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1
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67649723378
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Ali R, Cusi K. New diagnostic and treatment approaches in nonalcoholic fatty liver disease (NAFLD). Ann Med 2009. [Epub ahead of print]. http://dx.doi.org/10.1080/07853890802552437 Comprehensive overview of the risk factors for the development of NASH with emphasis on future diagnostic and treatment approaches.
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Ali R, Cusi K. New diagnostic and treatment approaches in nonalcoholic fatty liver disease (NAFLD). Ann Med 2009. [Epub ahead of print]. http://dx.doi.org/10.1080/07853890802552437 Comprehensive overview of the risk factors for the development of NASH with emphasis on future diagnostic and treatment approaches.
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2
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34250732933
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Bugianesi E, Vanni E, Marchesini G. NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes.Curr Diab Rep 2007; 7:175-180. Detailed review about the close relationship in patients with diabetes between NASH, cirrhosis and hepatocellular carcinoma.
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Bugianesi E, Vanni E, Marchesini G. NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes.Curr Diab Rep 2007; 7:175-180. Detailed review about the close relationship in patients with diabetes between NASH, cirrhosis and hepatocellular carcinoma.
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3
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53549112749
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Increased risk of cardiovascular disease in nonalcoholic fatty liver disease: Causal effect or epiphenomenon?
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Review assessing the cluster of cardiovascular risk factors associated with NAFLD and the specific risk associated with the presence of fatty liver
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Targher G, Marra F, Marchesini G. Increased risk of cardiovascular disease in nonalcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 2008; 51:1947-1953. Review assessing the cluster of cardiovascular risk factors associated with NAFLD and the specific risk associated with the presence of fatty liver.
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Diabetologia
, vol.51
, pp. 1947-1953
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Targher, G.1
Marra, F.2
Marchesini, G.3
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4
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49649090452
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Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease
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Targher G, Chonchol M, Bertolini L, et al. Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease. J Am Soc Nephrol 2008; 19:1564-1570.
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J Am Soc Nephrol
, vol.19
, pp. 1564-1570
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Targher, G.1
Chonchol, M.2
Bertolini, L.3
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5
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37349053742
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Impact of fatty liver disease on healthcare utilization and costs in a general population: A 5-year observation
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Baumeister SE, Völzke H, Marschall P, et al. Impact of fatty liver disease on healthcare utilization and costs in a general population: a 5-year observation. Gastroenterology 2008; 134:85-94.
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Gastroenterology
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Baumeister, S.E.1
Völzke, H.2
Marschall, P.3
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6
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10644220306
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Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
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Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004; 40:1387-1395.
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Hepatology
, vol.40
, pp. 1387-1395
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Browning, J.D.1
Szczepaniak, L.S.2
Dobbins, R.3
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7
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67649848860
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The prevalence of NAFLD in T2DM is highest among Hispanics and is closely related to hepatic and adipose tissue insulin resistance [abstract]
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Chen J, Mathew M, Finch J, Cusi K. The prevalence of NAFLD in T2DM is highest among Hispanics and is closely related to hepatic and adipose tissue insulin resistance [abstract]. Diabetes 2009; 58 (Suppl 1).
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Diabetes
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Chen, J.1
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Finch, J.3
Cusi, K.4
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8
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Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
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Targher G, Lorenzo B, Roberto P, et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 2007; 30:1212-1218.
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Diabetes Care
, vol.30
, pp. 1212-1218
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Targher, G.1
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Roberto, P.3
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9
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57749183469
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Prevalence and associated factors of nonalcoholic fatty liver disease in patients with type-2 diabetes mellitus
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Leite N, Salles G, Araujo A, Villela-Nogueira C, Cardoso C. Prevalence and associated factors of nonalcoholic fatty liver disease in patients with type-2 diabetes mellitus. Liver Int 2009; 29:113-119.
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Liver Int
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Leite, N.1
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10
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0037566201
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Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
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Mofrad P. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 2003; 37:1286-1292.
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Hepatology
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Mofrad, P.1
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7244250409
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Silent nonalcoholic fatty liver disease-a clinical-histological study
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Sorrentino P. Silent nonalcoholic fatty liver disease-a clinical-histological study. J Hepatol 2004; 41:751-757.
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J Hepatol
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Sorrentino, P.1
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12
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13944280671
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Clinical spectrum and natural history of nonalcoholic steatohepatitis with normal alanine aminotransferase values
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Amarapurkar D, Patel N. Clinical spectrum and natural history of nonalcoholic steatohepatitis with normal alanine aminotransferase values. Trop Gastroenterol 2004; 25:130-134.
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Trop Gastroenterol
, vol.25
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Amarapurkar, D.1
Patel, N.2
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13
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51349083814
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Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes
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Valuable study in a large cohort of patients with NASH about the possibility of significant liver disease in NASH even in the presence of normal liver transaminases
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Fracanzani A, Valenti L, Bugianesi E, et al. Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 2008; 48:792-798. Valuable study in a large cohort of patients with NASH about the possibility of significant liver disease in NASH even in the presence of normal liver transaminases.
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(2008)
Hepatology
, vol.48
, pp. 792-798
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Fracanzani, A.1
Valenti, L.2
Bugianesi, E.3
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14
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33644772843
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Cryptogenic cirrhosis and NAFLD: Are they related?
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Maheshwari A, Paul JT. Cryptogenic cirrhosis and NAFLD: are they related? Am J Gastroenterol 2006; 101:664-668.
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(2006)
Am J Gastroenterol
, vol.101
, pp. 664-668
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Maheshwari, A.1
Paul, J.T.2
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15
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67649857648
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Cryptogenic cirrhosis. AASLD Postgraduate Course 2008
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State-of-the-art review on cryptogenic cirrhosis and its frequent association with obesity and T2DM
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Caldwell S, Lee V. Cryptogenic cirrhosis. AASLD Postgraduate Course 2008; 2008:48-57. State-of-the-art review on cryptogenic cirrhosis and its frequent association with obesity and T2DM.
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(2008)
, pp. 48-57
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Caldwell, S.1
Lee, V.2
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16
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33750606061
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Long-term follow-up of patients with NAFLD and elevated liver enzymes
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Ekstedt M, Franzén L, Mathiesen U, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44:865-873.
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(2006)
Hepatology
, vol.44
, pp. 865-873
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Ekstedt, M.1
Franzén, L.2
Mathiesen, U.3
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17
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45849133826
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Nonalcoholic fatty liver disease in children: A single center experience
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A-Kader H, Henderson J, Vanhoesen K, et al. Nonalcoholic fatty liver disease in children: a single center experience. Clin Gastroenterol Hepatol 2008; 6:799-802.
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Clin Gastroenterol Hepatol
, vol.6
, pp. 799-802
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A-Kader, H.1
Henderson, J.2
Vanhoesen, K.3
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18
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34548125265
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Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents
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Schwimmer J. Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. Semin Liver Dis 2007; 27:312-318.
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Semin Liver Dis
, vol.27
, pp. 312-318
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Schwimmer, J.1
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19
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49149114288
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Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease
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Highlights the early development of cardiovascular risk factors in children with NAFLD
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Schwimmer J, Pardee P, Lavine J, et al. Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation 2008; 118:277-283. Highlights the early development of cardiovascular risk factors in children with NAFLD.
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(2008)
Circulation
, vol.118
, pp. 277-283
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Schwimmer, J.1
Pardee, P.2
Lavine, J.3
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20
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55549115371
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Intima-media thickness of carotid artery and susceptibility to atherosclerosis in obese children with nonalcoholic fatty liver disease
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Demircioglu F, Kocyigit A, Arslan N, et al. Intima-media thickness of carotid artery and susceptibility to atherosclerosis in obese children with nonalcoholic fatty liver disease. J Pediatric Gastroenterol Nutr 2008; 47:68-75.
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J Pediatric Gastroenterol Nutr
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, pp. 68-75
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Demircioglu, F.1
Kocyigit, A.2
Arslan, N.3
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21
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52649112178
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Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease
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Valuable examination of risk factors in a large population of patients with NAFLD
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Harrison S, Oliver D, Arnold H, et al. Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease. Gut 2008; 57:1441-1447. Valuable examination of risk factors in a large population of patients with NAFLD.
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(2008)
Gut
, vol.57
, pp. 1441-1447
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Harrison, S.1
Oliver, D.2
Arnold, H.3
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23
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38649091680
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Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
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Perseghin G, Lattuada G, De Cobelli F, et al. Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver. Hepatology 2008; 47:51-58.
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(2008)
Hepatology
, vol.47
, pp. 51-58
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Perseghin, G.1
Lattuada, G.2
De Cobelli, F.3
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24
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35048878739
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Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes
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Zib I, Jacob A, Lingvay I, et al. Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes. J Investig Med 55:ePub (electronic version); 2007.
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(2007)
J Investig Med 55:ePub (electronic version)
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Zib, I.1
Jacob, A.2
Lingvay, I.3
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25
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50849087307
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Noninvasive means of measuring hepatic fat content
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Mehta SR, Thomas EL, Bell JD, et al. Noninvasive means of measuring hepatic fat content. World J Gastroenterol 2008; 14:3476-3483.
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(2008)
World J Gastroenterol
, vol.14
, pp. 3476-3483
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Mehta, S.R.1
Thomas, E.L.2
Bell, J.D.3
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26
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33751545838
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A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
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Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006; 355:2297-2307.
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N Engl J Med
, vol.355
, pp. 2297-2307
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Belfort, R.1
Harrison, S.A.2
Brown, K.3
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27
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Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
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Gastaldelli A, Cusi K, Pettiti M, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 2007; 133:496-506.
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Gastroenterology
, vol.133
, pp. 496-506
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Gastaldelli, A.1
Cusi, K.2
Pettiti, M.3
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28
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33845207096
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Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholic steatohepatitis in patients with nonalcoholic fatty liver disease
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and the LIDO study group, and the CYTOL study group
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Poynard T, Ratziu V, Charlotte F, et al., and the LIDO study group, and the CYTOL study group. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholic steatohepatitis in patients with nonalcoholic fatty liver disease. BMC Gastroenterol 2006; 6:34.
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(2006)
BMC Gastroenterol
, vol.6
, pp. 34
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Poynard, T.1
Ratziu, V.2
Charlotte, F.3
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29
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33644607568
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Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with nonalcoholic fatty liver disease
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and the LIDO study group, and the CYTOL study group
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Ratziu V, Massard J, Charlotte F, et al., and the LIDO study group, and the CYTOL study group. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with nonalcoholic fatty liver disease. BMC Gastroenterol 2006; 6:6.
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BMC Gastroenterol
, vol.6
, pp. 6
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Ratziu, V.1
Massard, J.2
Charlotte, F.3
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30
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34247384560
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The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
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Angulo P, Hui J, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007; 45:846-854.
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(2007)
Hepatology
, vol.45
, pp. 846-854
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Angulo, P.1
Hui, J.2
Marchesini, G.3
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31
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34548306754
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Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future
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Excellent review on the current role and future potential of plasma biomarkers for the management of NAFLD and NASH
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Wieckowska A, McCullough A, Feldstein A. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 2007; 46:582-589. Excellent review on the current role and future potential of plasma biomarkers for the management of NAFLD and NASH.
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(2007)
Hepatology
, vol.46
, pp. 582-589
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Wieckowska, A.1
McCullough, A.2
Feldstein, A.3
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32
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41349094999
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Performance of transient elastography for the staging of liver fibrosis: A meta-analysis
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Comprehensive review on the role of this imaging technique from the available literature
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Friedrich-Rust M, Ong MF, Martens S, et al. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 2008; 134:960-974. Comprehensive review on the role of this imaging technique from the available literature.
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(2008)
Gastroenterology
, vol.134
, pp. 960-974
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Friedrich-Rust, M.1
Ong, M.F.2
Martens, S.3
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33
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41249100719
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Noninvasive evaluation of liver fibrosis using transient elastography
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Castera L, Forns X, Alberti A. Noninvasive evaluation of liver fibrosis using transient elastography. J Hepatol 2008; 48:835-847.
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(2008)
J Hepatol
, vol.48
, pp. 835-847
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Castera, L.1
Forns, X.2
Alberti, A.3
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34
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33745904468
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In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
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Wieckowska A, McCullough A, Feldstein A, et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006; 44:27-33.
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Hepatology
, vol.44
, pp. 27-33
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Wieckowska, A.1
McCullough, A.2
Feldstein, A.3
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35
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41849148981
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Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD)
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Yoneda M, Mawatari H, Fujita K, et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD). Digest Liver Dis 2008; 40:371-378.
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Digest Liver Dis
, vol.40
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Yoneda, M.1
Mawatari, H.2
Fujita, K.3
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36
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49649105500
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Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis
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The following ref, 37-42, are all outstanding reviews by leaders in the field on the mechanisms that lead to NAFLD and NASH
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Nobili V, Vizzutti F, Arena U, et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 2008; 48:442-448. The following (ref. [37-42]) are all outstanding reviews by leaders in the field on the mechanisms that lead to NAFLD and NASH
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(2008)
Hepatology
, vol.48
, pp. 442-448
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Nobili, V.1
Vizzutti, F.2
Arena, U.3
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37
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34249792393
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Role of mitochondria in nonalcoholic fatty liver disease
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Pessayre D. Role of mitochondria in nonalcoholic fatty liver disease. J Gastroenterol Hepatol 2007; 22:S20-S27.
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(2007)
J Gastroenterol Hepatol
, vol.22
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Pessayre, D.1
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38
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34548321204
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Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis
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Elsharkawy A, Mann D. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 2007; 46:590-597.
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(2007)
Hepatology
, vol.46
, pp. 590-597
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Elsharkawy, A.1
Mann, D.2
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40
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Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
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Choi SS, Diehl AM. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol 2008; 19:295-300.
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Curr Opin Lipidol
, vol.19
, pp. 295-300
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Choi, S.S.1
Diehl, A.M.2
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41
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43949108922
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The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity
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Li Z, Berk M, McIntyre TM, et al. The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology 2008; 47:1495-1503.
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Hepatology
, vol.47
, pp. 1495-1503
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Li, Z.1
Berk, M.2
McIntyre, T.M.3
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42
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39149104311
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Molecular basis and mechanisms of progression of nonalcoholic steatohepatitis
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Marra F, Gastaldelli A, Svegliati Baroni G, et al. Molecular basis and mechanisms of progression of nonalcoholic steatohepatitis. Trends Mol Med 2008; 14:72-81.
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Trends Mol Med
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, pp. 72-81
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Marra, F.1
Gastaldelli, A.2
Svegliati Baroni, G.3
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43
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37849188713
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Fructose-mediated stress signaling in the liver: Implications for hepatic insulin resistance
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Wei Y, Wang D, Topczewski F, Pagliassotti M. Fructose-mediated stress signaling in the liver: implications for hepatic insulin resistance. J Nutr Biochem 2007; 18:1-9.
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(2007)
J Nutr Biochem
, vol.18
, pp. 1-9
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Wei, Y.1
Wang, D.2
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Pagliassotti, M.4
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44
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43049170503
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Fructose consumption as a risk factor for nonalcoholic fatty liver disease
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Ouyang X, Cirillo P, Sautin Y, et al. Fructose consumption as a risk factor for nonalcoholic fatty liver disease. J Hepatol 2008; 48:993-999.
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(2008)
J Hepatol
, vol.48
, pp. 993-999
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Ouyang, X.1
Cirillo, P.2
Sautin, Y.3
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45
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33846783170
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The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: A pilot study
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Tendler D, Lin S, Yancy WS Jr, et al. The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. Digest Dis Sci 2007; 52:589-593.
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Digest Dis Sci
, vol.52
, pp. 589-593
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Tendler, D.1
Lin, S.2
Yancy Jr, W.S.3
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46
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34247643885
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Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults
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Ryan MC, Abbasi F, Lamendola C, et al. Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults. Diabetes Care 2007; 30:1075-1080.
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Diabetes Care
, vol.30
, pp. 1075-1080
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Ryan, M.C.1
Abbasi, F.2
Lamendola, C.3
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47
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40749137040
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Fatty liver, insulin resistance, and dyslipidemia
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Excellent review on the topic
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Adiels M, Taskinen M-R, Boren J. Fatty liver, insulin resistance, and dyslipidemia. Curr Diabetes Rep 2008; 8:60-64. Excellent review on the topic.
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(2008)
Curr Diabetes Rep
, vol.8
, pp. 60-64
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Adiels, M.1
Taskinen, M.-R.2
Boren, J.3
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48
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42949178538
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Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects
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Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008; 134:1369-1375.
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(2008)
Gastroenterology
, vol.134
, pp. 1369-1375
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Korenblat, K.M.1
Fabbrini, E.2
Mohammed, B.S.3
Klein, S.4
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49
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18244382304
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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
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Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115:1343-1351.
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(2005)
J Clin Invest
, vol.115
, pp. 1343-1351
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Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
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50
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41149102818
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Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans
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Stefan N, Peter A, Cegan A, et al. Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia 2008; 51:648-656.
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(2008)
Diabetologia
, vol.51
, pp. 648-656
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Stefan, N.1
Peter, A.2
Cegan, A.3
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51
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37349083834
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PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism
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Vinciguerra M, Veyrat-Durebex C, Moukil MA, et al. PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. Gastroenterology 2008; 134:268-280.
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Gastroenterology
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, pp. 268-280
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Vinciguerra, M.1
Veyrat-Durebex, C.2
Moukil, M.A.3
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52
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