Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4- benzotriazine 1,4-dioxide (tirapazamine)

Journal of the American Chemical Society

Volumn 132, Issue 8, 2010, Pages 2591-2599

  Shinde, Sujata S ^a,b   Maroz, Andrej ^a   Hay, Michael P ^b   Patterson, Adam V ^b   Denny, William A ^b   Anderson, Robert F ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANAEROBIC INCUBATION; AQUEOUS SOLUTIONS; BIOLOGICAL TARGETS; CANCER CELLS; CARBON-CENTERED RADICALS; CHAIN REACTION; CYTOCHROME P450; CYTOTOXINS; DENSITY FUNCTIONAL THEORY CALCULATIONS; ELECTRON PARAMAGNETIC RESONANCE; ENZYMATIC REDUCTION; EXPERIMENTAL SPECTRA; FORMATE IONS; METHOXY; OXIDIZING RADICALS; PRODRUGS; PULSE RADIOLYSIS; REACTIVE RADICALS; STEADY-STATE RADIOLYSIS; TIRAPAZAMINE;

DAMAGE DETECTION; DENSITY FUNCTIONAL THEORY; ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; PARAMAGNETIC RESONANCE; PARAMAGNETISM; PETROLEUM TAR; QUANTUM THEORY; RADIATION CHEMISTRY;

RADIOLYSIS;

1,2,4 BENZOTRIAZINE 1,4 DIOXIDE; DNA; N TERT BUTYL ALPHA PHENYLNITRONE; OXIDIZING AGENT; RADICAL; TIRAPAZAMINE;

AQUEOUS SOLUTION; ARTICLE; CANCER CELL; DENSITY FUNCTIONAL THEORY; ELECTRON SPIN RESONANCE; INCUBATION TIME; PULSE RADIOLYSIS; RADIOLYSIS; STEADY STATE;

ANTINEOPLASTIC AGENTS; CYTOTOXINS; ELECTRON SPIN RESONANCE SPECTROSCOPY; MICROSOMES; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; PULSE RADIOLYSIS; QUANTUM THEORY; TRIAZINES;

EID: 77649287770     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja908689f     Document Type: Article

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