Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats

Neuroscience Letters

Volumn 292, Issue 2, 2000, Pages 115-118

  Dogrul, Ahmet ^a   Ossipov, Michael H ^b   Lai, Josephine ^b   Malan Jr , T Philip ^b   Porreca, Frank ^b  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Metabotropic glutamate receptors; mGluR5; Neuropathic pain; SIB 1757; Tactile allodynia; Thermal hyperalgesia

Indexed keywords

6 METHYL 2 PHENYLAZO 3 PYRIDINOL; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYPERALGESIA; MALE; NERVE INJURY; NERVE LIGATION; NEURALGIA; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL NERVE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; HYPERALGESIA; LIGATION; MALE; NERVE FIBERS; NOCICEPTORS; PAIN THRESHOLD; PHENAZOPYRIDINE; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL NERVES;

EID: 0034613452     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01458-0     Document Type: Article

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