Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat

Neuropharmacology

Volumn 44, Issue 4, 2003, Pages 423-430

  Hama, Aldric T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Central sensitization; Metabotropic glutamate subtype 5 receptor; Nociception; Rat; Spinal cord

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; RECEPTOR SUBTYPE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLD EXPOSURE; COLD SENSITIVITY; CONTROLLED STUDY; HINDLIMB; MALE; NERVE INJURY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR SENSITIVITY; ROOM TEMPERATURE; SCIATIC NERVE; SPINAL CORD;

EID: 0037334233     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00026-1     Document Type: Article

References (44)

1. Alvarez F.J., Villalba R.M., Carr P.A., Grandes P., Somohano P.M. Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord. Journal of Comparative Neurology. 422:2000;464-487.
2. Baranauskas G., Nistri A. Sensitization of pain pathways in the spinal cord: cellular mechanisms. Progress in Neurobiology. 54:1998;349-365.
3. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:1988;87-107.
4. Berthele A., Boxall S.J., Urban A., Anneser J.M., Zieglgansberger W., Urban L., et al. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord. Brain Research. Developmental Brain Research. 112:1999;39-53.
5. Dogrul A., Ossipov M.H., Lai J., Malan T.P. Jr., Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neuroscience Letters. 292:2000;115-118.
6. Dolan S., Nolan A.M. Behavioural evidence supporting a differential role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission. Neuropharmacology. 39:2000;1132-1138.
7. Fisher K., Coderre T.J. Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists. Neuroreport. 7:1996a;2743-2747.
8. Fisher K., Coderre T.J. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. Pain. 68:1996b;255-263.
9. Fisher K., Coderre T.J. Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats. Neuroreport. 9:1998;1169-1172.
10. Fisher K., Fundytus M.E., Cahill C.M., Coderre T.J. Intrathecal administration of the mGluR compound, (S)-4CPG, attenuates hyperalgesia and allodynia associated with sciatic nerve constriction injury in rats. Pain. 77:1998;59-66.
11. Fisher K., Lefebvre C., Coderre T.J. Antinociceptive effects following intrathecal pretreatment with selective metabotropic glutamate receptor compounds in a rat model of neuropathic pain. Pharmacology, Biochemistry and Behavior. 73:2002;411-418.
12. Fundytus M.E., Fisher K., Dray A., Henry J.L., Coderre T.J. In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats. Neuroreport. 9:1998;731-735.
13. Furuyama T., Kiyama H., Sato K., Park H.T., Maeno H., Takagi H., et al. Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Brain Research. Molecular Brain Research. 18:1993;141-151.
14. Gasparini F., Lingenhohl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology. 38:1999;1493-1503.
15. Haley J., Sullivan A., Dickenson A. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Research. 518:1990;218-226.
16. Hylden J., Nahin R., Traub R., Dubner R. Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms. Pain. 37:1989;229-243.
17. Karim F., Wang C.C., Gereau R.W.T. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. Journal of Neuroscience. 21:2001;3771-3779.
18. Kolhekar R., Meller S.T., Gebhart G.F. Characterization of the role of spinal N-methyl-D-aspartate receptors in thermal nociception in the rat. Neuroscience. 57:1993;385-395.
19. Lefebvre C., Fisher K., Cahill C.M., Coderre T.J. Evidence that DHPG-induced nociception depends on glutamate release from primary afferent C-fibres. Neuroreport. 11:2000;1631-1635.
20. Lorrain D.S., Correa L., Anderson J., Varney M. Activation of spinal group I metabotropic glutamate receptors in rat evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyradine pretreatment. Neuroscience Letters. 327:2002;198-202.
21. Mao J., Price D.D., Hayes R.L., Lu J., Mayer D.J. Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Research. 598:1992;271-278.
22. Marsala M., Malmberg A.B., Yaksh T.L. The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. Journal of Neuroscience Methods. 62:1995;43-53.
23. Mertens P., Ghaemmaghami C., Bert L., Perret-Liaudet A., Sindou M., Renaud B. Amino acids in spinal dorsal horn of patients during surgery for neuropathic pain or spasticity. Neuroreport. 11:2000;1795-1798.
24. Mills C.D., Xu G.Y., McAdoo D.J., Hulsebosch C.E. Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat. Journal of Neurochemistry. 79:2001;835-848.
25. Neugebauer V., Chen P.S., Willis W.D. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells. Journal of Neurophysiology. 82:1999;272-282.
26. Neugebauer V., Lucke T., Schaible H.G. Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons. European Journal of Neuroscience. 6:1994;1179-1186.
27. O'Leary D.M., Movsesyan V., Vicini S., Faden A.I. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. British Journal of Pharmacology. 131:2000;1429-1437.
28. Palecek J., Paleckova V., Dougherty P.M., Willis W.D. The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons. Pain. 56:1994;261-269.
29. Petralia R.S., Wang Y.X., Wenthold R.J. The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. Journal of Neuroscience. 14:1994;6102-6120.
30. Pogatzki E.M., Zahn P.K., Brennan T.J. Effect of pretreatment with intrathecal excitatory amino acid receptor antagonists on the development of pain behavior caused by plantar incision. Anesthesiology. 93:2000;489-496.
31. Sluka K.A., Jordan H.H., Willis W.D., Westlund K.N. Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on spinal release of amino acids after development of acute arthritis in rats. Brain Research. 664:1994;77-84.
32. Sluka K.A., Westlund K.N. An experimental arthritis in rats: dorsal horn aspartate and glutamate increases. Neuroscience Letters. 145:1992;141-144.
33. Sluka K.A., Westlund K.N. Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation. Pain. 55:1993;217-225.
34. Soliman A., Coderre T. The effects of intrathecally administered mGluR agents on capsaicin-induced thermal and mechanical hypersensitivity. Society for Neuroscience Annual Meeting. 26:2000.
35. Sutton J.L., Maccecchini M.L., Kajander K.C. The kainate receptor antagonist 2S,4R-4-methylglutamate attenuates mechanical allodynia and thermal hyperalgesia in a rat model of nerve injury. Neuroscience. 91:1999;283-292.
36. Valerio A., Rizzonelli P., Paterlini M., Moretto G., Knopfel T., Kuhn R., et al. mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study. Neuroscience Research. 28:1997;49-57.
37. Walker K., Bowes M., Panesar M., Davis A., Gentry C., Kesingland A., et al. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. Neuropharmacology. 40:2001a;1-9.
38. Walker K., Reeve A., Bowes M., Winter J., Wotherspoon G., Davis A., et al. mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology. 40:2001b;10-19.
39. Woolf C. Evidence for a central component of post-injury pain hypersensitivity. Nature. 306:1983;686-688.
40. Yaksh T., Rudy T. Chronic catheterization of the spinal subarachnoid space. Physiology and Behavior. 17:1976;1031-1036.
41. Young M.R., Fleetwood-Walker S.M., Mitchell R., Munro F.E. Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons. Neuropharmacology. 33:1994;141-144.
42. Young M.R., Fleetwood-Walker S.M., Dickinson T., Blackburn-Munro G., Sparrow H., Birch P.J., et al. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord. Brain Research. 777:1997;161-169.
43. Yu N., Lariosa L.D., Santori E.M., Jachec C., Washburn M.S., Pasieczny R., et al. Investigation of neuroprotective activity of selective mGluR5 antagonists, SIB-1893 (6-methyl-2-phenyl (phenylazo)-3-pyridinol) and MPEP (2-methyl-6-phenyl-ethynyl pyridine). Society for Neuroscience Annual Meeting. 27:2001.
44. Zahn P.K., Brennan T.J. Intrathecal metabotropic glutamate receptor antagonists do not decrease mechanical hyperalgesia in a rat model of postoperative pain. Anesthesia and Analgesia. 87:1998;1354-1359.