Differential Roles of Peripheral Metabotropic Glutamate Receptors in Bee Venom-Induced Nociception and Inflammation in Conscious Rats

Journal of Pain

Volumn 11, Issue 4, 2010, Pages 321-329

  Chen, Hui Sheng ^a   Qu, Fang ^a   He, Xiang ^a   Kang, Shuang Ming ^a   Liao, Dan ^a   Lu, Su Jie ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

Bee venom; hyperalgesia; inflammation; mGluRs; persistent spontaneous nociception

Indexed keywords

(1) 2 AMINO 4 PHOSPHONOBUTYRIC ACID; (2,4) 4 AMINOPYRROLIDINE 2,4 DICARBOXYLATE; 1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; A METHYLSERINE O PHOSPHATE; ANALGESIC AGENT; BEE VENOM; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HYPERALGESIA; INFLAMMATION; MALE; NOCICEPTION; NONHUMAN; OBSERVATIONAL STUDY; PAIN THRESHOLD; PERSISTENT SPONTANEOUS NOCICEPTION; RAT; SWELLING;

ANIMALS; BEE VENOMS; CONSCIOUSNESS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FOOT; GLUTAMIC ACID; HYPERALGESIA; INFLAMMATION; MALE; NOCICEPTORS; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SENSORY RECEPTOR CELLS; TREATMENT OUTCOME;

EID: 77949918008     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2009.07.013     Document Type: Article

References (64)

1. Adwanikar H., Karim F., and Gereau IV R.W. Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain 111 (2004) 125-135
2. Ahn D.K., Kim K.H., Jung C.Y., Choi H.S., Lim E.J., Youn D.H., and Bae Y.C. Role of peripheral group I and II metabotropic glutamate receptors in IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats. Pain 118 (2005) 53-60
3. Bhave G., Karim F., Carlton S.M., and Gereau R.W. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci 4 (2001) 417-423
4. Carlton S.M. Peripheral excitatory amino acids. Curr Opin Pharmacol 1 (2001) 52-56
5. Carlton S.M., and Hargett G.L. Colocalization of metabotropic glutamate receptors in rat dorsal root ganglion cells. J Comp Neurol 501 (2007) 780-789
6. Carlton S.M., Hargett G.L., and Coggeshall R.E. Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat. Neuroscience 105 (2001) 957-969
7. Chen H.S., He X., Qu F., Kang S.M., Yu Y., Liao D., and Lu S.J. Differential roles of peripheral MAPK signal transduction pathways in bee venom-induced nociception and inflammation in conscious rats. J Pain 10 (2009) 201-207
8. Chen H.S., He X., Wang Y., Wen W.W., You H.J., and Arendt-Nielsen L. Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: A systematic comparative study in conscious rats. Experimental Neurology 204 (2007) 244-251
9. Chen H.S., Lei J., He X., Qu F., Wang Y., Wen W.W., You H.J., and Arendt-Nielsen L. Peripheral involvement of PKA and PKC in subcutaneous bee venom-induced persistent nociception, mechanical hyperalgesia, and inflammation in rats. Pain 135 (2008) 31-36
10. Chen H.S., Lei J., He X., Wang Y., Wen W.W., Wei X.Z., Graven-Nielsen T., You H.J., and Arendt-Nielsen L. Pivotal involvement of neurogenic mechanism in subcutaneous bee venom induced inflammation and allodynia in unanesthetized conscious rats. Experimental Neurology 200 (2006) 386-391
11. Chen H.S., Li M.M., Shi J., and Chen J. Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: A comparative study between formalin test and bee venom test in the rat. Anesthesiology 98 (2003) 1231-1236
12. Chen J., Li H.L., Luo C., Li Z., and Zheng J. Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat. Brain Res 844 (1999) 98-105
13. Chiechio S., Copani A., Melchiorri D., Canudas A.M., Storto M., Calvani M., Nicolai R., and Nicoletti F. Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain. J Endocrinol Invest 27 (2004) 171-176
14. Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37 (1997) 205-237
15. Dogrul A., Ossipov M.H., Lai J., Malan T.P., and Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neurosci Lett 292 (2000) 115-118
16. Dolan S., and Nolan A.M. Behavioral evidence supporting a differential role for spinal group I and II metabotropic glutamate receptors in inflammatory hyperalgesia in sheep. Neuropharmacology 43 (2002) 319-326
17. Du J., Zhou S., and Carlton S.M. Group II metabotropic glutamate receptor activation attenuates peripheral sensitization in inflammatory states. Neuroscience 154 (2008) 754-766
18. El-Kouhen O., Lehto S.G., Pan J.B., Chang R., Baker S.J., Zhong C., Hollingsworth P.R., Mikusa J.P., Cronin E.A., Chu K.L., McGaraughty S.P., Uchic M.E., Miller L.N., Rodell N.M., Patel M., Bhatia P., Mezler M., Kolasa T., Zheng G.Z., Fox G.B., Stewart A.O., Decker M.W., Moreland R.B., Brioni J.D., and Honore P. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: Effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol 149 (2006) 761-774
19. Fisher K., and Coderre T.J. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. Pain 68 (1996) 255-263
20. Fisher K., Fundytus M.E., Cahill C.M., and Coderre T.J. Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. Pain 77 (1998) 59-66
21. Fisher K., Lefebvre C., and Coderre T.J. Antinociceptive effects following intrathecal pretreatment with selective metabotropic glutamate receptor compounds in a rat model of neuropathic pain. Pharmacol Biochem Behav 73 (2002) 411-418
22. Fundytus M.E. Glutamate receptors and nociception: Implications for the drug treatment of pain. CNS Drugs 15 (2001) 29-58
23. Goudet C., Chapuy E., Alloui A., Acher F., Pin J.P., and Eschalier A. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain 137 (2008) 112-124
24. Hama A.T. Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat. Neuropharmacology 44 (2003) 423-430
25. Ji R.R., Samad T.A., Jin S.X., Schmoll R., and Woolf C.J. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36 (2002) 57-68
26. Jones C.K., Eberle E.L., Peters S.C., Monn J.A., Shannon H.E., Fisher K., and Coderre T.J. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. NeuroReport 7 (1996) 2743-2747
27. Jones C.K., Eberle E.L., Peters S.C., Monn J.A., and Shannon H.E. Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing. Neuropharmacology 49 (2005) 206-218
28. Jung C.Y., Choi H.S., Ju J.S., Park H.S., Kwon T.G., Bae Y.C., and Ahn D.K. Central metabotropic glutamate receptors differentially participate in interleukin-1beta-induced mechanical allodynia in the orofacial area of conscious rats. J Pain 7 (2006) 747-756
29. Jung C.Y., Lee S.Y., Choi H.S., Lim E.J., Lee M.K., Yang G.Y., Han S.R., Youn D.H., and Ahn D.K. Participation of peripheral group I and II metabotropic glutamate receptors in the development or maintenance of IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats. Neurosci Lett 409 (2006) 173-178
30. Kohara A., Nagakura Y., Kiso T., Toya T., Watabiki T., Tamura S., Shitaka Y., Itahana H., and Okada M. Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models. Eur J Pharmacol 571 (2007) 8-16
31. Lee H.J., Choi H.S., Ju J.S., Bae Y.C., Kim S.K., Yoon Y.W., and Ahn D.K. Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats. Brain Res Bull 70 (2006) 378-385
32. Lee M.K., Choi B.Y., Yang G.Y., Jeon H.J., Kyung H.M., Kwon O.W., Park H.S., Bae Y.C., Mokha S.S., and Ahn D.K. Low doses of cannabinoids enhance the antinociceptive effects of intracisternally administered mGluRs groups II and III agonists in formalin-induced TMJ nociception in rats. Pain 139 (2008) 367-375
33. Lee K.S., Kim J., Yoon Y.W., Lee M.G., Hong S.K., and Han H.C. The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation. Neurosci Lett 416 (2007) 123-127
34. Lee J.S., and Ro J.Y. Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. Neuroscience 146 (2007) 375-383
35. Li H., Ohishi H., Kinoshita A., Shigemoto R., Nomura S., and Mizuno N. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: An electron microscope study in the rat. Neurosci Lett 223 (1997) 153-156
36. Li J.L., Ohishi H., Kaneko T., Shigemoto R., Neki A., Nakanishi S., and Mizuno N. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. Neurosci Lett 204 (1996) 9-12
37. Marabese I., de Novellis V., Palazzo E., Scafuro M.A., Vita D., Rossi F., and Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology 52 (2007) 253-262
38. Nagy I., Santha P., Jancso G., and Urban L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol 500 (2004) 351-369
39. Neugebauer V. Glutamate receptor ligands. Handb Exp Pharmacol 177 (2007) 217-249
40. Neugebauer V., Chen P.S., and Willis W.D. Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells. J Neurophysiol 84 (2000) 2998-3009
41. Neugebauer V., Chen P.S., and Willis W.D. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells. J Neurophysiol 82 (1999) 272-282
42. Ohishi H., Nomura S., Ding Y.Q., Shigemoto R., Wada E., Kinoshita A., Li J.L., Neki A., Nakanishi S., and Mizuno N. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat. Neurosci Lett 202 (1995) 85-88
43. Sevostianova N., and Danysz W. Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test. Neuropharmacology 51 (2006) 623-630
44. Scotland P.E., and Coderre T.J. Enhanced 3,5-dihydroxyphenylglycine-induced sustained nociceptive behaviors in rats with neuropathy or chronic inflammation. Behav Brain Res 184 (2007) 150-156
45. Simmons R.M.A., Webster A.A., Kalra A.B., and Iyengar S. Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats. Pharmacol Biochem Behav 73 (2002) 419-427
46. Soliman A.C., Yu J.S., and Coderre T.J. mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity. Neuropharmacology 48 (2005) 325-332
47. Stanfa L.C., and Dickenson A.H. Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones. Eur J Pharmaco 347 (1998) 165-172
48. Tominaga M., and Tominaga T. Structure and function of TRPV1. Pflugers Arch 451 (2005) 143-150
49. Valerio A., Rizzonelli P., Paterlin M., Moretto G., Knopfel T., Kuhn R., Memo M., and Spano P. mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: A developmental study. Neuroscience Research 28 (1997) 49-57
50. Varney M.A., and Gereau R.W. Metabotropic glutamate receptor involvement in models of acute and persistent pain: Prospects for the development of novel analgesics. Current Drug Targets 1 (2002) 215-225
51. Walker K., Bowes M., Panesar M., Davis A., Gentry C., Kesingland A., Gasparini F., Spooren W., Stoehr N., Pagano A., Flor P.J., Vranesic I., Lingenhoehl K., Johnson E.C., Varney M., Urban L., and Kuhn R. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. Neuropharmacology 40 (2001) 1-9
52. Walker K., Reeve A., Bowes M., Winter J., Wotherspoon G., Davis A., Schmid P., Gasparini F., Kuhn R., and Urban L. mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology 40 (2001) 10-19
53. Yang D., and Gereau R.W. Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. J Neurosci 22 (2002) 6388-6393
54. Yang D., and Gereau R.W. Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation. Pain 106 (2003) 411-417
55. Yashpal K., Fisher K., Chabot J.G., and Coderre T.J. Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats. Pain 94 (2001) 17-29
56. You H.J., Chen J., Morch C.D., and Arendt-Nielsen L. Differential effect of peripheral glutamate (NMDA, non-NMDA) receptor antagonists on bee venom-induced spontaneous nociception and sensitization. Brain Res Bull 58 (2002) 561-567
57. Young M.R., Fleetwood-Walker S.M., Dickinson T., Blackburn-Munro G., Sparrow H., Birch P.J., and Bountra C. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord. Brain Res 777 (1997) 161-169
58. Zhang L., Lu Y., Chen Y., and Westlund K.N. Group I metabotropic glutamate receptor antagonists block secondary thermal hyperalgesia in rats with knee joint inflammation. J Pharmacol Exp Ther 300 (2002) 149-156
59. Zhang T., Zhang J., Shi J., Feng Y., Sun Z.S., and Li H. Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity. Brain Res Bull 79 (2009) 219-223
60. Zhou S., Komak S., Du J., and Carlton S.M. Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: Their role in nociception. Brain Res 913 (2001) 18-26
61. Zhu C.Z., Baker S., Ei-Kouhen O., Lehto S.G., Hollingsworth P.R., Gauvin D.M., Hernandez G., Zheng G., Chang R., Moreland R.B., Stewart A.O., Brioni J.D., and Honore P. Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. Eur J Pharmacol 580 (2008) 314-321
62. Zhu C.Z., Hsieh G., Ei-Kouhen O., Wilson S.G., Mikusa J.P., Hollingsworth P.R., Chang R., Moreland R.B., Brioni J., Decker M.W., and Honore P. Role of central and peripheral mGluR5 receptors in post-operative pain in rats. Pain 114 (2005) 195-202
63. Zhu C.Z., Wilson S.G., Mikusa J.P., Wismer C.T., Gauvin D.M., Lynch III J.J., Wade C.L., Decker M.W., and Honore P. Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. Eur J Pharmacol 506 (2004) 107-118
64. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110