A multi-step NMR screen for the identification and evaluation of chemical leads for drug discovery

Combinatorial Chemistry and High Throughput Screening

Volumn 12, Issue 3, 2009, Pages 285-295

  Mercier, Kelly A ^a   Shortridge, Matthew D ^a   Powers, Robert ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

2D 1H 15N HSQC; Human serum albumin; Line broadening; Multi step NMR screen; Protein PrgI; Protein ligand binding; Salmonella typhimurium; Saturation transfer difference

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; CINOXACIN; COUMARIN DERIVATIVE; FOLIC ACID; HUMAN SERUM ALBUMIN; IBUPROFEN; PROLINE; PROTEIN PRG 1; UNCLASSIFIED DRUG; WARFARIN; LIGAND; PROTEIN; SERUM ALBUMIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; HETERONUCLEAR SINGLE QUANTUM COHERENCE; LIGAND BINDING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SALMONELLA TYPHIMURIUM; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; HUMAN; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING;

SALMONELLA TYPHIMURIUM;

BACTERIAL PROTEINS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEINS; SALMONELLA TYPHIMURIUM; SERUM ALBUMIN;

EID: 65549146338     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620709787581738     Document Type: Article

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