Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

Nature Biotechnology

Volumn 28, Issue 3, 2010, Pages 249-255

  Gohil, Vishal M ^a,b,c   Sheth, Sunil A ^a,b,c   Nilsson, Roland ^a,b,c   Wojtovich, Andrew P ^d,e   Lee, Jeong Hyun ^a   Perocchi, Fabiana ^a,b,c   Chen, William ^a,b,c   Clish, Clary B ^b   Ayata, Cenk ^a   Brookes, Paul S ^d,e   Mootha, Vamsi K ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Department of Pharmacology and Physiology ^*  (United States)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOPROTECTION; DRUG ACTION; ENERGY METABOLISM; GENE FUNCTION; HUMAN FIBROBLAST; ISCHEMIA-REPERFUSION INJURY; ISCHEMIC INJURIES; MITOCHONDRIAL RESPIRATION; MODEL SYSTEM; MURINE MODEL; NEUROPROTECTION; OXIDATIVE METABOLISM; PRE-TREATMENT; RELATIVE ACTIVITIES; SMALL MOLECULES;

CELL CULTURE; GLUCOSE; NUTRIENTS; PATHOLOGY; PHYSIOLOGY; SUGAR (SUCROSE);

METABOLISM;

GALACTOSE; GLUCOSE; MECLOZINE; MEPYRAMINE; SCOPOLAMINE; SUGAR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANONICAL ANALYSIS; CELL VIABILITY; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; ENERGY METABOLISM; GENE FUNCTION; GLYCOLYSIS; GROWTH; HEART PROTECTION; HUMAN; HUMAN CELL; ISCHEMIA; MALE; MITOCHONDRIAL RESPIRATION; MOLECULE; NEUROPROTECTION; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANIMALS; CELL LINE; CELL SURVIVAL; DRUG DISCOVERY; FIBROBLASTS; GALACTOSE; GLUCOSE; GLYCOLYSIS; HUMANS; MALE; MECLIZINE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MODELS, BIOLOGICAL; OXIDATIVE PHOSPHORYLATION;

MURINAE;

EID: 77749298746     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1606     Document Type: Article

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