메뉴 건너뛰기




Volumn 24, Issue 2, 2010, Pages 131-146

Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter

Author keywords

Colon cancer; Gene therapies, general; Research and development

Indexed keywords

ANNEXIN; BETA GALACTOSIDASE; CELL ANTIBODY; GANCICLOVIR; PLASMID VECTOR; PROPIDIUM IODIDE; PROTEIN P53; THYMIDINE KINASE; UROKINASE RECEPTOR;

EID: 77949315684     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.2165/11530840-000000000-00000     Document Type: Article
Times cited : (16)

References (85)
  • 1
    • 32944465417 scopus 로고    scopus 로고
    • Cancer occurrence in Iran in 2002: An international perspective
    • Jul;
    • Sadjadi A, Nouraie M, Mohagheghi MA, et al. Cancer occurrence in Iran in 2002: an international perspective. Asian Pac J Cancer Prev 2005 Jul; 6 (3): 359-63
    • (2005) Asian Pac J Cancer Prev , vol.6 , Issue.3 , pp. 359-363
    • Sadjadi, A.1    Nouraie, M.2    Mohagheghi, M.A.3
  • 3
    • 0034755297 scopus 로고    scopus 로고
    • High-level, beta-catenin/TCF- dependent transgene expression in secondary colorectal cancer tissue
    • Oct;
    • Lipinski KS, Djeha AH, Ismail T, et al. High-level, beta-catenin/TCF- dependent transgene expression in secondary colorectal cancer tissue. Mol Ther 2001 Oct; 4 (4): 365-71
    • (2001) Mol Ther , vol.4 , Issue.4 , pp. 365-371
    • Lipinski, K.S.1    Djeha, A.H.2    Ismail, T.3
  • 4
    • 32844463327 scopus 로고    scopus 로고
    • Retrovirus-mediated tk gene therapy of implanted human breast cancer in nude mice under the regulation of Tet-On
    • Mar;
    • Zeng ZJ, Li ZB, Luo SQ, et al. Retrovirus-mediated tk gene therapy of implanted human breast cancer in nude mice under the regulation of Tet-On. Cancer Gene Ther 2006 Mar; 13 (3): 290-7
    • (2006) Cancer Gene Ther , vol.13 , Issue.3 , pp. 290-297
    • Zeng, Z.J.1    Li, Z.B.2    Luo, S.Q.3
  • 5
    • 12444263241 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of enhanced herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing
    • May;
    • Wiewrodt R, Amin K, Kiefer M, et al. Adenovirus-mediated gene transfer of enhanced herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing. Cancer Gene Ther 2003 May; 10 (5): 353-64
    • (2003) Cancer Gene Ther , vol.10 , Issue.5 , pp. 353-364
    • Wiewrodt, R.1    Amin, K.2    Kiefer, M.3
  • 6
    • 27144497008 scopus 로고    scopus 로고
    • Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy
    • Oct 15;
    • Sterman DH, Recio A, Vachani A, et al. Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy. Clin Cancer Res 2005 Oct 15; 11 (20): 7444-53
    • (2005) Clin Cancer Res , vol.11 , Issue.20 , pp. 7444-7453
    • Sterman, D.H.1    Recio, A.2    Vachani, A.3
  • 7
    • 10444280991 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells
    • Dec;
    • Konson A, Ben-Kasus T, Mahajna JA, et al. Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells. Cancer Gene Ther 2004 Dec; 11 (12): 830-40
    • (2004) Cancer Gene Ther , vol.11 , Issue.12 , pp. 830-840
    • Konson, A.1    Ben-Kasus, T.2    Mahajna, J.A.3
  • 8
    • 0027483695 scopus 로고
    • The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
    • Nov 1;
    • Freeman SM, Abboud CN, Whartenby KA, et al. The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993 Nov 1; 53 (21): 5274-83
    • (1993) Cancer Res , vol.53 , Issue.21 , pp. 5274-5283
    • Freeman, S.M.1    Abboud, C.N.2    Whartenby, K.A.3
  • 9
    • 33847212832 scopus 로고    scopus 로고
    • Five-year follow-up of trial of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer
    • Mar;
    • Freytag SO, Stricker H, Peabody J, et al. Five-year follow-up of trial of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer. Mol Ther 2007 Mar; 15 (3): 636-42
    • (2007) Mol Ther , vol.15 , Issue.3 , pp. 636-642
    • Freytag, S.O.1    Stricker, H.2    Peabody, J.3
  • 10
    • 0034694011 scopus 로고    scopus 로고
    • A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    • Nov 20;
    • Rainov NG. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 2000 Nov 20; 11 (17): 2389-401
    • (2000) Hum Gene Ther , vol.11 , Issue.17 , pp. 2389-2401
    • Rainov, N.G.1
  • 11
    • 3142742769 scopus 로고    scopus 로고
    • Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors
    • Apr 15;
    • Zabala M, Wang L, Hernandez-Alcoceba R, et al. Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors. Cancer Res 2004 Apr 15; 64 (8): 2799-804
    • (2004) Cancer Res , vol.64 , Issue.8 , pp. 2799-2804
    • Zabala, M.1    Wang, L.2    Hernandez-Alcoceba, R.3
  • 12
    • 27744603174 scopus 로고    scopus 로고
    • Selective gene therapy for prostate cancer cells using liposomes conjugated with IgM type monoclonal antibody against prostate-specific membrane antigen
    • Mar;
    • Ikegami S, Tadakuma T, Yamakami K, et al. Selective gene therapy for prostate cancer cells using liposomes conjugated with IgM type monoclonal antibody against prostate-specific membrane antigen. Hum Cell 2005 Mar; 18 (1): 17-23
    • (2005) Hum Cell , vol.18 , Issue.1 , pp. 17-23
    • Ikegami, S.1    Tadakuma, T.2    Yamakami, K.3
  • 13
    • 0034175969 scopus 로고    scopus 로고
    • Gene therapy: Designer promoters for tumour targeting
    • Apr;
    • Nettelbeck DM, Jerome V, Muller R. Gene therapy: designer promoters for tumour targeting. Trends Genet 2000 Apr; 16 (4): 174-81
    • (2000) Trends Genet , vol.16 , Issue.4 , pp. 174-181
    • Nettelbeck, D.M.1    Jerome, V.2    Muller, R.3
  • 14
    • 0028802872 scopus 로고
    • Prostate tissue specificity of the prostate-specific antigen promoter isolated from a patient with prostate cancer
    • Nov;
    • Pang S, Taneja S, Dardashti K, et al. Prostate tissue specificity of the prostate-specific antigen promoter isolated from a patient with prostate cancer. Hum Gene Ther 1995 Nov; 6 (11): 1417-26
    • (1995) Hum Gene Ther , vol.6 , Issue.11 , pp. 1417-1426
    • Pang, S.1    Taneja, S.2    Dardashti, K.3
  • 15
    • 0028984807 scopus 로고
    • Transcriptional regulatory sequences of carcinoembryonic antigen: Identification and use with cytosine deaminase for tumor-specific gene therapy
    • Jul;
    • Richards CA, Austin EA, Huber BE. Transcriptional regulatory sequences of carcinoembryonic antigen: identification and use with cytosine deaminase for tumor-specific gene therapy. Hum Gene Ther 1995 Jul; 6 (7): 881-93
    • (1995) Hum Gene Ther , vol.6 , Issue.7 , pp. 881-893
    • Richards, C.A.1    Austin, E.A.2    Huber, B.E.3
  • 16
    • 0035908493 scopus 로고    scopus 로고
    • Blocking oncogenic Ras signaling for cancer therapy
    • Jul 18;
    • Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 2001 Jul 18; 93 (14): 1062-74
    • (2001) J Natl Cancer Inst , vol.93 , Issue.14 , pp. 1062-1074
    • Adjei, A.A.1
  • 17
    • 0034076511 scopus 로고    scopus 로고
    • Activation of c-K-ras mutations in human gastrointestinal tumors
    • Jun;
    • Arber N, Shapira I, Ratan J, et al. Activation of c-K-ras mutations in human gastrointestinal tumors. Gastroenterology 2000 Jun; 118 (6): 1045-50
    • (2000) Gastroenterology , vol.118 , Issue.6 , pp. 1045-1050
    • Arber, N.1    Shapira, I.2    Ratan, J.3
  • 18
    • 0642307769 scopus 로고    scopus 로고
    • Ras interference as cancer therapy
    • Aug;
    • Duursma AM, Agami R. Ras interference as cancer therapy. Semin Cancer Biol 2003 Aug; 13 (4): 267-73
    • (2003) Semin Cancer Biol , vol.13 , Issue.4 , pp. 267-273
    • Duursma, A.M.1    Agami, R.2
  • 19
    • 0023898932 scopus 로고
    • The ras gene family and human carcinogenesis
    • May;
    • Bos JL. The ras gene family and human carcinogenesis. Mutat Res 1988 May; 195 (3): 255-71
    • (1988) Mutat Res , vol.195 , Issue.3 , pp. 255-271
    • Bos, J.L.1
  • 20
    • 0030020388 scopus 로고    scopus 로고
    • Frequent K-ras mutations in small bowel adenocarcinomas
    • Jan;
    • Sutter T, Arber N, Moss SF, et al. Frequent K-ras mutations in small bowel adenocarcinomas. Dig Dis Sci 1996 Jan; 41 (1): 115-8
    • (1996) Dig Dis Sci , vol.41 , Issue.1 , pp. 115-118
    • Sutter, T.1    Arber, N.2    Moss, S.F.3
  • 21
    • 0023256456 scopus 로고
    • Prevalence of ras gene mutations in human colorectal cancers
    • May 28;
    • Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987 May 28; 327 (6120): 293-7
    • (1987) Nature , vol.327 , Issue.6120 , pp. 293-297
    • Bos, J.L.1    Fearon, E.R.2    Hamilton, S.R.3
  • 22
    • 0031425883 scopus 로고    scopus 로고
    • Distribution of p53 and K-ras mutations in human lung cancer tissues
    • Mar;
    • Gao HG, Chen JK, Stewart J, et al. Distribution of p53 and K-ras mutations in human lung cancer tissues. Carcinogenesis 1997 Mar; 18 (3): 473-8
    • (1997) Carcinogenesis , vol.18 , Issue.3 , pp. 473-478
    • Gao, H.G.1    Chen, J.K.2    Stewart, J.3
  • 23
    • 34249340845 scopus 로고    scopus 로고
    • BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK
    • Jul;
    • Beck SE, Jung BH, Del RE, et al. BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. Cell Signal 2007 Jul; 19 (7): 1465-72
    • (2007) Cell Signal , vol.19 , Issue.7 , pp. 1465-1472
    • Beck, S.E.1    Jung, B.H.2    Del, R.E.3
  • 24
    • 0033981639 scopus 로고    scopus 로고
    • A genome-wide survey of RAS transformation targets
    • Feb;
    • Zuber J, Tchernitsa OI, Hinzmann B, et al. A genome-wide survey of RAS transformation targets. Nat Genet 2000 Feb; 24 (2): 144-52
    • (2000) Nat Genet , vol.24 , Issue.2 , pp. 144-152
    • Zuber, J.1    Tchernitsa, O.I.2    Hinzmann, B.3
  • 25
    • 13944249516 scopus 로고    scopus 로고
    • Oncogenic K-RAS is required to maintain changesincytoskeletal organization, adhesion, and motilityincolon cancer cells
    • Feb 15;
    • Pollock CB, Shirasawa S, Sasazuki T, et al. Oncogenic K-RAS is required to maintain changesincytoskeletal organization, adhesion, and motilityincolon cancer cells. Cancer Res 2005 Feb 15; 65 (4): 1244-50
    • (2005) Cancer Res , vol.65 , Issue.4 , pp. 1244-1250
    • Pollock, C.B.1    Shirasawa, S.2    Sasazuki, T.3
  • 26
    • 36849039525 scopus 로고    scopus 로고
    • LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses
    • Jan;
    • Wu M, Huang C, Li X, et al. LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses. J Cell Physiol 2008 Jan; 214 (1): 65-74
    • (2008) J Cell Physiol , vol.214 , Issue.1 , pp. 65-74
    • Wu, M.1    Huang, C.2    Li, X.3
  • 27
    • 33746166501 scopus 로고    scopus 로고
    • Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling
    • Jul 1;
    • Mesa Jr C, Mirza M, Mitsutake N, et al. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling. Cancer Res 2006 Jul 1; 66 (13): 6521-9
    • (2006) Cancer Res , vol.66 , Issue.13 , pp. 6521-6529
    • Mesa Jr, C.1    Mirza, M.2    Mitsutake, N.3
  • 28
    • 33744536437 scopus 로고    scopus 로고
    • Ras up-regulation of cyclooxygenase-2
    • Backlund MG, Mann JR, Wang D, et al. Ras up-regulation of cyclooxygenase-2. Methods Enzymol 2005; 407: 401-10
    • (2005) Methods Enzymol , vol.407 , pp. 401-410
    • Backlund, M.G.1    Mann, J.R.2    Wang, D.3
  • 29
    • 0032537811 scopus 로고    scopus 로고
    • Stimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and-independent signaling modules
    • Jul 16;
    • Gum R, Juarez J, Allgayer H, et al. Stimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and-independent signaling modules. Oncogene 1998 Jul 16; 17 (2): 213-25
    • (1998) Oncogene , vol.17 , Issue.2 , pp. 213-225
    • Gum, R.1    Juarez, J.2    Allgayer, H.3
  • 30
    • 0032541650 scopus 로고    scopus 로고
    • Increasing complexity of Ras signaling
    • Sep 17;
    • Campbell SL, Khosravi-Far R, Rossman KL, et al. Increasing complexity of Ras signaling. Oncogene 1998 Sep 17; 17: 1395-413
    • (1998) Oncogene , vol.17 , pp. 1395-1413
    • Campbell, S.L.1    Khosravi-Far, R.2    Rossman, K.L.3
  • 31
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Sep 1;
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989 Sep 1; 49 (17): 4682-9
    • (1989) Cancer Res , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 32
    • 0036334994 scopus 로고    scopus 로고
    • Genetic profiling of colon cancer
    • Aug;
    • Neibergs HL, Hein DW, Spratt JS. Genetic profiling of colon cancer. J Surg Oncol 2002 Aug; 80 (4): 204-13
    • (2002) J Surg Oncol , vol.80 , Issue.4 , pp. 204-213
    • Neibergs, H.L.1    Hein, D.W.2    Spratt, J.S.3
  • 33
    • 0035125157 scopus 로고    scopus 로고
    • Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma
    • Feb;
    • Andreyev HJ, Ross PJ, Cunningham D, et al. Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma. Gut 2001 Feb; 48 (2): 230-7
    • (2001) Gut , vol.48 , Issue.2 , pp. 230-237
    • Andreyev, H.J.1    Ross, P.J.2    Cunningham, D.3
  • 34
    • 33644527626 scopus 로고    scopus 로고
    • Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway
    • Oct;
    • Dvory-Sobol H, Kazanov D, Arber N. Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway. Biomed Pharma-cother 2005 Oct; 59 Suppl. 2: S370-4
    • (2005) Biomed Pharma-cother , vol.59 , Issue.SUPPL. 2
    • Dvory-Sobol, H.1    Kazanov, D.2    Arber, N.3
  • 35
    • 0026762889 scopus 로고
    • An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites
    • Jul;
    • Reddy MA, Langer SJ, Colman MS, et al. An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites. Mol Endocrinol 1992 Jul; 6 (7): 1051-60
    • (1992) Mol Endocrinol , vol.6 , Issue.7 , pp. 1051-1060
    • Reddy, M.A.1    Langer, S.J.2    Colman, M.S.3
  • 36
    • 0037869895 scopus 로고    scopus 로고
    • New developments in the urokinase-type plasminogen activator system
    • Dec;
    • Rosenberg S. New developments in the urokinase-type plasminogen activator system. Expert Opin Ther Targets 2001 Dec; 5 (6): 711-22
    • (2001) Expert Opin Ther Targets , vol.5 , Issue.6 , pp. 711-722
    • Rosenberg, S.1
  • 37
    • 33645241296 scopus 로고    scopus 로고
    • Connexin 32 down-regulates the fibrinolytic factors in metastatic renal cell carcinoma cells
    • Apr 4;
    • Hagiwara H, Sato H, Shirai S, et al. Connexin 32 down-regulates the fibrinolytic factors in metastatic renal cell carcinoma cells. Life Sci 2006 Apr 4; 78 (19): 2249-54
    • (2006) Life Sci , vol.78 , Issue.19 , pp. 2249-2254
    • Hagiwara, H.1    Sato, H.2    Shirai, S.3
  • 38
    • 33749159851 scopus 로고    scopus 로고
    • Structural basis of interaction between urokinase-type plasminogen activator and its receptor
    • Oct 20;
    • Barinka C, Parry G, Callahan J, et al. Structural basis of interaction between urokinase-type plasminogen activator and its receptor. J Mol Biol 2006 Oct 20; 363 (2): 482-95
    • (2006) J Mol Biol , vol.363 , Issue.2 , pp. 482-495
    • Barinka, C.1    Parry, G.2    Callahan, J.3
  • 39
    • 11144358203 scopus 로고    scopus 로고
    • Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice
    • May 20;
    • D'Alessio S, Margheri F, Pucci M, et al. Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice. Int J Cancer 2004 May 20; 110 (1): 125-33
    • (2004) Int J Cancer , vol.110 , Issue.1 , pp. 125-133
    • D'Alessio, S.1    Margheri, F.2    Pucci, M.3
  • 40
    • 3242662746 scopus 로고    scopus 로고
    • Begum FD, Hogdall CK, Kjaer SK, et al. The prognostic value of plasma soluble urokinase plasminogen activator receptor (suPAR) levels in stage III ovarian cancer patients. Anticancer Res 2004 May; 24 (3b): 1981-5
    • Begum FD, Hogdall CK, Kjaer SK, et al. The prognostic value of plasma soluble urokinase plasminogen activator receptor (suPAR) levels in stage III ovarian cancer patients. Anticancer Res 2004 May; 24 (3b): 1981-5
  • 41
    • 33646376457 scopus 로고    scopus 로고
    • LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system
    • Jun 1;
    • Bagheri-Yarmand R, Mazumdar A, Sahin AA, et al. LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system. Int J Cancer 2006 Jun 1; 118 (11): 2703-10
    • (2006) Int J Cancer , vol.118 , Issue.11 , pp. 2703-2710
    • Bagheri-Yarmand, R.1    Mazumdar, A.2    Sahin, A.A.3
  • 42
    • 0031738954 scopus 로고    scopus 로고
    • Stromal expression of urokinase-type plasminogen activator receptor (uPAR) is associated with invasive growth in primary liver cancer
    • Dec;
    • Akahane T, Ishii M, Ohtani H, et al. Stromal expression of urokinase-type plasminogen activator receptor (uPAR) is associated with invasive growth in primary liver cancer. Liver 1998 Dec; 18 (6): 414-9
    • (1998) Liver , vol.18 , Issue.6 , pp. 414-419
    • Akahane, T.1    Ishii, M.2    Ohtani, H.3
  • 43
    • 0031015122 scopus 로고    scopus 로고
    • Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma
    • Cantero D, Friess H, Deflorin J, et al. Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma. Br J Cancer 1997; 75 (3): 388-95
    • (1997) Br J Cancer , vol.75 , Issue.3 , pp. 388-395
    • Cantero, D.1    Friess, H.2    Deflorin, J.3
  • 44
    • 2542436741 scopus 로고    scopus 로고
    • Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells
    • Jul;
    • Albo D, Tuszynski GP. Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells. J Surg Res 2004 Jul; 120 (1): 21-6
    • (2004) J Surg Res , vol.120 , Issue.1 , pp. 21-26
    • Albo, D.1    Tuszynski, G.P.2
  • 45
    • 0037345705 scopus 로고    scopus 로고
    • Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach
    • Mar;
    • Ahmed N, Oliva K, Wang Y, et al. Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach. Proteomics 2003 Mar; 3 (3): 288-98
    • (2003) Proteomics , vol.3 , Issue.3 , pp. 288-298
    • Ahmed, N.1    Oliva, K.2    Wang, Y.3
  • 46
    • 20944451167 scopus 로고    scopus 로고
    • Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor
    • May;
    • Bauer TW, Fan F, Liu W, et al. Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. Ann Surg 2005 May; 241 (5): 748-56
    • (2005) Ann Surg , vol.241 , Issue.5 , pp. 748-756
    • Bauer, T.W.1    Fan, F.2    Liu, W.3
  • 47
    • 40649121508 scopus 로고    scopus 로고
    • Evolving role of uPA/uPAR system in human cancers
    • Apr;
    • Dass K, Ahmad A, Azmi AS, et al. Evolving role of uPA/uPAR system in human cancers. Cancer Treat Rev 2008 Apr; 34 (2): 122-36
    • (2008) Cancer Treat Rev , vol.34 , Issue.2 , pp. 122-136
    • Dass, K.1    Ahmad, A.2    Azmi, A.S.3
  • 48
    • 0032778698 scopus 로고    scopus 로고
    • Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis
    • Aug;
    • Allgayer H, Wang H, Shirasawa S, et al. Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis. Br J Cancer 1999 Aug; 80 (12): 1884-91
    • (1999) Br J Cancer , vol.80 , Issue.12 , pp. 1884-1891
    • Allgayer, H.1    Wang, H.2    Shirasawa, S.3
  • 49
    • 0029148763 scopus 로고
    • Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras
    • Sep 29;
    • Lengyel E, Stepp E, Gum R, et al. Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras. J Biol Chem 1995 Sep 29; 270 (39): 23007-12
    • (1995) J Biol Chem , vol.270 , Issue.39 , pp. 23007-23012
    • Lengyel, E.1    Stepp, E.2    Gum, R.3
  • 50
    • 0034696784 scopus 로고    scopus 로고
    • Regulation of urokinase receptor transcription by Ras-and Rho-family GTPases
    • Apr 21;
    • Muller SM, Okan E, Jones P. Regulation of urokinase receptor transcription by Ras-and Rho-family GTPases. Biochem Biophys Res Commun 2000 Apr 21; 270 (3): 892-8
    • (2000) Biochem Biophys Res Commun , vol.270 , Issue.3 , pp. 892-898
    • Muller, S.M.1    Okan, E.2    Jones, P.3
  • 51
    • 29344473741 scopus 로고    scopus 로고
    • Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected color-ectal cancers
    • Dec 15;
    • Schewe DM, Biller T, Maurer G, et al. Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected color-ectal cancers. Clin Cancer Res 2005 Dec 15; 11 (24 Pt 1): 8538-48
    • (2005) Clin Cancer Res , vol.11 , Issue.24 PART 1 , pp. 8538-8548
    • Schewe, D.M.1    Biller, T.2    Maurer, G.3
  • 53
    • 17644388408 scopus 로고    scopus 로고
    • Evaluation of stimulatory effects of HTLV-I tax protein on CREB and NFKB related signaling pathways two B-glycosidase based reporter plasmids
    • Azadmanesh K, Rohvand F, Amini S, et al. Evaluation of stimulatory effects of HTLV-I tax protein on CREB and NFKB related signaling pathways two B-glycosidase based reporter plasmids. Yakhteh Med J 2005; 6 (24): 218-25
    • (2005) Yakhteh Med J , vol.6 , Issue.24 , pp. 218-225
    • Azadmanesh, K.1    Rohvand, F.2    Amini, S.3
  • 54
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2 CT method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 CT method. Methods 2001; 25 (4): 402-8
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 55
    • 1642586736 scopus 로고    scopus 로고
    • Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir therapy of hepatocellular carcinoma: The woodchuck animal model
    • May;
    • Bilbao R, Gerolami R, Bralet MP, et al. Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir therapy of hepatocellular carcinoma: the woodchuck animal model. Cancer Gene Ther 2000 May; 7 (5): 657-62
    • (2000) Cancer Gene Ther , vol.7 , Issue.5 , pp. 657-662
    • Bilbao, R.1    Gerolami, R.2    Bralet, M.P.3
  • 56
    • 0028961480 scopus 로고
    • Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors
    • Feb 24;
    • Hauck W, Stanners CP. Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors. J Biol Chem 1995 Feb 24; 270 (8): 3602-10
    • (1995) J Biol Chem , vol.270 , Issue.8 , pp. 3602-3610
    • Hauck, W.1    Stanners, C.P.2
  • 57
    • 4644287822 scopus 로고    scopus 로고
    • CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase/5-fluorocytosine therapy directed by the carcinoembryonic antigen promoter
    • Dabrowska A, Szary J, Kowalczuk M et al. CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase/5-fluorocytosine therapy directed by the carcinoembryonic antigen promoter. Acta Biochim Pol 2004; 51 (3): 723-34
    • (2004) Acta Biochim Pol , vol.51 , Issue.3 , pp. 723-734
    • Dabrowska, A.1    Szary, J.2    Kowalczuk, M.3
  • 58
    • 0037351661 scopus 로고    scopus 로고
    • Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer
    • Mar;
    • Ueda K, Iwahashi M, Nakamori M, et al. Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer. Surgery 2003 Mar; 133 (3): 309-17
    • (2003) Surgery , vol.133 , Issue.3 , pp. 309-317
    • Ueda, K.1    Iwahashi, M.2    Nakamori, M.3
  • 59
    • 0036870082 scopus 로고    scopus 로고
    • Block A, Milasinovic D, Mueller J et al. Amplified Muc1-specific gene expression in colon cancer cells utilizing a binary system in adenoviral vectors. Anticancer Res 2002 Nov-Dec; 22 (6A): 3285-92
    • Block A, Milasinovic D, Mueller J et al. Amplified Muc1-specific gene expression in colon cancer cells utilizing a binary system in adenoviral vectors. Anticancer Res 2002 Nov-Dec; 22 (6A): 3285-92
  • 60
    • 0034981040 scopus 로고    scopus 로고
    • Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers
    • Mar;
    • Yamamoto M, Alemany R, Adachi Y, et al. Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers. Mol Ther 2001 Mar; 3 (3): 385-94
    • (2001) Mol Ther , vol.3 , Issue.3 , pp. 385-394
    • Yamamoto, M.1    Alemany, R.2    Adachi, Y.3
  • 61
    • 0034666839 scopus 로고    scopus 로고
    • Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: A mechanism leading to increased malignancy in epithelial cells
    • Oct 15;
    • Lehmann K, Janda E, Pierreux CE, etal. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev 2000 Oct 15; 14 (20): 2610-22
    • (2000) Genes Dev , vol.14 , Issue.20 , pp. 2610-2622
    • Lehmann, K.1    Janda, E.2    Pierreux, C.E.3
  • 62
    • 0032521205 scopus 로고    scopus 로고
    • Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study
    • Mar 15;
    • Ahnen DJ, Feigl P, Quan G, et al. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. Cancer Res 1998 Mar 15; 58 (6): 1149-58
    • (1998) Cancer Res , vol.58 , Issue.6 , pp. 1149-1158
    • Ahnen, D.J.1    Feigl, P.2    Quan, G.3
  • 63
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • Apr 2;
    • Shirasawa S, Furuse M, Yokoyama N, et al. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 1993 Apr 2; 260 (5104): 85-8
    • (1993) Science , vol.260 , Issue.5104 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3
  • 64
    • 0031983177 scopus 로고    scopus 로고
    • The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells
    • Jan 2;
    • Dumler I, Weis A, Mayboroda OA, et al. The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J Biol Chem 1998 Jan 2; 273 (1): 315-21
    • (1998) J Biol Chem , vol.273 , Issue.1 , pp. 315-321
    • Dumler, I.1    Weis, A.2    Mayboroda, O.A.3
  • 65
    • 0001099364 scopus 로고    scopus 로고
    • Mechanisms of signaling through urokinase receptor and the cellular response
    • Aug;
    • Koshelnick Y, Ehart M, Stockinger H, et al. Mechanisms of signaling through urokinase receptor and the cellular response. Thromb Haemost 1999 Aug; 82 (2): 305-11
    • (1999) Thromb Haemost , vol.82 , Issue.2 , pp. 305-311
    • Koshelnick, Y.1    Ehart, M.2    Stockinger, H.3
  • 66
    • 0032540943 scopus 로고    scopus 로고
    • Tang H, Kerins DM, Hao Q, et al. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J Biol Chem 1998 Jul 17; 273 (29): 18268-72
    • Tang H, Kerins DM, Hao Q, et al. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J Biol Chem 1998 Jul 17; 273 (29): 18268-72
  • 67
    • 20444466479 scopus 로고    scopus 로고
    • Elevated expression of Wnt antagonists is a common event in hepatoblastomas
    • Jun 15;
    • Koch A, Waha A, Hartmann W, et al. Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin Cancer Res 2005 Jun 15; 11 (12): 4295-304
    • (2005) Clin Cancer Res , vol.11 , Issue.12 , pp. 4295-4304
    • Koch, A.1    Waha, A.2    Hartmann, W.3
  • 68
    • 0028800787 scopus 로고
    • Structure of the human urokinase receptor gene and its similarity to CD59 and the Ly-6 family
    • Jan 15;
    • Wang Y, Dang J, Johnson LK, et al. Structure of the human urokinase receptor gene and its similarity to CD59 and the Ly-6 family. Eur J Biochem 1995 Jan 15; 227 (1-2): 116-22
    • (1995) Eur J Biochem , vol.227 , Issue.1-2 , pp. 116-122
    • Wang, Y.1    Dang, J.2    Johnson, L.K.3
  • 69
    • 4143137812 scopus 로고    scopus 로고
    • Transcriptional regulation of urokinase receptor in high-(95D) and low-metastatic (95C) human lung cancer cells
    • Jun;
    • Li CY, Tan L, Zhang GJ, et al. Transcriptional regulation of urokinase receptor in high-(95D) and low-metastatic (95C) human lung cancer cells. Acta Biochim Biophys Sin (Shanghai) 2004 Jun; 36 (6): 405-11
    • (2004) Acta Biochim Biophys Sin (Shanghai) , vol.36 , Issue.6 , pp. 405-411
    • Li, C.Y.1    Tan, L.2    Zhang, G.J.3
  • 70
    • 0033582506 scopus 로고    scopus 로고
    • Transactivation of the urokinase-type plasminogen activator receptor gene through a novel promoter motif bound with an activator protein-2alpha-related factor
    • Feb 19;
    • Allgayer H, Wang H, Wang Y, et al. Transactivation of the urokinase-type plasminogen activator receptor gene through a novel promoter motif bound with an activator protein-2alpha-related factor. J Biol Chem 1999 Feb 19; 274 (8): 4702-14
    • (1999) J Biol Chem , vol.274 , Issue.8 , pp. 4702-4714
    • Allgayer, H.1    Wang, H.2    Wang, Y.3
  • 71
    • 34250321756 scopus 로고    scopus 로고
    • Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer
    • May;
    • Leupold JH, Asangani I, Maurer GD, et al. Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer. Mol Cancer Res 2007 May; 5 (5): 485-96
    • (2007) Mol Cancer Res , vol.5 , Issue.5 , pp. 485-496
    • Leupold, J.H.1    Asangani, I.2    Maurer, G.D.3
  • 72
    • 0029058766 scopus 로고
    • A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene
    • Jul 15;
    • Soravia E, Grebe A, De LP, et al. A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene. Blood 1995 Jul 15; 86 (2): 624-35
    • (1995) Blood , vol.86 , Issue.2 , pp. 624-635
    • Soravia, E.1    Grebe, A.2    De, L.P.3
  • 73
    • 0033567413 scopus 로고    scopus 로고
    • A region between-141 and-61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor
    • Aug;
    • Dang J, Boyd D, Wang H, et al. A region between-141 and-61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor. Eur J Biochem 1999 Aug; 264 (1): 92-9
    • (1999) Eur J Biochem , vol.264 , Issue.1 , pp. 92-99
    • Dang, J.1    Boyd, D.2    Wang, H.3
  • 74
    • 0033603453 scopus 로고    scopus 로고
    • Allgayer H, Wang H, Gallick GE, et al. Transcriptional induction of the urokinase receptor gene by a constitutively active Src: requirement of an upstream motif (-152/-135) bound with Sp1. J Biol Chem 1999 Jun 25; 274 (26): 18428-37
    • Allgayer H, Wang H, Gallick GE, et al. Transcriptional induction of the urokinase receptor gene by a constitutively active Src: requirement of an upstream motif (-152/-135) bound with Sp1. J Biol Chem 1999 Jun 25; 274 (26): 18428-37
  • 75
    • 0034118807 scopus 로고    scopus 로고
    • Identification of a novel nuclear factor-kappa B sequence involved in expression of urokinase-type plasminogen activator receptor
    • Jun;
    • Wang Y, Dang J, Wang H, et al. Identification of a novel nuclear factor-kappa B sequence involved in expression of urokinase-type plasminogen activator receptor. Eur J Biochem 2000 Jun; 267 (11): 3248-54
    • (2000) Eur J Biochem , vol.267 , Issue.11 , pp. 3248-3254
    • Wang, Y.1    Dang, J.2    Wang, H.3
  • 76
    • 0035015311 scopus 로고    scopus 로고
    • beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter
    • Mar;
    • Hapke S, Gawaz M, Dehne K, et al. beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter. Mol Cell Biol 2001 Mar; 21 (6): 2118-32
    • (2001) Mol Cell Biol , vol.21 , Issue.6 , pp. 2118-2132
    • Hapke, S.1    Gawaz, M.2    Dehne, K.3
  • 77
    • 0037838422 scopus 로고    scopus 로고
    • Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers
    • Jun;
    • Schewe DM, Leupold JH, Boyd DD, et al. Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers. Clin Cancer Res 2003 Jun; 9 (6): 2267-76
    • (2003) Clin Cancer Res , vol.9 , Issue.6 , pp. 2267-2276
    • Schewe, D.M.1    Leupold, J.H.2    Boyd, D.D.3
  • 78
    • 32844465993 scopus 로고    scopus 로고
    • Targeting of autonomous parvoviruses to colon cancer by insertion of Tcf sites in the P4 promoter
    • Mar;
    • Malerba M, Nikolova D, Cornelis J, et al. Targeting of autonomous parvoviruses to colon cancer by insertion of Tcf sites in the P4 promoter. Cancer Gene Ther 2006 Mar; 13 (3): 273-80
    • (2006) Cancer Gene Ther , vol.13 , Issue.3 , pp. 273-280
    • Malerba, M.1    Nikolova, D.2    Cornelis, J.3
  • 79
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • Oct 13;
    • Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000 Oct 13; 103 (2): 311-20
    • (2000) Cell , vol.103 , Issue.2 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 80
    • 0141788260 scopus 로고    scopus 로고
    • Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences
    • Sep;
    • Uch R, Gerolami R, Faivre J, et al. Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences. Cancer Gene Ther 2003 Sep; 10 (9): 689-95
    • (2003) Cancer Gene Ther , vol.10 , Issue.9 , pp. 689-695
    • Uch, R.1    Gerolami, R.2    Faivre, J.3
  • 81
    • 0033974798 scopus 로고    scopus 로고
    • Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: Implications for gene therapeutic approaches
    • Jan;
    • Thust R, Tomicic M, Klocking R, et al. Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches. Cancer Gene Ther 2000 Jan; 7 (1): 107-17
    • (2000) Cancer Gene Ther , vol.7 , Issue.1 , pp. 107-117
    • Thust, R.1    Tomicic, M.2    Klocking, R.3
  • 82
    • 0030770449 scopus 로고    scopus 로고
    • Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
    • Sep 22;
    • Caulin C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 1997 Sep 22; 138 (6): 1379-94
    • (1997) J Cell Biol , vol.138 , Issue.6 , pp. 1379-1394
    • Caulin, C.1    Salvesen, G.S.2    Oshima, R.G.3
  • 83
    • 0033587708 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases
    • Jul 20;
    • Beltinger C, Fulda S, Kammertoens T, et al. Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases. Proc Natl Acad Sci U S A 1999 Jul 20; 96 (15): 8699-704
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.15 , pp. 8699-8704
    • Beltinger, C.1    Fulda, S.2    Kammertoens, T.3
  • 84
    • 0033067561 scopus 로고    scopus 로고
    • Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase
    • Mar;
    • Wei SJ, Chao Y, Shih YL, et al. Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase. Gene Ther 1999 Mar; 6 (3): 420-31
    • (1999) Gene Ther , vol.6 , Issue.3 , pp. 420-431
    • Wei, S.J.1    Chao, Y.2    Shih, Y.L.3
  • 85
    • 0037192631 scopus 로고    scopus 로고
    • Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: Critical role of DNA breaks, Bcl-2 decline and caspase-9 activation
    • Mar 28;
    • Tomicic MT, Thust R, Kaina B. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene 2002 Mar 28; 21 (14): 2141-53
    • (2002) Oncogene , vol.21 , Issue.14 , pp. 2141-2153
    • Tomicic, M.T.1    Thust, R.2    Kaina, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.