Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer

International Journal of Colorectal Disease

Volumn 21, Issue 3, 2006, Pages 248-257

  Theodoropoulos, George E ^a,c   Lazaris, Andreas C ^b   Theodoropoulos, Vasilios E ^b   Papatheodosiou, Kalliopi ^b   Gazouli, Maria ^b   Bramis, John ^a   Patsouris, Efstratios ^b   Panoussopoulos, Dimitrios ^a  

^a HIPPOKRATION HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c NONE   (Greece)

Author keywords

Apoptotic index; HIF 1; Hypoxia inducible factor; Immunohistichemistry; Microvessel density; Rectal cancer; Vascular endothelial factor

Indexed keywords

BIOLOGICAL MARKER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BCL 2; PROTEIN P53; VASCULOTROPIN;

ADULT; ADVANCED CANCER; AGED; APOPTOSIS; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER LOCALIZATION; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; MULTIVARIATE ANALYSIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECTUM CANCER; STATISTICAL SIGNIFICANCE; TUMOR VASCULARIZATION; UNIVARIATE ANALYSIS; UPREGULATION;

AGED; ANOXIA; APOPTOSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; RECTAL NEOPLASMS; RECURRENCE; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 33244495520     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-005-0788-4     Document Type: Article

References (39)

1. Theodoropoulos G, Wise WE, Padmanabhan A, Kerner BA, Taylor CW, Aguilar PS, Khanduja KS (2002) T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 45:895-903
2. NIH Consensus Conference (1990) Adjuvant therapy for patients with colon and rectal cancer. JAMA 264(11):1444-1450
3. Bleday R, Wong WD (1993) Recent advances in surgery for colon and rectal cancer. Curr Probl Cancer 17:1-65
4. Vaughn DJ, Haller DG (1997) Adjuvant therapy for colorectal cancer: Past accomplishments, future directions. Cancer Investig 15:435-447
5. Dachs GU, Stratford IJ (1996) The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy. Br J Cancer Suppl 27:S126-S132
6. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157:411-421
7. Semenza GL (1999) Regulation of mammalian O 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551-578
8. Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 10:721-732
9. Jeong HJ, Cho SW, Kim HA, Lee SH, Cho JH, Choi DH, Kwon H, Cha WT, Han JE, Cha KY (2004) G769A Variation of inhibin alpha-gene in Korean women with premature ovarian failure. Yonsei Med J 45:479-482
10. Berra E, Pages G, Pouyssegur J (2000) MAP kinases and hypoxia in the control of VEGF expression. Cancer Metastasis Rev 19:139-145
11. Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47
12. Weidner N, Semple JP, Welch WR et al (1991) Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324:1-8
13. Uzzan B, Nicolas P, Cucherat M, Perret GY (2004) Microvessel density as a prognostic factor in women with breast cancer: A systematic review of the literature and meta-analysis. Cancer Res 64:2941-2955
14. Schwandner O, Schiedeck TH, Bruch HP, Duchrow M, Windhoevel U, Broll R (2000) Apoptosis in rectal cancer: Prognostic significance in comparison with clinical histopathologic, and immunohistochemical variables. Dis Colon Rectum 43:1227-1236
15. Cascinu S, Graziano F, Catalano V, Staccioli MP, Rossi MC, Baldelli AM, Barni S, Brenna A, Secondino S, Muretto P, Catalano G (2002) An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. Br J Cancer 86:744-749
16. Onita T, Ji PG, Xuan JW, Sakai H, Kanetake H, Maxwell PH, Fong GH, Gabril MY, Moussa M, Chin JL (2002) Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/ hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer. Clin Cancer Res 8:471-480
17. Birner P, Schindl M, Obermair A, Breitenecker G, Oberhuber G (2001) Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy. Clin Cancer Res 7:1661-1668
18. Reiher F, Ozer O, Pins M, Jovanovic BD, Eggener S, Campbell SC (2002) p53 and microvessel density in primary resection specimens of superficial bladder cancer. J Urol 167:1469-1474
19. Konstantinidou A, Korkolopoulou P, Patsouris E, Mahera H, Hranioti S, Kotsiakis X, Davaris P (2001) Apoptosis detected with monoclonal antibody to single-stranded DNA is a predictor of recurrence in intracranial meningiomas. J Neuro-oncol 55:1-9
20. Frankfurt OS, Robb JA, Sugarbaker EV, Villa L (1997) Apoptosis in breast carcinomas detected with monoclonal antibody to single-stranded DNA: relation to bcl-2 expression, hormone receptors, and lymph node metastases. Clin Cancer Res 3:465-471
21. Kirsh EJ, Baunoch DA, Stadler WM (1998) Expression of bcl-2 and bcl-X in bladder cancer. J Urol 159:1348-1353
22. Nanni O, Volpi A, Frassineti GL, De Paola F, Granato AM, Dubini A, Zoli W, Scarpi E, Turci D, Oliverio G, Gambi A, Amadori D (2002) Role of biological markers in the clinical outcome of colon cancer. Br J Cancer 87:868-875
23. Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI (2002) Tumor and Angiogenesis Research Group. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 95:1055-1063
24. Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH, Semenza GL (2001) Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61:2911-2916
25. Matsuura T, Kuratate I, Teramachi K, Osaki M, Fukuda Y, Ito H (1999) Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas. Cancer Res 59:5037-5040
26. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835
27. Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, Gatter KC, Harris AL (2001) Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 85:881-890
28. Kurokawa T, Miyamoto M, Kato K, Cho Y, Kawarada Y, Hida Y, Shinohara T, Itoh T, Okushiba S, Kondo S, Katoh H (2003) Overexpression of hypoxia-inducible-factor 1alpha (HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Br J Cancer 89:1042-1047
29. Theodoropoulos V, Lazaris Ach, Sofras F, Gerzelis I, Tsoukala V, Ghikonti I, Manikas K, Kastriotis I (2004) Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavourable prognosis in bladder cancer. European Urol (in press)
30. Lazaris AC, Theodoropoulos GE, Davaris PS, Panoussopoulos D, Nakopoulou L, Kittas C, Golematis BC (1995) Heat shock protein 70 and HLA-DR molecules tissue expression. Prognostic implications in colorectal cancer. Dis Colon Rectum 38:739-745
31. Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC (2004) Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res 64(5):1765-1772
32. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM (1995) Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55:3964-3968
33. Ishigami SI, Arii S, Furutani M, Niwano M, Harada T, Mizumoto M, Mori A, Onodera H, Imamura M (1998) Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br J Cancer 78:1379-1384
34. Cascinu S, Staccioli MP, Gasparini G, Giordani P, Catalano V, Ghiselli R, Rossi C, Baldelli AM, Graziano F, Saba V, Muretto P, Catalano G (2000) Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer. Clin Cancer Res 6:2803-2807
35. Lee JC, Chow NH, Wang ST, Huang SM (2000) Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer 36:748-753
36. Bossi P, Viale G, Lee AK, Alfano R, Coggi G, Bosari S (1995) Angiogenesis in colorectal tumors: Microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res 55:5049-5053
37. Elsaleh H, Soontrapornchai P, Grieu F, Joseph D, Iacopetta B (1999) P53 alterations have no prognostic or predictive significance in Dukes' C rectal carcinomas. Int J Oncol 15:1239-1243
38. Nehls O, Klump B, Holzmann K, Lammering G, Borchard F, Gruenagel HH, Gaco V, Gregor M, Porschen R (1999) Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma. Cancer 85:2541-2548
39. Sturm I, Kohne CH, Wolff G, Petrowsky H, Hillebrand T, Hauptmann S, Lorenz M, Dorken B, Daniel PT (1999) Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol 17:1364-1374