Preoperative radiotherapy downregulates the nuclear expression of hypoxia-inducible factor-1α in rectal cancer

Scandinavian Journal of Gastroenterology

Volumn 45, Issue 3, 2010, Pages 340-348

  Korkeila, Eija ^a   Jaakkola, P M ^a,b   Syrjanen K ^a   Sundstrom J ^a   Pyrhonen S ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Chemotherapy; Hypoxia inducible factor 1 ; Predictive factor; Prognosis; Radiotherapy; Rectal cancer

Indexed keywords

CAPECITABINE; FLUOROURACIL; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; DISEASE FREE SURVIVAL; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CANCER; SURVIVAL; TREATMENT RESPONSE; UPREGULATION;

CELL HYPOXIA; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; NEOPLASM STAGING; PREOPERATIVE CARE; RECTAL NEOPLASMS;

EID: 77149172527     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365520903483635     Document Type: Article

References (34)

1. Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005;16:481-488
2. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-1186
3. Dachs G, Stratford I. The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy. Br J Cancer Suppl 1996;27:S126-32.
4. Semenza G. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-732
5. Semenza G. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 2000;35:71-103.
6. Höckel M, Schlenger K, Mitze M, Schäffer U, Vaupel P. Hypoxia and radiation response in human tumors. Semin Radiat Oncol 1996;6:3-9.
7. Harris A. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
8. Wang G, Semenza G. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993;268:21513-21518
9. Greijer A, Delis-van Diemen P, Fijneman R, Giles R, Voest E, van Hinsbergh V, et al. Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. Virchows Arch 2008;452:535-544
10. Wang G, Semenza G. General involvement of hypoxiainducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A 1993;90:4304-4308
11. Wang G, Jiang B, Rue E, Semenza G. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995;92:5510-5514
12. Koukourakis M, Giatromanolaki A, Polychronidis A, Simopoulos C, Gatter K, Harris A, et al. Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer. Cancer Sci 2006;97:582-588
13. Maxwell P, Pugh C, Ratcliffe P. Activation of the HIF pathway in cancer. Curr Opin Genet Dev 2001;11:293-299
14. Jaakkola P, Mole D, Tian Y, Wilson M, Gielbert J, Gaskell S, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-472
15. Weidemann A, Johnson R. Biology of HIF-1alpha. Cell Death Differ 2008;15:621-627
16. Theodoropoulos G, Lazaris A, Theodoropoulos V, Papatheodosiou K, Gazouli M, Bramis J, et al. Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer. Int J Colorectal Dis 2006;21:248-257
17. Lu X, Xing C, Feng Y, Chen J, Deng C. Clinical significance of immunohistochemical expression of hypoxia-inducible factor-1alpha as a prognostic marker in rectal adenocarcinoma. Clin Colorectal Cancer 2006;5:350-353
18. Koukourakis M, Giatromanolaki A, Sivridis E, Simopoulos C, Turley H, Talks K, et al. Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 2002;53:1192-1202
19. Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56:4509-4515
20. Korkeila E, Talvinen K, Jaakkola P, Minn H, Syrjänen K, Sundström J, et al. Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer. Br J Cancer 2009;100:874-880
21. Van Cutsem E, Dicato M, Wils J, Cunningham D, Diaz- Rubio E, Glimelius B, et al. Adjuvant treatment of colorectal cancer (current expert opinion derived from the Third International Conference: Perspectives in Colorectal Cancer, Dublin, 2001). Eur J Cancer 2002;38:1429-1436
22. Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin Cancer Res 2006;12:1080-1087
23. Wiesener M, Münchenhagen P, Berger I, Morgan N, Roigas J, Schwiertz A, et al. Constitutive activation of hypoxia- inducible genes related to overexpression of hypoxiainducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001;61:5215-5222
24. Rödel C, Martus P, Papadoupolos T, Füzesi L, Klimpfinger M, Fietkau R, et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 2005;23:8688-8696
25. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 1997;12:19-23.
26. Semenza G, Roth P, Fang H, Wang G. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994;269:23757-23763
27. Ravizza R, Molteni R, Gariboldi M, Marras E, Perletti G, Monti E. Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil. Eur J Cancer 2009;45:890-898
28. Appelhoff R, Tian Y, Raval R, Turley H, Harris A, Pugh C, et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 2004;279:38458-38465
29. Koukourakis M, Giatromanolaki A, Sivridis E, Pastorek J, Karapantzos I, Gatter K, et al. Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2004;59:67-71.
30. Cleven A, van Engeland M, Wouters B, de Bruïne A. Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol 2007;29:229-240
31. Yoshimura H, Dhar D, Kohno H, Kubota H, Fujii T, Ueda S, et al. Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res 2004;10:8554-8560
32. Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 2000; 60:4693-4696
33. Brizel D, Scully S, Harrelson J, Layfield L, Bean J, Prosnitz L, et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 1996;56:941-943
34. Semenza G. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 2007;12:853-859