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Volumn 75, Issue 3, 1997, Pages 388-395

Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma

Author keywords

Immunohistochemistry; Northern blot analysis; Pancreatic cancer; Urokinase plasminogen activator (uPA); Urokinase plasminogen activator receptor (uPAR)

Indexed keywords

MEMBRANE RECEPTOR; MESSENGER RNA; SERINE PROTEINASE; UROKINASE;

EID: 0031015122     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.63     Document Type: Article
Times cited : (193)

References (47)
  • 3
    • 0023197175 scopus 로고
    • Urokinase-type plasminogen activator: Proenzyme, receptor, and inhibitors
    • Blasi F, Vassalli J and Dano K (1987) Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors. J Cell Biol 104: 801-804
    • (1987) J Cell Biol , vol.104 , pp. 801-804
    • Blasi, F.1    Vassalli, J.2    Dano, K.3
  • 4
    • 0028672967 scopus 로고
    • Prognosis in carcinoma of the pancreas
    • Bornman PC and Krige JEJ (1994) Prognosis in carcinoma of the pancreas. Dig Surg 11: 342-345
    • (1994) Dig Surg , vol.11 , pp. 342-345
    • Bornman, P.C.1    Krige, J.E.J.2
  • 5
    • 0028090482 scopus 로고
    • Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies
    • Carriero M, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP and Salvatore M (1994) Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies. Cancer Res 54: 5445-5454
    • (1994) Cancer Res , vol.54 , pp. 5445-5454
    • Carriero, M.1    Franco, P.2    Del Vecchio, S.3    Massa, O.4    Botti, G.5    D'Aiuto, G.6    Stoppelli, M.P.7    Salvatore, M.8
  • 6
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 8
    • 0018893682 scopus 로고
    • On the regulation and control of fibrinolysis
    • Collen D (1980) On the regulation and control of fibrinolysis. Thromb Haemostas 43: 77-89
    • (1980) Thromb Haemostas , vol.43 , pp. 77-89
    • Collen, D.1
  • 12
    • 0029065722 scopus 로고
    • Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer
    • Duggan C, Maguire T, McDermott H, O'Higgins N, Fennelly JJ and Duffy MJ (1995) Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer. Int J Cancer 61: 597-600
    • (1995) Int J Cancer , vol.61 , pp. 597-600
    • Duggan, C.1    Maguire, T.2    McDermott, H.3    O'Higgins, N.4    Fennelly, J.J.5    Duffy, M.J.6
  • 14
    • 0027939437 scopus 로고
    • Coexpression of the c-met protooncogene and hepatocyte growth factor in human pancreatic cancer
    • Ebert M, Yokoyama M, Friess H, Büchler MW and Korc M (1994b) Coexpression of the c-met protooncogene and hepatocyte growth factor in human pancreatic cancer. Cancer Res 54: 5775-5778
    • (1994) Cancer Res , vol.54 , pp. 5775-5778
    • Ebert, M.1    Yokoyama, M.2    Friess, H.3    Büchler, M.W.4    Korc, M.5
  • 15
    • 0024508318 scopus 로고
    • Plasminogen activation initiated by single-chain urokinase-type plasminogen activator: Potentiation by U937 cells
    • Ellis V, Scully MF and Kakkar VV (1989) Plasminogen activation initiated by single-chain urokinase-type plasminogen activator: potentiation by U937 cells. J Biol Chem 264: 2185-2188
    • (1989) J Biol Chem , vol.264 , pp. 2185-2188
    • Ellis, V.1    Scully, M.F.2    Kakkar, V.V.3
  • 16
    • 0025336879 scopus 로고
    • The receptor for urokinase-type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes
    • Estreicher A, Mühlhauser J, Carpentier JL, Orci L and Vasalli JD (1990) The receptor for urokinase-type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol 111: 783-792
    • (1990) J Cell Biol , vol.111 , pp. 783-792
    • Estreicher, A.1    Mühlhauser, J.2    Carpentier, J.L.3    Orci, L.4    Vasalli, J.D.5
  • 17
    • 0028049194 scopus 로고
    • Urokinase-type plasminogen activator and its receptor: New targets for anti-metastatic therapy?
    • Fazioli F and Blasi F (1994) Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy? Trends Pharmacol Sci 15: 25-29
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 25-29
    • Fazioli, F.1    Blasi, F.2
  • 18
    • 0017831547 scopus 로고
    • The biology of cancer invasion and metastasis
    • Fidler IJ, Gersten DM and Hart IR (1978) The biology of cancer invasion and metastasis. Adv Cancer Res 28: 149-150
    • (1978) Adv Cancer Res , vol.28 , pp. 149-150
    • Fidler, I.J.1    Gersten, D.M.2    Hart, I.R.3
  • 19
    • 0027131252 scopus 로고
    • Enhanced expression of transforming growth factor B isoforms in pancreatic cancer correlates with decreased survival
    • Friess H, Yamanaka Y, Büchler MW, Ebert M, Beger HG, Gold LI and Korc M (1993a) Enhanced expression of transforming growth factor B isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 105: 1846-1856
    • (1993) Gastroenterology , vol.105 , pp. 1846-1856
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.W.3    Ebert, M.4    Beger, H.G.5    Gold, L.I.6    Korc, M.7
  • 20
    • 0027195937 scopus 로고
    • Enhanced expression of the type II transforming growth factor-beta receptor in human pancreatic cancer cells without alteration of type III receptor expression
    • Friess H, Yamanaka Y, Büchler MW, Beger HG, Kobrin MS, Baldwin RL and Korc M (1993b) Enhanced expression of the type II transforming growth factor-beta receptor in human pancreatic cancer cells without alteration of type III receptor expression. Cancer Res 53: 2704-2707
    • (1993) Cancer Res , vol.53 , pp. 2704-2707
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.W.3    Beger, H.G.4    Kobrin, M.S.5    Baldwin, R.L.6    Korc, M.7
  • 21
    • 0028799821 scopus 로고
    • Enhanced erbB-3 expression in human pancreatic cancer correlates with tumour progression
    • Friess H, Yamanaka Y, Kobrin MS, Do AD, Büchler MW and Korc M (1995) Enhanced erbB-3 expression in human pancreatic cancer correlates with tumour progression. Clin Cancer Res 1: 1413-1420
    • (1995) Clin Cancer Res , vol.1 , pp. 1413-1420
    • Friess, H.1    Yamanaka, Y.2    Kobrin, M.S.3    Do, A.D.4    Büchler, M.W.5    Korc, M.6
  • 22
    • 0030024411 scopus 로고    scopus 로고
    • Pancreatic cancer: The potential clinical relevance of alterations in growth factors and their receptors
    • Friess H, Berberat P, Schilling M, Kunz J, Korc M and Büchler MW (1996) Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. J Mol Med 74: 35-42
    • (1996) J Mol Med , vol.74 , pp. 35-42
    • Friess, H.1    Berberat, P.2    Schilling, M.3    Kunz, J.4    Korc, M.5    Büchler, M.W.6
  • 23
    • 0029080314 scopus 로고
    • Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix proteases in pancreatic cancer
    • Gress TM, Müller-Pillasch F, Lerch MM, Friess H, Büchler M and Adler G (1995) Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix proteases in pancreatic cancer. Int J Cancer 62: 407-413
    • (1995) Int J Cancer , vol.62 , pp. 407-413
    • Gress, T.M.1    Müller-Pillasch, F.2    Lerch, M.M.3    Friess, H.4    Büchler, M.5    Adler, G.6
  • 24
    • 0023626809 scopus 로고
    • Cancer of the pancreas: 50 years of surgery
    • Gudjonsson B (1987) Cancer of the pancreas: 50 years of surgery. Cancer 60: 2284-2303
    • (1987) Cancer , vol.60 , pp. 2284-2303
    • Gudjonsson, B.1
  • 27
    • 0027361935 scopus 로고
    • Expression and localization of elements of the plasminogen activation system in benign breast disease and breast cancers
    • Jankum J, Merrick H and Goldblatt PJ (1993) Expression and localization of elements of the plasminogen activation system in benign breast disease and breast cancers J Cell Biochem 53: 135-144
    • (1993) J Cell Biochem , vol.53 , pp. 135-144
    • Jankum, J.1    Merrick, H.2    Goldblatt, P.J.3
  • 28
    • 0027365931 scopus 로고
    • Aberrant expression of the type I fibroblast growth factor receptor in human pancreatic adenocarcinomas
    • Kobrin MS, Yamanaka Y, Friess H, Lopez ME and Korc M (1993) Aberrant expression of the type I fibroblast growth factor receptor in human pancreatic adenocarcinomas. Cancer Res 53: 4741-4744
    • (1993) Cancer Res , vol.53 , pp. 4741-4744
    • Kobrin, M.S.1    Yamanaka, Y.2    Friess, H.3    Lopez, M.E.4    Korc, M.5
  • 29
    • 0024500214 scopus 로고
    • Comparison of the immunohistochemical localisation of urokinase in normal and cancerous human colon tissue
    • Kohga S, Harvey SR, Suzumiya J, Sumiyoshi A and Markus G (1989) Comparison of the immunohistochemical localisation of urokinase in normal and cancerous human colon tissue. Fibrinolysis 3: 17-22
    • (1989) Fibrinolysis , vol.3 , pp. 17-22
    • Kohga, S.1    Harvey, S.R.2    Suzumiya, J.3    Sumiyoshi, A.4    Markus, G.5
  • 30
    • 0026462778 scopus 로고
    • Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increase in the levels of epidermal growth factor and transforming growth factor alpha
    • Korc M, Chandrasekar B, Yanianaka Y, Friess H, Büchler MW and Beger HG (1992) Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increase in the levels of epidermal growth factor and transforming growth factor alpha. J Clin Invest 90: 1352-1360
    • (1992) J Clin Invest , vol.90 , pp. 1352-1360
    • Korc, M.1    Chandrasekar, B.2    Yanianaka, Y.3    Friess, H.4    Büchler, M.W.5    Beger, H.G.6
  • 31
    • 0019850184 scopus 로고
    • Effect of plasminogen activator, plasmin and thrombin on glycoprotein and collagenous components of basement membrane
    • Liotta LA, Goldfarb RH, Brundage R, Siegal GP, Terranova V and Garbisa S (1981) Effect of plasminogen activator, plasmin and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res 41: 4629-4636
    • (1981) Cancer Res , vol.41 , pp. 4629-4636
    • Liotta, L.A.1    Goldfarb, R.H.2    Brundage, R.3    Siegal, G.P.4    Terranova, V.5    Garbisa, S.6
  • 32
    • 0025968060 scopus 로고
    • Inhibition of urokinase-type plasminogen activator by antibodies: The effect on dissemination of a human tumour in the nude mouse
    • Ossowski L, Russo-Payne H and Wilson EL (1991) Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumour in the nude mouse. Cancer Res 51: 274-281
    • (1991) Cancer Res , vol.51 , pp. 274-281
    • Ossowski, L.1    Russo-Payne, H.2    Wilson, E.L.3
  • 34
    • 0025853770 scopus 로고
    • Urokinase-type plasminogen activator is expressed in stromal cells and its receptor at invasive loci in human colon adenocarcinomas
    • Pyke C, Kristensen P, Ralfkiaer E, Grondal-Hansen J, Eriksen J, Blasi F and Dano K (1991) Urokinase-type plasminogen activator is expressed in stromal cells and its receptor at invasive loci in human colon adenocarcinomas. Am J Pathol 138: 1059-1067
    • (1991) Am J Pathol , vol.138 , pp. 1059-1067
    • Pyke, C.1    Kristensen, P.2    Ralfkiaer, E.3    Grondal-Hansen, J.4    Eriksen, J.5    Blasi, F.6    Dano, K.7
  • 35
    • 0025052018 scopus 로고
    • Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis
    • Roldan AL, Cubellis MV, Masucci MT, Behrendt N, Lund LR, Dano K, Appella E and Blasi F (1990) Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J 9: 467-474
    • (1990) EMBO J , vol.9 , pp. 467-474
    • Roldan, A.L.1    Cubellis, M.V.2    Masucci, M.T.3    Behrendt, N.4    Lund, L.R.5    Dano, K.6    Appella, E.7    Blasi, F.8
  • 37
    • 0029086675 scopus 로고
    • Primary tumour and metastasis in ovarian cancer differ in their content of urokinase-type plasminogen activator, its receptor, and inhibitors types 1 and 2
    • Schmalfeldt B, Kuhn W, Reuning U, Pache L, Deltmar P, Schmitt M, Jänicke F, Höfler H and Graeff H (1995) Primary tumour and metastasis in ovarian cancer differ in their content of urokinase-type plasminogen activator, its receptor, and inhibitors types 1 and 2. Cancer Res 55: 3958-3963
    • (1995) Cancer Res , vol.55 , pp. 3958-3963
    • Schmalfeldt, B.1    Kuhn, W.2    Reuning, U.3    Pache, L.4    Deltmar, P.5    Schmitt, M.6    Jänicke, F.7    Höfler, H.8    Graeff, H.9
  • 39
  • 40
    • 0027515071 scopus 로고
    • Expression of plasminogen activators and their inhibitors in human pancreatic carcinoma: Immunohistochemical study
    • Takeuchi Y, Nakao A, Harada A, Nonamy T, Fukatsu T and Takagi H (1993) Expression of plasminogen activators and their inhibitors in human pancreatic carcinoma: immunohistochemical study. Am J Gastroenterol 88: 1928-1933
    • (1993) Am J Gastroenterol , vol.88 , pp. 1928-1933
    • Takeuchi, Y.1    Nakao, A.2    Harada, A.3    Nonamy, T.4    Fukatsu, T.5    Takagi, H.6
  • 42
  • 43
    • 0027293748 scopus 로고
    • Coexpression of epidermal growth factor receptor and its ligands is associated with enhanced aggressiveness of human pancreatic cancer
    • Yamanaka Y, Friess H, Büchler MW, Kobrin MS, Beger HG and Korc M (1993a) Coexpression of epidermal growth factor receptor and its ligands is associated with enhanced aggressiveness of human pancreatic cancer. Anticancer Res 13: 565-570
    • (1993) Anticancer Res , vol.13 , pp. 565-570
    • Yamanaka, Y.1    Friess, H.2    Büchler, M.W.3    Kobrin, M.S.4    Beger, H.G.5    Korc, M.6
  • 44
    • 0027435936 scopus 로고
    • Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumour stage
    • Yamanaka Y, Friess H, Büchler MW, Beger HG, Uchida E, Masahiko O, Kobrin MS and Korc M (1993b) Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumour stage. Cancer Res 53: 5289-5296
    • (1993) Cancer Res , vol.53 , pp. 5289-5296
    • Yamanaka, Y.1    Friess, H.2    Büchler, M.W.3    Beger, H.G.4    Uchida, E.5    Masahiko, O.6    Kobrin, M.S.7    Korc, M.8
  • 46
    • 0028918095 scopus 로고
    • Amphiregulin is a potent mitogen in human pancreatic cancer cells: Correlation with patients' survival
    • Yokoyama M, Ebert M, Funatomi H, Friess H, Büchler MW, Johnson GK and Korc M (1995a) Amphiregulin is a potent mitogen in human pancreatic cancer cells: correlation with patients' survival. Int J Oncol 6: 625-631
    • (1995) Int J Oncol , vol.6 , pp. 625-631
    • Yokoyama, M.1    Ebert, M.2    Funatomi, H.3    Friess, H.4    Büchler, M.W.5    Johnson, G.K.6    Korc, M.7
  • 47
    • 0029147169 scopus 로고
    • Betacellulin, a member of the epidermal growth factor family, is overexpressed in human pancreatic cancer
    • Yokoyama M, Funatomi H, Kobrin MS, Ebert M, Friess H, Büchler MW and Korc M (1995b) Betacellulin, a member of the epidermal growth factor family, is overexpressed in human pancreatic cancer. Int J Oncol 7: 825-829
    • (1995) Int J Oncol , vol.7 , pp. 825-829
    • Yokoyama, M.1    Funatomi, H.2    Kobrin, M.S.3    Ebert, M.4    Friess, H.5    Büchler, M.W.6    Korc, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.