Cancer 1997, 79, 2385-2390.
19. Nathan, C. A.; Franklin, S.; Abreo, F. W.; Nassar, R.; de Benedetti, A.; Williams, J.; Stucker, F. J. Expression of eIF4E During Head and Neck Tumorigenesis: Possible Role in Angiogenesis. Laryngoscope 1999, 109, 1253-1258.
20. Li, B. D.; McDonald, J. C.; Nassar, R.; De Benedetti, A. Clinical Outcome in Stage I to III Breast Carcinoma and eIF4E Overexpression. Ann. Surg. 1998, 227, 756-761.
21. Meric, F.; Hunt, K. K. Translation Initiation in Cancer: a Novel Target for Therapy. Mol. Cancer Ther. 2002, 1, 971-979.
22. Zimmer, S. G.; DeBenedetti, A.; Graff, J. R. Translational Control of Malignancy: the mRNA Cap-Binding Protein, eIF-4E, as a Central Regulator of Tumor Formation, Growth, Invasion and Metastasis. Anticancer Res. 2000, 20, 1343-1351.
23. Dua, K.; Williams, T. M.; Beretta, L. Translational Control of the Proteome: Relevance to Cancer. Proteomics 2001, 1, 1191-1199.
24. Hayashi, S.; Nishimura, K.; Fukuchi-Shimogori, T.; Kashiwagi, K.; Igarashi, K. Increase in Cap- and IRES-Dependent Protein Synthesis by Overproduction of Translation Initiation Factor eIF4G. Biochem. Biophys. Res. Commun. 2000, 277, 117-123.
25. Fukuchi-Shimogori, T.; Ishii, I.; Kashiwagi, K.; Mashiba, H.; Ekimoto, H.; Igarashi, K. Malignant Transformation by Overproduction of Translation Initiation Factor eIF4G. Cancer Res. 1997, 57, 5041-5044.
26. Brass, N.; Heckel, D.; Sahin, U.; Pfreundschuh, M.; Sybrecht, G. W.; Meese, E. Translation Initiation Factor eIF-4Gamma is Encoded by an Amplified Gene and Induces an Immune Response in Squamous Cell Lung Carcinoma. Hum. Mol. Genet. 1997, 6, 33-39.
27. Rosenwald, I. B.; Hutzler, M. J.; Wang, S.; Savas, L.; Fraire, A. E. Expression of Eukaryotic Translation Initiation Factors 4E and 2Alpha is Increased Frequently in Bronchioloalveolar but not in Squamous Cell Carcinomas of the Lung. Cancer 2001, 92, 2164-2171.
28. Lobo, M. V.; Martin, M. E.; Perez, M. I.; Alonso, F. J.; Redondo, C.; Alvarez, M. I.; Salinas, M. Levels, Phosphorylation Status and Cellular Localization of Translational Factor eIF2 in Gastrointestinal Carcinomas. Histochem. J. 2000, 32, 139-150.
29. Hwang, S. Y.; Kim, M. K.; Kim, J. C. Cloning of hHRI, Human Heme-Regulated Eukaryotic Initiation Factor 2Alpha Kinase: Down-Regulated in Epithelial Ovarian Cancers. Mol. Cells 2000, 10, 584-591.
30. Lin, L.; Holbro, T.; Alonso, G.; Gerosa, D.; Burger, M. M. Molecular Interaction Between Human Tumor Marker Protein p150, the Largest Subunit of eIF3, and Intermediate Filament Protein K7. J. Cell Blochem. 2001, 80, 483-490.
31. Pincheira, R.; Chen, Q.; Zhang, J. T. Identification of a 170-kDa Protein Over-Expressed in Lung Cancers. Br. J. Cancer 2001, 84, 1520-1527.
32. Rothe, M.; Ko, Y.; Albers, P.; Wernert, N. Eukaryotic Initiation Factor 3 p110 mRNA is Overexpressed in Testicular Seminomas. Am. J. Pathol. 2000, 157, 1597-1604.
33. Nupponen, N. N.; Porkka, K.; Kakkola, L.; Tanner, M.; Persson, K.; Borg, A.; Isola, J.; Visakorpi, T. Amplification and Overexpression of p40 Subunit of Eukaryotic Translation Initiation Factor 3 in Breast and Prostate Cancer. Am. J. Pathol. 1999, 154, 1777-1783.
34. Shuda, M.; Kondoh, N.; Tanaka, K.; Ryo, A.; Wakatsuki, T.; Hada, A.; Goseki, N.; Igari, T.; Hatsuse, K.; Aihara, T.; Horiuchi, S.; Shichita, M.; Yamamoto, N.; Yamamoto, M. Enhanced Expression of Translation Factor mRNAs in Hepatocellular Carcinoma. Anticancer Res. 2000, 20, 2489-2494.
35. Eberle, J.; Krasagakis, K.; Orfanos, C. E. Translation Initiation Factor eIF-4A1 mRNA is Consistently Overexpressed in Human Melanoma Cells In Vitro. Int. J. Cancer 1997, 71, 396-401.
36. Pogue-Geile, K.; Geiser, J. R.; Shu, M.; Miller, C.; Wool, I. G.; Meisler, A. I.; Pipas, J. M. Ribosomal Protein Genes are Overexpressed in Colorectal Cancer: Isolation of a cDNA Clone Encoding the Human S3 Ribosomal Protein. Mol. Cell. Biol. 1991, 11, 3842-3849.
37. Kondoh, N.; Shuda, M.; Tanaka, K.; Wakatsuki, T.; Hada, A.; Yamamoto, M. Enhanced Expression of S8, L12, L23a, L27 and L30 Ribosomal Protein mRNAs in Human Hepatocellular Carcinoma. Anticancer Res. 2001, 21, 2429-2433.
38. Kozak, M. The Scanning Model for Translation: an Update. J. Cell. Biol. 1989, 229-241.
39. Peri, S.; Pandey, A. A Reassessment of the Translation Initiation Codon in Vertebrates. Trends Genet. 2001, 17, 685-687.
40. Kozak, M. An Analysis of 5'-Noncoding Sequences from 699 Vertebrate Messenger RNAs. Nucleic Acids Res. 1987, 15, 8125-8148.
41. Willis, A. E. Translational Control of Growth Factor and Proto-Oncogene Expression. Int. J. Biochem. Cell Biol. 1999, 31, 73-86.
42. Signori, E.; Bagni, C.; Papa, S.; Primerano, B.; Rinaldi, M.; Amaldi, F. ; Fazio, V. M. A Somatic Mutation in the 5'UTR of BRCAI Gene in Sporadic Breast Cancer Causes Down-Modulation of Translation Efficiency. Oncogene 2001, 20, 4596-4600.
43. Liu, L.; Dilworth, D.; Gao, L.; Monzon, J.; Summers, A.; Lassam, N.; Hogg, D. Mutation of the CDKN2A 5' UTR Creates an Aberrant Initiation Codon and Predisposes to Melanoma. Nat. Genet. 1999, 21, 128-132.
44. Saito, H.; Hayday, A. C.; Wiman, K.; Hayward, W. S.; Tonegawa, S. Activation of the C-myc Gene by Translocation: a Model for Translational Control. Proc. Natl. Acad. Sci. USA 1983, 80, 7476-7480.
45. Wiman, K. G.; Clarkson, B.; Hayday, A. C.; Saito, H.; Tonegawa, S.; Hayward, W. S. Activation of a Translocated C-myc Gene: Role of Structural Alterations in the Upstream Region. Proc. Natl. Acad. Sci. USA 1984, 81, 6798-6802.
46. Darveau, A.; Pelletier, J.; Sonenberg, N. Differential Efficiencies of In Vitro Translation of Mouse C-myc Transcripts Differing in the 5' Untranslated Region. Proc. Natl. Acad. Sci. U S A 1985, 82, 2315-2319.
47. Jackson, R. J. A Comparative View of Initiation Site Selection Mechanisms. In Translational Control of Gene Expression; Sonenberg, N.; Hershey, J. W. B.; Mathews, M. B., Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor Laboratory, 2000, pp. 127-183.
48. Pelletier, J.; Sonenberg, N. Internal Initiation of Translation of Eukaryotic mRNA Directed by a Sequence Derived from Poliovirus RNA. Nature 1988, 334, 320-325.
49. Nevins, T. A.; Harder, Z. M.; Korneluk, R. G.; Holcik, M. Distinct Regulation of Internal Ribosome Entry Site-mediated Translation Following Cellular Stress is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1. J. Biol. Chem. 2003, 278, 3572-3579.
50. Henis-Korenblit, S.; Shani, G.; Sines, T.; Marash, L.; Shohat, G.; Kimchi, A. The Caspase-Cleaved DAP5 Protein Supports Internal Ribosome Entry Site-Mediated Translation of Death Proteins. Proc. Natl. Acad Sci. USA 2002, 99, 5400-5405.
51. Brostrom, C. O.; Brostrom, M. A. Regulation of Translational Initiation During Cellular Responses to Stress. Prog. Nucleic Acid Res. Mol. Biol. 1998, 58, 79-125.
52. Clemens, M. J.; Bushell, M.; Jeffrey, I. W.; Pain, V. M.; Morley, S. J. Translation Initiation Factor Modifications and the Regulation of Protein Synthesis in Apoptotic Cells. Cell Death Differ. 2000, 7, 603-615.
53. Stein, I.; Itin, A.; Einat, P.; Skaliter, R.; Grossman, Z.; Keshet, E. Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia. Mol. Cell. Biol. 1998, 18, 3112-3119.
54. Gerlitz, G.; Jagus, R.; Elroy-Stein, O. Phosphorylation of Initiation Factor-2Alpha is Required for Activation of Internal Translation Initiation During Cell Differentiation. Eur. J. Biochem. 2002, 269, 2810-2819.
55. Fernandez, J.; Yaman, I.; Sarnow, P.; Snider, M. D.; Hatzoglou, M. Regulation of Internal Ribosomal Entry Site-Mediated Translation by Phosphorylation of the Translation Initiation Factor eIF2Alpha. J. Biol. Chem. 2002, 277, 19198-19205.
56. Martinez-Salas, E.; Ramos, R.; Lafuente, E.; Lopez De Quinto, S. Functional Interactions in Internal Translation Initiation Directed by Viral and Cellular IRES Elements. J. Gen. Virol. 2001, 82, 973-984.
57. Mitchell, S. A.; Brown, E. C.; Coldwell, M. J.; Jackson, R. J.; Willis, A. E. Protein Factor Requirements of the Apaf-1 Internal Ribosome Entry Segment: Roles of Polypyrimidine Tract Binding Protein and Upstream of N-ras. Mol. Cell. Biol. 2001, 21, 3364-3374.
58. Holcik, M.; Korneluk, R. G. Functional Characterization of the X-Linked Inhibitor of Apoptosis (XIAP) Internal Ribosome Entry Site Element: Role of La Autoantigen in XIAP Translation. Mol. Cell. Biol. 2000, 20, 4648-4657.
59. Kim, Y. K.; Back, S. H.; Rho, J.; Lee, S. H.; Jang, S. K. La Autoantigen Enhances Translation of BiP mRNA. Nucleic Acids Res. 2001, 29, 5009-5016.
60. Holcik, M.; Gordon, B. W.; Korneluk, R. G. The Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Protein XIAP Is Modulated by the Heterogeneous Nuclear Ribonucleoproteins C1 and C2. Mol. Cell. Biol. 2003, 23, 280-288.
61. Sella, O.; Gerlitz, G.; Le, S. Y.; Elroy-Stein, O. Differentiation-Induced Internal Translation of c-sis mRNA: Analysis of the Cis Elements and Their Differentiation-Linked Binding to the hnRNP C Protein. Mol. Cell. Biol. 1999, 19, 5429-5440.
62. Henis-Korenblit, S.; Strumpf, N. L.; Goldstaub, D.; Kimchi, A. A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation. Mol. Cell. Biol. 2000, 20, 496-506.
63. Kullmann, M.; Gopfert, U.; Siewe, B.; Hengst, L. ELAV/Hu Proteins Inhibit p27 Translation via an IRES Element in the p27 5'UTR. Genes Dev. 2002, 16, 3087-3099.
64. Creancier, L.; Mercier, P.; Prats, A. C.; Morello, D. C-myc Internal Ribosome Entry Site Activity Is Developmentally Controlled and Subjected to a Strong Translational Repression in Adult Transgenic Mice. Mol. Cell. Biol. 2001, 21, 1833-1840.
65. Holcik, M.; Sonenberg, N.; Korneluk, R. G. Internal Ribosome Initiation of Translation and the Control of Cell Death. Trends in Gen. 2000, 16, 469-473.
66. Sachs, A. B. Cell Cycle-Dependent Translation Initiation: IRES Elements Prevail. Cell 2000, 101, 243-245.
67. Subkhankulova, T.; Mitchell, S. A.; Willis, A. E. Internal Ribosome Entry Segment-Mediated Initiation of C-myc Protein Synthesis Following Genotoxic Stress. Biochem. J. 2001, 359, 183-192.
68. Holcik, M.; Yeh, C.; Korneluk, R. G.; Chow, T. Translational Upregulation of X-Linked Inhibitor of Apoptosis (XIAP) Increases Resistance to Radiation Induced Cell Death. Oncogene 2000, 19, 4174-4177.
69. Thiede, B.; Dimmler, C.; Siejak, F.; Rudel, T. Predominant Identification of RNA-Binding Proteins in Fas-Induced Apoptosis by Proteome Analysis. J. Biol. Chem. 2001, 276, 26044-26050.
70. Brockstedt, E.; Rickers, A.; Kostka, S.; Laubersheimer, A.; Dorken, B.; Wittmann-Liebold, B.; Bommert, K.; Otto, A. Identification of Apoptosis-Associated Proteins in a Human Burkitt Lymphoma Cell Line. Cleavage of Heterogeneous Nuclear Ribonucleoprotein A1 by Caspase 3. J. Biol. Chem. 1998, 273, 28057-28064.
71. Waterhouse, N.; Kumar, S.; Song, Q.; Strike, P.; Sparrow, L.; Dreyfuss, G.; Alnemri, E. S.; Litwack, G.; Lavin, M.; Watters, D. Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, are Specific Targets of Interleukin 1Beta-Converting Enzyme-Like Proteases in Apoptosis. J. Biol. Chem. 1996, 271, 29335-29341.
72. Bartova, E.; Kozubek, S.; Kozubek, M.; Jirsova, P.; Lukasova, E.; Skalnikova, M.; Buchnickova, K. The Influence of the Cell Cycle, Differentiation and Irradiation on the Nuclear Location of the Abl, Bcr and C-myc Genes in Human Leukemic Cells. Leuk. Res. 2000, 24, 233-241.
73. West, M. J.; Sullivan, N. F.; Willis, A. E. Translational Upregulation of the C-myc Oncogene in Bloom's Syndrome Cell Lines. Oncogene 1995, 11, 2515-2524.
74. Paulin, F. E.; West, M. J.; Sullivan, N. F.; Whitney, R. L.; Lyne, L.; Willis, A. E. Aberrant Translational Control of the C-mye Gene in Multiple Myeloma. Oncogene 1996, 13, 505-513.
75. Nanbru, C.; Lafon, I.; Audigier, S.; Gensac, M. C.; Vagner, S.; Huez, G. ; Prats, A. C. Alternative Translation of the Proto-Oncogene C-myc by an Internal Ribosome Entry Site. J. Biol. Chem. 1997, 272, 32061-32066.
76. Stoneley, M.; Paulin, F. E.; Le Quesne, J. P.; Chappell, S. A.; Willis, A. E. C-myc 5' Untranslated Region Contains an Internal Ribosome Entry Segment. Oncogene 1998, 16, 423-428.
77. Chappell, S. A. LeQuesne, J. P.; Paulin, F. E.; deSchoolmeester, M. L.; Stoneley, M.; Soutar, R. L.; Ralston, S. H.; Helfrich, M. H.; Willis, A. E. A Mutation in the C-myc-IRES Leads to Enhanced Internal Ribosome Entry in Multiple Myeloma: A Novel Mechanism of Oncogene De-Regulation. Oncogene 2000, 19, 4437-4440.
78. Stoneley, M.; Chappell, S. A.; Jopling, C. L.; Dickens, M.; MacFarlane, M.; Willis, A. E. C-myc Protein Synthesis is Initiated from the Internal Ribosome Entry Segment During Apoptosis. Mol. Cell. Biol. 2000, 20, 1162-1169.
79. Jopling, C. L.; Willis, A. E. N-myc Translation is Initiated via an Internal Ribosome Entry Segment that Displays Enhanced Activity in Neuronal Cells. Oncogene 2001, 20, 2664-2670.
80. Sehgal, A.; Briggs, J.; Rinehart-Kim, J.; Basso, J.; Bos, T. J. The Chicken C-jun 5' Untranslated Region Directs Translation by Internal Initiation. Oncogene 2000, 19, 2836-2845.
81. Pyronnet, S.; Pradayrol, L.; Sonenberg, N. A Cell Cycle-Dependent Internal Ribosome Entry Site. Mol. Cell 2000, 5, 607-616.
82. Bonneau, A. M.; Sonenberg, N. Involvement of the 24-kDa Cap-Binding Protein in Regulation of Protein Synthesis in Mitosis. J. Biol. Chem. 1987, 262, 11134-11139.
83. Khaleghpour, K.; Pyronnet, S.; Gingras, A. C.; Sonenberg, N. Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein I and p70 S6 Kinase Activities. Mol. Cell. Biol. 1999, 19, 4302-4310.
84. Cornelis, S.; Bruynooghe, Y.; Denecker, G.; Van Huffel, S.; Tinton, S.; Beyaert, R. Identification and Characterization of a Novel Cell Cycle-Regulated Internal Ribosome Entry Site. Mol. Cell 2000, 5, 597-605.
85. Eipers, P. G.; Barnoski, B. L.; Han, J.; Carroll, A. J.; Kidd, V. J. Localization of the Expressed Human p58 Protein Kinase Chromosomal Gene to Chromosome 1p36 and a Highly Related Sequence to Chromosome 15. Genomics 1991, 11, 621-629.
86. Miskimins, W. K.; Wang, G.; Hawkinson, M.; Miskimins, R. Control of Cyclin-Dependent Kinase Inhibitor p27 Expression by Cap-Independent Translation. Mol. Cell. Biol. 2001, 21, 4960-4967.
87. Hengst, L.; Reed, S. I. Translational Control of p27Kip1 Accumulation During the Cell Cycle. Science 1996, 271, 1861-1864.
88. Lloyd, R. V.; Erickson, L. A.; Jin, L.; Kulig, E.; Qian, X.; Cheville, J. C.; Scheithauer, B. W. p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers. Am. J. Pathol. 1999, 154, 313-323.
89. Millard, S. S.; Yan, J. S.; Nguyen, H.; Pagano, M.; Kiyokawa, H.; Koff, A. Enhanced Ribosomal Association of p27Kip1 mRNA Is a Mechanism Contributing to Accumulation During Growth Arrest. J. Biol. Chem. 1997, 272, 7093-7098.
90. Patry, V.; Bugler, B.; Maret, A.; Potier, M.; Prats, H. Endogenous Basic Fibroblast Growth Factor Isoforms Involved in Different Intracellular Protein Complexes. Biochem. J. 1997, 326, 259-264.
91. Bugler, B.; Amalric, F.; Prats, H. Alternative Initiation of Translation Determines Cytoplasmic or Nuclear Localization of Basic Fibroblast Growth Factor. Mol. Cell. Biol. 1991, 11, 573-577.
92. Brigstock, D. R.; Sasse, J.; Klagsbrun, M. Subcellular Distribution of Basic Fibroblast Growth Factor in Human Hepatoma Cells. Growth Factors 1991, 4, 189-196.
93. Vagner, S.; Touriol, C.; Galy, B.; Audigier, S.; Gensac, M. C.; Amalric, F.; Bayard, F.; Prats, H.; Prats, A. C. Translation of CUG- but not AUG-Initiated Forms of Human Fibroblast Growth Factor 2 is Activated in Transformed and Stressed Cells. J. Cell. Biol. 1996, 135, 1391-1402.
94. Vagner, S.; Gensac, M. C.; Maret, A.; Bayard, F.; Amalric, F.; Prats, H. ; Prats, A. C. Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes. Mol. Cell. Biol. 1995, 15, 35-44.
95. Kevil, C.; Carter, P.; Hu, B.; DeBenedetti, A. Translational Enhancement of FGF-2 by eIF-4 Factors, and Alternate Utilization of CUG and AUG Codons for Translation Initiation. Oncogene 1995, 11, 2339-2348.
96. Gospodarowicz, D.; Neufeld, G.; Schweigerer, L. Fibroblast Growth Factor. Mol. Cell. Endocrinol. 1986, 46, 187-204.
97. Huez, I.; Creancier, L.; Audigier, S.; Gensac, M. C.; Prats, A. C.; Prats, H. Two Independent Internal Ribosome Entry Sites are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA. Mol. Cell. Biol. 1998, 18, 6178-6190.
98. Plate, K. H.; Breier, G.; Weich, H. A.; Risau, W. Vascular Endothelial Growth Factor is a Potential Tumour Angiogenesis Factor in Human Gliomas In Vivo. Nature 1992, 359, 845-848.
99. Jones, A.; Harris, A. L. New Developments in Angiogenesis: a Major Mechanism for Tumor Growth and Target for Therapy. Cancer J. Sci. Am. 1998, 4, 209-217.
100. Baek, J. H.; Jang, J. E.; Kang, C. M.; Chung, H. Y.; Kim, N. D.; Kim, K. W. Hypoxia-Induced VEGF Enhances Tumor Survivability via Suppression of Serum Deprivation-Induced Apoptosis. Oncogene 2000, 19, 4621-4631.
101. Lang, K. J. D.; Kappel, A.; Goodall, G. J. Hypoxia-Inducible Factor-1Alpha mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation During Normoxia and Hypoxia. Mol. Biol. Cell 2002, 13, 1792-1801.
102. Horvath, P.; Suganuma, A.; Inaba, M.; Pan, Y. B.; Gupta, K. C. Multiple Elements in the 5' Untranslated Region Down-Regulate c-sis Messenger RNA Translation. Cell Growth Differ. 1995, 6, 1103-1110.
103. Bernstein, J.; Shefler, I.; Elroy-Stein, O. The Translational Repression Mediated by the Platelet-Derived Growth Factor 2/c-sis mRNA Leader is Relieved During Megakaryocytic Differentiation. J. Biol. Chem. 1995, 270, 10559-10565.
104. Bernstein, J.; Sella, O.; Le, S. Y.; Elroy-Stein, O. PDGF2/c-sis mRNA Leader Contains a Differentiation-Linked Internal Ribosomal Entry Site (D-IRES). J. Biol. Chem. 1997, 272, 9356-9362.
105. Kim, H. R.; Yu, J.; Ustach, C. Platelet-Derived Growth Factor Signaling and Human Cancer. J. Biochem. Mol. Biol. 2003, 36, 49-59.
106. Nielsen, F. C. The Molecular and Cellular Biology of Insulin-Like Growth Factor II. Prog. Growth Factor Res. 1992, 4, 257-290.
107. Pedersen, S. K.; Christiansen, J.; Hansen, T. O.; Larsen, M. R.; Nielsen, F. C. Human Insulin-Like Growth Factor II Leader 2 Mediates Internal Initiation of Translation. Biochem. J. 2002, 363, 37-44.
108. Moorehead, R. A.; Sanchez, O. H.; Baldwin, R. M.; Khokha, R. Transgenic Overexpression of IGF-II Induces Spontaneous Lung Tumors: a Model for Human Lung Adenocarcinoma. Oncogene 2003, 22, 853-857.
109. Cui, H.; Onyango, P.; Brandenburg, S.; Wu, Y.; Hsieh, C. L.; Feinberg, A. P. Loss of Imprinting in Colorectal Cancer Linked to Hypomethylation of H19 and IGF2. Cancer Res. 2002, 62, 6442-6446.
110. Guo, N.; Ye, J. J.; Liang, S. J.; Mineo, R.; Li, S. L.; Giannini, S.; Plymate, S. R.; Sikes, R. A.; Fujita-Yamaguchi, Y. The Role of Insulin-Like Growth Factor-II in Cancer Growth and Progression Evidenced by the Use of Ribozymes and Prostate Cancer Progression Models. Growth Horm. IGF Res. 2003, 13, 44-53.
111. Yao, X.; Hu, J. F.; Daniels, M.; Shiran, H.; Zhou, X.; Yan, H.; Lu, H.; Zeng, Z.; Wang, Q.; Li, T.; Hoffman, A. R. A Methylated Oligonucleotide Inhibits IGF2 Expression and Enhances Survival in a Model of Hepatocellular Carcinoma. J. Clin. Invest. 2003, 111, 265-273.
112. Johannes, G.; Carter, M. S.; Eisen, M. B.; Brown, P. O.; Sarnow, P. Identification of Eukaryotic mRNAs That are Translated at Reduced Cap Binding Complex eIF4F Concentrations Using a cDNA Microarray. Proc. Natl. Acad. Sci. USA 1999, 96, 13118-13123.
113. Morley, S. J. The Regulation of eIF4F During Cell Growth and Cell Death. Prog. Mol. Subcell. Biol. 2001, 1-37.
114. Holcik, M.; Korneluk, R. G. XIAP, the Guardian Angel. Nat. Rev. Mol. Cell. Biol. 2001, 2, 550-556.
115. Lagace, M.; Xuan, J. Y.; Young, S. S.; McRoberts, C.; Maier, J.; Rajcan-Separovic, E.; Korneluk, R. G. Genomic Organization of the X-Linked Inhibitor of Apoptosis and Identification of a Novel Testis-Specific Transcript. Genomics 2001, 77, 181-188.
116. Holcik, M.; Lefebvre, C. A.; Yeh, C.; Chow, T.; Korneluk, R. G. A New Internal-Ribosome-Entry-Site Motif Potentiates XIAP-Mediated Cytoprotection. Nature Cell Biology 1999, 1, 190-192.
117. Tamm, I.; Kornblau, S. M.; Segall, H.; Krajewski, S.; Welsh, K.; Kitada, S.; Scudiero, D. A.; Tudor, G.; Qui, Y. H.; Monks, A.; Andreeff, M.; Reed, J. C. Expression and Prognostic Significance of IAP-Family Genes in Human Cancers and Myeloid Leukemias. Clin. Cancer Res. 2000, 6, 1796-1803.
118. Zhang, J.; Li, Y.; Shen, B. Up-Regulation of XIAP by M-CSF is Associated with Resistance of Myeloid Leukemia Cells to Apoptosis. Leukemia 2002. 16, 2163-2165.
119. Bilim, V.; Kasahara, T.; Hara, N.; Takahashi, K.; Tomita, Y. Role of XIAP in the Malignant Phenotype of Transitional Cell Cancer (TCC) and Therapeutic Activity of XIAP Antisense Oligonucleotides Against Multidrug-Resistant TCC In Vitro. Int. J. Cancer 2003, 103, 29-37.
120. Hofmann, H. S.; Simm, A.; Hammer, A.; Silber, R. E.; Bartling, B. Expression of Inhibitors of Apoptosis (IAP) Proteins in Non-Small Cell Human Lung Cancer. J. Cancer Res. Clin. Oncol. 2002, 128, 554-560.
121. Hu, Y.; Cherton-Horvat, G.; Dragowska, V.; Baird, S.; Korneluk, R. G.; Durkin, J. P.; Mayer, L. D.; LaCasse, E. C. Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity Against Lung Cancer Cells In Vitro and In Vivo. Clin. Cancer Res. 2003, 9, 2826-2836.
122. Sasaki, H.; Sheng, Y.; Kotsuji, F.; Tsang, B. K. Down-Regulation of X-Linked Inhibitor of Apoptosis Protein Induces Apoptosis in Chemoresistant Human Ovarian Cancer Cells. Cancer Res. 2000, 60, 5659-5666.
123. Takayama, S.; Krajewski, S.; Krajewska, M.; Kitada, S.; Zapata, J. M.; Kochel, K.; Knee, D.; Scudiero, D.; Tudor, G.; Miller, G. J.; Miyashita, T.; Yamada, M.; Reed, J. C. Expression and Location of Hsp70/Hsc-Binding Anti-Apoptotic Protein BAG-1 and its Variants in Normal Tissues and Tumor Cell Lines. Cancer Res. 1998, 58, 3116-3131.
124. Bimston, D.; Song, J.; Winchester, D.; Takayama, S.; Reed, J. C.; Morimoto, R. I. BAG-1, a Negative Regulator of Hsp70 Chaperone Activity, Uncouples Nucleotide Hydrolysis from Substrate Release. EMBO J. 1998, 17, 6871-6878.
125. Wang, H. G.; Takayama, S.; Rapp, U. R.; Reed, J. C. Bcl-2 Interacting Protein, BAG-1, Binds to and Activates the Kinase Raf-1. Proc. Natl. Acad. Sci. USA 1996, 93, 7063-7068.
126. Tang, S. C. BAG-1, an Anti-Apoptotic Tumour Marker. IUBMB Life 2002, 53, 99-105.
127. Coldwell, M. J.; deSchoolmeester, M. L.; Fraser, G. A.; Pickering, B. M. ; Packham, G.; Willis, A. E. The p36 Isoform of BAG-1 is Translated by Internal Ribosome Entry Following Heat Shock. Oncogene 2001, 20, 4095-4100.
128. Adams, J. M.; Cory, S. Apoptosomes: Engines for Caspase Activation. Curr. Opin. Cell Biol. 2002, 14, 715-720.
129. Coldwell, M. J.; Mitchell, S. A.; Stoneley, M.; MacFarlane, M.; Willis, A. E. Initiation of Apaf-1 Translation by Internal Ribosome Entry. Oncogene 2000, 19, 899-905.
130. Marchetti, A.; Buttitta, F.; Pellegrini, S.; Bertacca, G.; Callahan, R. Reduced Expression of INT-6/eIF3-p48 in Human Tumors. Int. J. Oncol. 2001, 18, 175-179.
131. Berkel, H. J.; Turbat-Herrera, E. A.; Shi, R.; de Benedetti, A. Expression of the Translation Initiation Factor eIF4E in the Polyp-Cancer Sequence in the Colon. Cancer Epidemiol. Biomarkers Prev. 2001, 10, 663-666.
132. Kerekatte, V.; Smiley, K.; Hu, B.; Smith, A.; Gelder, F.; De Benedetti, A. The Proto-Oncogene/Translation Factor eIF4E: a Survey of its Expression in Breast Carcinomas. Int. J. Cancer 1995, 64, 27-31.
133. Guan, X. Y.; Sham, J. S.; Tang, T. C.; Fang, Y.; Huo, K. K.; Yang, J. M. Isolation of a Novel Candidate Oncogene Within a Frequently Amplified Region at 3q26 in Ovarian Cancer. Cancer Res. 2001, 61, 3806-3809.
134. Watkins, S. J.; Norbury, C. J. Translation Initiation and its Deregulation During Tumorigenesis. Br. J. Cancer 2002, 86, 1023-1027.
135. Oh, S. K.; Scott, M. P.; Sarnow, P. Homeotic Gene Antennapedia mRNA Contains 5'-Noncoding Sequences that Confer Translational Initiation by Internal Ribosome Binding. Genes Dev. 1992, 6, 1643-1653.
136. Ye, X.; Fong, P.; Iizuka, N.; Choate, D.; Cavener, D. R. Ultrabithorax and Antennapedia 5' Untranslated Regions Promote Developmentally Regulated Internal Translation Initiation. Mol. Cell. Biol. 1997, 17, 1714-1721.
137. Kim, J. G.; Armstrong, R. C.; Berndt, J. A.; Kim, N. W.; Hudson, L. D. A Secreted DNA-Binding Protein that is Translated Through an Internal Ribosome Entry Site (IRES) and Distributed in a Discrete Pattern in the Central Nervous System. Mol. Cell. Neurosci. 1998, 12, 119-140.
138. Oumard, A.; Hennecke, M.; Hauser, H.; Nourbakhsh, M. Translation of NRF mRNA is Mediated by Highly Efficient Internal Ribosome Entry. Mol. Cell. Biol. 2000, 20, 2755-2759.
139. Pozner, A.; Goldenberg, D.; Negreanu, V.; Le, S. Y.; Elroy-Stein, O.; Levanon, D.; Groner, Y. Transcription-Coupled Translation Control of AML1/RUNXI is Mediated by Cap- and Internal Ribosome Entry Site-Dependent Mechanisms. Mol. Cell. Biol. 2000, 20, 2297-2307.
140. Chappell, S. A.; Edelman, G. M.; Mauro, V. P. A 9-nt Segment of a Cellular mRNA Can Function as an Internal Ribosome Entry Site (IRES) and when Present in Linked Multiple Copies Greatly Enhances IRES activity. Proc. Natl. Acad. Sci. U S A 2000, 97, 1536-1541.
141. Stoneley, M.; Spencer, J. P.; Wright, S. C. An Internal Ribosome Entry Segment in the 5' Untranslated Region of the mnt Gene. Oncogene 2001, 20, 893-897.
142. Heppner Goss, K.; Trzepacz, C.; Tuohy, T. M.; Groden, J. Attenuated APC Alleles Produce Functional Protein from Internal Translation Initiation. Proc. Natl. Acad. Sci. USA 2002, 99, 8161-8166.
143. Fernandez, J.; Yaman, I.; Mishra, R.; Merrick, W. C.; Snider, M. D.; Lamers, W.H.; Hatzoglou, M. Internal Ribosome Entry Site-Mediated Translation of a Mammalian mRNA is Regulated by Amino Acid Availability. J. Biol. Chem. 2001, 276, 12285-12291.
144. Lauring, A. S.; Overbaugh, J. Evidence that an IRES within the Notch2 Coding Region Can Direct Expression of a Nuclear Form of the Protein. Mol. Cell 2000, 6, 939-945.
145. Barraille, P.; Chinestra, P.; Bayard, F.; Faye, J. C. Alternative Initiation of Translation Accounts for a 67/45 kDa Dimorphism of the Human Estrogen Receptor ERAlpha. Biochem. Biophys. Res. Commun. 1999, 257, 84-88.
146. Giraud, S.; Greco, A.; Brink, M.; Diaz, J. J.; Delafontaine, P. Translation Initiation of the Insulin-Like Growth Factor I Receptor mRNA Is Mediated by an Internal Ribosome Entry Site. J. Biol. Chem. 2001, 276, 5668-5675.
147. Negulescu, D.; Leong, L. E.; Chandy, K. G.; Semler, B. L.; Gutman, G. A. Translation Initiation of a Cardiac Voltage-Gated Potassium Channel by Internal Ribosome Entry. J. Biol. Chem. 1998, 273, 20109-20113.
148. Pinkstaff, J. K.; Chappell, S. A.; Mauro, V. P.; Edelman, G. M.; Krushel, L. A. Internal Initiation of Translation of Five Dendritically Localized Neuronal mRNAs. Proc. Natl. Acad. Sci. USA 2001, 98, 2770-2775.
149. Macejak, D. G.; Sarnow, P. Internal Initiation of Translation Mediated by the 5' Leader of a Cellular mRNA. Nature 1991, 353, 90-94.
150. Carter, M. S.; Sarnow, P. Distinct mRNAs that Encode La Autoantigen are Differentially Expressed and Contain Internal Ribosome Entry Sites. J. Biol. Chem. 2000, 275, 28301-28307.
151. Izquierdo, J. M.; Cuezva, J. M. Internal-Ribosome-Entry-Site Functional Activity of the 3'-Untranslated Region of the mRNA for the Beta Subunit of Mitochondrial H+-ATP Synthase. Biochem. J. 2000, 346, 849-855.
152. Maier, D.; Nagel, A. C.; Preiss, A. Two Isoforms of the Notch Antagonist Hairless are Produced by Differential Translation Initiation. Proc. Natl. Acad. Sci. USA 2002, 99, 15480-15485.
153. Morrish, B. C.; Rumsby, M. G. The 5' UTR of Protein Kinase C Epsilon Confers Translational Regulation In Vitro and In Vivo. Biochem. Biophys. Res. Commun. 2001, 283, 1091-1098.
154. Schiavi, A.; Hudder, A.; Werner, R. Connexin 43 mRNA Contains a Functional Internal Ribosome Entry Site. FEBS Lett. 1999, 464, 118-122.
155. Hudder, A.; Werner, R. Analysis of a Charcot-Marie-Tooth Disease Mutation Reveals an Essential Internal Ribosome Entry Site Element in the Connexin-32 Gene. J. Biol. Chem. 2000, 275, 34586-34591.
156. Chiang, P. W.; Carpenter, L. E.; Hagerman, P. J. The 5'-Untranslated Region of the fmrl Message Facilitates Translation by Internal Ribosome Entry. J. Biol. Chem. 2001, 276, 37916-37921.
157. Shiroki, K.; Ohsawa, C.; Sugi, N.; Wakiyama, M.; Miura, K.; Watanabe, M. ; Suzuki, Y.; Sugano, S. Internal Ribosome Entry Site-Mediated Translation of Smad5 In Vivo: Requirement for a Nuclear Event. Nucleic Acids Res. 2002, 30, 2851-2861.
158. Chappell, S. A.; Owens, G. C.; Mauro, V. P. A 5' Leader of Rbm3, a Cold Stress-Induced mRNA, Mediates Internal Initiation of Translation with Increased Efficiency Under Conditions of Mild Hypothermia. J. Biol. Chem. 2001, 276, 326917-326922.