Reactivity profiling: Covalent modification of single nucleophile peptides for skin sensitization risk assessment

Toxicological Sciences

Volumn 108, Issue 2, 2009, Pages 401-411

  Aleksic, Maja ^a   Thain, Emma ^a   Roger, Delphine ^a   Saib, Ouarda ^a   Davies, Michael ^a   Li, Jin ^a   Aptula, Aynur ^a   Zazzeroni, Raniero ^a  

^a UNILEVER RESEARCH   (United Kingdom)

Author keywords

Covalent binding; Hapten; In chemico; Mass spectrometry; Model peptide; Skin sensitization

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 6 METHYLCOUMARIN; ACETYLACETONE; ACRYLIC ACID ETHYL ESTER; AMINO TERMINAL TELOPEPTIDE; ARGININE; BENZALDEHYDE; BENZOQUINONE; BENZYL BROMIDE; BUTANOL; CINNAMALDEHYDE; CINNAMYL ALCOHOL; CYSTEINE; DODECYL GALLATE; FORMALDEHYDE; GLUTARALDEHYDE; GLYCEROL; GLYOXAL; HAPTEN; HISTIDINE; HYDROQUINONE; HYDROXYCITRONELLAL; ISOEUGENOL; LACTIC ACID; LYSINE; NUCLEOPHILE; OXAZOLONE; SALICYLIC ACID; TYROSINE; UNINDEXED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COVALENT BOND; DNA ADDUCT; IMMUNOGENICITY; INCUBATION TIME; LIQUID CHROMATOGRAPHY; PROTEIN DEPLETION; PROTEIN MODIFICATION; PROTEIN POLYMERIZATION; PROTEIN TARGETING; RISK ASSESSMENT; SKIN SENSITIZATION; TANDEM MASS SPECTROMETRY; TOXICITY TESTING;

ALLERGENS; AMINO ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLUSTER ANALYSIS; DERMATITIS, CONTACT; HAPTENS; HUMANS; KINETICS; PEPTIDES; RISK ASSESSMENT; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; TANDEM MASS SPECTROMETRY;

ANIMALIA;

EID: 64349117376     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp030     Document Type: Article

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