메뉴 건너뛰기




Volumn 10, Issue 2, 1997, Pages 207-216

Cytochrome P450-dependent enzyme activities in Normal adult Human Keratinocytes and transformed human keratinocytes

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; 7 ETHOXYCOUMARIN DEETHYLASE; CELL ENZYME; CYTOCHROME P450; DRUG METABOLIZING ENZYME; ETHOXYRESORUFIN DEETHYLASE; PENTOXYRESORUFIN; PROADIFEN;

EID: 0030841509     PISSN: 10979336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (14)

References (41)
  • 1
    • 29344466050 scopus 로고
    • Modulation of the xenobiotic metabolizing enzyme cytochrome P4501A1 in the human keratinocyte cell line HaCaT
    • Washington
    • BECK, H., POLLET, D., BRACHER, M., and HOPPE, U. (1995). Modulation of the xenobiotic metabolizing enzyme cytochrome P4501A1 in the human keratinocyte cell line HaCaT, in: ISSX proceedings, Fourth International ISSX meeting Seattle, Washington, p. 102.
    • (1995) ISSX Proceedings, Fourth International ISSX Meeting Seattle , pp. 102
    • Beck, H.1    Pollet, D.2    Bracher, M.3    Hoppe, U.4
  • 2
    • 0025675615 scopus 로고
    • Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes
    • BERGHARD, A., GRADIN, K., and TOFTGARD, R. (1990). Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes. J. Biol. Chem. 265, 21086-21090.
    • (1990) J. Biol. Chem. , vol.265 , pp. 21086-21090
    • Berghard, A.1    Gradin, K.2    Toftgard, R.3
  • 3
    • 0022521630 scopus 로고
    • Pharmacological modification of epidermal detoxification systems
    • BICKERS, D.R., DAS, M., and MUKHTAR, H. (1986). Pharmacological modification of epidermal detoxification systems. Br. J. Dermatol. 115, 9-16.
    • (1986) Br. J. Dermatol. , vol.115 , pp. 9-16
    • Bickers, D.R.1    Das, M.2    Mukhtar, H.3
  • 5
    • 0022357068 scopus 로고
    • Ethoxy-, Pentoxy- and benzoxyphenoxazone and homologous: A series of substrates to distinguish between different induced cytochrome P-450
    • BURKE, M.D., THOMPSON, S., ELCOMBE, C.R., HALPERT, J., HAAPARANTA, T., and MEYER, R.T. (1985). Ethoxy-, Pentoxy- and benzoxyphenoxazone and homologous: A series of substrates to distinguish between different induced cytochrome P-450. Biochem. Pharmacol. 34, 3337-3345.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3337-3345
    • Burke, M.D.1    Thompson, S.2    Elcombe, C.R.3    Halpert, J.4    Haaparanta, T.5    Meyer, R.T.6
  • 6
    • 29344457914 scopus 로고
    • Assessment of cutaneous irritancy
    • A. Rougier, A.M. Goldberg, and H.I. Maibach (eds.) Mary Ann Liebert, Inc: NY
    • COHEN, C., SELVI-BIGNON, C., BARBIER, A., ROUGIER, A., LACHERETZ, F., and ROGUET, R. (1994). Assessment of cutaneous irritancy, in: In Vitro Skin Toxicology. A. Rougier, A.M. Goldberg, and H.I. Maibach (eds.) Mary Ann Liebert, Inc: NY, pp. 133-140.
    • (1994) In Vitro Skin Toxicology , pp. 133-140
    • Cohen, C.1    Selvi-Bignon, C.2    Barbier, A.3    Rougier, A.4    Lacheretz, F.5    Roguet, R.6
  • 8
    • 0342275500 scopus 로고
    • Skin metabolism by oxidation and conjugation
    • FINNEN, M.J. (1987). Skin metabolism by oxidation and conjugation. Pharmacol. Skin. 1, 163-169.
    • (1987) Pharmacol. Skin. , vol.1 , pp. 163-169
    • Finnen, M.J.1
  • 10
    • 0025189750 scopus 로고
    • Levels of cytochrome P-450-mediated aryl hydrocarbon hydroxylase (AHH) are higher in differentiated than in germinative cutaneous keratinocytes
    • GUO, J.F., BROWN, R., ROTHWELL, C.E., and BERNSTEIN, I.A. (1990). Levels of cytochrome P-450-mediated aryl hydrocarbon hydroxylase (AHH) are higher in differentiated than in germinative cutaneous keratinocytes. J. Invest. Derm. 94, 86-93.
    • (1990) J. Invest. Derm. , vol.94 , pp. 86-93
    • Guo, J.F.1    Brown, R.2    Rothwell, C.E.3    Bernstein, I.A.4
  • 11
    • 0002494957 scopus 로고
    • Cytochrome P-450 in humans
    • J.B. Schenkman and H. Greim (eds.) Springer-Verlag: Germany
    • GONZALEZ, F.J. (1993). Cytochrome P-450 in humans, in: Cytochrome P-450. Handbook of Experimental Pharmacology. J.B. Schenkman and H. Greim (eds.) Springer-Verlag: Germany, pp. 239-257.
    • (1993) Cytochrome P-450. Handbook of Experimental Pharmacology , pp. 239-257
    • Gonzalez, F.J.1
  • 12
    • 0026573153 scopus 로고
    • Ethoxyresorufin O-deethylase activity in intact human cells
    • HAMMOND, D.K., and STROBEL, H.W. (1992). Ethoxyresorufin O-deethylase activity in intact human cells. Toxicol. In Vitro. 6, 41-46.
    • (1992) Toxicol. In Vitro. , vol.6 , pp. 41-46
    • Hammond, D.K.1    Strobel, H.W.2
  • 13
    • 0028936561 scopus 로고
    • In vitro expression of drug metabolizing enzyme activities in human adult keratinocytes under various culture conditions and their responses to inducers
    • HIREL, B., CHESNE, C., PAILHERETS, J.P., and GULLOUZO, A. (1995). In vitro expression of drug metabolizing enzyme activities in human adult keratinocytes under various culture conditions and their responses to inducers. Toxicol. In Vitro. 9, 49-56.
    • (1995) Toxicol. In Vitro. , vol.9 , pp. 49-56
    • Hirel, B.1    Chesne, C.2    Pailherets, J.P.3    Gullouzo, A.4
  • 14
    • 0028366090 scopus 로고
    • Multiple cytochrome P-450 isoenzymes in murine skin: Induction of P-450 1A, 2B, 2E and 3A by dexamethasone
    • JUGERT, F.K., AGARWAL, R., KUHN, A., BICKERS, D.R., MERK, H., and MUKHTAR, H. (1994). Multiple cytochrome P-450 isoenzymes in murine skin: induction of P-450 1A, 2B, 2E and 3A by dexamethasone. J. Invest. Dermatol. 102, 970-975.
    • (1994) J. Invest. Dermatol. , vol.102 , pp. 970-975
    • Jugert, F.K.1    Agarwal, R.2    Kuhn, A.3    Bickers, D.R.4    Merk, H.5    Mukhtar, H.6
  • 15
    • 0023101443 scopus 로고
    • Interindividual variation of arylhydrocarbon hydroxylase activity in cultured epidermal and dermal cells
    • KUROKI, T., HOSOMI, J., CHIDA, K., HOSOI, J., and NEMOTO, N. (1987). Interindividual variation of arylhydrocarbon hydroxylase activity in cultured epidermal and dermal cells. Jpn. J. Cancer Res. 78, 45-53.
    • (1987) Jpn. J. Cancer Res. , vol.78 , pp. 45-53
    • Kuroki, T.1    Hosomi, J.2    Chida, K.3    Hosoi, J.4    Nemoto, N.5
  • 16
    • 0028596358 scopus 로고
    • The metabolism of a series of pro-drugs by NCTC 2544 cells, skin homogenate and LDE skin
    • LAMB, K.A., DENYER, S.P., SANDERSON, F.D., and SHAW, P.N. (1994). The metabolism of a series of pro-drugs by NCTC 2544 cells, skin homogenate and LDE skin. J. Pharm. Pharmacol. 46, 905-973.
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 905-973
    • Lamb, K.A.1    Denyer, S.P.2    Sanderson, F.D.3    Shaw, P.N.4
  • 17
    • 0023253786 scopus 로고
    • Skin metabolism of topically applied compounds
    • MARTIN, R.J., DENYER, S.P., and HADGRAFT, J. (1987). Skin metabolism of topically applied compounds. Int. J. Pharm. 39, 23-32.
    • (1987) Int. J. Pharm. , vol.39 , pp. 23-32
    • Martin, R.J.1    Denyer, S.P.2    Hadgraft, J.3
  • 18
    • 0024318829 scopus 로고
    • Effect of topical application of clotrimazole to rats on epidermal and hepatic monoxygenase activities and cytochrome P-450
    • MERK, H.F., KHAN, W.A., CUHN, C., BICKERS, D.R., and MUKHTAR, H. (1989). Effect of topical application of clotrimazole to rats on epidermal and hepatic monoxygenase activities and cytochrome P-450. Arch. Dermatol. Res. 281, 198-202.
    • (1989) Arch. Dermatol. Res. , vol.281 , pp. 198-202
    • Merk, H.F.1    Khan, W.A.2    Cuhn, C.3    Bickers, D.R.4    Mukhtar, H.5
  • 19
    • 0020396355 scopus 로고
    • Cytochrome P-450 dependent deethylase activity in rat and hairless mouse skin microsomes
    • MOLONEY, S.T., FROMSON, J.M., and BRIDGES, J.W. (1982). Cytochrome P-450 dependent deethylase activity in rat and hairless mouse skin microsomes. Biochem. Pharmacol. 31, 4011-4018.
    • (1982) Biochem. Pharmacol. , vol.31 , pp. 4011-4018
    • Moloney, S.T.1    Fromson, J.M.2    Bridges, J.W.3
  • 20
    • 0019403369 scopus 로고
    • Drug metabolism in skin: Comparative activity of the mixed-function oxygenase, ethoxide hydratase and gluthatione-S-transferase in liver and skin of neonatal rat
    • MUKHTAR, H. and BICKERS, D.R. (1981). Drug metabolism in skin: Comparative activity of the mixed-function oxygenase, ethoxide hydratase and gluthatione-S-transferase in liver and skin of neonatal rat. Drug Metab. Dispos. 9, 311-314.
    • (1981) Drug Metab. Dispos. , vol.9 , pp. 311-314
    • Mukhtar, H.1    Bickers, D.R.2
  • 21
    • 0001926437 scopus 로고
    • Cutaneous biotransformation and some pharmacological and lexicological implications
    • F.N. Marzulli and H.I. Maibach (eds.) Hemisphère Publishing Corp: NY
    • NOONAN, P.K., and WESTER, R.C. (1983). Cutaneous biotransformation and some pharmacological and lexicological implications, in: Dermatotoxicology. 2nd ed. F.N. Marzulli and H.I. Maibach (eds.) Hemisphère Publishing Corp: NY, pp 71-78.
    • (1983) Dermatotoxicology. 2nd Ed. , pp. 71-78
    • Noonan, P.K.1    Wester, R.C.2
  • 24
    • 0025324070 scopus 로고
    • Use of keratinocyte and fibroblast culture for toxicity studies of topically applied compounds
    • PONEC, M., HAVERKART, M., and SOEI, Y.L. (1990). Use of keratinocyte and fibroblast culture for toxicity studies of topically applied compounds. J. Pharm. Sci. 79, 312-316.
    • (1990) J. Pharm. Sci. , vol.79 , pp. 312-316
    • Ponec, M.1    Haverkart, M.2    Soei, Y.L.3
  • 25
    • 0028359709 scopus 로고
    • Measurement and modulation of cytochrome P-450 dependent enzyme activity in cultured human keratinocytes
    • RAFFALI, F., ROUGIER, A., and ROGUET, R. (1994). Measurement and modulation of cytochrome P-450 dependent enzyme activity in cultured human keratinocytes. Skin Pharmacol. 7, 345-354.
    • (1994) Skin Pharmacol. , vol.7 , pp. 345-354
    • Raffali, F.1    Rougier, A.2    Roguet, R.3
  • 27
    • 0025179066 scopus 로고
    • Fluorescence assay for per-cell estimation of cytochrome P-450-dependent monoxygenase activities in keratinocyte suspension and cultures
    • REINERS, J.J., JR., CANTU, A.R., PAVONE, A., SMITH, S.C., GARDNER, C.R., and LASKIN, D.L. (1990b). Fluorescence assay for per-cell estimation of cytochrome P-450-dependent monoxygenase activities in keratinocyte suspension and cultures. Anal. Biochem. 188, 317-324.
    • (1990) Anal. Biochem. , vol.188 , pp. 317-324
    • Reiners Jr., J.J.1    Cantu, A.R.2    Pavone, A.3    Smith, S.C.4    Gardner, C.R.5    Laskin, D.L.6
  • 28
    • 0022503221 scopus 로고
    • Expression of high molecular weight (67K) keratin in human keratinocytes on dead de-epidermized dermis
    • REGNIER, M., SCHWEIZER, J., MICHEL, S., BAILLY, C., and PRUNIERAS, M. (1986). Expression of high molecular weight (67K) keratin in human keratinocytes on dead de-epidermized dermis. Exp. Cell Res. 165, 63-70.
    • (1986) Exp. Cell Res. , vol.165 , pp. 63-70
    • Regnier, M.1    Schweizer, J.2    Michel, S.3    Bailly, C.4    Prunieras, M.5
  • 29
    • 0023001854 scopus 로고
    • Major differences between lung, skin and liver in the microsomal metabolism of homologous series of resorufin and coumarins ether
    • RETTIE, A.E., WILLIAMS, F.M., RAWLINS, M.D., MAYER, R.T., and BURKE, M.D. (1986). Major differences between lung, skin and liver in the microsomal metabolism of homologous series of resorufin and coumarins ether. Biochem. Pharmacol. 35, 3495-3500.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 3495-3500
    • Rettie, A.E.1    Williams, F.M.2    Rawlins, M.D.3    Mayer, R.T.4    Burke, M.D.5
  • 30
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes. The formation of keratinizing colonies from single cells
    • RHEINWALD, J.G., and GREEN, H. (1975). Serial cultivation of strains of human epidermal keratinocytes. The formation of keratinizing colonies from single cells. Cell 6, 331-344.
    • (1975) Cell , vol.6 , pp. 331-344
    • Rheinwald, J.G.1    Green, H.2
  • 31
    • 0028283681 scopus 로고
    • Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P-450 isoforms in cultured rat hepatocytes
    • SAAD, B., THOMAS, H., SCHAWALDER, H., WAECHTER, F., and MAIER, P. (1994). Oxygen tension, insulin, and glucagon affect the preservation and induction of cytochrome P-450 isoforms in cultured rat hepatocytes. Toxicol. Appl. Pharmacol. 126, 372-379.
    • (1994) Toxicol. Appl. Pharmacol. , vol.126 , pp. 372-379
    • Saad, B.1    Thomas, H.2    Schawalder, H.3    Waechter, F.4    Maier, P.5
  • 32
    • 0001457937 scopus 로고
    • Cytochrome P-450 in primary and permanent liver cell culture
    • J.B. Schenkman, and H. Greim (eds.) Springer-Verlag: Germany
    • SCHWARZ, L.R. and WEIBEL, F.J. (1993). Cytochrome P-450 in primary and permanent liver cell culture, in: Cytochrome P-450. Handbook of Experimental Pharmacology. J.B. Schenkman, and H. Greim (eds.) Springer-Verlag: Germany, pp. 399-413.
    • (1993) Cytochrome P-450. Handbook of Experimental Pharmacology , pp. 399-413
    • Schwarz, L.R.1    Weibel, F.J.2
  • 33
    • 0025772460 scopus 로고
    • Species differences in metabolism and pharmacokinetics: Are we close to an understanding?
    • SMITH D. (1991). Species differences in metabolism and pharmacokinetics: Are we close to an understanding? Drug Metab. Rev. 23, 355-373.
    • (1991) Drug Metab. Rev. , vol.23 , pp. 355-373
    • Smith, D.1
  • 34
    • 0025186071 scopus 로고
    • A comparative study of antiseptic toxicity on basal keratinocytes, transformed human keratinocytes and fibroblasts
    • TATNALL, F.M., LEIGH, I.M., and GIBSON, J.R. (1990). A comparative study of antiseptic toxicity on basal keratinocytes, transformed human keratinocytes and fibroblasts. Skin Pharmacol. 3, 157-163.
    • (1990) Skin Pharmacol. , vol.3 , pp. 157-163
    • Tatnall, F.M.1    Leigh, I.M.2    Gibson, J.R.3
  • 35
    • 0025095143 scopus 로고
    • Vitamin A esterification in human epidermis: A relation to keratinocyte differentiation
    • TÖRMA, H., and VAHLQUIST, A. (1990). Vitamin A esterification in human epidermis: A relation to keratinocyte differentiation. J. Invest. Dermatol. 94, 132-138.
    • (1990) J. Invest. Dermatol. , vol.94 , pp. 132-138
    • Törma, H.1    Vahlquist, A.2
  • 36
    • 0004246546 scopus 로고
    • Molecular aspects of regulation and structure of the drug-metabolizing enzymes
    • W.B. Pratt and P. Taylor (eds.) Churchill Livingstone Inc.
    • TUKEY, R.H., and JOHNSON, E.F. (1990). Molecular aspects of regulation and structure of the drug-metabolizing enzymes, in: Principles of Drug Action. W.B. Pratt and P. Taylor (eds.) Churchill Livingstone Inc. pp. 423-467.
    • (1990) Principles of Drug Action , pp. 423-467
    • Tukey, R.H.1    Johnson, E.F.2
  • 37
    • 0024154832 scopus 로고
    • Cytochrome P-450 dependent metabolism of retinoic acid in rat skin microsomes: Inhibition by ketaconazole
    • VANDEN BOSSCHE, H., WILLEMSENS, G., and JANSEN, P.A.J. (1988). Cytochrome P-450 dependent metabolism of retinoic acid in rat skin microsomes: Inhibition by ketaconazole. Skin Pharmacol. 1, 176-185.
    • (1988) Skin Pharmacol. , vol.1 , pp. 176-185
    • Vanden Bossche, H.1    Willemsens, G.2    Jansen, P.A.J.3
  • 38
    • 0025018016 scopus 로고
    • Immunolocalization of cytochrome P-450 isoenzymes in cultured human epithelial cells
    • VAN PELT, F.N.A.M., MEIERINK, Y.J.M., and WETERINGS, P.J.J.M. (1990). Immunolocalization of cytochrome P-450 isoenzymes in cultured human epithelial cells. J. Histochem. Cytochem. 38, 1847-1851.
    • (1990) J. Histochem. Cytochem. , vol.38 , pp. 1847-1851
    • Van Pelt, F.N.A.M.1    Meierink, Y.J.M.2    Weterings, P.J.J.M.3
  • 39
    • 0026020683 scopus 로고
    • Micronucleus formation in cultured human keratinocytes following exposure to mitomycin C and cyclophosphamide
    • VAN PELT, F.N.A.M., HARING, R.G., OVERKAMPM, J.I., and WETERINGS, P.J.J.M. (1991). Micronucleus formation in cultured human keratinocytes following exposure to mitomycin C and cyclophosphamide. Mutat. Res. 252, 45-50.
    • (1991) Mutat. Res. , vol.252 , pp. 45-50
    • Van Pelt, F.N.A.M.1    Haring, R.G.2    Overkampm, J.I.3    Weterings, P.J.J.M.4
  • 40
    • 0028964218 scopus 로고
    • Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes
    • VECCHINI, F., MACE, K., MAGDALOU, J., MAHE, Y., BERNARD, B.A., and SHROOT, B. (1995). Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes. Br. J. Derm. 132, 14-21.
    • (1995) Br. J. Derm. , vol.132 , pp. 14-21
    • Vecchini, F.1    Mace, K.2    Magdalou, J.3    Mahe, Y.4    Bernard, B.A.5    Shroot, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.