Structure-activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p-benzoquinone compounds

Journal of Applied Toxicology

Volumn 28, Issue 5, 2008, Pages 608-620

  Chan, Katie ^a   Jensen, Neil ^b   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b In Vitro Technologies Inc   (United States)

Author keywords

Benzoquinones; Chemical reactivity; Covalent binding; Cryopreserved human hepatocytes; Cytotoxicity; Glutathione; Hepatocytes; QSAR

Indexed keywords

1,4 BENZOQUINONE; 1,4 BENZOQUINONE DERIVATIVE; 2 BROMOBENZOQUINONE; 2 METHYLBENZOQUINONE; 2 TERT BUTYLQUINONE; 2,3,5 TRIMETHYLBENZOQUINONE; 2,3,5,6 TETRAMETHYLBENZOQUINONE; 2,5 DICHLOROBENZOQUINONE; 2,6 DIMETHOXYBENZOQUINONE; 2,6 DIMETHYLBENZOQUINONE; ALKYLATING AGENT; CHLOROANIL; GLUTATHIONE;

ANIMAL CELL; ARTICLE; CELL SUSPENSION; CHEMICAL REACTION; CORRELATION ANALYSIS; COVALENT BOND; CRYOPRESERVATION; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RISK; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOQUINONES; CELL SURVIVAL; CELLS, CULTURED; CHEMISTRY, PHYSICAL; GLUTATHIONE; HEPATOCYTES; HUMANS; LETHAL DOSE 50; LINEAR MODELS; MALE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; SULFHYDRYL COMPOUNDS;

RATTUS;

EID: 47549116966     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1312     Document Type: Article

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