The in chemico-in silico interface: Challenges for integrating experimental and computational chemistry to identify toxicity

Alternatives to Laboratory Animals

Volumn 37, Issue 5, 2009, Pages 513-521

  Cronin, Mark T D ^a   Bajot, Fania ^a   Enoch, Steven J ^a   Madden, Judith C ^a   Roberts, David W ^a   Schwöbel, Johannes ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Alternatives; In chemico; In silico; Integrated testing strategy; Reactivity; Toxicity

Indexed keywords

REACTIVE OXYGEN METABOLITE; DRUG; ORGANIC COMPOUND;

ACUTE TOXICITY; ALCOHOL INTOLERANCE; ANALYTIC METHOD; BLOOD TOXICITY; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPUTER MODEL; DNA BINDING; DRUG INDUCED DISEASE; DRUG SCREENING; DRUG TARGETING; MACROMOLECULE; MATHEMATICAL MODEL; OXIDATION REDUCTION REACTION; PREDICTIVE VALIDITY; PRIORITY JOURNAL; REVIEW; SKIN SENSITIZATION; TETRAHYMENA PYRIFORMIS; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS; ANIMAL TESTING ALTERNATIVE; ARTICLE; BIOLOGY; CHEMISTRY; HUMAN; METHODOLOGY; TOXICITY TESTING;

ANIMAL TESTING ALTERNATIVES; COMPUTATIONAL BIOLOGY; HUMANS; ORGANIC CHEMICALS; PHARMACEUTICAL PREPARATIONS; TOXICITY TESTS;

EID: 77949877169     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290903700508     Document Type: Review

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