Genetic profiling of colon cancer

Journal of Surgical Oncology

Volumn 80, Issue 4, 2002, Pages 204-213

  Neibergs, Holly L ^a   Hein, David W ^b   Spratt, John S ^b  

^a Norton Healthcare   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYP; ARTICLE; CANCER GENETICS; CHROMOSOME TRANSLOCATION; COLON CANCER; COLON CARCINOGENESIS; DNA REPAIR; FAMILIAL CANCER; GENE AMPLIFICATION; GENE FUNCTION; GENE INACTIVATION; GENE LOCUS; GENE LOSS; GENE OVEREXPRESSION; GENOME IMPRINTING; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTO ONCOGENE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

COLONIC NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA METHYLATION; GENES, APC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, GENETIC; MOLECULAR BIOLOGY; MUTATION; NEOPLASTIC SYNDROMES, HEREDITARY; PHENOTYPE; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 0036334994     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/jso.10131     Document Type: Article

References (105)

1. DNA methylation in tumorigenesis: Epigenetics joins genetics
2. How many mutations are required for tumorigenesis? Implications from human cancer data
3. Molecular profiling of human cancer
4. An approach to analysis of large scale correlations between genome changes and clinical endpoints in ovarian cancer
5. Cancer genetics
6. Proliferation, cell cycle and apoptosis in cancer
7. The Hedgehog (Hh) and Wingless (Wnt) signaling pathways in cancer
8. Cholesterol modification of Hedgehog signaling proteins in animal development
9. Transducing hedgehog: The story so far
10. Hedgehog and patched in neural development and disease
11. Transducing the Hedgehog signal
12. Feedback control of intercellular signaling in development
13. Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene
14. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
15. Deletion of an aminoterminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein
16. Wnt signaling and cancer
17. Linking colorectal cancer to Wnt signaling
18. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
19. Identification of c-MYC as a target of the APC pathway
20. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
21. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
22. The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells
23. Nonstochastic coexpression of activation receptors on murine natural killer cells
24. Consitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma
25. Stabilization of beta-catenin by genetic defects in melanoma cell lines
26. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer
27. Induction of a β-catenin-LEF-1 complex by wnt-1 and transforming mutants of β-catenin
28. The APC variants 11307K and E1217Q are associated with colorectal tumors but not always with a family history
29. Adenomatous lesions of the large bowel: An autopsy survey
30. A new verdict for an old convict
31. Wildtype Kras2 can inhibit lung carcinogenesis in mice
32. Impications of the p53 tumor suppressor gene in clinical oncology
33. Our current understanding of genetic alterations in colorectal cancer and implications for clinical use
34. Genetic susceptibility to nonpolyposis colorectal cancer
35. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colorectal cancer
36. Genetic mapping of a locus predisposing to human colorectal cancer
37. MLH3: A DNA mismatch repair gene associated with mammalian microsatellite instability
38. Hereditary nonpolyposis colorectal cancer: The syndrome, the genes and historical perspectives
39. Cancer risk in mutation carriers of DNA-mismatch-repair gene
40. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
41. Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer
42. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
43. Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences
44. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer
45. Frequent mutation of betacatenin and APC genes in primary colorectal tumors form patients with hereditary nonpolyposis colorectal cancer
46. Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients
47. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
48. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
49. MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal cancer
50. A gene for familial juvenile polyposis maps to chromosome 18q21
51. Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients
52. The molecular basis of Turcot's syndrome
53. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
54. Somatic mutations in the Peutz-Jeghers (LDB1/STKII) gene in sporadic malignant melanomas
55. Mutations of the STK11 gene in sporadic gastric carcinoma
56. Dimerization of cell surface receptors in signal transduction
57. Oncogenic kinase signaling
58. The protein tyrosine kinase family of the human genome
59. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
60. Activating SRC mutation in a subset of advanced human colon cancers
61. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
62. Allelic loss on chromosome 18q and prognosis in colorectal cancer
63. Hypermethylation associated inactivation of p14 (ARF) is independent of p16 (INK4a) methylation and p53 mutational status
64. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorecal carcinoma
65. Relaxation of imprinted genes in human cancer
66. Dose-dependence of 2amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenicity in rats
67. Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s)
68. Sulfation and sulfotransferases 4: Bioactivation of mutagens via sulfation
69. Role of aromatic amine acetyltransferase in human colorectal cancer
70. Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps
71. Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells
72. N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells
73. Relationship of SULT1A1 genotype to sulfotransferase activity phenotype in platelet cytosol: Effect of genotype on heterocyclic amine activation
74. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms
75. Endemic and morphologic similarities existing between spontaneous colon neoplasms in man and 3:2′-dimethyl-4-aminobiphenyl induced colonic neoplasms in rats
76. Well-done, grilled red meat increases the risk of colorectal adenomas
77. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than Wistar Kyoto (slow) acetylator inbred rats
78. Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc(+) allele
79. Early detection of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-indcued mutations within the Apc gene of rat colon
80. Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-metnyl-6-phenylimidazo[4, 5-b] pyridine: Perinatal susceptibility, regional varation, and correlation with DNA adducts
81. Cancer-susceptiblity genes: Gate-keepers and caretakers
82. Cancer risk of ehterocylic amines in cooked foods: An analysis and implications for research
83. Metabolic activation of carcinogenic heterocyclic amines by human liver and colon
84. Pharmacogenetics of sulfotransferase
85. Molecular genetics of cancer susceptibility
86. Combined effects of well-done meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk
87. Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas
88. Acetylator (NAT2)dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2-dimethyl-4-aminobiphenyl
89. Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2′-dimethyl-4-aminobiphenyl
90. Effect of acetylator genotype on 3,2′-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters
91. Detecting colorectal cancer in stool with the use of multiple genetic targets
92. Molecular predictors of survival after adjuvant chemotherapy for colon cancer
93. Determination of microsatellite instavility, p53 and K-RAS mutations in hepatic metases from patients with colorectal cancer: Relationship with response to 5-fluorouracil and survival
94. p53 gene mutation, microsatellite instability and adjuvant chemotherapy: Impact on survival of 388 patients with Dukes' C colon carcinoma
95. Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans
96. MDR1 pharmacogenetics: Frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
97. Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas
98. Clinical significance of KRas mutations in intraoperative tumor drainage blood from patients with colorectal carcinoma
99. A phosphatase associatcced with metastasis of colorectal cancer
100. The lognormal frequency distribution and human cancer