Structural correlates of antibodies associated with acute reversal of amyloid β-related behavioral deficits in a mouse model of Alzheimer disease

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 3417-3427

  Basi, Guriqbal S ^a   Feinberg, Hadar ^c   Oshidari, Farshid ^a   Anderson, John ^a   Barbour, Robin ^a,b   Baker, Jeanne ^a,b   Comery, Thomas A ^d   Diep, Linnea ^a   Gill, Davinder ^d   Johnson Wood, Kelly ^a   Goel, Amita ^a   Grantcharova, Katerina ^a   Lee, Mike ^a   Li, Jingzhi ^c   Partridge, Anthony ^a   Griswold Prenner, Irene ^a   Piot, Nicolas ^a   Walker, Don ^a   Widom, Angela ^d   Pangalos, Menelas N ^d   Seubert, Peter ^a,b   Jacobsen, J Steven ^d   Schenk, Dale ^a,b   Weis, William I ^c   more..

^a ELAN PHARMACEUTICALS   (United States)

^b Janssen Alzheimer Immunotherapy Research and Development   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID DEPOSITION; ANTIGEN RECOGNITION; ATOMIC LEVELS; CLINICAL TRIAL; COGNITIVE DEFICITS; FAB FRAGMENTS; HEAVY CHAIN; IN-VITRO; IN-VIVO; LINEAR EPITOPES; MOUSE MODELS; STRUCTURAL BASIS; STRUCTURAL DIFFERENCES; TRANSGENIC MICE;

ABILITY TESTING; CRYSTAL ATOMIC STRUCTURE; GLYCOPROTEINS; PEPTIDES;

ANTIBODIES;

AMYLOID BETA PROTEIN; EPITOPE; CROSS LINKING REAGENT; RECOMBINANT PROTEIN;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; IMMUNOPATHOGENESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; CONFORMATION; DISEASE MODEL; HETEROZYGOTE; HUMAN; IMMUNOLOGY; KINETICS; MALE; METABOLISM; METHODOLOGY; MOUSE; X RAY CRYSTALLOGRAPHY;

MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BEHAVIOR, ANIMAL; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; EPITOPES; HETEROZYGOTE; HUMANS; KINETICS; MALE; MICE; MOLECULAR CONFORMATION; RECOMBINANT PROTEINS;

EID: 77449115957     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.045187     Document Type: Article

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