Group I metabotropic glutamate receptor antagonists block secondary thermal hyperalgesia in rats with knee joint inflammation

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 1, 2002, Pages 149-156

  Zhang, Liping ^a   Lu, Ying ^a   Chen, Ying ^b   Westlund, Karin N ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 AMINO 2 (3 CARBOXYCYCLOBUTYL) 3 (9 THIOXANTHYL)PROPIONIC ACID; 4 CARBOXY 2 METHYLPHENYLGLYCINE; CARRAGEENAN; GLUTAMATE RECEPTOR; KAOLIN; METABOTROPIC RECEPTOR ANTAGONIST;

ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; HEAT ACCLIMATIZATION; HYPERALGESIA; KNEE ARTHRITIS; MALE; MICRODIALYSIS; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SKIN TEMPERATURE; THERMAL STIMULATION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BENZOATES; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HEAT; HINDLIMB; HYPERALGESIA; KAOLIN; MALE; MICRODIALYSIS; NEURONS; PAIN MEASUREMENT; POSTERIOR HORN CELLS; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL CORD;

EID: 0036137084     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.1.149     Document Type: Article

References (40)

1. Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn
2. Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurons in viva
3. Involvement of mGluR5 on acute nociceptive transmission
4. Neuropretective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4-carboxyphenylglycine (LY367385): Comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors
5. Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid
6. Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (±)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl) propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model
7. (+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonizes metabotropic glutamate mGluR1 receptors
8. Discharge characteristics of fine medial articular afferents at rest and during passive movements of inflamed knee joints
9. Pharmacology and functions of metabotropic glutamate receptors
10. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGluR5) antagonist, in experimental neuropathic pain in rats
11. The contribution of metabotropic glutamate receptors to formalin-induced nociception
12. DHPG-induced LTD in area CA1 of juvenile rat hippocampus: Characterization and sensitivity to novel mGlu receptor antagonists
13. In vivo antino-ciceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats
14. Interactions between metabotropic and ionotropic glutamate receptor agonists in the rat spinal cord in vitro
15. Neuropreotectlve actions of novel and potent ligands of group I and group II metabotropic glutamate receptors
16. Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord
17. Peripheral and spinal component of the sensitization of spinal neurons during an acute experimental arthritis
18. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
19. Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons
20. Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee
21. Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine
22. Evaluation of agonists and antagonists acting at group I metabotropic glutamate receptors in the thalamus in vivo
23. Effects of an experimental arthritis on the sensory properties of fine articular afferent units
24. Response of spinal cord neurons to stimulation of articular afferent fibers in the cat
25. Enhancement of the responses of ascending tract cells in the cat spinal cord by acute inflammation of the knee joint
26. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridisation study in adult and developing rat
27. Immunohistochemical localization of a metabotropic glutamate receptors, mGluR5, in the rat brain
28. Neurogenic hyperalgesia: Central neural correlates in responses of spinothalamic tract neurons
29. An experimental arthritis in rats: Dorsal horn aspartate and glutamate increases
30. Behavioral and immunohistochemical changes in an experimental arthritis model in rats
31. Central control of peripheral joint inflammation and heat hyperalgesia
32. Neural changes in acute arthiritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn
33. Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons
34. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
35. mGlu5 receptors and nociceptlve function II. MGlu5 receptors functionally expressed on peripheral sensory neurons mediate inflammatory hyperalgesia
36. The presence of ineffective synapses and the circumstances which unmask them
37. Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission
38. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord
39. The involvement of metabotropic glutamate receptors and their intracellular signalling pathways in sustained nociceptive transmission in rat dorsal horn neurons
40. The role of type I metabotropic glutamate receptors in the generation of dorsal root reflexes induced by acute arthritis or the spinal infusion of 4-aminopyridine in the anesthetized rat