Transcriptional regulation of urokinase receptor in High- (95D) and Low-metastatic (95C) human lung cancer cells

Acta Biochimica et Biophysica Sinica

Volumn 36, Issue 6, 2004, Pages 405-411

  Chun Yang, L I ^a   Tan, Li ^a   Zhang, Guo Jing ^a   Ping, L I ^a   Tong, Chang ^a   Fan, Jing ^a   Zhu, Yun Song ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Promoter; Transcriptional regulation; uPAR

Indexed keywords

LUCIFERASE; NUCLEAR FACTOR; UROKINASE RECEPTOR;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVITY; ENZYME ASSAY; GENE AMPLIFICATION; GENE CONSTRUCT; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CANCER; LUNG METASTASIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMOSOME MAPPING; COLLAGEN; DRUG COMBINATIONS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; LAMININ; LUCIFERASES; LUNG NEOPLASMS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROMOTER REGIONS (GENETICS); PROTEOGLYCANS; RECEPTORS, CELL SURFACE; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 4143137812     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. r receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification. J Biol Chem, 1988, 263(5): 2358-2363
2. 2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins. J Biol Chem, 1993, 268(23): 17539-17546
3. Hollas W, Soravia E, Mazar A, Henkin J, Blasi F, Boyd D. Decreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line. Biochem J, 1992, 285(Pt2): 629-634
4. Bruckner A, Filderman AE, Kirchheimer JC, Binder BR, Remold HG. Endogenous receptor-bound urokinase mediates tissue invasion of the human lung carcinoma cell lines A549 and Calu-1. Cancer Res, 1992, 52(11): 3043-3047
5. Crowley CW, Cohen RL, Lucas BK, Liu G, Shuman MA, Levinson AD. Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci USA, 1993, 90(11): 5021-2025
6. Pedersen H, Brunner N, Francis D, Osterlind K, Ronne E, Hansen HH, Dano K et al. Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue. Cancer Res, 1994, 54(17): 4671-4675
7. Kobayashi H, Gotoh J, Fujie M, Shinohara H, Moniwa N, Terao T. Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model. Int J Cancer, 1994, 57(5): 727-733
8. Liu G, Shuman MA, Cohen RL. Co-expression of urokinase, urokinase receptor and PAI-1 is necessary for optimum invasiveness of cultured lung cancer cells. Int J Cancer, 1995, 60(4): 501-506
9. Yang JL, Seetoo D, Wang Y, Ranson M, Berney CR, Ham JM, Russell PJ et al. Urokinase-type plasminogen activator and its receptor in colorectal cancer: Independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets. Int J Cancer, 2000, 89(5): 431-439
10. Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev, 1993, 73(1): 161-195
11. Blasi F. Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness. Bioassays, 1993, 15(2): 105-111
12. Kook YH, Adamski J, Zelent A, Ossowski L. The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy. EMBO J, 1994, 13(17): 3983-3991
13. Chen LZ. Establishment of human pulmonary giant cell carcinoma cell line (PLA-801) and observations of its biologic properties. Chinese Journal of Oncology, 1983, 5(6): 409-413
14. Lu YL. Spontaneous metastasis of clonal cell subpopulations of human lung giant cell carcinoma after subcutaneous inoculation in nude mice. Chinese Journal of Oncology, 1989, 11(1): 1-7
15. He C, He P, Liu LP, Zhu YS. Analysis of expressions of components in the plasminogen activator system in high- and low-metastatic human lung cancer cells. J Cancer Res Clin Oncol, 2001, 127(3): 180-186
16. Lengyel E, Wang H, Stepp E, Juarez J, Wang Y, Doe W, Pfarr CM et al. Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene. J Biol Chem, 1996, 271: 23176-23184
17. Dang J, Boyd D, Wang H, Allgayer H, Doe WF, Wang Y. A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor. Eur J Biochem, 1999, 264(1): 92-99
18. Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G et al. Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma. Cancer Res, 2000, 60(6): 1546-1551
19. Wang Y, Dang J, Wang H, Allgayer H, Murrell GA, Boyd D. Identification of a novel nuclear factor-kappaB sequence involved in expression of urokinase-type plasminogen activator receptor. Eur J Biochem, 2000, 267(11): 3248-3254